DE1045717B - Gastropod control agents - Google Patents

Gastropod control agents

Info

Publication number
DE1045717B
DE1045717B DEF23647A DEF0023647A DE1045717B DE 1045717 B DE1045717 B DE 1045717B DE F23647 A DEF23647 A DE F23647A DE F0023647 A DEF0023647 A DE F0023647A DE 1045717 B DE1045717 B DE 1045717B
Authority
DE
Germany
Prior art keywords
oxy
control agents
gastropod control
gastropod
snails
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DEF23647A
Other languages
German (de)
Inventor
Dr Rudolf Goennert
Dr Ernst Schraufstaetter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DEF23647A priority Critical patent/DE1045717B/en
Publication of DE1045717B publication Critical patent/DE1045717B/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
    • A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A01N37/30—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof containing the groups —CO—N< and, both being directly attached by their carbon atoms to the same carbon skeleton, e.g. H2N—NH—CO—C6H4—COOCH3; Thio-analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A01N37/48—Nitro-carboxylic acids; Derivatives thereof

Description

Gastropodenbekämpfungsmittel Schnecken sind nicht nur landwirtschaftliche Schädlinge, ihnen kommt auch große Bedeutung als Zwischenwirte für menschliche und tierische Infektionen zu. Alle Saugwürmer (Trematoden) machen in der Schnecke eine komplizierte Entwicklung durch, in deren Verlauf es zu intensiver ungeschlechtlicher Vermehrung der Larvenstadien kommt. So. verläuft z. B. der Entwicklungszyklus der Saugwürmer der Gattung Schistosoma, welche die wichtige tropische Bilharzioseerkrankung des Menschen hervorrufen, folgendermaßen Die Wurmeier werden mit den Fäkalien ausgeschieden. Sie enthalten eine voll entwickelte Larve (Miracidium), die im Wasser aus dem Ei schlüpft und in Schnecken eindringt, die als Zwischenwirte geeignet sind. In diesen entwickeln sich aus dem Miracidium bis zu 40000 Cercarien, die aus der Schnecke auswandern und befähigt sind, die intakte menschliche Haut zu durchbohren. Im Menschen wachsen die Parasiten dann zur Geschlechtsreife heran.Gastropod Control Snails are not just agricultural Pests, they are also of great importance as intermediate hosts for human and animal infections too. All flukes (trematodes) make one in the snail complicated development in the course of which it becomes more intense asexual The larval stages multiply. So. z. B. the development cycle of the Flukes of the genus Schistosoma, which are the important tropical schistosomiasis disease of humans, as follows: The worm eggs are excreted with the faeces. They contain a fully developed larva (Miracidium) that is in the water from the egg hatches and enters snails, which are suitable as intermediate hosts. In these Up to 40,000 cercariae develop from the miracidium, those from the snail emigrate and are able to pierce intact human skin. In man the parasites then grow to sexual maturity.

Eine Bekämpfung der Trematodenerkrankungen kann demnach auf zwei verschiedenen Wegen erfolgen: 1. medikamentöse Behandlung der infizierten Menschen oder Tiere, 2. Vernichtung der als Zwischenwirte dienenden Schnecken und damit Unterbrechung des Entwicklungszyklus der Parasiten.Combating trematode diseases can therefore be based on two different methods Because of: 1. drug treatment of infected humans or animals, 2. Destruction of the snails serving as intermediate hosts and thus interruption the development cycle of the parasites.

