DE102016224689A1 - Oral and dental care and cleaning products for gum health - Google Patents

Abstract

Oral and dental care and cleaning compositions containing, by weight, at least one extract of Quassia Amara, from 0.0001 to 1% by weight of one or more radical scavengers selected from the group - b1) Dimethylmethoxy chromanol (lipochroman) - b2) Vitamin C - b3) Hydroxytyrosine - b4) Epigallocatechin gallate - b5) Arginine - b6) Bis-2-ethylhexyl hydroxydimethoxy Benzyl malonates - b7) Polyphenols (resveratrol, silylmarine, apigenin etc.) - b8) Carotenoids (lycopene etc.) relates to the total amount of ingredients b1) to b8), and at least one silica, especially precipitated silica, having an average particle size D50 according to ISO-13320 of 8.0 to 15.0 microns vitalize the gums already during the cleaning process and strengthen his Resistance, so that in this way prevents the formation of small micro injuries and - should it have been caused small injuries - the regeneration ability of the gums is increased.

Description

The invention relates to preparations for oral and dental care and cleaning, which cause increased gum protection and thus increase the gum health and the insensitivity of the teeth, especially the tooth necks.

Mouth and tooth cleaning agents are available in various forms on the market and serve primarily the cleaning of the tooth surface, the prevention of tooth and gum disease and the fight against halitosis.

Dentifrices usually contain a combination of polishes, humectants, surfactants, binders, flavorings and fluoride-containing and antimicrobial agents. In addition to toothpowder, which play a minor role because of their increased abrasiveness, dentifrices are mainly offered in paste, cream and translucent or transparent gel form. In recent years, liquid or liquid tooth creams have become increasingly important.

The mouth is lined with a moisturized mucous membrane (mucosa). This consists generally of two layers: a multi-layered, usually not horny squamous epithelium and the underlying connective tissue. In contrast to normal skin, the mucous membrane has no horny layer. Gum is the epithelial component of the periodontium. This also consists of a multi-layered squamous epithelium, which also has only a few horny layers.

An important characteristic of oral mucosa and gums is consequently the lack or very weak formation of the horny layer. With this horny layer, the entire oral region also lacks an important external barrier to mechanical, chemical and physical influences. The mucosal cells are thus exposed to all the aforementioned stresses without protective layer and therefore react more sensitive to the caused by brushing the mechanical stresses and associated with the use of dental creams chemical stimuli.

In addition, many consumers, however, also want a visually pleasing-looking gums. In particular, no visible discoloration or changes should be recognizable on the gums, as this is perceived visually as unpleasant by many people. Furthermore, the gum color should have a hue that is perceived by consumers as aesthetically pleasing.

There is therefore a need for active ingredients in oral and dental cleansers whose use leads to an optical beautification of the appearance of the gums, in particular to reduced optically unsightly discolorations and an aesthetically pleasing gum color.

The present application was therefore based on the object to provide an optimized for both the teeth and for the gums and oral mucosa tooth cleaning and care products, which allows the use of indispensable for cleaning teeth and caries prophylactic ingredients such as abrasives and surfactants, but at the same time their minimizes negative impact on the gums, vitalizes the gums and strengthens their resistance as well
leads to an optical beautification of the appearance of the gums. At the same time, however, these active ingredients should not have any negative influence on the cleaning performance and the stability of the mouth and tooth cleaning agents.

• a) mindestens einen Extrakt aus Quassia Amara,
• b) 0,0001 bis 1 Gew.-% eines oder mehrerer Radikalfänger aus der Gruppe – b1) Dimethylmethoxy chromanol (Lipochroman) – b2) Vitamin C – b3) Hydroxytyrosin – b4) Epigallocatechingallat – b5) Arginin – b6) Bis-2-Ethylhexyl Hydroxydimethoxy Benzylmalonate – b7) Polyphenole (Resveratrol, Silylmarin, Apigenin etc.) – b8) Carotinoide (Lycopene etc.) wobei sich die Mengenangabe auf die Gesamtmenge an Inhaltstoffen b1) bis b8) bezieht
• c) mindestens eine Kieselsäure, insbesondere Fällungskieselsäure, mit einer mittleren Teilchengröße D₅₀ nach ISO-13320 von 8,0 bis 15,0 µm.

The present invention relates in a first embodiment to oral and dental care and cleaning compositions, containing - based on their weight -

• a) at least one extract from Quassia Amara,
• b) 0.0001 to 1% by weight of one or more radical scavengers from the group b1) dimethylmethoxy chromanol (lipochroman) b2) vitamin C b3) hydroxytyrosine b4) epigallocatechin gallate b5) arginine b6) bis-2 Ethylhexyl hydroxydimethoxy benzylmalonates - b7) polyphenols (resveratrol, silylmarine, apigenin, etc.) - b8) carotenoids (lycopene etc.) where the quantity refers to the total amount of ingredients b1) to b8)
• c) at least one silica, in particular precipitated silica, having an average particle size D ₅₀ after ISO-13320 from 8.0 to 15.0 μm.

Oral and dental care products as well as mouth and tooth cleaning agents in the sense of the invention are mouthwashes and toothpowder, oral and toothpastes, liquid mouthwashes and toothpastes, oral and dental rinses, and oral and dental gels. Preferably suitable are toothpastes and liquid dentifrices. For this, the oral and dental care and cleaning agents, e.g. in the form of toothpastes, liquid toothpastes, toothpowder, mouthwashes or possibly also as gum, e.g. B. as chewing gum, present. Preferably, however, they are present as more or less flowable or plastic toothpastes, as they are used for cleaning the teeth using a toothbrush.

An extract in the sense of the present application is a substance or substance mixture which has been obtained by extraction and partial or complete evaporation of the extraction solution. A distinction is made according to the nature of dry extracts ie extracts evaporated to dryness, ie extracts made with solvents so that at most 2 parts of fluid extract are obtained from one part of the drug, viscous extracts or thick extracts, ie extracts in which a part of the solvent is evaporated.

The extracts used in the invention can be obtained from the harvest-fresh plants, but also from stored goods.

