DE102016104913B4 - Vorrichtung zur effektiven, invasiven und amplitudenmodulierten Neurostimulation - Google Patents

Vorrichtung zur effektiven, invasiven und amplitudenmodulierten Neurostimulation Download PDF

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Publication number
DE102016104913B4
DE102016104913B4 DE102016104913.1A DE102016104913A DE102016104913B4 DE 102016104913 B4 DE102016104913 B4 DE 102016104913B4 DE 102016104913 A DE102016104913 A DE 102016104913A DE 102016104913 B4 DE102016104913 B4 DE 102016104913B4
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Prior art keywords
pulse
stimulation
signal
neurons
tissue
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DE102016104913A1 (de
Inventor
Peter Alexander Tass
Oleksandr Popovych
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Boston Scientific Neuromodulation Corp
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Forschungszentrum Jülich
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Priority to DE102016104913.1A priority Critical patent/DE102016104913B4/de
Application filed by Forschungszentrum Jülich filed Critical Forschungszentrum Jülich
Priority to ES17710870T priority patent/ES2784002T3/es
Priority to CN201780017882.4A priority patent/CN109069829B/zh
Priority to JP2018545345A priority patent/JP6937767B2/ja
Priority to AU2017235269A priority patent/AU2017235269B2/en
Priority to US16/084,751 priority patent/US11013918B2/en
Priority to EP17710870.1A priority patent/EP3429682B1/de
Priority to PCT/EP2017/055915 priority patent/WO2017157890A1/de
Publication of DE102016104913A1 publication Critical patent/DE102016104913A1/de
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  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Neurosurgery (AREA)
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  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
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  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Optics & Photonics (AREA)
  • Electrotherapy Devices (AREA)
DE102016104913.1A 2016-03-16 2016-03-16 Vorrichtung zur effektiven, invasiven und amplitudenmodulierten Neurostimulation Active DE102016104913B4 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE102016104913.1A DE102016104913B4 (de) 2016-03-16 2016-03-16 Vorrichtung zur effektiven, invasiven und amplitudenmodulierten Neurostimulation
CN201780017882.4A CN109069829B (zh) 2016-03-16 2017-03-14 用于有效侵入式并且振幅受到调制的神经元刺激的设备
JP2018545345A JP6937767B2 (ja) 2016-03-16 2017-03-14 効果的な侵襲性振幅変調神経刺激のための装置と方法
AU2017235269A AU2017235269B2 (en) 2016-03-16 2017-03-14 Device for effective, invasive and amplitude-modulated neurostimulation
ES17710870T ES2784002T3 (es) 2016-03-16 2017-03-14 Dispositivo para la neuro-estimulación eficaz, invasiva y modulada en amplitud
US16/084,751 US11013918B2 (en) 2016-03-16 2017-03-14 Device and method for effective, invasive, and amplitude-modulated neurostimulation
EP17710870.1A EP3429682B1 (de) 2016-03-16 2017-03-14 Vorrichtung zur effektiven, invasiven und amplitudenmodulierten neurostimulation
PCT/EP2017/055915 WO2017157890A1 (de) 2016-03-16 2017-03-14 Vorrichtung zur effektiven, invasiven und amplitudenmodulierten neurostimulation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102016104913.1A DE102016104913B4 (de) 2016-03-16 2016-03-16 Vorrichtung zur effektiven, invasiven und amplitudenmodulierten Neurostimulation

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DE102016104913A1 DE102016104913A1 (de) 2017-09-21
DE102016104913B4 true DE102016104913B4 (de) 2018-04-26

