DE102023136398A1 - Retaining element for a fluid connection of an analysis device - Google Patents

Abstract

An analysis device (10) for analyzing a fluid sample is described, the analysis device (10) comprising:i) a housing (110); andii) a holding element (100), which is coupled to the housing (110), for holding a fluid connection (26), in particular a hose; wherein the holding element (100) is movable with respect to the housing (110).

Description

TECHNICAL BACKGROUND

The present invention relates to an analysis device (e.g. a chromatography device) for analyzing a fluidic sample, the analysis device having a housing and a holding element which is coupled to the housing. The holding element is here set up to hold a fluid connection (e.g. a solvent hose) and is movable (e.g. displaceable, rotatable, etc.) with respect to the housing. The invention further relates to an analysis device arrangement, an analysis device system, and a method for operating the analysis device.

Analysis devices are, for example, chromatography devices, in particular sample separation devices, for analyzing a sample, in particular fluidic sample, for example for carrying out a chromatographic separation of the sample.

For example, in a high performance liquid chromatography (HPLC) chromatography machine, a liquid (mobile phase) is flowed at a very precisely controlled flow rate (e.g. in the range of microliters to milliliters per minute) and at a high pressure (typically 20 to 1000 bar and beyond, currently up to 2000 bar), at which the compressibility of the liquid can be noticeable, moved through a so-called stationary phase (for example in a chromatographic column) to separate individual fractions of a sample liquid introduced into the mobile phase separate. After passing through the stationary phase, the separated fractions of the fluidic sample are detected in a detector. Such an HPLC system is known, for example, from EP 0,309,596 B1 same applicant, Agilent Technologies, Inc.

One or more solvents are usually used for the mobile phase, into whose flow the sample to be analyzed is then injected. A solvent is a consumable that is stored in a container (e.g. a bottle, a container, etc.). For example, a first container is filled with a first solvent (e.g. water), while a second container is filled with a second solvent (e.g. methanol).

In 3A A conventional chromatography device is shown, which has a housing 210 in which the analytical domain is located. On the housing 210, containers 25 for solvents (eg water and methanol as described above) are arranged in a storage area 28 or a container holding device above the actual chromatography device. Each container 25 is connected to analytical elements (in the housing 210) via a fluid line 26, for example by means of a fluid pump, which is usually arranged in the lower part of the housing 210. For this purpose, the fluid lines 26 usually hang loosely from the respective container 25 down to the lower part of the housing 210.

However, with the conventional arrangement of hanging down the fluid lines, it is usually not easy to track which solvent leads to which pump channel. This can increase the susceptibility to errors and the fluid lines take up an unnecessarily large amount of space.

A conventional solution is to locate the fluid lines within the housing. However, this entails additional effort because all the doors of the housing must always be opened in order to arrange, replace or remove the fluid lines. Furthermore, additional space is then required within the housing and the accessibility of the parts within the housing (e.g. for service, problem solving, maintenance) is blocked.

In the example of 3A A conventional solution is also shown, in which the fluid lines 26 are attached to the side wall of the housing 210 by means of a holder 200. 3B shows a detailed view of the holder 200. It can be seen that the fluid lines 26 are fixed next to one another by means of the holder 200. However, this solution is not ideal either because additional space is still required on the side wall of the chromatography device. For example, two chromatography devices cannot be placed close to each other (with a minimal distance) next to each other. The fluid lines would also still be insufficiently accessible and difficult to see.

SUMMARY OF THE INVENTION

There may be a need to arrange fluid connections of an analysis device in an efficient, space-saving and user-friendly manner.

An analysis device, an analysis device arrangement, an analysis device system, a method for operating an analysis device, and use are described below.

1. i) ein Gehäuse (in welchem die analytische Domäne bzw. die analytischen Einheiten/Elemente untergebracht ist/sind, z.B. Fluidpumpe, Detektor, Trennsäule, etc.); und
2. ii) ein Haltelement (z.B. eine Haltebasis mit einer Haltestruktur), das mit dem Gehäuse gekoppelt (z.B. angeordnet, angebracht, befestigt) ist, zum Halten einer Fluidverbindung (z.B. einer Fluidleitung, insbesondere eines Schlauches (für Lösungsmittel)) (insbesondere zumindest zwei Fluidverbindungen).

Das Haltelement ist hierbei (insbesondere zusammen mit der Fluidverbindung) bezüglich des Gehäuses bewegbar (bzw. beweglich).According to a first aspect of the invention, an analysis device (eg a chromatography device) for analyzing a fluidic sample is described, the analysis device having:

1. i) a housing (in which the analytical domain or the analytical units/elements is/are housed, e.g. fluid pump, detector, separation column, etc.); and
2. ii) a holding element (eg a holding base with a holding structure), which is coupled (eg arranged, attached, fastened) to the housing, for holding a fluid connection (eg a fluid line, in particular a hose (for solvents)) (in particular at least two fluid connections ).

The holding element is movable (or movable) with respect to the housing (in particular together with the fluid connection).

According to a second aspect of the invention, an analysis device arrangement is described, comprising: an analysis device as described above, and a container (e.g. a solvent bottle) for consumables (e.g. solvent), the container being in a storage area (of the analysis device, in particular on the housing). is stored, and wherein the fluid connection is connected to the container (in particular a first fluid connection is connected to a first container, and a second fluid connection is connected to a second container, etc.) and / or is held by the holding element (in particular wherein the fluid connection is connected to the container and is movably attached to the housing by means of the holding element).

According to a third aspect of the invention, an analysis device system is described, comprising an analysis device or an analysis device arrangement as described above, and a further analysis device which is arranged next to, in particular with physical contact, the analysis device, the holding element being at least partially between the two analysis devices is arranged. In other words, two or more analysis devices as described above are provided, each comprising a holding element as described above, arranged next to one another, in particular with physical contact, the respective holding element being attached to the respective analysis device in such a way that it is between an external position and an internal position is movable.

• i) Lagern von einem Behälter für Verbrauchsmaterial (insbesondere auf einem Gehäuse der Analysevorrichtung);
• ii) Verbinden von einer Fluidverbindung mit dem Behälter;
• iii) Halten von der Fluidverbindung mittels eines Halteelements in Bezug zu einem Gehäuse der Analysevorrichtung; und
• iv) Bewegen des Haltelements (mit der gehaltenen Fluidverbindung) bezüglich des Gehäuses.