The extracts may be prepared with water, as well as polar or nonpolar organic solvents, as well as mixtures thereof in a manner known to those skilled in the art. The extracts used according to the invention are obtained by extraction, preferably with organic solvents, water or mixtures thereof. Preferred organic solvents are ketones (eg acetone), ethers, esters, alcohols or halogenated hydrocarbons. Particularly preferred extractants are water and / or alcohols. Among the alcohols, (C ₁ to C ₆ ) alcohols, such as ethanol and isopropanol, both as the sole extractant and in admixture with water, are preferred. Particularly preferred extractants are water, ethanol, 2-propanol, 1,2-propylene glycol, 1,3-butylene glycol, very particular preference is given to water, ethanol, 2-propanol and 1,2-propylene glycol and mixtures thereof, for example a mixture 1, 2-propylene glycol / water in the ratio 4: 1. Extracts that can be obtained by extraction with ethanol or water / ethanol mixtures are particularly preferred.

It is possible to use both the extracts in the original extractant and also extracts in water or other organic solvents and / or mixtures thereof, in particular ethanol and also ethanol / water mixtures. Preferably, extracted or pressed material is used as a solid to which the solvent (in particular as gently as possible) was removed. However, it is also possible to use those extracts to which the solvent has been partly removed, so that a thickened extract is used.

In particular, the extracts are used in solid form. The extraction is preferably carried out at a temperature of 25 ° C to 90 ° C.

Depending on the choice of the extraction agent, it may be preferable to stabilize the extract by adding a solubilizer. Suitable solubilizers are, for. B. Ethoxylation products of optionally hydrogenated vegetable and animal oils. Preferred solubilizers are ethoxylated mono-, di- and triglycerides of C8-22 fatty acids having from 4 to 50 ethylene oxide units, e.g. Hydrogenated ethoxylated castor oil, olive oil ethoxylate, almond oil ethoxylate, mink oil ethoxylate, polyoxyethylene glycol caprylic / capric acid glycerides, polyoxyethylene glycerol monolaurate and polyoxyethylene glycol coconut fatty acid glycerides. Olive oil ethoxylate (INCI name: PEG-10 Olive Glycerides) is particularly preferred.

The dry matter of the extract is dependent on the molecular weight and the solubility of the dispersed ingredients and is usually 1 to 80 wt .-%, in each case based on the weight of the extract. Preferably, the dry matter is 15 to 50 wt .-% and particularly preferably 20 to 35 wt .-%. With a molecular weight of the ingredients above 100,000 daltons, a dry matter of 1 to 20 wt .-% may be preferred and a dry matter of 1 to 10 wt .-% may be particularly preferred. Particularly preferred cosmetic agents are characterized in that the dry matter of the extract is 5-80% by weight, based on the weight of the extract.

As the first essential ingredient, the compositions according to the invention contain at least one extract from Quassia Amara.

The Quassia Amara, Brazilian Quassia tree, Quassia tree, Quassia tree, Bitter quassia or as some other species also called Bitter wood, is a plant in the family Bitter family (Simaroubaceae). It is widespread in the Neotropics. The extracts used according to the invention are preferably obtained from the wood, leaves, flowers, fruits, particularly preferably from the wood.

Extract of Quassia Amara can according to known manufacturing processes in variable composition with solvents such. As water, methanol, ethanol, acetone, etc., and mixtures thereof at temperatures from room temperature to 100 ° C under mild to vigorous mixing within 10 min. To 24 hours. Under atmospheric pressure up to 200 bar. For enrichment of effectiveness-determining components further concentration steps can be carried out such. B. liquid-liquid distribution with z. B. 1-butanol / water or ethyl acetate / water, adsorption-desorption on ion exchanger, LH20, HP20 and other resins or chromatographic separations over RP18, silica gel, etc. If the further processing to dry extracts is desired, this is done by per se known methods Stripping off the solvent at elevated temperature and / or reduced pressure. The weight fraction of Quassia Amara on the total weight of the compositions of the invention are based on the dry matter of the extract.

Very preferred according to the invention is an extract obtainable by extraction of Quassia Amara wood with water. This is also known under the INCI name QUASSIA AMARA WOOD EXTRACT.

The commercial product of the extract from Quassia Amara may contain, in addition to extractants, additional solvents to improve the shelf life of the product. For example, propylene glycol, 1,3-butylene glycol and pentylene glycol are such antimicrobial solvents.

Agents which are preferred according to the invention use the extract (s) from Quassia Amara within narrow quantitative ranges. Here oral and dental care and cleaning compositions according to the invention are preferred, which - based on their weight - 0.001-5 wt .-%, preferably 0.001-4 wt .-%, particularly preferably 0.002-2 wt .-%, most preferably 0.003 -1 wt .-% and in particular 0.005 to 0.5 wt .-% extract (s) from Quassia Amara included.

It may also be preferred in another embodiment that the extract comprises at least one polar solvent selected from ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, ethylene glycol, 1,2-propylene glycol, 1,3- Butylene glycol, glycerol and water, and mixtures thereof.

Surprisingly, it has been found that Quassia Amara stimulates collagen synthesis in gingival fibroblasts and the ATP synthesis of gingiva keratinocytes, which promotes cell vitality. This plays a special role in oral hygiene, as gingival inflammation in gingivitis causes the underlying matrix, which consists largely of collagen, to be broken down and the gums to retract. In addition, it is beneficial to stimulate collagen production in the gums as it strengthens the gums and protects against inflammation. In addition, it is known that the gums u.a. due to declining matrix components in the deeper layers of old age and thus also more susceptible to inflammation. By "filling in" natural matrix components (collagen), this process can be prevented. In addition, the stimulation of ATP synthesis is advantageous because, in particular, the gums are susceptible to inflammation and the gum resistance can be enhanced by promoting cell metabolism.

The combination of radical scavengers b) with stimulators of the body's defense a) against radicals leads to a comprehensive and sustainable protection against cell damage and aging of the gums. The harmful effects of free radicals are mitigated, the regeneration of the structures damaged by free radicals is promoted, so that the gums, mouth and necks become more resistant and less sensitive to pain.

