DE112020006626A5 - Fosalvudine and fozivudintidoxil for use in the treatment of the disease Covid-19 and the use of their structurally simplified derivatives - Google Patents

Fosalvudine and fozivudintidoxil for use in the treatment of the disease Covid-19 and the use of their structurally simplified derivatives Download PDF

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Publication number
DE112020006626A5
DE112020006626A5 DE112020006626.6T DE112020006626T DE112020006626A5 DE 112020006626 A5 DE112020006626 A5 DE 112020006626A5 DE 112020006626 T DE112020006626 T DE 112020006626T DE 112020006626 A5 DE112020006626 A5 DE 112020006626A5
Authority
DE
Germany
Prior art keywords
fozivudintidoxil
fosalvudine
treatment
structurally simplified
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE112020006626.6T
Other languages
German (de)
Inventor
Ralf Zuhse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiracon GmbH
Original Assignee
Chiracon GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiracon GmbH filed Critical Chiracon GmbH
Publication of DE112020006626A5 publication Critical patent/DE112020006626A5/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
DE112020006626.6T 2020-03-30 2020-03-30 Fosalvudine and fozivudintidoxil for use in the treatment of the disease Covid-19 and the use of their structurally simplified derivatives Pending DE112020006626A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2020/052996 WO2021198725A1 (en) 2020-03-30 2020-03-30 Fosalvudine and fozivudine tidoxil for use in the treatment of covid-19, and use of the structurally simplified derivatives thereof

Publications (1)

Publication Number Publication Date
DE112020006626A5 true DE112020006626A5 (en) 2022-12-08

Family

ID=70289825

Family Applications (1)

Application Number Title Priority Date Filing Date
DE112020006626.6T Pending DE112020006626A5 (en) 2020-03-30 2020-03-30 Fosalvudine and fozivudintidoxil for use in the treatment of the disease Covid-19 and the use of their structurally simplified derivatives

Country Status (3)

Country Link
DE (1) DE112020006626A5 (en)
TW (1) TW202140041A (en)
WO (1) WO2021198725A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4026265A1 (en) 1990-08-20 1992-02-27 Boehringer Mannheim Gmbh NEW PHOSPHOLIPID DERIVATIVES OF NUCLEOSIDES, THEIR PRODUCTION AND THEIR USE AS ANTIVIRAL MEDICINAL PRODUCTS
DE4402492A1 (en) 1994-01-28 1995-08-03 Boehringer Mannheim Gmbh Process for the production of asymmetrical phosphoric acid diesters
US20080249066A1 (en) * 2007-03-23 2008-10-09 Ardea Biosciences, Inc. Antiviral compounds and compositions

Also Published As

Publication number Publication date
WO2021198725A1 (en) 2021-10-07
TW202140041A (en) 2021-11-01

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