According to a fourth aspect of the invention, a method for operating an analysis device is described, the method comprising:

• i) storing a container for consumables (in particular on a housing of the analysis device);
• ii) connecting a fluid connection to the container;
• iii) holding the fluid connection by means of a holding element in relation to a housing of the analysis device; and
• iv) moving the retaining element (with the retained fluid connection) with respect to the housing.

According to a fifth aspect of the invention, using a holding element is described in order to fasten two or more solvent tubes and to move them relative to a housing of an analysis device, in particular a chromatography device, by means of a holding element.

In the context of this document, the term “container” may refer in particular to a device that has a volume in which a consumable can be accommodated. In principle, the container can be designed as a container, for example. In a specific example, the container may be designed as a solvent bottle. The container can be fluidly coupled to further components of the analysis device, in particular to a flow path that leads to a fluid drive.

In the context of this document, the term “consumable material” can in particular refer to a material that is at least partially consumed when carrying out an analysis in an analysis device. If the analysis device is designed, for example, as a chromatography device, the consumable material can be a solvent by means of which the mobile phase is provided.

In the context of this document, the term “fluidic sample” is understood to mean in particular a medium, more particularly a liquid, which contains the matter actually to be analyzed (for example a biological sample), such as a protein solution, a pharmaceutical sample , Etc.

In the context of the present document, the term “mobile phase” is understood to mean in particular a fluid, more particularly a liquid, which serves as a carrier medium for transporting the fluidic sample between a fluid drive and a sample separation device. However, mobile phase can also be used in a fluid delivery device to influence the fluidic sample. For example, the mobile phase may be a solvent (e.g., organic and/or inorganic) or a solvent composition (e.g., water and ethanol).

In the context of this document, the term “analysis device” can in particular denote a device that is capable and configured to examine a fluidic sample, in particular to separate it, and further in particular to separate it into different fractions. For example, such sample separation can be carried out using chromatography or electrophoresis. Preferably, the analysis device can be a liquid chromatography sample separation device. The analysis device is in particular configured to carry out an analysis method or a (possibly planned or programmed) sequence of analysis methods or procedures. Furthermore, the term “analysis method” can also be used to represent a sequence, a sequence, a program, an execution list of analysis methods, procedures or regulations, including adjustment, preparation, equilibration (intermediate) steps, etc.

The elements/units necessary for a corresponding analysis (e.g. fluid pump, separation device, detector, sample injector) can preferably be arranged at least partially within a “housing”. In one exemplary embodiment, the housing can have side walls, for example made of plastic or metal. In one example, the analysis device has a single housing in which the elements for analysis are arranged. In a further example, at least two of the elements of the analysis device each have their own housing. For example, one or more of the elements such as fluid drive, sampler, sample separation device, detector can each be arranged in a separate housing (see e.g 2 ). In one example, these separate housings can be stacked in a vertical direction, so that the separate housings can be viewed as a (common) housing of the analysis device.

In the context of this document, the term “fluid connection” can refer in particular to a device which is suitable for a fluid to flow through at least partially. The fluid can be, for example, a solvent or a sample in a mobile phase. In one example, a fluid connection can be designed as a fluid line, in particular, for example, as one of a (solvent) hose, a capillary, a channel, a conduit, a column, a sample holder, a loop.

In the context of this document, the term “holding element” can refer in particular to a device or a component which is suitable for holding at least one fluid connection and being moved or movable with respect to a housing (see above) of an analysis device. In a preferred example, the holding element is set up to hold, in particular to fasten, two or more fluid connections (in particular essentially parallel to one another). For example, the holding element can have fastening means such as latching elements (e.g. clippers) or insertion elements (e.g. openings), which can hold fluid connections. With regard to the housing, the holding element can be mounted on a rail, for example, so that the holding element can be moved guided by the rail. In a further example, the holding element can be rotatably mounted on a side wall or an edge of the housing by means of a hinge. In a preferred example, the holding element is elongated so that it can be arranged along a side wall of the housing (and extends in the vertical direction as a preferred direction). In a simple exemplary embodiment, the holding element can be designed as an elongated plate (holding base) which has clips (holding structures) for fluid lines. In a more complex exemplary embodiment, the holding element can have openings through which a fluid line can be pulled. The movement of the holding element with respect to the housing can be guided or predetermined in one exemplary embodiment. For example, a sliding movement can be specified using a rail or a rotating movement using a hinge.

According to an exemplary embodiment, the invention can be based on the idea that fluid connections of an analysis device can be arranged efficiently, in a space-saving, and user-friendly manner if a holding element is provided on/in a housing of the analysis device, which holds one or more fluid connections while it is is movable with respect to the housing and as a result the fluid connections are also (defined) movable.

The holding element described can arrange the fluid connections (in particular all fluid connections) of a large number of (solvent) containers in an orderly, clear and easily accessible manner. Moving the holding element (with the fluid connections held) allows for a very flexible design. For example, the holding element (with the held fluid connections) can be moved between an internal position and an external position. This can, for example, make it possible for the fluid connections to be moved from a space-saving (and protected) position to an easily accessible position (e.g. for maintenance, service, etc.).

By means of this structure, it can also be made possible to place two or more analysis devices at a short distance (in particular directly next to each other). The fluid connections work differently than in the prior art (see above). are no longer a nuisance, but can be stored in a space-saving indoor position, for example. At the same time, sliding it out to an external position can enable efficient access when needed. Furthermore, the organization by means of the holding element can enable the fluid connections to be assigned easily and thereby reduce the susceptibility to errors in the system. The holding element described can also be implemented directly and easily in existing analysis devices.

EXEMPLARY EMBODIMENTS

Additional preferred embodiments are described below.

According to one exemplary embodiment, the holding element is guided and/or movable in a defined manner with respect to the housing and/or relative to the housing. This can have the advantage of providing efficient and reliable movement. For example, the housing can have a rail as a guide structure, by means of which the holding element can be guided (in particular pushed) along a defined path. In a further example, the holding element can be connected to the housing by means of a hinge, so that a guided or defined rotational movement can be provided. However, a defined movement can also be realized by briefly removing the holding element from the housing and reattaching it at a specific point (on the housing) (coupling and decoupling).