• – b1) Dimethylmethoxy chromanol (Lipochroman)
• – b2) Vitamin C
• – b3) Hydroxytyrosin
• – b4) Epigallocatechingallat
• – b5) Arginin
• – b6)) Bis-2-Ethylhexyl Hydroxydimethoxy Benzylmalonate
• – b7) Polyphenole (Resveratrol, Silylmarin, Apigenin etc.)
• – b8) Carotinoide (Lycopene etc.)

wobei sich die Mengenangabe auf die Gesamtmenge an Inhaltstoffen b1) bis b8) bezieht. Das heißt, ein erfindungsgemäßes Mittel kann 1 Gew.-% Vitamin C enthalten und ist dann naturgemäß (weil die Obergrenze erreicht ist) frei von anderen Radikalfängern aus der o.g. Gruppe. Selbstverständlich kann ein erfindungsgemäßes Mittel auch zwei, drei, vier, fünf, sechs, sieben, acht oder noch mehr der o.g. Radikalfänger enthalten, hier ist dann die Gesamtmenge an allen diesen Stoffen im Bereich 0,0001 bis 1 Gew.-% zu wählen. As a second essential ingredient, the agents according to the invention contain from 0.0001 to 1% by weight of one or more radical scavengers from the group

• B1) dimethylmethoxy chromanol (lipochroman)
• - b2) Vitamin C
• - b3) hydroxytyrosine
• - b4) epigallocatechin gallate
• - b5) arginine
• - b6)) bis-2-ethylhexyl hydroxydimethoxy benzyl malonates
• - b7) polyphenols (resveratrol, silylmarine, apigenin, etc.)
• - b8) carotenoids (lycopene etc.)

where the quantity refers to the total amount of ingredients b1) to b8). This means that an agent according to the invention can contain 1% by weight of vitamin C and is naturally (because the upper limit is reached) free of other radical scavengers from the abovementioned group. Of course, an agent according to the invention may also contain two, three, four, five, six, seven, eight or even more of the abovementioned radical scavengers; here, the total amount of all these substances in the range from 0.0001 to 1% by weight must be selected.

According to the invention, preferred oral and dental care and cleaning compositions contain, based on their weight, from 0.0005 to 0.9% by weight, preferably from 0.00075 to 0.8% by weight, more preferably from 0.001 to 0.7% by weight. -%, particularly preferably 0.0015 to 0.6 wt .-% and in particular 0.002 to 0.5 wt .-% of one or more radical scavengers from the group b1) to b8), wherein the amount specified on the total amount of ingredients b1 ) to b8).

Always taking into account the total amount of all substances b1) to b8) in the range from 0.0001 to 1% by weight, agents according to the invention of the following embodiments are particularly preferred:
Oral and dental care and cleaning compositions, which - based on their weight - 0.0005 to 0.9% by weight, preferably 0.00075 to 0.8 wt .-%, more preferably 0.001 to 0.7 parts by weight %, more preferably 0.0015 to 0.6 wt .-% and in particular 0.002 to 0.5 wt .-% dimethylmethoxy chromanol (lipochroman).

Oral and dental care and cleaning compositions, which - based on their weight - 0.0005 to 0.9% by weight, preferably 0.00075 to 0.8 wt .-%, more preferably 0.001 to 0.7 parts by weight %, more preferably 0.0015 to 0.6 wt .-% and in particular 0.002 to 0.5 wt .-% vitamin C.

Oral and dental care and cleaning compositions, which - based on their weight - 0.0005 to 0.9% by weight, preferably 0.00075 to 0.8 wt .-%, more preferably 0.001 to 0.7 parts by weight %, more preferably 0.0015 to 0.6 wt .-% and in particular 0.002 to 0.5 wt .-% hydroxy tyrosine.

Oral and dental care and cleaning compositions, which - based on their weight - 0.0005 to 0.9% by weight, preferably 0.00075 to 0.8 wt .-%, more preferably 0.001 to 0.7 parts by weight %, more preferably 0.0015 to 0.6 wt .-% and in particular 0.002 to 0.5 wt .-% Epigallocatechingallat included.

Oral and dental care and cleaning compositions, which - based on their weight - 0.0005 to 0.9% by weight, preferably 0.00075 to 0.8 wt .-%, more preferably 0.001 to 0.7 parts by weight %, more preferably 0.0015 to 0.6 wt .-% and in particular 0.002 to 0.5 wt .-% arginine.

Oral and dental care and cleaning compositions, which - based on their weight - 0.0005 to 0.9% by weight, preferably 0.00075 to 0.8 wt .-%, more preferably 0.001 to 0.7 parts by weight %, more preferably 0.0015 to 0.6 wt .-% and in particular 0.002 to 0.5 wt .-% bis-2-ethylhexyl hydroxydimethoxy Benzylmalonate included.

Oral and dental care and cleaning compositions, which - based on their weight - 0.0005 to 0.9% by weight, preferably 0.00075 to 0.8 wt .-%, more preferably 0.001 to 0.7 parts by weight %, more preferably 0.0015 to 0.6 wt .-% and in particular 0.002 to 0.5 wt .-% polyphenols.

Oral and dental care and cleaning compositions, which - based on their weight - 0.0005 to 0.9% by weight, preferably 0.00075 to 0.8 wt .-%, more preferably 0.001 to 0.7 parts by weight %, more preferably 0.0015 to 0.6 wt .-% and in particular 0.002 to 0.5 wt .-% Resveratrol contained.

Oral and dental care and cleaning compositions, which - based on their weight - 0.0005 to 0.9% by weight, preferably 0.00075 to 0.8 wt .-%, more preferably 0.001 to 0.7 parts by weight %, more preferably 0.0015 to 0.6 wt .-% and in particular 0.002 to 0.5 wt .-% silylmarine.

Oral and dental care and cleaning compositions, which - based on their weight - 0.0005 to 0.9% by weight, preferably 0.00075 to 0.8 wt .-%, more preferably 0.001 to 0.7 parts by weight %, more preferably 0.0015 to 0.6 wt .-% and in particular 0.002 to 0.5 wt .-% of apigenin.

Oral and dental care and cleaning compositions, which - based on their weight - 0.0005 to 0.9% by weight, preferably 0.00075 to 0.8 wt .-%, more preferably 0.001 to 0.7 parts by weight %, more preferably 0.0015 to 0.6 wt .-% and in particular 0.002 to 0.5 wt .-% carotenoids.

Oral and dental care and cleaning compositions, which - based on their weight - 0.0005 to 0.9% by weight, preferably 0.00075 to 0.8 wt .-%, more preferably 0.001 to 0.7 parts by weight %, more preferably 0.0015 to 0.6 wt .-% and in particular 0.002 to 0.5 wt .-% Lycopene contained.