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US (1) US11013918B2 (cg-RX-API-DMAC10.html)
EP (1) EP3429682B1 (cg-RX-API-DMAC10.html)
JP (1) JP6937767B2 (cg-RX-API-DMAC10.html)
CN (1) CN109069829B (cg-RX-API-DMAC10.html)
AU (1) AU2017235269B2 (cg-RX-API-DMAC10.html)
DE (1) DE102016104913B4 (cg-RX-API-DMAC10.html)
ES (1) ES2784002T3 (cg-RX-API-DMAC10.html)
WO (1) WO2017157890A1 (cg-RX-API-DMAC10.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10780274B2 (en) 2016-08-22 2020-09-22 Boston Scientific Neuromodulation Corporation Systems and methods for delivering spinal cord stimulation therapy
US20220152399A1 (en) * 2019-03-14 2022-05-19 University Of Connecticut Deep brain stimulation system with amplitude-modulated temporal patterns
EP3937810A1 (en) * 2019-03-15 2022-01-19 Boston Scientific Scimed, Inc. Spatially multiplexed waveform for selective cell ablation
CN111030134B (zh) * 2019-10-17 2021-09-03 武汉大学 一种基于圆盘定理的次/超同步振荡控制方法
US11697023B2 (en) * 2020-03-30 2023-07-11 Medtronic, Inc. Medical device and method for generating modulated high frequency electrical stimulation pulses
JP7781766B2 (ja) * 2020-04-01 2025-12-08 シンクロン オーストラリア ピーティーワイ リミテッド 神経関連信号の検知された変化を使用してデバイスを制御するためのシステムおよび方法
US12390643B2 (en) * 2020-06-02 2025-08-19 University Of Washington High frequency epidural stimulation to control sensation
WO2021257548A1 (en) 2020-06-18 2021-12-23 Diagnostyx, Inc. Treatment of neurological abnormalities using dynamic electroencephalography
US11872397B2 (en) * 2020-07-22 2024-01-16 Nexalin Technology, Inc. Transcranial alternating current dynamic frequency stimulation (TACS) system
CN111973181B (zh) * 2020-08-24 2023-12-08 中国科学院上海微系统与信息技术研究所 一种集成采集刺激功能的皮层脑电极及其制作方法
CN115177256B (zh) * 2022-09-13 2022-11-29 北京昆迈医疗科技有限公司 一种视频脑磁图系统
LU505149B1 (en) * 2023-09-22 2025-03-25 Precisis Gmbh A method for suppression of seizures, and a related neurological stimulation device
WO2026002049A1 (zh) * 2024-06-28 2026-01-02 杭州诺为医疗技术有限公司 脉冲发生器及电刺激设备

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007051848A1 (de) 2007-10-30 2009-05-07 Forschungszentrum Jülich GmbH Vorrichtung zur Stimulation von Neuronenverbänden

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6944501B1 (en) * 2000-04-05 2005-09-13 Neurospace, Inc. Neurostimulator involving stimulation strategies and process for using it
DE10233960B4 (de) * 2002-07-29 2006-11-02 Forschungszentrum Jülich GmbH Vorrichtung zur bedarfsgesteuerten Modulation physiologischer und pathologischer neuronaler rhythmischer Aktivität im Gehirn mittels sensorischer Stimulation
DE10318071A1 (de) * 2003-04-17 2004-11-25 Forschungszentrum Jülich GmbH Vorrichtung zur Desynchronisation von neuronaler Hirnaktivität
DE10355652A1 (de) * 2003-11-28 2005-06-30 Forschungszentrum Jülich GmbH Verfahren und Vorrichtung zur Desynchronisation neuronaler Hirnaktivität
DE102004025945A1 (de) * 2004-05-27 2005-12-29 Forschungszentrum Jülich GmbH Verfahren und Vorrichtung zur Entkopplung und/oder Desynchronisation neuronaler Hirnaktivität
DE102004060514A1 (de) * 2004-12-16 2006-06-29 Forschungszentrum Jülich GmbH Verfahren und Vorrichtung zur Desynchronisation neuronaler Hirnaktivität, Steuerung, sowie Verfahren zur Behandlung neuronaler und/oder psychiatrischer Erkrankungen
DE102005014383A1 (de) * 2005-03-24 2006-09-28 Forschungszentrum Jülich GmbH Impulsstimulationsvorrichtung und Verfahren, mit deren Hilfe unerwünschte Synchronisierung ausgeschaltet oder gesteuert werden kann
JP2006271907A (ja) * 2005-03-25 2006-10-12 Hideo Yamamura 生体刺激用装置、イオン導入装置等、および、生体刺激用プログラム、イオン導入装置等用プログラム。
US8406876B2 (en) * 2005-04-05 2013-03-26 Cardiac Pacemakers, Inc. Closed loop neural stimulation synchronized to cardiac cycles
US8103341B2 (en) * 2006-08-25 2012-01-24 Cardiac Pacemakers, Inc. System for abating neural stimulation side effects
US8121692B2 (en) * 2006-08-30 2012-02-21 Cardiac Pacemakers, Inc. Method and apparatus for neural stimulation with respiratory feedback
DE102008015259B4 (de) * 2008-03-20 2010-07-22 Anm Adaptive Neuromodulation Gmbh Vorrichtung und Verfahren zur auditorischen Stimulation
WO2009151516A2 (en) * 2008-05-08 2009-12-17 Cardiac Pacemakers, Inc. Smart delay for intermittent stress therapy
DE102008052078B4 (de) * 2008-10-17 2011-06-01 Forschungszentrum Jülich GmbH Vorrichtung zur konditionierten desynchronisierenden Stimulation
WO2010104700A1 (en) * 2009-03-09 2010-09-16 Cardiac Pacemakers, Inc. Systems for autonomic nerve modulation comprising electrodes implantable in a lymphatic vessel
US20130053922A1 (en) * 2009-10-22 2013-02-28 Zaghloul Ahmed Dipole electrical stimulation employing direct current for recovery from spinal cord injury
US20120221075A1 (en) * 2009-11-02 2012-08-30 Y.K.L. Brain Tech Ltd. Computerized system or device and method for diagnosis and treatment of human, physical and planetary conditions
DE102010016404A1 (de) 2010-04-12 2012-12-27 Forschungszentrum Jülich GmbH Vorrichtung und Verfahren zur konditionierten desynchronisierenden nicht-invasiven Stimulation
DE102012002436B4 (de) * 2012-02-08 2014-08-21 Forschungszentrum Jülich GmbH Vorrichtung zur Eichung einer nicht-invasiven desynchronisierenden Neurostimulation
CN105163801B (zh) * 2013-02-22 2017-11-07 波士顿科学神经调制公司 具有用于组合脉冲串的装置的多通道神经调制系统
DE102013013278A1 (de) * 2013-08-08 2015-02-12 Forschungszentrum Jülich GmbH Vorrichtung und Verfahren zur Eichung einer akustischen desynchronisierenden Neurostimulation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007051848A1 (de) 2007-10-30 2009-05-07 Forschungszentrum Jülich GmbH Vorrichtung zur Stimulation von Neuronenverbänden