According to one embodiment, the holding element is movable from an internal position to an external position (and/or vice versa). The inside position can be protected and designed to save space, while the outside position enables efficient and user-friendly access to the fluid connections held by the holding element.

According to one exemplary embodiment, the analysis device or the housing has: a recess (in particular a shaft). The holding element is movable (at least partially) into the recess, in particular into an internal position, and/or the holding element is movable (at least partially) out of the recess, in particular into an external position. This can have the advantage that the inside position and the outside position can be implemented in a simple but efficient and robust manner. The recess can accommodate the holding element (at least partially) in the internal position, whereby the internal position is provided in a space-saving and safe manner. Outside the recess, the holding element can be particularly easily accessible. In one example, the recess is provided on/in a side wall of the housing. In a further example, the recess is provided on an edge/corner of the housing. In particular if several analysis devices are positioned next to one another, the recess can enable particularly space-saving storage of the holding element and the fluid connections.

According to one embodiment, the recess is arranged on a side wall and/or on an edge of the housing. According to one exemplary embodiment, the internal position is arranged (essentially), in particular completely, within the housing. According to one embodiment, the fluid connections are inaccessible (to a user) in the indoor position. According to one embodiment, the external position is (substantially) arranged outside the housing.

According to one embodiment, the fluid connection is accessible (to a user) in the external position. According to one embodiment, moving from the inside position to the outside position and/or from the outside position to the inside position occurs automatically and/or manually (by a user). According to one exemplary embodiment, the holding element is fixed in the inside position and/or the outside position (e.g. clicked in, blocked, prestressed, fastened, held by means of a force (e.g. magnetic force)). These embodiments can enable an efficient and robust retainer architecture.

According to one exemplary embodiment, a hybrid variant of automatic and manual movement takes place. In one example, automatic retraction occurs after manual operation (cf. kitchen drawer) or vice versa. In another example, an automatic extension occurs after a lock has been released by manual operation (cf. retractable sockets).

According to one exemplary embodiment, the holding element is set up for (soluble) fastening of the fluid connection. This can have the advantage that holding can be carried out in a flexible manner using the holding element. For example, fastening can be achieved by clicking in, clamping or pushing in. As a result, fluid connections can be reliably attached in a particularly simple manner and quickly released or replaced if necessary.

According to one exemplary embodiment, the holding element has a holding structure, wherein the holding structure is designed to hold the fluid connection. The holding element preferably has at least two holding structures, each holding structure being designed to hold at least one fluid connection. The term “holding structure” in this context can refer to any element that is suitable for holding or attaching a fluid connection to the holding element, in particular a holding element base. For example, the holding element base can be designed as an elongated plate (with a preferred direction), with the holding structure holding the fluid connection (essentially) parallel to the preferred direction. The holding structure is preferably set up to keep the fluid connections straight and organized.

According to one embodiment, the holding structure is designed as a click-in (e.g. clip) and/or snap-in structure and/or clamping structure. According to one exemplary embodiment, the holding structure has a fastening mechanism, for example by means of a spring, a magnet, etc. According to one exemplary embodiment, the holding structure is designed as an insertion structure, for example as an opening through which a fluid connection can be partially pushed or inserted. According to one embodiment, the holding structure is designed as an opening through which the fluid connection extends. According to one embodiment, the holding structure is designed so that the fluid connections in the holding element are oriented (substantially) parallel to one another. These exemplary embodiments can describe particularly efficient and stable configurations of the holding structure.

According to one embodiment, the holding structure has a foam and/or silicone. This can embed/encapsulate the fluid connections. Furthermore, openings can be provided in the foam/silicone through which the fluid connections can extend.

According to one exemplary embodiment, the analysis device is set up so that moving the holding element with respect to the housing comprises at least one of the following: i) pushing the holding element, in particular by means of a rail (see e.g 4A , 4B , 8A , 8B , 9A , 9B) , ii) turning (rotating) the holding element, in particular by means of a hinge, (see e.g 5 , 6 , 11 ), iii) a folding of the holding element (see e.g 7 or 14 ), in particular around an edge/corner of the housing, iv) a temporary decoupling and coupling (briefly removing and attaching) the holding element with respect to the housing (see e.g 12 ). These exemplary embodiments can describe particularly efficient and stable configurations of movement.

According to one exemplary embodiment, the holding element is coupled to the housing in a detachable or non-detachable manner, in particular when moving, in particular wherein the coupling has at least one of the following: a magnetic coupling, a hooking, a clicking, a snapping, a hooking. This can have the advantage that the holding element can be moved particularly flexibly with respect to the housing. In this case, the movement can be at least partially defined/guided and can be carried out at least partially freely. For example, the holding element can be decoupled manually (or by a robot arm) from a first position and coupled to a second position. Particularly advantageous here can be correspondingly flexible holding means such as magnets, hooking elements or hanging elements.

According to an exemplary embodiment, the analysis device further comprises: a guide structure or a guide element, in particular a rail, for guiding the holding element (at least partially) during movement with respect to the housing. This means that a guided/defined movement can be implemented particularly easily and reliably.

According to one exemplary embodiment, the holding element is mounted parallel to (or lies against) a side wall of the housing. According to one exemplary embodiment, the holding element is (at least partially) movable (eg displaceable) parallel to the side wall of the housing. According to one embodiment, the holding element is movable from a first position, abutting the side wall of the housing, to a second position, not abutting the side wall of the housing (see e.g 4A and 4B) . According to an exemplary embodiment, the holding element is movable (in particular rotatable, see e.g.) from a first position, parallel to the side wall of the housing, to a second position, perpendicular to the side wall of the housing. 5 or 11 ). According to one exemplary embodiment, the holding element is (at least partially) mounted on an edge (or corner between two side walls) of the housing. According to one exemplary embodiment, the holding element is (at least partially) movable (eg foldable) around the edge of the housing. According to one exemplary embodiment, the edge has an inclined surface (in particular, the holding element can be placed on the inclined surface, see e.g 6 ). According to one embodiment, the holding element is movable from a first position, adjacent to the inclined surface, to a second position, not adjacent to the inclined surface. These exemplary embodiments can describe particularly efficient and stable configurations of the positioning of the holding element. This also shows the high design flexibility of the holding element functionality.

