DE1081609B - Skin disinfectants - Google Patents

Skin disinfectants

Info

Publication number
DE1081609B
DE1081609B DEF25143A DEF0025143A DE1081609B DE 1081609 B DE1081609 B DE 1081609B DE F25143 A DEF25143 A DE F25143A DE F0025143 A DEF0025143 A DE F0025143A DE 1081609 B DE1081609 B DE 1081609B
Authority
DE
Germany
Prior art keywords
glycol
skin
monoethers
disinfectants
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DEF25143A
Other languages
German (de)
Inventor
Dr Ernst Gottsacker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DEF25143A priority Critical patent/DE1081609B/en
Priority to CH6971559A priority patent/CH375492A/en
Priority to GB723459A priority patent/GB906870A/en
Publication of DE1081609B publication Critical patent/DE1081609B/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Description

DEUTSCHESGERMAN

Es wurde gefunden, daß sich Monoäther aus Glykol und niederen aliphatischen Alkoholen — insbesondere aus Äthyl-, Propyl- und Butylalkoholen — hervorragend als Hautdesinfektionsmittel 'eignen.It has been found that monoethers of glycol and lower aliphatic alcohols - in particular made from ethyl, propyl and butyl alcohols - excellent as skin disinfectants.

Dies ist überraschend; denn wäßrige Lösungen von Glykolmonoalkyläthern der angeführten Art besitzen in vitro ein Keimtötungsvermögen, welches wesentlich geringer ist als das Keimtötungsvermögen von wäßrigen Lösungen gebräuchlicher Desinfektionsmittel von der Art der quaternären Ammoniumverbindungen, die einen aliphatischen Kohlenwasserstoffrest von mindestens 9 Kohlenstoffatomen am Stickstoffatom gebunden enthalten; das Keimtötungsvermögen derartiger quaternärer Ammoniumverbindungen auf der Haut ist jedoch unzulänglich. Hierauf ist es auch zurückzuführen, daß Glykolmonoalkyläther als Hautdesinfektionsmittel — z. B. in der ärztlichen Praxis zur Desinfektion der Hände — bislang noch niemals empfohlen worden sind.This is surprising; because have aqueous solutions of glycol monoalkyl ethers of the type mentioned in vitro a germicidal power which is significantly lower than the germicidal power of aqueous Solutions of common disinfectants of the quaternary ammonium compound type, which have an aliphatic hydrocarbon radical of at least 9 carbon atoms attached to the nitrogen atom contain; the germicidal ability of such quaternary ammonium compounds on the skin however, it is inadequate. It is also due to this that glycol monoalkyl ethers are used as skin disinfectants - e.g. B. in the medical practice for disinfecting the hands - so far never recommended have been.

Anmelder:Applicant:

Farbenfabriken Bayer Aktiengesellschaft, Leverkusen-BayerwerkPaint factories Bayer Aktiengesellschaft, Leverkusen-Bayerwerk

Dr. Ernst Gottsacker, Wuppertal-Bannen,
ist als Erfinder genannt wordenDr. Ernst Gottsacker, Wuppertal bans,
has been named as the inventor

Die nicht vorauszusehende Umkehrung der Wirkungsverhältnisse sei an Hand der Tabelle noch näher erläutert.The inversion of the effect relationships, which cannot be foreseen, is even closer on the basis of the table explained.

Desinfektionswirkung
in vitro Disinfection effect
in vitro

DesinfektionswirkungDisinfection effect

auf der Hauton the skin

Glykolmonoäthyläther Glycol monoethyl ether

Glykolmonopropyläther Glycol monopropyl ether

Glykolmonobutyläther Glycol monobutyl ether

Dimethyl-dodecyl-benzyl-ammoniumchlorid ..Dimethyl-dodecyl-benzyl-ammonium chloride ..

Dimethyl-dodecyl-S^-dichlorbenzyl-ammoniurn chlorid Dimethyl-dodecyl-S ^ -dichlorobenzyl-ammonium chloride

Die Bestimmung der Werte der Spalte a erfolgte durch Infizieren von Verdünnungsreihen der angegebenen Desinfektionsmittel in Wasser mit Coli-Bakterien und durch Abimpfen .in geeignete Nährböden nach 5 Minuten.The values in column a were determined by infecting dilution series of the specified Disinfectant in water with coli bacteria and by vaccinating in suitable culture media after 5 minutes.