As a third essential ingredient, the compositions according to the invention comprise at least one silica, in particular precipitated silica, having an average particle size D ₅₀ ISO-13320 from 8.0 to 15.0 μm. Suitable silicic acids are, for example, gel silicas, hydrogel silicic acids and precipitated silicas. Gel silicas are prepared by reacting sodium silicate solutions with strong, aqueous mineral acids to form a hydrosol, aging to the hydrogel, washing and drying. If the drying takes place under mild conditions to water contents of 15 to 35 wt .-%, the so-called hydrogel silicas are obtained. Drying to water contents below 15% by weight results in an irreversible shrinkage of the previously loose structure of the hydrogel to the dense structure of the so-called xerogel.

A second, preferably suitable group of silica polishing agents are the precipitated silicas. These are obtained by precipitation of silica from dilute alkali silicate solutions by addition of strong acids under conditions in which aggregation to the sol and gel can not occur. Suitable methods for preferably suitable is a precipitated silica having a BET surface area of 15-110 m ² / g and a viscosity in 30% glycerol-water (1: 1) dispersion of 30-60 Pa · s (20 ° C ) in an amount of 10-20% by weight of the dentifrice. Particularly suitable precipitated silicas of this type have rounded corners and edges and are commercially available under the trade name ^® Sident 12 DS (DEGUSSA).

Other precipitated silicas of this type are ident ^® 8 (DEGUSSA) and Sorbosil® ^® AC 39 (Crosfield Chemicals). These silicas are characterized by a lower thickening effect and a slightly higher average particle size of 8-14 microns at a specific surface area of 40-75 m ² / g (according to BET) and are particularly suitable for liquid Toothpastes. These should have a viscosity (25 ° C, shear rate D = 10 s ^-1 ) of 10-100 Pa · s.

According to preferred mouth and Zahnpflege- and -reinigungsmittel contain - based on their weight - 3 to 25 wt .-%, preferably 4 to 20 wt .-% and in particular 5 to 15 wt .-% silica, especially precipitated silica, with an average Particle size D ₅₀ after ISO-13320 from 8.0 to 15.0 μm.

In accordance with the invention particularly preferred oral and dental care and cleaning agents, the silica (s) c) has a BET surface ISO-9277 from 40 to 80 m ² / g.

As a further polishing agent component, e.g. Aluminum oxide in the form of slightly calcined alumina containing alumina in an amount of about 1-5 wt .-%. Such a suitable alumina is available, for example, under the trade name "Polianton earth P10 fine" (Giulini Chemie).

As a polishing agent are all further known for toothpastes friction body such. B. sodium aluminum silicates such. As zeolite A, organic polymers such. As polymethacrylate or mixtures of these and the aforementioned friction body.

Calcium containing polishing components such as e.g. Chalk, calcium pyrophosphate, dicalcium phosphate dihydrate can also be present in amounts of up to 5% by weight, based on the total composition.

Furthermore, it is advantageous in the context of the present invention if the oral and dental cleaning agents used according to the invention additionally contain at least one fluoride-containing compound. Preference is given here to a fluoride-containing compound selected from the group of sodium fluorides; (ii) disodium monofluorophosphates; (iii) potassium fluorides; (iv) stannous fluorides; (v) amine fluorides and (vi) their mixtures.

Oral and dental care and cleaning agents particularly preferred according to the invention contain 500 to 1600 ppm, preferably 1225 to 1575 ppm, more preferably 1250 to 1550 ppm, even more preferably 1275 to 1525 ppm, even more preferably 1300 to 1500 ppm, even more preferably 1325 to 1475 ppm and especially 1350 to 1450 ppm fluoride.

When fluoride is provided in the form of sodium fluoride, 1% by weight of sodium fluoride corresponds to about 4524 ppm of fluoride, so that preferred agents of the invention are from 0.27 to 0.35% by weight, preferably from 0.28 to 0.34% by weight. more preferably 0.29 to 0.33 wt .-% and in particular 0.30 to 0.32 wt .-% sodium fluoride.

It has been shown that theophylline can increase the effect of the combination according to the invention superadditive. Preferred oral and dental care and cleaning compositions according to the invention therefore contain, based on their weight, from 0.0001 to 0.1% by weight, preferably from 0.0005 to 0.09% by weight, more preferably from 0.00075 to 0, 08 wt .-%, more preferably 0.001 to 0.07 and especially 0.001 to 0.05 wt .-% theophylline ,.

The mouth and tooth cleaning agents according to the invention preferably contain surfactants which support the mechanical plaque removal, in particular at locations which are difficult to achieve with the toothbrush. The removed contaminants, such as plaque and food particles, are dispersed by the surfactants, preventing re-deposition on the tooth surface. In addition, the surfactants used should generate a certain amount of foam in order to ensure a uniform distribution of the components of the oral and tooth cleaning agent used according to the invention during tooth brushing in the mouth. The surfactants used in the mouth and tooth cleaning agents used in the invention must be well tolerated by skin or mucous membranes and toxicologically harmless to avoid endangering the consumer. Finally, the oral and dentifrice of the present invention must have good foam stability and foam consistency, as these are important factors for consumer product acceptance.

In the context of the present invention, the surfactants used are preferably particularly skin-compatible amphoteric surfactants. Preferred embodiments of the present invention are therefore characterized in that the oral and dental cleaning composition additionally comprises at least one C _8-12 alkylamido (C _1-4 ) alkylbetaine, in particular a C _8-12 -alkyldimethylamidopropylbetaine, in a total amount of 0.1 to 5.0% by weight, preferably from 0.1 to 3.0% by weight, in particular from 0.1 to 2.0% by weight, based on the total weight of the mouth and tooth cleaning agent.

To increase the amount of foam and the foam stability, it may also be advisable to use an anionic surfactant. Typical examples of anionic surfactants are soaps, alkylbenzenesulfonates, alkanesulfonates, olefinsulfonates, alkyl ether sulfonates, glycerol ether sulfonates, α-methyl ester sulfonates, sulfo fatty acids, alkyl sulfates, fatty alcohol ether sulfates, glycerol ether sulfates, hydroxy mixed ether sulfates, monoglyceride (ether) sulfates, fatty acid amide (ether) sulfates, mono- and dialkyl sulfosuccinates, mono- and dialkylsulfosuccinamates, sulfotriglycerides, amide soaps, ether carboxylic acids and their salts, fatty acid isethionates, fatty acid sarcosinates, fatty acid taurides, N-acyl amino acids such as acyl lactylates, acyl tartrates, acyl glutamates and acyl aspartates, alkyl oligoglucoside sulfates, protein fatty acid condensates (especially vegetable based wheat products) and alkyl (ether ) phosphates. If the anionic surfactants contain polyglycol ether chains, these may have a conventional, but preferably a narrow homolog distribution.