According to one exemplary embodiment, the analysis device has a preferred direction, in particular a main extension direction, more particularly in the vertical direction (Z) (in particular parallel to the direction of gravity (G)). The fluid connections (in particular held by the holding element) can be guided along this main extension direction.

According to one exemplary embodiment, the holding element is (essentially) movable perpendicular to the preferred direction of the analysis device, e.g. displaceable, rotatable, foldable, etc.

According to an exemplary embodiment, the analysis device has: a storage area for storing at least one container for consumables, in particular wherein the storage area is arranged on a surface and/or on top of the analysis device and/or the housing. The storage area can be designed, for example, as a tub, bowl or tray in which the containers are placed. The storage area can also have, for example, a scale and/or a drain. Typically, solvent bottles are placed on top of a chromatography machine. This common practice can therefore be implemented directly.

According to one exemplary embodiment, the container is designed as a solvent container. According to one exemplary embodiment, the fluid connection is designed as a solvent hose. According to one embodiment, the fluid connection is coupled to the analysis device, in particular connected within the housing (e.g. to a fluid drive). This allows direct implementation in the area of HPLC.

According to one embodiment, the holding element is movable between an internal position (between two analysis devices) (e.g. in a recess) and an external position (at least partially beyond the two analysis devices). This embodiment can enable an efficient and space-saving arrangement of analysis devices.

According to one embodiment, the analysis device is designed as a sample separation device. According to one embodiment, the analysis device has a fluid drive for driving a mobile phase and a fluidic sample injected into the mobile phase. According to one embodiment, the analysis device has a sample separation device for separating the fluidic sample injected into the mobile phase. According to one embodiment, the analysis device is configured to analyze at least one physical, chemical and/or biological parameter of the fluidic sample. According to one embodiment, the analysis device is configured as a sample separation device for separating the fluidic sample.

In the context of the present application, the term “sample separation device” can be understood in particular to mean a device for analyzing a fluidic sample, in particular into different fractions. For this purpose, components of the fluidic sample can first be adsorbed on the sample separation device and then desorbed separately (in particular fractionally). For example, such a sample separation device can be designed as a chromatographic separation column.

According to one embodiment, the analysis device is a chromatography device, in particular a liquid chromatography device, a gas chromatography device, an SFC (supercritical liquid chromatography) device or an HPLC (high-performance liquid chromatography) device.

According to one embodiment, the analysis device is configured as a microfluidic device. According to one embodiment, the analysis device is configured as a nanofluidic device.

According to one exemplary embodiment, the sample separation device is designed as a chromatographic separation device, in particular as a chromatography separation column.

According to one embodiment, the fluid drive is configured to drive the mobile phase and the fluidic sample under high pressure.

According to one embodiment, the fluid drive is configured for driving the mobile phase and the fluidic sample with a pressure of at least 500 bar, in particular at least 1000 bar, more particularly at least 1200 bar, more particularly at least 1500 bar.

According to one exemplary embodiment, the analysis device has a detector for detecting the analyzed, in particular separated, fluidic sample.

According to one embodiment, the analysis device has a fractionator for fractionating separate fractions of the fluidic sample.

The analysis device can be a microfluidic measuring device, a life science device, a liquid chromatography device, a gas chromatograph phy device, an HPLC (High Performance Liquid Chromatography), a UHPLC system or an SFC (supercritical liquid chromatography) device. However, many other applications are possible.

According to one exemplary embodiment, the sample separation device can be designed as a chromatographic separation device, in particular as a chromatography separation column. In the case of a chromatographic separation, the chromatographic separation column can be provided with an adsorption medium. The fluidic sample can be stopped at this and only then be detached fractionally again in the presence of a specific solvent composition, thereby accomplishing the separation of the sample into its fractions.

A pump system for conveying fluid can, for example, be set up to convey the fluid or the mobile phase through the system at a high pressure, for example a few 100 bar up to 1000 bar and more. The analysis device can have a sample injector for introducing the sample into the fluidic separation path. Such a sample injector can have a sample or injection needle that can be coupled to a needle seat in a corresponding liquid path, whereby the sample needle can be moved out of this needle seat in order to take up sample. After reinserting the sample needle into the needle seat, the sample can be in a fluid path that can be switched into the separation path of the system, for example by switching a valve. In another embodiment of the invention, a sample injector or sampler can be used with a sample needle that is operated without a needle seat.

The analysis device may have a fraction collector for collecting the separated components. Such a fraction collector can, for example, lead the various components of the separated sample into different liquid containers. The analyzed sample can also be fed to a drain container.

Preferably, the analysis device can have a detector for detecting the separated components. Such a detector can produce a signal that can be observed and/or recorded and which is indicative of the presence and amount of the sample components in the fluid flowing through the system.

According to an exemplary embodiment, a sampling space is delimited by a housing in which the sample handling arrangement or sample movement device is arranged.

According to an exemplary embodiment, solvent lines are attached to a movable rack that can be hidden in an HPLC device.

According to one exemplary embodiment, the analysis device has at least two holding elements. In particular, the two holding elements can be moved independently of one another. Both holding elements can be arranged in physical contact with one another. The holding elements can (each) be mounted in a recess in the side wall or directly on the side wall (adjacent). The holding elements can be arranged (essentially) parallel to one another (one behind the other). The holding elements can be arranged at the same location or at different locations (e.g. on opposite side walls) of the housing. In one example, the holding elements may be movable in the same way or in different ways (e.g. one is pushed, one is rotated).

According to an exemplary embodiment, the holding element is completely removable and can be attached to various positions (e.g. on the side or front of the housing), for example when the analysis device is installed in the laboratory. One or more of these positions can enable the holding element to be rotated or pushed.

For example, if there is enough space on the side of the analysis device, the holding element can be attached there. This position does not take up space on the front/front of the analyzer (access to other modules). In this position, the holding element can, for example, be rotated for better access by the user.

However, if there is little or no space on the side of the analysis device (other instruments are placed directly next to it), the holding element can be attached to the front. Here, however, the holding element takes up space and, in order to access the modules from the front, the holding element can, for example, be rotated or moved (to the side), so that access is made possible.