Zur Bestimmung der Werte der Spalte b wurden von den Glykolmonoalkyläthern jeweils 1,5 g in Form 5O°/oiger wäßriger Lösungen auf den mit Coli-Bakterien stark infizierten Händen verschiedener Versuchspersonen 2 Minuten verrieben; durch Auskneten der Fingerkuppen in Nährbrühe und durch bakteriologische Untersuchung der Brühe wurde dann festgestellt, ob noch lebende Coli-Bakterien vorhanden waren. Zur Prüfung der quaternären Ammoniumverbindungen wurden die Hände der Versuchspersonen 5 Minuten in 2 1 wäßrigen Lösungen gewaschen, die im Liter 1 g dieser Wirkstoffe enthielten; konzentriertere Lösungen konnten nicht angewandt werden, 1:2 Abtötung
1:20 keine AbtötungTo determine the values in column b, 1.5 g of each of the glycol monoalkyl ethers, in the form of 50% aqueous solutions, were rubbed for 2 minutes on the hands of various test persons heavily infected with Coli bacteria; by kneading the fingertips in nutrient broth and by bacteriological examination of the broth it was then determined whether there were still living Coli bacteria present. To test the quaternary ammonium compounds, the hands of the test subjects were washed for 5 minutes in 2 liters of aqueous solutions containing 1 g of these active ingredients per liter; more concentrated solutions could not be used, 1: 2 kill
1:20 no kill

1:2 Abtötung1: 2 kill

1:20 keine Abtötung1:20 no kill

1:2 Abtötung
1:20 keine Abtötung1: 2 kill
1:20 no kill

1:5000 Abtötung
1:10 000 Abtötung1: 5000 kill
1:10 000 kill

in 80% der Fälle Abtötung in 100% der Fälle Abtötungin 80% of the cases killing in 100% of the cases killing

in 100% der Fälle Abtötung in 46% der Fälle Abtötungin 100% of the cases killing in 46% of the cases killing

in 25 %> der Fälle Abtötungin 25%> of the cases death

da sie von der Haut nicht vertragen werden. Anschließend wurde ebenfalls auf lebende Coli-Bakterien geprüft. as they are not tolerated by the skin. It was then also tested for live Coli bacteria.

Gewünschtenfalls können die Monoäther aus Glykol und niederen aliphatischen Alkoholen auch in Mischung mit anderen desinfizierenden Substanzen, z. B. mit 3,4-Dichlorbenzylalkohol oder mit quaternären Ammoniumverbindungen, als Hautdesinfektionsmittel verwendet werden.If desired, the monoethers of glycol and lower aliphatic alcohols can also be mixed with other disinfecting substances, e.g. B. with 3,4-dichlorobenzyl alcohol or with quaternary Ammonium compounds, used as skin disinfectants.

Es ist bekannt, daß Mischungen des Monophenyl- und des Mono-p-chlorphenyläthers des Glykols mit dem Monobutyläther des Glykols für Desinfektionszwecke aller Art verwendet werden können, wenn es sich um die Konservierung zersetzlicher Stoffe handelt. Die Daten, die in diesem Zusammenhang für die Desinfektionswirkung derartiger Mischungen in vitro angegeben sind, besagen, daß dem Monobutyläther des Glykols keine nennenswerte DesinfektionswirkungIt is known that mixtures of monophenyl and mono-p-chlorophenyl ethers of glycol with the monobutyl ether of glycol can be used for disinfection purposes of all kinds, if it is about the preservation of decomposable substances. The data in this context for the disinfection effect such mixtures are indicated in vitro, say that the monobutyl ether des Glycol has no notable disinfectant effect