Therefore, according to the invention preferred oral and Zahnpflege- and -reinigungsmittel contain 0 to 5 wt .-%, preferably 0.1 to 4.5 wt .-%, particularly preferably 0.5 to 4 wt .-%, more preferably 0.75 to 3.5 wt .-% and in particular 1 to 3 wt .-% of anionic surfactants.

It is inventively preferred if the oral and dental cleaning agent at least one C _8-18 alkyl (ether) sulfate having 0 or 1 to 6 ethylene oxide units, in particular a C ₁₂ alkyl sulfate, in a total amount of 0.1 to 5.0 wt .-%, preferably from 0.5 to 4.0 wt .-%, in particular from 1.0 to 3.0 wt .-%, based on the total weight of the oral and dentifrice contains.

With particular preference, the agents according to the invention contain, in addition or as an alternative to the anionic surfactants, amphoteric surfactant (s). Ampholytic surfactants and emulsifiers are understood to mean those surface-active compounds which, apart from a C ₈ -C ₂₄ -alkyl or -acyl group, contain at least one free amino group and at least one -COOH or -SO ₃ H group and are capable of forming internal salts , Examples of suitable ampholytic surfactants are N-alkylglycines, N-alkylaminopropionic acids, N-alkylaminobutyric acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamidopropylglycines, N-alkyltaurines, N-alkylsarcosines, 2-alkylaminopropionic acids and alkylaminoacetic acids each having about 8 to 24 C Atoms in the alkyl group. Particularly preferred ampholytic surfactants are N-cocoalkylaminopropionate, cocoacylaminoethylaminopropionate and C ₁₂ -C ₁₈ acylsarcosine.

Particularly preferred mouth and dental care and cleaning agents according to the invention are characterized in that they contain 0.01 to 2% by weight, preferably 0.05 to 1.5% by weight, more preferably 0.1 to 1% by weight. %, even more preferably 0.12 to 0.7 wt .-% and in particular 0.15 to 0.6 wt .-% amphoteric (s) surfactant (s) included.

• – N-Alkylglycine,
• – N-Alkylpropionsäuren,
• – N-Alkylaminobuttersäuren,
• – N-Alkyliminodipropionsäuren,
• – N-Hydroxyethyl-N-alkylamidopropylglycine,
• – N-Alkyltaurine,
• – N-Alkylsarcosine,
• – 2-Alkylaminopropionsäuren mit jeweils etwa 8 bis 24 C-Atomen in der Alkylgruppe,
• – Alkylaminoessigsäuren mit jeweils etwa 8 bis 24 C-Atomen in der Alkylgruppe,
• – N-Kokosalkylaminopropionat,
• – Kokosacylaminoethylaminopropionat
• – C₁₂-C₁₈-Acylsarcosin,
• – N-Alkyl-N,N-dimethylammonium-glycinate, beispielsweise Kokosalkyl-dimethylammoniumglycinat,
• – N-Acyl-aminopropyl-N,N-dimethylammoniumglycinate, beispielsweise Kokosacylaminopropyl-dimethylammoniumglycinat,
• – 2-Alkyl-3-carboxymethyl-3-hydroxyethyl-imidazoline mit jeweils 8 bis 18 C-Atomen in der Alkyl- oder Acylgruppe
• – Kokosacylaminoethylhydroxyethylcarboxymethylglycinat
• – der unter der INCI-Bezeichnung Cocamidopropyl Betain bekannten Verbindungen,
• – der unter der INCI-Bezeichnung Disodium Cocoamphodiacetate bekannten Verbindungen

enthalten. Particularly preferred mouth and dental care and cleaning agents according to the invention are characterized in that they contain amphoteric surfactant (s) from the groups of

• - N-alkylglycines,
• N-alkylpropionic acids,
• N-alkylaminobutyric acids,
• N-alkyliminodipropionic acids,
• N-hydroxyethyl-N-alkylamidopropylglycines,
• N-alkyl taurines,
• N-alkyl sarcosines,
• 2-alkylaminopropionic acids each having about 8 to 24 C atoms in the alkyl group,
• Alkylaminoacetic acids each having about 8 to 24 C atoms in the alkyl group,
• N-cocoalkylaminopropionate,
• - cocoacylaminoethylaminopropionate
• C ₁₂ -C ₁₈ acyl sarcosine,
• N-alkyl-N, N-dimethylammonium glycinates, for example cocoalkyldimethylammonium glycinate,
• N-acyl-aminopropyl-N, N-dimethylammonium glycinates, for example cocoacylaminopropyl-dimethylammonium glycinate,
• - 2-Alkyl-3-carboxymethyl-3-hydroxyethyl-imidazolines each having 8 to 18 carbon atoms in the alkyl or acyl group
• Cocoacylaminoethylhydroxyethylcarboxymethylglycinate
• The compounds known by the INCI name cocamidopropyl betaine,
• - The known under the INCI name Disodium Cocoamphodiacetate compounds

contain.

in der R für einen geradkettigen oder verzweigten, gesättigten oder ein- bzw. mehrfach ungesättigten Alkyl- oder Alkenlyrest mit 8 bis 24 Kohlenstoffatomen steht. Particularly preferred oral and dental care and cleaning agents contain as amphoteric surfactants betaines of the formula (Bet-I)

in which R is a straight-chain or branched, saturated or mono- or polyunsaturated alkyl or alkenyl radical having 8 to 24 carbon atoms.

