DE102018123224A1 - Gout treatment medication and its preparation method - Google Patents

Abstract

The present invention discloses a medicament for treating gout and its method of preparation. The weight loss medication includes Radix Bupleuri 5-15, Dandelion 10-15, Unprocessed Pinellie 13-20, Oatmeal or Oatmeal 12-28 and Herba Pyrolae 5-12 by weight. The medication for gout treatment according to the present invention contains different ingredients than conventional drugs and can overcome disadvantages of conventional drugs.

Description

Technical field

The present invention relates to the field of medicines, in particular a medication for treating gout and its method of preparation.

background

Gout is a chronic metabolic disorder, a disease characterized by the excessive formation of urine salt in the human body or decreased kidney excretion of uric acid, which causes an increased concentration of urine salt in the blood, and is known clinically as hyperuricemia. Urine salt is an end product of purine metabolism, whereby purine is formed by the metabolism of human cells. When the blood urine salt increases to a certain degree, it is stored in the organism, especially in the joints and kidneys, which leads to arthritis outbreaks and even leads to joint malfunction or deformity, which is clinically known as gouty arthritis. The storage of uric acid in the kidneys leads to uric acid kidney stone and damage to the renal parenchyma, which is known clinically as uric acid kidney disease and also known as gouty kidney disease, it can cause renal outbreaks, hematuria, hydronephrosis and kidney function damage, and even kidney failure and uremia, making it one of the main reasons is the death of gout patients. Because gout is a chronic, lifelong disease that can last for decades and occurs sporadically, gout patients tend to pay less attention to it and are not sufficiently aware of its harmfulness.

Currently, gout is primarily treated with drug delivery according to clinical symptoms, with the patient being treated primarily with cholchicine and pain relievers during a gout onset to rapidly reduce inflammation and relieve pain, while temporarily giving the patient purine and the like to avoid another To reduce outbreak of uric acid. Basically, all western drugs used to treat gout have strong side effects and are soothing. In addition, with all temporarily administered western drugs, gout will return quickly as soon as drug administration is interrupted, causing an attack of transitive gout due to a very rapid dissolution of uric acid.

In any case, the treatment effects of the above treatment methods are not good. In addition, the current drugs have different toxic effects. Therefore, there is an urgent need for new gout treatment drugs to address the above disadvantages.

Summary of the invention

In the light of the above problems, it is an object of the present invention to provide a medicament for gout treatment used to overcome the disadvantages of inadequate treatment effects in conventional medicaments, which at least partially solves the above problems,
In a first aspect, the invention provides a medicament for treating gout, comprising parts by weight of Radix Bupleuri 5-15, dandelion 10-15, unprocessed pine 13-20, oatmeal or oatmeal 12-28 and Herba Pyrolae 5-12.

The medication for treating gout according to the present invention has other ingredients than conventional medicines and can overcome the disadvantages of conventional medicines.

Detailed description of exemplary embodiments

In one embodiment of the present invention, a medicament for treating gout comprises parts by weight of Radix Bupleuri 5-15, dandelion 10-15, unprocessed pine 13-20, oatmeal or oatmeal 12-28 and Herba Pyrolae 5-12.

In addition, the drug also includes Carapax Eretmochelyos 20-30 by weight.

In addition, the drug also includes Rhizoma Smilacis Glabrae 12-18 by weight.

The above Carapax Eretmochelyos and Rhizoma Smilacis Glabrae are just a few specific examples and are not restrictive. Other ingredients, such as wolfberry, Gynostemma pentaphyllum, 12 tragacanth seeds (12 semen Astragali Complanati), Radix Dipsaci, Herba Eclipta, Fructus Ligustri Lucidi, etc. are also possible. Other possible ingredients are not described in detail.

In one exemplary embodiment of the present invention, ingredients to revitalize the blood circulation, such as Carcuma longa, Szechuan lovage (Ligusticum chuanxiong Hort), Radix Salviae Miltiorrhizae and evening primrose, can optionally be added.

In addition, in one embodiment of the present invention, the medicament can be used to improve the pharmacological effect also contain ingredients for lowering the temperature, such as Fructus Gardeniae, Flos Chrysanthemi, Cassia seeds, Cortex Fraxini, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Andrographis Paniculata, etc

In addition, the drug may also contain ingredients to remove moisture and promote urine output, such as Herba Sedi, Abrus Herb, etc.

In addition, the medicament may also include internal warming ingredients such as pepper.