BRIEF DESCRIPTION OF THE FIGURES

• 1 zeigt eine Analysevorrichtung konfiguriert als Chromatografiegerät, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.
• 2 zeigt eine Implementierung des Chromatografiegeräts mit Behältern für Verbrauchsmaterial, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.
• 3A und 3B zeigen einen konventionellen Halter eines Chromatografiegeräts.
• 4A und 4B zeigen eine Analysevorrichtung mit einem schiebbaren Halteelement, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.
• 5 zeigt eine Analysevorrichtung mit einem drehbaren Halteelement, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.
• 6 zeigt eine Analysevorrichtung mit einem drehbaren Halteelement an einer schrägen Gehäusefläche, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.
• 7 zeigt eine Analysevorrichtung mit einem drehbaren Halteelement an einer Gehäusekante, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.
• 8A und 8B zeigen eine Analysevorrichtung mit einem Halteelement, das aus dem Gehäuse heraus schiebbar ist, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.
• 9A und 9B zeigen eine Analysevorrichtung mit einem Halteelement, das an der Seitenwand des Gehäuses heraus schiebbar ist, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.
• 10A und 10B zeigen mehrere Analysevorrichtungen (Analysevorrichtung System) zwischen denen ein Halteelement heraus schiebbar ist, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.
• 11 zeigt eine Analysevorrichtung mit einem Halteelement, das aus einer Aussparung des Gehäuses ausklappbar ist, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.
• 12 zeigt eine Analysevorrichtung mit einem Halteelement, das aus der Aussparung und um eine Kante des Gehäuses bewegbar ist, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.
• 13 zeigt eine Analysevorrichtung mit einem Halteelement, das entlang einer Seitenwand des Gehäuses verschiebbar ist, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.
• 14 zeigt eine Analysevorrichtung Anordnung mit einem Halteelement, das um eine Seitenkante des Gehäuses herum klappbar ist, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.
• 15A bis 15C zeigen eine Analysevorrichtung Anordnung mit einem Lagerbereich, wobei das Halteelement aus dem Gehäuse heraus- bzw. herein schiebbar ist, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.
• 16A und 16B zeigen eine Analysevorrichtung mit zwei Halteelementen, welche nebeneinander angeordnet und unabhängig voneinander verschiebbar sind, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.
• 17 zeigt eine Analysevorrichtung mit zwei Halteelementen, welche an gegenüberliegenden Seitenwänden des Gehäuses angeordnet sind, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.
• 18 zeigt eine Analysevorrichtung mit zwei Halteelementen, welche nebeneinander angeordnet und unabhängig voneinander drehbar sind, gemäß einem exemplarischen Ausführungsbeispiel der Erfindung.

Other objects and many of the attendant advantages of embodiments of the present invention will become readily apparent and better understood with reference to the following more detailed description of exemplary embodiments in connection with the accompanying drawings. Features that are essentially or functionally the same or similar are given the same reference numerals.

• 1 shows an analysis device configured as a chromatography device, according to an exemplary embodiment of the invention.
• 2 shows an implementation of the chromatography device with containers for consumables, according to an exemplary embodiment of the invention.
• 3A and 3B show a conventional holder of a chromatography device.
• 4A and 4B show an analysis device with a sliding holding element, according to an exemplary embodiment of the invention.
• 5 shows an analysis device with a rotatable holding element, according to an exemplary embodiment of the invention.
• 6 shows an analysis device with a rotatable holding element on an inclined housing surface, according to an exemplary embodiment of the invention.
• 7 shows an analysis device with a rotatable holding element on a housing edge, according to an exemplary embodiment of the invention.
• 8A and 8B show an analysis device with a holding element that can be pushed out of the housing, according to an exemplary embodiment of the invention.
• 9A and 9B show an analysis device with a holding element that can be pushed out on the side wall of the housing, according to an exemplary embodiment of the invention.
• 10A and 10B show several analysis devices (analysis device system) between which a holding element can be pushed out, according to an exemplary embodiment of the invention.
• 11 shows an analysis device with a holding element that can be folded out of a recess in the housing, according to an exemplary embodiment of the invention.
• 12 shows an analysis device with a holding element that is movable out of the recess and around an edge of the housing, according to an exemplary embodiment of the invention.
• 13 shows an analysis device with a holding element that is displaceable along a side wall of the housing, according to an exemplary embodiment of the invention.
• 14 shows an analysis device arrangement with a holding element that can be folded around a side edge of the housing, according to an exemplary embodiment of the invention.
• 15A to 15C show an analysis device arrangement with a storage area, wherein the holding element can be pushed out or in of the housing, according to an exemplary embodiment of the invention.
• 16A and 16B show an analysis device with two holding elements, which are arranged next to one another and can be moved independently of one another, according to an exemplary embodiment of the invention.
• 17 shows an analysis device with two holding elements, which are arranged on opposite side walls of the housing, according to an exemplary embodiment of the invention.
• 18 shows an analysis device with two holding elements, which are arranged next to one another and can be rotated independently of one another, according to an exemplary embodiment of the invention.

DETAILED DESCRIPTION OF THE FIGURES

The representation in the drawing is schematic.

1 shows the basic structure of an HPLC system as an example of an analysis device 10 designed as a sample separation device or chromatography device according to an exemplary embodiment of the invention, as can be used for liquid chromatography, for example. A fluid delivery device or fluid drive 20, which is supplied with solvents from a feed device 25 (or consumables from a container), drives a mobile phase through a sample separation device 30 (such as a chromatographic column) which contains a stationary phase.

The solvents here are a consumable material which is stored in one or more containers 25. The supply device usually comprises a first fluid component source (eg first container) for providing a first fluid or a first solvent component A (e.g. water) and a second fluid component source (e.g. second container) for providing another second fluid and a second solvent component B (e.g. an organic solvent), respectively.

An optional degasser 27 can degas the solvents provided by the first fluid component source and by the second fluid component source before they are supplied to the fluid drive 20. A sample application unit, which can also be referred to as an injector 40 (sampler), is arranged between the fluid drive 20 and the sample separation device 30 in order to first receive a sample liquid or a fluidic sample from a sample container into a sample receiving volume in an injector path, and subsequently by switching an injection valve of the injector 40 into a fluidic separation path between the fluid drive 20 and the sample separation device 30. The collection of fluidic sample from the sample container can be done in particular by moving a sample needle out of a sample seat and moving it into the sample container, sucking fluidic sample from the sample container through the sample needle into the sample receiving volume by means of a fluid delivery device designed as a dosing device, and the sample needle then moved back into the needle seat.