O09 509/346O09 509/346

Claims (1)

innewohnt; sie haben nicht vermuten lassen, daß die Monoäther aus Glykol und Butylalkohol oder anderen niederen aliphatischen Alkoholen eine hervorragende pesinfektionswirkung jedoch.-dann ausüben, wenn sie · auf .die Haut aufgebracht _sind... ._ ■_. , ■ · 5;resides; they have not suggested that the monoethers are made from glycol and butyl alcohol or any other However, lower aliphatic alcohols have an excellent disinfectant effect - when they applied to .the skin _are ... ._ ■ _. , ■ · 5; Die Glykolmonophenylr und,. Glykolmono-p-chlorphenyläther selbst· sind ebenso wie die als Desinfektionsmittel weiterhin bekannten Monoäther aus Glykol und mindestens 6 Kohlenstoffatomen enthaltenden Alkoholen in Wasser unlöslich und- infolgedessen für die Zwecke der Hautdesinfektion ungeeignet. Im Gegensatz, hierzu bilden die Monoäther aus Glykol und niederen, höchstens 4 Kohlenstoffatome enthaltenden 'aliphatischen Alkoholen, die gemäß der vorliegenden Erfindung erstmals als Hautdesinfektionsmittel vorgeschlagen sind, mit Wasser in jedem Verhältnis klare Lösungen.The glycol monophenylr and ,. Glycol mono-p-chlorophenyl ether themselves are just like the monoethers made of glycol, which are also known as disinfectants and alcohols containing at least 6 carbon atoms, and therefore insoluble in water unsuitable for the purposes of skin disinfection. In contrast, the monoethers form from glycol and lower, at most 4 carbon atoms containing 'aliphatic alcohols according to the present Invention first proposed as a skin disinfectant, clear with water in any ratio Solutions. „.- v .. Patentanspruch:".- v .. claim: Verwendung von Monoäthern aus Glykol und niederen, höchstens 4 Kohlenstoffatome enthaltenden aliphatischen Alkoholen als Hautdesinfektionsmittel. Use of monoethers made from glycol and lower, no more than 4 carbon atoms aliphatic alcohols as skin disinfectants. In Betracht gezogene Druckschriften:
Deutsche Patentschriften Nr. 649 206, 659 786,
853 634, 947 827.Considered publications:
German patent specifications No. 649 206, 659 786,
853 634, 947 827. © 009 509/346 5. 60>© 009 509/346 5. 60>
DEF25143A 1958-02-28 1958-02-28 Skin disinfectants Pending DE1081609B (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DEF25143A DE1081609B (en) 1958-02-28 1958-02-28 Skin disinfectants
CH6971559A CH375492A (en) 1958-02-28 1959-02-18 Use of glycol ethers for surgical hand disinfection
GB723459A GB906870A (en) 1958-02-28 1959-03-02 Skin disinfectant compositions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF25143A DE1081609B (en) 1958-02-28 1958-02-28 Skin disinfectants

Publications (1)

Publication Number Publication Date
DE1081609B true DE1081609B (en) 1960-05-12

Family

ID=7091501

Family Applications (1)

Application Number Title Priority Date Filing Date
DEF25143A Pending DE1081609B (en) 1958-02-28 1958-02-28 Skin disinfectants

Country Status (3)

Country Link
CH (1) CH375492A (en)
DE (1) DE1081609B (en)
GB (1) GB906870A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100249166A1 (en) 2007-09-19 2010-09-30 Xy, Inc. Differential evaporation potentiated disinfectant system

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE649206C (en) * 1934-09-23 1937-08-19 Henkel & Cie Gmbh Disinfection method
DE659786C (en) * 1934-12-23 1938-05-10 Henkel & Cie Gmbh Disinfection method
DE853634C (en) * 1950-08-27 1952-10-27 Chemische Werke Huels Ges Mit Procedure for disinfecting the air
DE947827C (en) * 1942-11-16 1956-08-23 Dr Erich Boehm Process for the preservation of decomposable substances

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE649206C (en) * 1934-09-23 1937-08-19 Henkel & Cie Gmbh Disinfection method
DE659786C (en) * 1934-12-23 1938-05-10 Henkel & Cie Gmbh Disinfection method
DE947827C (en) * 1942-11-16 1956-08-23 Dr Erich Boehm Process for the preservation of decomposable substances
DE853634C (en) * 1950-08-27 1952-10-27 Chemische Werke Huels Ges Mit Procedure for disinfecting the air

Also Published As

Publication number Publication date
GB906870A (en) 1962-09-26
CH375492A (en) 1964-02-29

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