DE10255276A1 - Precise, contamination-free dosing of liquids onto surface with hydrophilic or oleophilic areas surrounded by ultraphobic areas comprises applying drop of liquid to hydrophilic or oleophilic areas - Google Patents

Precise, contamination-free dosing of liquids onto surface with hydrophilic or oleophilic areas surrounded by ultraphobic areas comprises applying drop of liquid to hydrophilic or oleophilic areas Download PDF

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Publication number
DE10255276A1
DE10255276A1 DE2002155276 DE10255276A DE10255276A1 DE 10255276 A1 DE10255276 A1 DE 10255276A1 DE 2002155276 DE2002155276 DE 2002155276 DE 10255276 A DE10255276 A DE 10255276A DE 10255276 A1 DE10255276 A1 DE 10255276A1
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Prior art keywords
hydrophilic
layer
areas
oleophilic
ultraphobic
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DE2002155276
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German (de)
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Sunyx Surface Nanotechnologies GmbH
Scienion GmbH
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Sunyx Surface Nanotechnologies GmbH
Scienion GmbH
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Application filed by Sunyx Surface Nanotechnologies GmbH, Scienion GmbH filed Critical Sunyx Surface Nanotechnologies GmbH
Priority to DE2002155276 priority Critical patent/DE10255276A1/en
Priority to EP03742575A priority patent/EP1478456A1/en
Priority to US10/505,632 priority patent/US20060013735A1/en
Priority to PCT/EP2003/001858 priority patent/WO2003071274A1/en
Priority to PCT/EP2003/001859 priority patent/WO2003071275A1/en
Priority to US10/505,616 priority patent/US7456392B2/en
Priority to AU2003210342A priority patent/AU2003210342A1/en
Priority to AU2003215590A priority patent/AU2003215590A1/en
Priority to AU2003215589A priority patent/AU2003215589A1/en
Priority to EP03742573A priority patent/EP1478925A1/en
Priority to US10/505,617 priority patent/US20050282164A1/en
Priority to EP03742574A priority patent/EP1478926A1/en
Priority to PCT/EP2003/001860 priority patent/WO2003070364A1/en
Publication of DE10255276A1 publication Critical patent/DE10255276A1/en
Withdrawn legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
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    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614—Delimitation of the attachment areas
    • B01J2219/00617—Delimitation of the attachment areas by chemical means
    • B01J2219/00619—Delimitation of the attachment areas by chemical means using hydrophilic or hydrophobic regions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00677—Ex-situ synthesis followed by deposition on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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    • B01J2219/00743—Cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
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    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B01L2300/166—Suprahydrophobic; Ultraphobic; Lotus-effect
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
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    • C40—COMBINATORIAL TECHNOLOGY
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    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/22—Devices for withdrawing samples in the gaseous state

Abstract

Method for precise, contamination-free dosing of liquids (1) onto surface (2) with hydrophilic and/or oleophilic areas (3) surrounded by ultraphobic areas (5) comprises applying a drop (4) of liquid to the hydrophilic and/or oleophilic areas, to which the liquid adheres. An Independent claim is also included for use of the surfaces in analysis of samples using mass spectroscopy.

Description

In einer bevorzugten Ausführungsform wird die ultraphobe Oberfläche als Einmalartikel gestaltet.In a preferred embodiment becomes the ultraphobic surface designed as a disposable item.

Für diese Ausführungsform ist insbesondere ein mehrschichtiges Flächengebilde mit einer ersten Schicht mit einer ultraphoben Oberfläche und einer Trägerschicht geeignet, wobei die erste Schicht auf der Trägerschicht reversibel aufgebracht ist und die maximale lokale Abweichung des Flächengebildes von der Planheit < 100 μm, besonders bevorzugt < 20 μm auf einer Länge von 100 mm beträgt.For this embodiment is in particular a multi-layer fabric with a first layer with an ultraphobic surface and a backing layer suitable, the first layer being reversibly applied to the carrier layer and the maximum local deviation of the fabric from the flatness is <100 μm, particularly preferably <20 μm on one length of Is 100 mm.