In one embodiment of the present invention, the dosage form of the medicament is selected from film-coated tablets, sugar-coated tablets, acid-resistant tablets, dispersible tablets, capsules, granules, broth, mixture, sirum, wine, injection, oral solution and cloudy liquid.

In one embodiment of the present invention, the medicament optionally has an administration form for oral treatment.

In one embodiment of the present invention, the administration form for oral treatment comprises tablets, capsules, pills, injections, sustained-release preparations and controlled-release preparations.

The medicament of the embodiment indicated by the present invention or the medicament composition containing the same can be administered in a unit dosage form through the intestinal tract, the nasal cavity, oral mucosa, eyes, lungs, respiratory tract, skin, rectally, etc. and administered by oral administration, intravenous injection, intramuscular injection and subcutaneous injection.

The dosage form can be a liquid dosage form, a solid dosage form or a semi-solid dosage form. The liquid dosage form can be a solution, an emulsion, a suspension, an injection (with water injection, powder injection and transfusion), eye drops, nose drops, lotion and liniment. The solid dosage form can be a tablet (with uncoated tablets, acid-resistant tablets, buccal tablets, dispersible tablets, chewable tablets, effervescent tablets and tablets that can be dissolved in the mouth), capsules (with hard capsules, soft capsules, acid-resistant capsules), granules, powder, pellets, ingestion tablets, Suppositories, active film, paste, aerosol, spray, etc his. The semi-solid dosage form can be ointment, gel, paste, etc. his. The dosage form of the medicament is preferably a tablet, a capsule, a pill or an injection.

The medicament according to an exemplary embodiment of the present invention can be prepared in conventional preparations, retart preparations, controlled delay preparations, target preparations and various granule administration preparations.

In one embodiment of the present invention, various auxiliaries such as thinners, binders, humectants, grinding agents, lubricants and lubricants can be used to prepare the medicament according to the present invention in tablets. The diluent can be starch, dextrin, sucrose, glucose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose, calcium sulfate, calcium hydrogen phosphate, calcium carbonate and the like. The humectant can be water, ethanol, isopropanol and the like. The binder can be starch powder, dextrin, syrup, honey, a glucose solution, microcrystalline cellulose, gum arabic powder, gelatin powder, sodium carboxymethyl cellulose and methyl cellulose. The grinding agent can be dry starch, microcrystalline cellulose, low substituted hydroxypropyl celluloses. The lubricant and lubricant can be talc, silica, liquid paraffin and the like.

Furthermore, the medicament can also be a coated tablet, for example a sugar-coated tablet, a film tablet, an acid-resistant tablet and the like.

If the drug is prepared in capsules, the active ingredients can be prepared in granules or pellets with the addition of thinners, binders and grinding agents, which are then placed in a hard or soft capsule.

When the drug is prepared as an injection, the solvent can be made from water, ethanol, isopropanol, propylene glycol, or a mixture thereof. Furthermore, an appropriate amount of a solvent, cosolvent, pH adjusting agent, osmotic pressure adjusting agent can be added.

Dye, preservatives, perfume, correctors or other additives can also be added to the medicament.

• einen ersten Schritt: Wiegen in Gewichtsanteilen Radix Bupleuri 5-15, Löwenzahn 10-15, unbearbeitete Pinellie 13-20, Haferflocken oder Hafermehl 12-28 und Herba Pyrolae 5-12, Mischen zu einer Mixtur und Pulverisieren der Mixtur;
• einen zweiten Schritt: Zugeben von 70% Ethanol in die pulverisierte Lösung in einem Gewichtsverhältnis von (2-3):1;
• einen dritten Schritt: zweimaliges Rückflussextrahieren des Zwischenproduktes, jedes für 2-3h, und Filtern, um zwei Filtrate zu erhalten; und
• einen vierten Schritt: Mischen der zwei Filtrate, und Eindicken, um das Ethanol zu entfernen, um eine Extraktionslösung als zu gewinnendes Medikamentenpräparat zu erhalten.
• Nachstehend werden spezielle Beispiele des Verfahrens zur Zubereitung des Medikamentes zur Gichtbehandlung angegeben.