The stationary phase of the sample separation device 30 is intended to separate components of the sample. A detector 50, which may include a flow cell, detects separated components of the sample. A fractionation device or fractionator 60 may be provided to dispense separated components of the sample into designated containers. Liquids that are no longer needed can be dispensed into a drain container or waste line.

While a liquid path between the fluid drive 20 and the sample separation device 30 is typically under high pressure, the sample liquid is first introduced under normal pressure into an area separated from the liquid path, namely the sample loop or the sample receiving volume, of the sample application unit or the injector 40. The sample liquid is then introduced into the high-pressure separation path. A sample loop as a sample receiving volume (also referred to as a sample loop) can be understood as a section of a fluid line that is designed to receive or temporarily store a predetermined amount of fluidic sample. Preferably, before the sample liquid, which is initially under normal pressure, is switched on in the sample receiving volume into the high-pressure separation path, the contents of the sample receiving volume are brought to the system pressure of the analysis device 10 designed as HPLC (by means of a metering device in the form of the fluid conveying device). A control device or a control system 70 controls the individual components or elements 20, 25, 30, 40, 50, 60, etc., of the analysis device 10. Each of these components can have a separate housing, or two or more components can be in the same Housing be arranged.

2 shows an implementation of the chromatography device 10 with the containers 25 for consumables, according to an exemplary embodiment of the invention. In this example, the components of the chromatography device 10 are stacked on top of each other in a vertical direction. At the top there is a storage area 28 or a container holding device, for example a tray, in which a plurality of the containers 25 can be arranged (or placed). Each of the containers 25 is filled with the consumable material, which in the present example is a solvent (eg water, methanol, acetonitrile, etc.). By means of supply lines or fluid lines 26, the containers 25 are each coupled to the fluid drive 20, so that the consumable material from the respective container 25 is fed through the corresponding fluid line 26 via the fluid drive 20 into the analytical path (to the oven/column oven which contains the sample separation device 30 includes) the analysis device 10 can be introduced. While the storage area 28 is provided at the top of the analysis device 10, the fluid drive 20 is arranged at the bottom. Accordingly, the fluid lines 26 can hang down along the entire housing of the analysis device 10 (along the direction of gravity G).

As already for 1 described above, the chromatography device 10 further comprises the sample injection (autosampler) 40, sample separation device 30, and detector 50 units, which are stacked in this order (in this example) from bottom to top.

4A (and detailed view 4B) shows an analysis device 10 with a sliding holding element 100, according to an exemplary embodiment of the invention. The analysis device 10 is similar to that for 1 and 2 constructed as described. A housing 110 is shown schematically, which contains the analytical units. In an implementation, each unit can also have its own housing. A storage area 28 is provided on top of the housing, in which the containers 25 for solvents can be placed. Fluid connections 26 (in 4A not shown) can each be attached to a container 25 and then held by the holding element 100 and guided downward (for example to the fluid drive). 4B shows in the detailed view that the holding element 100 is designed as an elongated plate (holding base), with openings 105 extending as holding structures (each one for a fluid line 26) in the holding element 100 along its preferred direction (here vertically).

The holding element 100 is arranged on a side wall 112 (and corner/edge) of the housing 110. As shown by arrows, the retaining element 100 can be moved from a first position (inside position), resting against the side wall 112, to a second position (outside position), not against the side wall 112. In the same way, the holding element 100 can also be pushed back into the first position. While the first position is designed to save space and protect, the second position allows access from two opposite sides to the held fluid connections 26. Rails are also attached to the housing 110, which act as a guide element 115 during the movement or displacement of the holding element 100 with respect to the housing 110 serve. By means of the guide elements 115, a defined movement relative to the housing 110 is provided.

5 shows an analysis device 100 with a rotatable holding element 100, according to an exemplary embodiment of the invention. The analysis device 10 is similar to that for 4 described above, wherein the holding element 100 also rests on the side wall 112 of the housing 110 in the first position (internal position). However, moving into the second position (outer position) is not designed as pushing, but rather as turning (rotating). By means of a hinge (not shown) on the side wall 112, the holding element 100 can be rotated away from the side wall 112 (here at a right angle). In this second position, the holding element 100 is now also accessible from two opposite sides, so that the held fluid connections 26 are easily accessible.

6 shows an analysis device 10 with a rotatable holding element 100 on an inclined housing surface 113, according to an exemplary embodiment of the invention. The holding element 100 is mounted on an edge 111 or corner of the housing 110, the edge 111 having an inclined surface 113. In this example, the holding element 100 is movable or rotatable from a first position, adjacent to the inclined surface 113 (not shown), to a second position, not adjacent to the inclined surface 113.

7 shows an analysis device 10 with a rotatable holding element 100 on a housing edge 111, according to an exemplary embodiment of the invention. In contrast to the example of 6 the edge 111 is designed as a corner without an inclined surface 113. The holding element 100 is mounted in a first position on the side wall 112 of the housing 110 and can be moved or rotated around the edge 111 of the housing 110 when moving into a second position become. The example shows a 180° rotation, but a 270° rotation can also be realized around the edge 111 (from side wall to side wall).

The 8A and 8B show an analysis device arrangement 150 with the analysis device 10 and two containers 25, which are positioned in the storage area 28, according to an exemplary embodiment of the invention. The fluid connections 26 are connected here to one of the containers 25 and attached to the holding element 100.

8A shows a first position (internal position) in which the holding element 100 (not visible) is arranged in a recess 120 (a side wall 112) of the housing 110 or the analysis device 10. The interior position is located entirely within the housing 110, with the fluid connections 26 being inaccessible in the interior position.

8B shows a second position (outside position) in which the holding element 100 is pushed out of the recess 120. The external position is arranged outside the housing 110, with the fluid connections 26 being accessible (from two sides) in the external position. The holding element 100 can be fixed (eg clicked in) in the inside position and/or the outside position.

The 9A and 9B show an analysis device 10 with a holding element 100 that can be pushed out of a recess 120 on the side wall 112 of the housing 110, according to an exemplary embodiment of the invention. This embodiment is similar to that of 8th , wherein the recess 120 (for the internal position) is not attached to the side wall (surface) 112, but to an edge 111 of the housing 110.

