DE122011000008I1 - Herstellung enzymatischer aktiver glukocerebrosidase von rekombinanten zellen. - Google Patents

Herstellung enzymatischer aktiver glukocerebrosidase von rekombinanten zellen.

Info

Publication number
DE122011000008I1
DE122011000008I1 DE201112000008 DE122011000008C DE122011000008I1 DE 122011000008 I1 DE122011000008 I1 DE 122011000008I1 DE 201112000008 DE201112000008 DE 201112000008 DE 122011000008 C DE122011000008 C DE 122011000008C DE 122011000008 I1 DE122011000008 I1 DE 122011000008I1
Authority
DE
Germany
Prior art keywords
production
recombinant cells
enzymatic active
active glucocerebrosidase
glucocerebrosidase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE201112000008
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of DE122011000008I1 publication Critical patent/DE122011000008I1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE201112000008 1991-01-21 2011-02-24 Herstellung enzymatischer aktiver glukocerebrosidase von rekombinanten zellen. Pending DE122011000008I1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64415991A 1991-01-21 1991-01-21
PCT/US1992/000431 WO1992013067A1 (en) 1991-01-21 1992-01-17 Production of enzymatically active glucocerebrosidase from recombinant cells

Publications (1)

Publication Number Publication Date
DE122011000008I1 true DE122011000008I1 (de) 2012-09-20

Family

ID=24583696

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69213714T Expired - Lifetime DE69213714T2 (de) 1991-01-21 1992-01-17 Herstellung enzymatischer aktiver glukocerebrosidase von rekombinanten zellen
DE201112000008 Pending DE122011000008I1 (de) 1991-01-21 2011-02-24 Herstellung enzymatischer aktiver glukocerebrosidase von rekombinanten zellen.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69213714T Expired - Lifetime DE69213714T2 (de) 1991-01-21 1992-01-17 Herstellung enzymatischer aktiver glukocerebrosidase von rekombinanten zellen

Country Status (5)

Country Link
EP (1) EP0568647B1 (de)
CA (1) CA2099876C (de)
DE (2) DE69213714T2 (de)
IL (2) IL100715A (de)
WO (1) WO1992013067A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4113750A1 (de) * 1991-04-26 1992-10-29 Boehringer Mannheim Gmbh Verbesserung der renaturierung bei der sekretion von disulfidverbrueckten proteinen
DE69331805T2 (de) * 1992-12-10 2002-11-28 Enzon Inc Glycolipid enzym-polymer konjugate
USH1532H (en) * 1993-11-03 1996-05-07 Genetics Institute, Inc. Adaption of mammalian cell lines to high cell densities
US6083725A (en) 1996-09-13 2000-07-04 Transkaryotic Therapies, Inc. Tranfected human cells expressing human α-galactosidase A protein
US7138262B1 (en) 2000-08-18 2006-11-21 Shire Human Genetic Therapies, Inc. High mannose proteins and methods of making high mannose proteins
JP5570677B2 (ja) 2002-04-25 2014-08-13 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド α−ガラクトシダーゼＡ欠損症の治療
AU2013224728B2 (en) * 2006-02-07 2016-10-20 Takeda Pharmaceutical Company Limited Stabilized Compositions of Proteins Having a Free Thiol Moiety
EP2361613B1 (de) * 2006-02-07 2020-08-12 Shire Human Genetic Therapies, Inc. Stabilisierte Proteinzusammensetzungen mit einem freien Thiolanteil
EP2160403B1 (de) 2007-05-11 2018-08-08 Genzyme Corporation Verfahren zur herstellung eines sezernierten proteins
WO2010080720A2 (en) 2009-01-12 2010-07-15 Nektar Therapeutics Conjugates of a lysosomal enzyme moiety and a water soluble polymer
EP3354277B1 (de) 2009-07-28 2021-06-30 Takeda Pharmaceutical Company Limited Zusammensetzungen und verfahren zur behandlung der gaucher-krankheit
US9623090B2 (en) 2012-03-02 2017-04-18 Shire Human Genetic Therapies, Inc. Compositions and methods for treating type III gaucher disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910822A (en) * 1974-03-14 1975-10-07 Us Health Isolation of glucocerebrosidase from human placental tissue
WO1988000967A1 (en) * 1986-08-04 1988-02-11 The University Of New South Wales Serum free tissue culture medium containing polymeric cell-protective agent
WO1990007573A1 (en) * 1988-12-23 1990-07-12 Genzyme Corporation Enzymatically active recombinant glucocerebrosidase

Also Published As

Publication number Publication date
EP0568647B1 (de) 1996-09-11
CA2099876A1 (en) 1992-07-22
IL100715A0 (en) 1992-09-06
IL157458A0 (en) 2004-03-28
CA2099876C (en) 2002-03-26
IL100715A (en) 2004-07-25
WO1992013067A1 (en) 1992-08-06
DE69213714T2 (de) 1997-01-23
DE69213714D1 (de) 1996-10-17
EP0568647A1 (de) 1993-11-10
IL157458A (en) 2011-01-31

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