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
D. Harnack, C. Winter, W. Meissner, T. Reum, A. Kupsch, R. Morgenstern: The effects of electrode material, charge density and stimulation duration on the safety of high-frequency stimulation of the subthalamic nucleus in rats. J. Neurosci. Methods 138, 207 (2004
I. Adamchic, C. Hauptmann, U. B. Barnikol, N. Pawelcyk, O.V. Popovych, T. Barnikol, A. Silchenko, J. Volkmann, G. Deuschl, W. Meissner, M. Maarouf, V. Sturm, H.-J. Freund, P. A. Tass: Coordinated Reset Has Lasting Aftereffects in Patients with Parkinson's Disease. Movement Disorders 29, 1679 (2014)
M. G. Rosenblum, A. S. Pikovsky: Controlling synchronization in an ensemble of globally coupled oscillators. Phys. Rev. Lett. 92, 114102 (2004)
O. V. Popovych, C. Hauptmann, P. A. Tass: Control of neuronal synchrony by nonlinear delayed feedback. Biol. Cybern. 95, 69-85 (2006)
O. V. Popovych, C. Hauptmann, P. A. Tass: Effective desynchronization by nonlinear delayed feedback. Phys. Rev. Lett. 94, 164102 (2005)
S. B. Brummer, L. S. Robblee, F. T. Hambrecht: Criteria for selecting electrodes for electrical stimulation: theoretical and practical considerations. Ann. N. Y. Acad. Sci. 405. 159 (1983
vgl. M. G. Rosenblum, A. S. Pikovsky: Controlling synchronization in an ensemble of globally coupled oscillators. Physical Review Letters 92, 114102 (2004)
vgl. O. V. Popovych, C. Hauptmann, P. A. Tass: Effective Desynchronization by Nonlinear Delayed Feedback. Physical Review Letters 94, 164102 (2005)
vgl. P. A. Tass, L. Qin, C. Hauptmann, S. Doveros, E. Bezard, T. Boraud, W. G. Meissner: Coordinated reset neuromodulation has sustained after-effects in parkinsonian monkeys. Annals of Neurology 72, 816-820 (2012)
vgl. P. Temperli, J. Ghika, J.-G. Villemure, P. Burkhard, J. Bogousslavsky, and F. Vingerhoets: How do parkinsonian signs return after discontinuation of subthalamic DBS? Neurology 60, 78 (2003)
vgl. S. B. Brummer, M. Turner, M.: Electrical stimulation of the nervous system: the principle of safe charge injection with noble metal electrodes. Bioelectrochem. Bioenerg. 2, 13 (1975)

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