Dieses Flächengebilde hat den Vorteil, dass die erste Schicht mit der ultraphoben Oberfläche nach einmaliger oder mehrmaliger Verwendung von der Trägerschicht abgelöst werden kann und durch eine neue erste Schicht ersetzt werden kann, so dass ausgeschlossen ist, dass diese erste Schicht durch vorherige vorhergehende Experimente kontaminiert worden ist. Die erste Schicht mit der ultraphoben Oberfläche ist als Einmalartikel besonders günstig herzustellen. Durch die erfindungsgemäß definierte Planheit ist sichergestellt, dass das Flächengebilde in allen gängigen massenspektrometrischen und/oder optischen Analysegeräten einsetzbar ist.This fabric has the advantage that the first layer with the ultraphobic surface after single or multiple use of the carrier layer superseded can be replaced by a new first layer, so that this first layer is precluded by previous ones previous experiments has been contaminated. The first layer with the ultraphobic surface is particularly inexpensive to manufacture as a disposable item. Through the Flatness defined according to the invention it is ensured that the fabric in all common Mass spectrometric and / or optical analyzers can be used is.

In einer bevorzugten Ausführungsform des Flächengebildes ist die erste Schicht auf die Trägerschicht aufgeklebt.In a preferred embodiment of the fabric is the first layer on the backing layer glued.

Weiterhin bevorzugt besteht zwischen der ersten Schicht und der Trägerschicht ein elektrischer Kontakt. Diese Ausführungsform ist insbesondere bei massenspektroskopischen Analysen von Vorteil.Furthermore, there is preferably between the first layer and the support layer an electrical contact. This embodiment is particular advantageous for mass spectrometric analyzes.

Vorzugsweise weist die ultraphobe Oberfläche mindestens einen Bereich auf, der hydrophiler als die Umgebung ist, auf dem oben die auf dem Flächengebilde abgelegt werden, verankert werden können und dort während eines Trocknungsprozesses auskristallisieren.Preferably, the ultraphobic surface at least one area that is more hydrophilic than the environment, on top of that on the fabric can be stored, anchored and there during a Crystallize drying process.

Das erfindungsgemäße Flächengebilde ist manigfaltig einsetzbar, vorzugsweise eignet es sich jedoch bei massenspektroskopischen und/oder optischen Analysen.The fabric according to the invention is varied usable, but it is preferably suitable for mass spectrometry and / or optical analyzes.

Im folgenden wird das mehrschichtige Flächengebilde anhand von 1 erläutert. Diese Erläuterungen sind lediglich beispielhaft und schränken den allgemeinen Erfindungsgedanken nicht ein.In the following, the multi-layer fabric is based on 1 explained. These explanations are only examples and do not limit the general inventive concept.

1 zeigt das Flächengebilde 1, dass aus einer ersten Schicht 2 mit einer ultraphoben Oberfläche 3 und einer Trägerschicht 4 besteht. Die erste Schicht 2 ist auf der Trägerschicht mittels einer Klebschicht 5 fixiert. Der Fachmann erkennt, dass die Klebschicht 5 nicht notwendigerweise vorhanden sein muß. Die Klebschicht 5 besteht aus einem elektrisch leitenden Material, so dass ein elektrischer Kontakt zwischen der ersten Schicht 2 und dem Trägermaterial besteht. 1 shows the fabric 1 that from a first layer 2 with an ultraphobic surface 3 and a backing layer 4 consists. The first layer 2 is on the carrier layer by means of an adhesive layer 5 fixed. The person skilled in the art recognizes that the adhesive layer 5 need not necessarily be present. The adhesive layer 5 consists of an electrically conductive material, so that an electrical contact between the first layer 2 and the carrier material.

Claims (6)