According to an embodiment of the invention, a method for preparing the above medicament comprises the following steps:

• a first step: weighing in parts by weight of Radix Bupleuri 5-15, dandelion 10-15, unprocessed pine 13-20, oatmeal or oatmeal 12-28 and Herba Pyrolae 5-12, mixing to a mixture and pulverizing the mixture;
• a second step: adding 70% ethanol to the powdered solution in a weight ratio of (2-3): 1;
• a third step: refluxing the intermediate twice, each for 2-3 hours, and filtering to obtain two filtrates; and
• a fourth step: mixing the two filtrates, and thickening to remove the ethanol to obtain an extraction solution as a drug preparation to be obtained.
• Specific examples of the method for preparing the medication for treating gout are given below.

example 1

• a first step: weighing in parts by weight of Radix Bupleuri 5-15, dandelion 10-15, unprocessed pine 13-20, oatmeal or oatmeal 12-28 and Herba Pyrolae 5-12, mixing to a mixture and pulverizing the mixture;
• a second step: boil the mixture twice with water, each time for 4 h at 30 ° C. by adding 10 ml of water in an interval of 30 min and filtering in order to obtain two filtrates;
• a third step: mixing the two filtrates and adding 70% ethanol, the weight of ethanol being twice the absolute weight of the raw materials;
• a fourth step: refluxing the intermediate twice at room temperature, each for 2 hours, and filtering to obtain two filtrates; and
• a fifth step: mixing the two filtrates, and thickening to remove the ethanol to obtain an extraction solution as a drug preparation to be obtained.

Example 2

• a first step: weighing in parts by weight radix bupleuri 5, dandelion 10, unprocessed pine 13, oatmeal or oatmeal 28 and herba pyrolae 12;
• a second step: pulverize the above materials into fine powder, filter with a 200 mesh screen and mix evenly to obtain a pulverized mixture;
• a second step: pulverize the above materials into fine powder, filter with a 200 mesh screen and mix evenly to obtain a pulverized mixture;
• a third step: adding 70% ethanol to the pulverized mixture at a weight ratio of 3: 1;
• a fourth step: refluxing the intermediate twice, each for 3 hours, and filtering to obtain two filtrates; and
• a fifth step: mixing the two filtrates, and thickening to remove the ethanol to obtain an extraction solution as a drug preparation to be obtained.

Example 3

• a first step: weighing in parts by weight radix bupleuri 5, dandelion 10, unprocessed pine 13, oatmeal or oatmeal 28 and herba pyrolae 12;
• a second step: pulverize the above materials into fine powder, filter with a 200 mesh screen and mix evenly to obtain a pulverized mixture;
• a third step: add water to the above pulverized mixture and let it soak for at least 8 hours until the mixture is completely soaked,
• a fourth step: boil the mixture twice with water, each time for 4 h at 30 ° C by adding 10 ml of water in an interval of 30 min, and filtering to obtain two filtrates:
• a fifth step: mixing the two filtrates and adding 70% ethanol, the weight of ethanol being three times the absolute weight of the raw materials;
• a sixth step: refluxing the intermediate twice, each for 3 hours, and filtering to obtain two filtrates; and
• a seventh step: mixing the two filtrates, and thickening to remove the ethanol to obtain an extraction solution as a medicinal product to be obtained.

The medication for gout treatment according to the present invention contains different ingredients than conventional drugs and can overcome disadvantages of conventional drugs.

Claims (5)

Medicament for gout treatment, comprising in parts by weight of Radix Bupleuri 5-15, Dandelion 10-15, unprocessed pine 13-20, oatmeal or oatmeal 12-28 and Herba Pyrolae 5-12. Medication for gout treatment after Claim 1 , further comprising Carapax Eretmochelyos 20-30 by weight. Medication for gout treatment after Claim 1 , further comprising in parts by weight of Rhizoma Smilacis Glabrae 12-18. Medication for gout treatment after Claim 1 , wherein the administration form of the drug is selected from film-coated tablets, sugar-coated tablets, acid-resistant tablets, dispersible tablets, capsules, granules, broth, mixture, sirum, wine, injection, oral solution and cloudy liquid. Process for the preparation of the medicament according to any of the Claims 1 to 4th , comprising the following steps: a first step: weighing in parts by weight of Radix Bupleuri 5-15, dandelion 10-15, unprocessed pine 13-20, oatmeal or oatmeal 12-28 and Herba Pyrolae 5-12, mixing to a mixture and pulverizing the Mixture; a second step: adding 70% ethanol to the powdered solution in a weight ratio of (2-3): 1; a third step: refluxing the intermediate twice, each for 2-3 hours, and filtering to obtain two filtrates; and a fourth step: mixing the two filtrates, and thickening to remove the ethanol to obtain an extraction solution as a drug preparation to be obtained.