These surfactants are referred to the INCI nomenclature as Amidopropylbetaine, wherein the representatives derived from coconut fatty acids are preferred and are referred to as Cocoamidopropylbetaine. According to the invention, particular preference is given to using surfactants of the formula (Bet-I) which are a mixture of the following representatives: H ₃ C- (CH ₂ ) ₇ -C (O) -NH- (CH ₂ ) ₃ N ⁺ (CH ₃ ) ₂ CH ₂ COO ^- H ₃ C- (CH ₂ ) ₉ -C (O) -NH- (CH ₂ ) ₃ N ⁺ (CH ₃ ) ₂ CH ₂ COO ^- H ₃ C- (CH ₂ ) ₁₁ -C (O) -NH- (CH ₂ ) ₃ N ⁺ (CH ₃ ) ₂ CH ₂ COO ^- H ₃ C- (CH ₂ ) ₁₃ -C (O) -NH- (CH ₂ ) ₃ N ⁺ (CH ₃ ) ₂ CH ₂ COO ^- H ₃ C- (CH ₂ ) ₁₅ -C (O) -NH- (CH ₂ ) ₃ N ⁺ (CH ₃ ) ₂ CH ₂ COO ^- H ₃ C- (CH ₂ ) ₇ -CH = CH- (CH ₂ ) ₇ -C (O) -NH- (CH ₂ ) ₃ N ⁺ (CH ₃ ) ₂ CH ₂ COO ^-

Particular preference is given to using surfactants of the formula (Bet-I) within narrower ranges of amounts. Mouth and dental care and cleaning compositions according to the invention are preferred here which, based on their weight, are 0.1 to 4.0% by weight, preferably 0.2 to 3.0% by weight, more preferably 0.3 to 2.5 wt .-%, more preferably 0.4 to 2.0 wt .-% and in particular 0.5 to 1.0 wt .-% cocamidopropyl betaine.

The amphoteric and anionic surfactants are particularly preferably used in specific weight ratios. Preferred mouth and tooth cleaning agents according to the invention are therefore characterized in that a weight ratio of the at least one amphoteric surfactant to the at least one anionic surfactant is from 5: 1 to 1:20, preferably from 2: 1 to 1:15, preferably from 1: 1 to 1 : 12, more preferably from 1: 2 to 1:10, in particular from 1: 4 to 1: 9, is maintained.

The oral and dental care and cleaning compositions according to the invention contain further ingredients. Preference is given here to the use of so-called humectants, which prevent dehydration in toothpastes and increase the effectiveness of the combination according to the invention. In so-called liquid tooth creams with flowable rheology these serve as a matrix and are used in higher amounts. In mouthwashes and mouthwashes, these alcohols serve as consistency regulators and additional sweeteners.

Here oral and dental care and cleaning compositions according to the invention are preferred which - based on their weight - 0.5 to 60 wt .-%, preferably 0.75 to 55 wt .-%, particularly preferably 1 to 50 wt .-% and in particular 2 to 40 wt .-% of at least one polyhydric alcohol from the group sorbitol and / or glycerol and / or 1,2-Propylenglycol .-% or mixtures thereof.

For certain applications, it may be advantageous to use only one of the three ingredients mentioned above. In most cases, sorbitol is preferred. However, in other applications, mixtures of two of the three or all three may be preferred. Here, a mixture of glycerol, sorbitol and 1,2-propylene glycol in a weight ratio of 1: (0.5-1) :( 0.1-0.5) has proved to be particularly advantageous.

In addition to sorbitol or glycerol or 1,2-propylene glycol are suitable as further polyhydric alcohols are those having at least 2 OH groups, preferably mannitol, xylitol, polyethylene glycol, polypropylene glycol and mixtures thereof. Among these compounds, those having 2 to 12 OH groups, and especially those having 2, 3, 4, 5, 6 or 10 OH groups are preferred.

Polyhydroxy compounds having 2 OH groups are, for example, glycol (CH ₂ (OH) CH ₂ OH) and other 1,2-diols such as H- (CH ₂ ) _n -CH (OH) CH ₂ OH where n = 2, 3, 4 , 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20. Also 1,3-diols such as H- (CH ₂ ) _n -CH ( OH) CH ₂ CH ₂ OH with n = 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 used according to the invention. The (n, n + 1) or (n, n + 2) diols with non-terminal OH groups can also be used. Important representatives of polyhydroxy compounds having 2 OH groups are also the polyethylene and polypropylene glycols. As preferred further polyhydric alcohols may, for. B. xylitol, propylene glycols, polyethylene glycols, especially those having average molecular weights of 200-800 are used.

• i) 0 bis 15 Gew.-% Sorbitol
• ii) 0 bis 30 Gew.-% Glycerin,

enthalten, mit der Maßgabe, dass die Gesamtmenge an Inhaltsstoff(en) aus den Gruppen i) und ii) 5 bis 40 Gew.-% beträgt, sind besonders bevorzugte Ausführungsformen der vorliegenden Erfindung. It has been shown that glycerol and sorbitol in certain amounts can further positively influence the vitalization of the gums by the combination according to the invention. Mouth and dental care and cleaning compositions according to the invention

• i) 0 to 15 wt .-% sorbitol
• ii) 0 to 30% by weight of glycerol,

with the proviso that the total amount of ingredient (s) from groups i) and ii) is 5 to 40% by weight, are particularly preferred embodiments of the present invention.

Particularly preferred is the use of sorbitol, so that agents which contain no other polyhydric alcohols other than sorbitol, are particularly preferred.

With regard to fluoride deposition, it has proved advantageous to match the amounts of surfactant (s) and polishing agent (s). According to the invention, the weight ratio of polishing agent (s) to surfactant (s) is preferably ≦ 6, ie the polishing agents are used at a maximum of 6 times (by weight) excess to the surfactants. The weight ratio refers to the weight ratio of all substances from said groups to each other, whereby only the active substances are calculated. Contains an inventive agent, for example, 12 wt .-% polish and 4 wt .-% of a If a composition according to the invention contains, for example, 12% by weight of polishing agent and 4% by weight of a 50% surfactant solution and 1% by weight of pure sodium dodecylsulfate, the weight ratio is equal to 50% strength surfactant solution 12 / (2 + 1) = 4.

Particularly good values have been achieved for mouth and dental care and cleaning compositions in which the weight ratio of polish (s) to surfactant (s) in the range ≥ 5 to ≤ 15, preferably in the range ≥ 7.5 to ≤ 12.5, on is preferably in the range ≥ 10 to ≤ 12 and in particular in the range ≥ 10.25 to ≤ 11.9.