Mehrschichtiges Flächengebilde (1) mit einer ersten Schicht (2) mit einer ultraphoben Oberfläche (3) und mit einer Trägerschicht (4), dadurch gekennzeichnet, dass die erste Schicht (2) auf einer Trägerschicht (4) reversibel aufgebracht ist und die maximale lokale Abweichung des Flächengebildes von der Planheit < 100 μm beträgt.Multi-layer fabric ( 1 ) with a first layer ( 2 ) with an ultraphobic surface ( 3 ) and with a backing layer ( 4 ), characterized in that the first layer ( 2 ) on a carrier layer ( 4 ) is applied reversibly and the maximum local deviation of the fabric from the flatness is <100 μm. Flächengebilde nach Anspruch 1, dadurch gekennzeichnet, daß die erste Schicht (2) auf die Trägerschicht (4) aufgeklebt ist.Flat structure according to claim 1, characterized in that the first layer ( 2 ) on the carrier layer ( 4 ) is glued on. Flächengebilde nach einem der voranstehenden Ansprüche, dadurch gekennzeichnet, dass zwischen der ersten Schicht (2) und der Trägerschicht (4) ein elektrischer Kontakt besteht.Flat structure according to one of the preceding claims, characterized in that between the first layer ( 2 ) and the carrier layer ( 4 ) there is an electrical contact. Flächengebilde nach einem der voranstehenden Ansprüche, dadurch gekennzeichnet, dass die ultraphobe Oberfläche (3) mindestens einen hydrophilen Bereich aufweist.Flat structure according to one of the preceding claims, characterized in that the ultraphobic surface ( 3 ) has at least one hydrophilic area. Flächengebilde nach einem der voranstehenden Ansprüche, dadurch gekennzeichnet, dass die Schicht (2) ein Wegwerfartikel ist.Flat structure according to one of the preceding claims, characterized in that the layer ( 2 ) is a disposable item. Verwendung des Flächengebildes nach einem der voranstehenden Ansprüche zur massenspektroskopischen und/oder optischen Analyse.Use of the fabric according to one of the preceding claims for mass spectroscopic and / or optical analysis.
DE2002155276 2002-02-22 2002-11-26 Precise, contamination-free dosing of liquids onto surface with hydrophilic or oleophilic areas surrounded by ultraphobic areas comprises applying drop of liquid to hydrophilic or oleophilic areas Withdrawn DE10255276A1 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
DE2002155276 DE10255276A1 (en) 2002-11-26 2002-11-26 Precise, contamination-free dosing of liquids onto surface with hydrophilic or oleophilic areas surrounded by ultraphobic areas comprises applying drop of liquid to hydrophilic or oleophilic areas
EP03742575A EP1478456A1 (en) 2002-02-22 2003-02-24 Ultraphobic sample carrier having functional hydrophilic and/or oleophilic areas
US10/505,632 US20060013735A1 (en) 2002-02-22 2003-02-24 Ultraphobic surface having a multitude of reversibly producible hydrophilic and/or oleophilic areas
PCT/EP2003/001858 WO2003071274A1 (en) 2002-02-22 2003-02-24 Use of ultraphobic surfaces having a multitude of hydrophilic areas for analyzing samples
PCT/EP2003/001859 WO2003071275A1 (en) 2002-02-22 2003-02-24 Ultraphobic surface having a multitude of reversibly producible hydrophilic and/or oleophilic areas
US10/505,616 US7456392B2 (en) 2002-02-22 2003-02-24 Use of ultraphobic surfaces having a multitude of hydrophilic areas for analyzing samples
AU2003210342A AU2003210342A1 (en) 2002-02-22 2003-02-24 Use of ultraphobic surfaces having a multitude of hydrophilic areas for analyzing samples
AU2003215590A AU2003215590A1 (en) 2002-02-22 2003-02-24 Ultraphobic sample carrier having functional hydrophilic and/or oleophilic areas
AU2003215589A AU2003215589A1 (en) 2002-02-22 2003-02-24 Ultraphobic surface having a multitude of reversibly producible hydrophilic and/or oleophilic areas
EP03742573A EP1478925A1 (en) 2002-02-22 2003-02-24 Use of ultraphobic surfaces having a multitude of hydrophilic areas for analyzing samples
US10/505,617 US20050282164A1 (en) 2002-02-22 2003-02-24 Ultraphobic sample carrier having functional hydrophilic and/or oleophilic areas
EP03742574A EP1478926A1 (en) 2002-02-22 2003-02-24 Ultraphobic surface having a multitude of reversibly producible hydrophilic and/or oleophilic areas
PCT/EP2003/001860 WO2003070364A1 (en) 2002-02-22 2003-02-24 Ultraphobic sample carrier having functional hydrophilic and/or oleophilic areas

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2002155276 DE10255276A1 (en) 2002-11-26 2002-11-26 Precise, contamination-free dosing of liquids onto surface with hydrophilic or oleophilic areas surrounded by ultraphobic areas comprises applying drop of liquid to hydrophilic or oleophilic areas

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DE10255276A1 true DE10255276A1 (en) 2004-06-03

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