The 10A and 10B show an analysis device system 160 with several analysis devices next to each other in series, according to an exemplary embodiment of the invention. Here are an analysis device 10 (or an analysis device arrangement 150 with container 25 and connected fluid connections 26) and a further analysis device 11 with reference number provided. The analysis devices 10, 11 are set up at a minimal distance from one another, in particular in physical contact with one another. As in the example of 9 shown, the analysis device 10 has a recess 120 on a side edge 111 of the housing 110.

10A : In the internal position, the holding element 100 is protected and arranged to save space, while the analysis devices 10, 11 can be set up in direct contact with one another.

10B : In the outer position, the holding element 100 is easily accessible, while the analysis devices 10, 11 can still be set up in direct contact with one another. The holding element 100 is thus movable between an internal position (between the two analysis devices 10, 11) and an external position, which lies beyond the two analysis devices 10, 11.

11 shows an analysis device 10 with a holding element 100 which can be folded out of a recess 120 (in a side wall 112) of the housing 110, according to an exemplary embodiment of the invention. In the internal position, the holding element 100 (with the fluid connections 26 shown) rests in the recess 120 on the side wall 112. When folded out (by 90°) from the recess 120, the fluid connections 26 are easily accessible.

12 shows an analysis device 10 with a holding element 100 which can be moved out of the recess 120 and around an edge 111 of the housing 110, according to an exemplary embodiment of the invention. This example shows a more complex movement from the inside position to an outside position. In addition to moving out of the recess 120, there is also movement around the edge 111. This movement can be realized, for example, by means of a guide element 115 (eg a rail). Furthermore, the holding element 100 can also be briefly removed from the housing 100 and attached to it again, for example by hanging it into a corresponding hanging structure.

13 shows an analysis device 10 with a holding element 100 which is displaceable along a side wall 112 of the housing 110, according to an exemplary embodiment of the invention. Similar to the examples of 11 and 12 , but no recess 120 is provided in the side wall. Instead, sliding (or momentary removal) may be performed along the side wall 112 to bring the retaining member 100 into the outward position.

14 shows an analysis device arrangement 150 with a holding element 100 which can be folded around a side edge 111 of the housing 110, according to an exemplary embodiment of the invention. This example is similar to that of 7 , whereby the fluid connections 26 and their attachment are also shown in detail. The holding element 100 is rotated or folded around in four positions: 0°, 90°, 180°, and 270°.

15A to 15C show an analysis device arrangement 150 with a storage area 28, wherein the holding element 100 can be pushed out or in of the housing 110, according to an exemplary embodiment of the invention. The storage area 28 is designed here as a round tray (tray), with the fluid connections 26 being guided past the storage area 28 (along a surface of the housing 110) and running into the inner position, where they are attached to the holding element 100. In a preferred embodiment, the storage area 28 can be rotatable/rotatable. 15B shows the outside position and 15C a detailed view. It is shown that holding structures 105 of the holding element 100 are designed as clips, into which a solvent tube 26 can be clicked. Openings are also provided at the top of the holding element 100 through which the fluid connections 26 can be guided.

16A and 16B show an analysis device 10 with two holding elements 100, which are arranged next to one another and can be moved independently of one another, according to an exemplary embodiment of the invention. This example is similar to that of 4 , whereby instead of one holding element 100, two holding elements 100, 101 are provided. Both holding elements 100, 101 are mounted in a recess 120 in the side wall 112 or directly on the side wall 112 (adjacent). The holding elements 100, 101 are arranged (essentially) parallel to one another (one behind the other) and can be moved independently of one another. In 16A Both holding elements 100, 101 are shown in the inside position. In 16B the first holding element 100 is still arranged in the inside position, while the second holding element 101 has been moved (or pushed) into the outside position.

17 shows an analysis device 10 with two holding elements 100, 101, which are arranged on opposite side walls 112 of the housing 110, according to an exemplary embodiment of the invention. In contrast to the example of 16 the holding elements 100, 101 are not in direct contact, but are arranged (in recesses) on opposite sides of the housing 110 (parallel to one another). As in 16 the holding elements 100, 101 can be independent can be moved (or pushed) depending on one another.

18 shows an analysis device 10 with two holding elements 100, 101, which are arranged next to one another and can be rotated independently of one another, according to an exemplary embodiment of the invention. In the inside position, both holding elements 100, 101 are comparable 16A arranged. When changing the first holding element 100 into the outer position shown, the first holding element 100 is rotated independently of the second holding element 101. In this way, different fluid connections 26 can be made accessible independently of one another.

10

Analysevorrichtung

11

Weitere Analysevorrichtung

20

Fluidantrieb

25

Behälter für Verbrauchsmaterial

26

Fluidverbindung, Schlauch

27

Entgaser

28

Lagerbereich

30

Probentrenneinrichtung

40

Injektor

50

Detektor

60

Fraktionierer

70

Steuereinrichtung

100

Halteelement

101

Weiteres Halteelement

105

Haltestruktur

110

Gehäuse

111

Kante, Ecke

112

Seitenwand

113

Schräge Fläche

115

Führungsstruktur

120

Aussparung, Schacht

150

Analysevorrichtung Anordnung

160

Analysevorrichtung System

Reference symbols

10

Analysis device

11

Further analysis device

20

Fluid propulsion

25

Container for consumables

26

Fluid connection, hose

27

Degasser

28

storage area

30

Sample separation device

40

injector

50

detector

60

fractionator

70

Control device

100

Holding element

101

Another holding element

105

Support structure

110

Housing

111

edge, corner

112

Side wall

113

Sloping surface

115

Leadership structure

120

recess, shaft

150

Analysis device arrangement

160

Analysis device system

QUOTES INCLUDED IN THE DESCRIPTION

This list of documents listed by the applicant was generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Cited patent literature

• EP 0309596 B1 [0003]

Claims (20)