As a consistency regulator (or binder) serve z. Natural and / or synthetic water-soluble polymers such as alginates, carrageenates, tragacanth, starch and starch ethers, cellulose ethers such as carboxymethylcellulose (Na salt), hydroxyethylcellulose, methylhydroxypropylcellulose, guar, acacia, agar-agar, xanthan gum, succinoglycan-gum, locust bean flour, pectins, water-soluble carboxyvinyl polymers (eg. Carbopol ^® types), polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycols, particularly those having molecular weights of 1500 to 1,000,000.

Other substances that are suitable for viscosity control, z. B. phyllosilicates such. As montmorillonite clays, colloidal thickened silicas such. As airgel silicas, fumed silicas or finely ground precipitated silicas. It is also possible to use viscosity-stabilizing additives from the group of cationic, zwitterionic or ampholytic nitrogenous surfactants, hydroxypropyl-substituted hydrocolloids or polyethylene glycol / polypropylene glycol copolymers having an average molecular weight of 1000 to 5000 or a combination of the compounds mentioned in the toothpastes.

CMC and xanthan gum have proved to be particularly compatible with the combination of active substances according to the invention. When using these thickeners, the effect of the invention is particularly pronounced. According to the invention particularly preferred oral and dental care and cleaning agents are therefore characterized in that they - based on their weight - 0.2 to 7.5 wt .-%, preferably 0.25 to 5 wt .-%, particularly preferably 0 , 3 to 4 wt .-%, more preferably 0.4 to 3 wt .-%, still more preferably 0.45 to 2 wt .-% and in particular 0.5 to 0.8 wt .-% carboxymethylcellulose.

Further particularly preferred oral and dental care and cleaning agents are characterized in that they contain, based on their weight, from 0.15 to 5% by weight, preferably from 0.2 to 2.5% by weight, particularly preferably 0, 25 to 1 wt .-%, more preferably 0.3 to 0.75 wt .-%, even more preferably 0.35 to 0.6 wt .-% and in particular 0.4 to 0.5 wt .-% xanthan contain.

The agents according to the invention, in particular the toothpastes, may also contain substances for increasing the mineralizing potential, for example calcium-containing substances such as, for example, Calcium chloride, calcium acetate and dicalcium phosphate dihydrate. The concentration of the calcium-containing substance depends on the solubility of the substance and the interaction with other substances contained in the oral and dental care products. In addition to the compulsory components mentioned, the dentifrices according to the invention may contain further adjuvants and additives known per se. An additive which has been known for a long time as a toothpaste component is particularly effective in the dentifrices according to the invention: calcium glycerophosphate, the calcium salt of glycerol-1-phosphoric acid or glycerol-2-phosphoric acid or the glycerol-1-phosphoric acid enantiomer Glycerol-3-phosphoric acid or a mixture of these acids. The compound has a remineralizing effect in dentifrices as it provides both calcium and phosphate ions. In the dentifrices according to the invention calcium glycerophosphate is preferably used in amounts of 0.01-1 wt .-%. Overall, the dentifrices according to the invention may contain customary auxiliaries and additives in amounts of up to 10% by weight.

The dentifrices according to the invention may e.g. be improved by the addition of aromatic oils and sweeteners in their organoleptic properties.

As aroma oils, all the natural and synthetic flavors customary for oral and dental care products can be used. Natural flavors can be contained both in the form of natural essential oils isolated from drugs and the individual components isolated therefrom.

Suitable flavors are e.g. Peppermint oil, spearmint oil, eucalyptus oil, aniseed oil, fennel oil, caraway oil, menthyl acetate, cinnamic aldehyde, anethole, vanillin, thymol and mixtures of these components.

Suitable sweeteners are e.g. Saccharin sodium, sodium cyclamate, sucrose, lactose, maltose, fructose.

In the context of the present invention, it has surprisingly been found that the first relevant component of the oral and dental care and cleaning agent according to the invention, an extract from Quassia Amara, has outstanding suitability for Vitalization of cells of the gums and oral mucosa possesses.

The compositions of the invention can be used in a cosmetic, non-therapeutic method for cleaning the teeth while vitalizing or strengthening the gums and the oral mucosa.

Another object of the present invention is a method for cleaning teeth, in which a composition according to the invention is applied to the brush head of a toothbrush and the teeth are brushed with the toothbrush.

• a) Bereitstellung einer Zahnbürste, deren Bürstenkopf elektrisch in Bewegung versetzt werden kann;
• b) Applikation von 0,5 bis 5 g eines erfindungsgemäßen Mittels auf den Bürstenkopf,
• c) 30- bis 300-sekündiges Zähneputzen mit dem erfindungsgemäßen Mittel unter Einsatz des elektrisch in Bewegung versetzten Bürstenkopfes.

The gingival vitalization is even better with electric toothbrushes. Another object of the present invention is therefore a method for cleaning teeth, characterized by the steps

• a) providing a toothbrush, the brush head can be electrically set in motion;
• b) application of 0.5 to 5 g of an agent according to the invention onto the brush head,
• c) 30- to 300-second tooth brushing with the agent according to the invention using the electrically in motion offset brush head.

Application of the combination according to the invention of extract (s) from Quassia Amara and radical scavengers as well as possibly theophylline on the cells of the gingiva or oral mucosa increases their metabolic metabolic activity. As a result, more energy is available to the cells, and collagen production in the cells can be increased, resulting in strengthening of the gums.

• – b1) Dimethylmethoxy chromanol (Lipochroman)
• – b2) Vitamin C
• – b3) Hydroxytyrosin
• – b4) Epigallocatechingallat
• – b5) Arginin
• – b6) Bis-2-Ethylhexyl Hydroxydimethoxy Benzylmalonate
• – b7) Polyphenole (Resveratrol, Silylmarin, Apigenin etc.)
• – b8) Carotinoide (Lycopene etc.)
• – zur Verbesserung des optischen Erscheinungsbildes des Zahnfleisches
• – zur Vitalisierung und Kräftigung des Zahnfleischs und der Mundschleimhaut und/oder
• – zur Verbesserung der Zahnfleischregeneration und/oder
• – zur Verjüngung des Zahnfleisches und/oder
• – zum Schutz vor Zahnfleischentzündungen und/oder
• – zur Senkung der Zahnempfindlichkeit und/oder
• – zur Senkung der Zahnempfindlichkeit gegen süße Speisen und Getränke und/oder
• – zur Senkung der Zahnempfindlichkeit gegen saure Speisen und Getränke und/oder
• – zur Senkung der Zahnempfindlichkeit gegen heiße Speisen und Getränke und/oder
• – zur Senkung der Zahnempfindlichkeit gegen kalte Speisen und Getränke und/oder
• – zur Senkung der Zahnempfindlichkeit gegen taktile Reize.