Für epidemiologische Bekämpfungsmaßnahmen scheint der zweite Weg der erfolgversprechendere zu sein, ist es doch mit Hilfe der Chemotherapeutika bisher nicht gelungen, die Zahl der Bilharziosekranken wesentlich zu reduzieren. Als Schneckenbekämpfungsmittel wird seit langem Kupfersulfat verwendet. Neuerdings wird besonders Pentachlorphenol als Mollus,cicid empfohlen. Vor kurzem wurde auch die Schnecken abtötende Wirkung des 5,5'-Dibromsalicyls bekannt. Die Spezifität der genannten Verbindung ist jedoch noch relativ gering. So zeigen die bisher untersuchten Substanzen bestenfalls eine Wirkung bis zur Verdünnung von 10-5 bis 10-5.5.For epidemiological control measures, the second way seems to be So far, it has been more promising with the help of chemotherapeutic agents failed to significantly reduce the number of schistosomiasis patients. As a snail control agent copper sulfate has long been used. Recently, pentachlorophenol in particular has been used Recommended as a mollus, cicid. Recently the snail killing effect was also used of 5,5'-dibromosalicylic known. However, the specificity of the said compound is still relatively low. The substances examined so far show at best one Effect up to dilution from 10-5 to 10-5.5.

Es wurde nun gefunden, d'aß halogenierte 2-Oxythiobenzanilide bzw. deren acylierte Derivate oder Salze, die noch durch Nitrogruppen und gegebenenfalls weitere Gruppen, wie z. B. Alkylgruppen, substituiert sein können, hochwirksame Schneckenbekämpfungsmittel darstellen.It has now been found that halogenated 2-oxythiobenzanilides or their acylated derivatives or salts, which are also replaced by nitro groups and optionally other groups, such as B. alkyl groups, can be substituted, highly effective Represent snail control agents.

Geeignete Verbindungen sind z. B.: 2-Oxy-5-chlort'hiobenzanilid (Schmp.: 155° C) ; 2-Oxy-5, 4'-dichlorthiobenzanilid (Schmp.: 185° C) ; 2-Acetoxy-5, 4'-dichlor-thiobenzanilid (Schm.: 144° C) ; 2-Oxy-5, 3', 5'-trichlor-thiobenzanilid (Schmp.: 149° C) ; 2-Oxy-5-chlo-r-4'-nitrothiobenzanilid (Schmp.: 182° C). Die Herstellung dieser Verbindungen erfolgt nach an sich bekannten Methoden, z. B. durch Umsetzung von Phenylsenföl bzw. dessen Derivaten mit geeigneten Phenolen nach Friede 1- C r a f t s.Suitable compounds are e.g. E.g .: 2-oxy-5-chlorot'hiobenzanilide (m.p .: 155 ° C); 2-oxy-5, 4'-dichlorothiobenzanilide (m.p .: 185 ° C); 2-acetoxy-5, 4'-dichloro-thiobenzanilide (M.p .: 144 ° C); 2-oxy-5, 3 ', 5'-trichlorothiobenzanilide (m.p .: 149 ° C); 2-Oxy-5-chloro-r-4'-nitrothiobenzanilide (M.p .: 182 ° C). These compounds are prepared according to known methods Methods, e.g. B. by reacting phenyl mustard oil or its derivatives with suitable ones Phenols according to Friede 1- C r a f t s.