An analysis device (10) for analyzing a fluidic sample, the analysis device (10) comprising: a housing (110); and a holding element (100), which is coupled to the housing (110), for holding a fluid connection (26), in particular a hose; wherein the holding element (100) is movable with respect to the housing (110). The analysis device (10) according to Claim 1 , wherein the holding element (100) is guided and/or movable in a defined manner with respect to the housing (110) and/or relative to the housing (110). The analysis device (10) according to Claim 1 or 2 , wherein the housing (110) has: a recess (120), in particular a shaft, wherein the holding element (100) is at least partially movable into the recess (120), in particular into an internal position, and / or wherein the holding element (100 ) is at least partially movable out of the recess (120), in particular into an external position. The analysis device (10) according to Claim 3 , having at least one of the following features: wherein the recess is arranged on a side wall (112) and/or on an edge (111) of the housing (110); wherein the internal position is arranged substantially, in particular completely, within the housing (110), in particular wherein the fluid connections (26) are inaccessible in the internal position; wherein the external position is arranged substantially outside the housing (110), in particular wherein the fluid connections (26) are accessible in the external position; wherein moving from the inside position to the outside position and/or from the outside position to the inside position occurs automatically and/or manually; wherein the holding element (100) is fixed in the inside position and/or the outside position, in particular clicked in. The analysis device (10) according to one of the preceding claims, wherein the holding element (100) is designed to detachably fasten the fluid connection (26). The analysis device (10) according to one of the preceding claims, wherein the holding element (100) has a holding structure (105), the holding structure (105) being designed to hold the fluid connection (26). The analysis device (10) according to Claim 6 , having at least one of the following features: wherein the holding structure (105) is designed as a click-in and / or snap-in structure; wherein the holding structure (105) is designed as an insertion structure; wherein the holding structure (105) is designed as an opening through which the fluid connection (26) extends; wherein the holding structure (105) is designed so that two or more fluid connections (26) in the holding element (100) are oriented essentially parallel to one another. The analysis device (10) according to one of the preceding claims, arranged so that moving the holding element (110) with respect to the housing (110) comprises at least one of the following: pushing the holding element (100), in particular by means of a rail, rotating the holding element (100), in particular by means of a hinge, folding over the holding element (110), in particular around an edge (111), a temporary decoupling and coupling of the holding element (110) with respect to the housing (110). The analysis device (10) according to one of the preceding claims, wherein the holding element (100), in particular when moving, is detachably or non-detachably coupled to the housing (110), in particular, wherein the coupling has at least one of the following: a magnetic coupling, a hooking, a clicking, a snapping, a hooking. The analysis device (10) according to one of the preceding claims, further comprising: a guide structure (115), in particular a rail, for guiding the holding element (100) during movement with respect to the housing (110). The analysis device (10) according to one of the preceding claims, having at least one of the following features: wherein the holding element (100) is mounted parallel to a side wall (112) of the housing (110); wherein the holding element (100) is at least partially movable parallel to the side wall (112) of the housing (110); wherein the retaining member (100) is movable from a first position abutting the side wall (112) of the housing (110) to a second position non-adjacent to the side wall (112) of the housing (110); wherein the holding element (100) from a first position, parallel to the side wall (112) of the housing (110) is movable to a second position perpendicular to the side wall (112) of the housing (110); wherein the holding element (100) is at least partially mounted on an edge (111) of the housing (110); wherein the holding element (100) is at least partially movable around the edge (111) of the housing (110); wherein the edge (111) has an inclined surface (113); wherein the holding element (100) is movable from a first position adjacent to the inclined surface (113) to a second position not adjacent to the inclined surface (113). The analysis device (10) according to one of the preceding claims, wherein the analysis device (10) has a preferred direction, in particular a main extension direction, in the vertical direction (Z), in particular parallel to the direction of gravity (G), in particular, the holding element (100) being movable substantially perpendicular to the preferred direction of the analysis device (10). The analysis device (10) according to one of the preceding claims, comprising: a storage area (28) for storing at least one container (25) for consumables, in particular, wherein the storage area (28) is arranged on a surface, in particular on top, of the analysis device (10) and/or the housing (110). The analysis device (10) according to one of the preceding claims, further comprising at least one of the following features: the analysis device (10) is designed as a sample separation device; the analysis device (10) has a fluid drive (20) for driving a mobile phase and a fluidic sample injected into the mobile phase; the analysis device (10) has a sample separation device (30) for separating the fluidic sample injected into the mobile phase; the analysis device (10) is configured to analyze at least one physical, chemical and/or biological parameter of the fluidic sample; the analysis device (10) is configured as a sample separation device for separating the fluidic sample; the analysis device (10) is a chromatography device, in particular a liquid chromatography device, a gas chromatography device, an SFC (supercritical liquid chromatography) device or an HPLC (high-performance liquid chromatography) device; the analysis device (10) is configured as a microfluidic device; the analysis device (10) is configured as a nanofluidic device; the sample separation device (30) is designed as a chromatographic separation device, in particular as a chromatography separation column; the fluid drive (20) is configured to drive the mobile phase and the fluidic sample under high pressure; the fluid drive (20) is configured to drive the mobile phase and the fluidic sample with a pressure of at least 500 bar, in particular at least 1000 bar, more particularly at least 1200 bar; the analysis device (10) has a detector (50) for detecting the analyzed, in particular separated, fluidic sample; the analysis device (10) has a fractionator (60) for fractionating separate fractions of the fluidic sample. An analysis device arrangement (150), comprising: an analysis device (10) according to one of the preceding claims; a container (25) for consumables, the container (25) being stored in a storage area (28); and the fluid connection (26), which is connected to the container (25) and/or is held by the holding element (100). The analysis device arrangement (150) according to Claim 15 , having at least one of the following features: wherein the container (25) is designed as a solvent container; wherein the fluid connection (26) is designed as a solvent hose; wherein the fluid connection (26) is coupled to the analysis device (10), in particular connected within the housing (110). An analysis device system (160), comprising: an analysis device (150) or an analysis device arrangement (150) according to one of the preceding claims; a further analysis device (11), which is arranged next to, in particular with physical contact, the analysis device (10), wherein the holding element (100) is at least partially arranged between the two analysis devices (10, 11). The analysis device system (160) according to Claim 17 , wherein the holding element (100) is movable between an internal position between the two analysis devices (10, 11) and an external position, at least partially beyond the two analysis devices (10, 11). A method for operating an analysis device (10), the method comprising: storing a container (25) for consumables; connecting a fluid connection (26) to the container (25); Holding the fluid connection (26) by means of a holding element (100) in relation to a housing (110) of the analysis device (10); and moving the holding element (100) with respect to the housing (110). Using a holding element (100) to attach two or more solvent tubes (26) and moving them relative to a housing (110) of a chromatography device (10) by means of the holding element (100).

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