A further subject of the present invention is therefore the non-therapeutic, cosmetic use of a combination of extract (s) from Quassia Amara and radical scavenger (s) from group b1) to b8)

• B1) dimethylmethoxy chromanol (lipochroman)
• - b2) Vitamin C
• - b3) hydroxytyrosine
• - b4) epigallocatechin gallate
• - b5) arginine
• B6) bis-2-ethylhexyl hydroxydimethoxy benzyl malonates
• - b7) polyphenols (resveratrol, silylmarine, apigenin, etc.)
• - b8) carotenoids (lycopene etc.)
• - to improve the visual appearance of the gums
• - to revitalize and strengthen the gums and oral mucosa and / or
• To improve gum regeneration and / or
• - for rejuvenation of the gums and / or
• - to protect against gingivitis and / or
• - To reduce tooth sensitivity and / or
• - To reduce tooth sensitivity to sweet foods and drinks and / or
• - To reduce tooth sensitivity to acidic foods and drinks and / or
• - To reduce tooth sensitivity to hot foods and drinks and / or
• - To reduce tooth sensitivity to cold foods and drinks and / or
• - To reduce tooth sensitivity to tactile stimuli.

With regard to preferred embodiments of the method according to the invention and the use according to the invention, what has been said about the agents according to the invention applies mutatis mutandis.

QUOTES INCLUDE IN THE DESCRIPTION

This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Cited non-patent literature

• ISO-13320 [0009]
• ISO-13320 [0041]
• ISO-13320 [0044]
• ISO-9277 [0045]

Claims (10)

Oral and dental care and cleaning compositions containing - based on its weight - a) at least one extract of Quassia Amara, b) 0.0001 to 1 wt .-% of one or more radical scavanger from the group - b1) dimethylmethoxy chromanol (lipochroman B2) Vitamin C b3) hydroxytyrosine b4) epigallocatechin gallate b5) arginine b6 bis-2-ethylhexyl hydroxydimethoxy benzyl malonates b7) polyphenols (resveratrol, silylmarine, apigenin, etc.) b8) carotenoids (lycopene etc.) where the quantity refers to the total amount of ingredients b1) to b8) c) at least one silica, in particular precipitated silica, having an average particle size D ₅₀ according to ISO-13320 of 8.0 to 15.0 microns. Oral and dental care and cleaning agent according to claim 1, characterized in that it - based on its weight - 0.001-5 wt .-%, preferably 0.001-4 wt .-%, particularly preferably 0.002-2 wt .-%, most preferably 0.003-1 wt.%, and especially 0.005-0.5 wt.% Extract (s) from Quassia Amara. Oral and dental care and cleaning agent according to one of claims 1 or 2, characterized in that it - based on its weight - 0.0005 to 0.9% by weight, preferably 0.00075 to 0.8% by weight. % more preferably 0.001 to 0.7 wt .-%, particularly preferably 0.0015 to 0.6 wt .-% and in particular 0.002 to 0.5 wt .-% of one or more radical scavanger from the group b1) to b8) contains , where the quantity refers to the total amount of ingredients b1) to b8). Oral and dental care and cleaning agent according to one of claims 1 to 3, characterized in that it - based on its weight - 3 to 25 wt .-%, preferably 4 to 20 wt .-% and in particular 5 to 15 wt. % Silica, in particular precipitated silica, having an average particle size D ₅₀ according to ISO 13320 of 8.0 to 15.0 μm. Oral and dental care and cleaning agent according to one of claims 1 to 4, characterized in that the silica (s) c) has a BET surface area according to ISO 9277 of 40 to 80 m ² / g / have. Oral and dental care and cleaning agent according to one of claims 1 to 5, characterized in that it is more preferably 500 to 1600 ppm, preferably 1225 to 1575 ppm, more preferably 1250 to 1550 ppm, even more preferably 1275 to 1525 ppm 1300 to 1500 ppm, even more preferably 1325 to 1475 ppm and in particular 1350 to 1450 ppm fluoride. Mouth and dental care and cleaning agent according to one of claims 1 to 6, characterized in that it - based on its weight - 0.0001 to 0.1 wt .-%, preferably 0.0005 to 0.09 wt .-% , more preferably 0.00075 to 0.08 wt .-%, even more preferably 0.001 to 0.07 and in particular 0.001 to 0.05 wt .-% theophylline contains. Mouth and dental care and cleaning agent according to one of claims 1 to 7, characterized in that it 0 to 5 wt .-%, preferably 0.1 to 4.5 wt .-%, particularly preferably 0.5 to 4 wt. -%, more preferably 0.75 to 3.5 wt .-% and in particular 1 to 3 wt .-% anionic surfactants. A method for cleaning teeth, characterized in that a composition according to any one of claims 1 to 8 applied to the brush head of a toothbrush and brushed with the toothbrush teeth. Non-therapeutic cosmetic use of a combination of Quassia Amara extract (s) from radical b1) to b8) - b1) Dimethylmethoxy chromanol (lipochroman) - b2) Vitamin C - b3) Hydroxytyrosine - b4) Epigallocatechin gallate - b5) arginine - b6) bis-2-ethylhexyl hydroxydimethoxy benzylmalonates - b7) polyphenols (resveratrol, silylmarine, apigenin, etc.) - b8) carotenoids (lycopene etc.) - to improve the visual appearance of the gums - to revitalize and strengthen the body Gums and the oral mucosa and / or - to improve gingival regeneration and / or - to rejuvenate the gums and / or - to protect against gingivitis and / or - to reduce tooth sensitivity and / or - to reduce tooth sensitivity to sweet foods and drinks and / or - to reduce tooth sensitivity to acidic foods and drinks and / or - to reduce tooth sensitivity to hot foods and drinks and / or - to reduce tooth sensitivity to cold foods and drinks and / or - to reduce tooth sensitivity to tactile stimuli.