Die wirksamen Verbindungen können allein oder als Gemisch von zwei oder mehreren solcher Verhindungen angewandt werden. Sie können als solche oder nach Verarbeitung mit einem geeigneten Träger, wobei gegebenenfalls noch ein anderes molluscicides Mittel zugesetzt werden kann, angewendet werden. Geeignete Träger für staubförmige Zubereitungen sind z. B. Fullererde, Bentonit, Talkum, Holzmehl usw. Diesen pulverförmigen Produkten können auch noch Netzmittel zugesetzt werden. Flüssige Zubereitungen erhält man, wenn man die Wirkstoffe mit einem Emulgator und Wasser und/oder einem organischen Lösungsmittel verarbeitet. Beispiel l Je zehn Schnecken (Australarbis guadelupensis) werden in Bechergläser verschiedenen Konzentrationen der zu untersuchenden Substanzen ausgesetzt. Auf diese Weise wird diejenige Konzentration ermittelt, bei der nach 24stündiger Einwirkung sämtliche Schnecken abgetötet werden. Die Ergebnisse dieser Prüfung sind in folgender Tabelle zusammengestellt: Geprüfte Verbindung Wirksame Konzentration Pentachlorphenol ............... 10-5 5, 5'-Dibromsalicil . . . . . . . . . . . . . . 10-5 2-Oxy-5, 4'-dichlo-r-thiobenzanilid . . 10-s 2-Oxy-5, 3', 5'-trichlor-thiobenz- an.ilid . ... ....... ....... 10-s 2-Oxy-5-chlor-4'-nitro-thiobenz- anilid ....................... 10-s Beispiel 2 50g 2-Oxy-5, 4'-dichlor-thiobenzanilid werden mit 50g Talkum vermischt und fein vermahlen. Beispiel 3 15g 2-Oxy-5, 3', 5'-trichlor-thiobenzanilid werden mit 80g Glykolmonobutyläther und 5 g eines Polyglykolphenylätheremulgators zu einer Suspension verarbeitet und diese Suspension zur Schneckenbekämpfung verwendet.The active compounds can be used alone or as a mixture of two or more such preventions. They can be used as such or after processing with a suitable carrier, with another molluscicidal agent optionally also being able to be added. Suitable carriers for powdered preparations are, for. B. Fuller's earth, bentonite, talc, wood flour, etc. Wetting agents can also be added to these powdery products. Liquid preparations are obtained when the active ingredients are processed with an emulsifier and water and / or an organic solvent. Example 1 Ten snails (Australarbis guadelupensis) are exposed to different concentrations of the substances to be examined in beakers. In this way, the concentration at which all snails are killed after 24 hours of exposure is determined. The results of this test are summarized in the following table: Tested connection effective concentration Pentachlorophenol ............... 10-5 5,5'-dibromosalicil. . . . . . . . . . . . . . 10-5 2-Oxy-5, 4'-dichlo-r-thiobenzanilide. . 10-s 2-oxy-5, 3 ', 5'-trichloro-thiobenz- an.ilid. ... ....... ....... 10-s 2-oxy-5-chloro-4'-nitro-thiobenz- anilide ....................... 10-s Example 2 50 g of 2-oxy-5, 4'-dichloro-thiobenzanilide are mixed with 50 g of talc and finely ground. Example 3 15 g of 2-oxy-5, 3 ', 5'-trichlorothiobenzanilide are processed into a suspension with 80 g of glycol monobutyl ether and 5 g of a polyglycol phenyl ether emulsifier and this suspension is used for combating snails.

Claims (2)

PATENTANSPRÜCHE: 1. Gastropodenbekämpfungsmittel, enthaltend halogenierte 2-Oxy-thiobenzanilide bzw. deren acylierte Derivate oder Salze, die noch durch Nitrogruppen substituiert sein können. PATENT CLAIMS: 1. Gastropod control agents containing halogenated 2-Oxy-thiobenzanilides or their acylated derivatives or salts, which are still through nitro groups can be substituted. 2. Gastropodenbekämpfungsmittel nach Anspruch 1, dadurch gekennzeichnet, daß es den Wirkstoff in Staubform mit einem staubförmigen Träger gemischt oder in suspendierter Form oder in einem Lösungsmittel gelöst enthält.2. gastropod control agent according to claim 1, characterized characterized in that it takes the active ingredient in dust form with a dust-like carrier contains mixed or in suspended form or dissolved in a solvent.
DEF23647A 1956-07-06 1956-07-06 Gastropod control agents Pending DE1045717B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DEF23647A DE1045717B (en) 1956-07-06 1956-07-06 Gastropod control agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF23647A DE1045717B (en) 1956-07-06 1956-07-06 Gastropod control agents

Publications (1)

Publication Number Publication Date
DE1045717B true DE1045717B (en) 1958-12-04

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ID=7090928

Family Applications (1)

Application Number Title Priority Date Filing Date
DEF23647A Pending DE1045717B (en) 1956-07-06 1956-07-06 Gastropod control agents

Country Status (1)

Country Link
DE (1) DE1045717B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1568522B1 (en) * 1966-05-06 1970-11-12 Bayer Ag Thionosalicylic acid anilides and process for their preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1568522B1 (en) * 1966-05-06 1970-11-12 Bayer Ag Thionosalicylic acid anilides and process for their preparation

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