DE102013226337A1 - Textile for drug-releasing clothing - Google Patents

Abstract

The invention relates to a drug-releasing textile comprising a charge fragile microcapsules of polyurethane, wherein the microcapsules are such that they break under mechanical force and release their content in the textile. The content of the microcapsules comprises a skin care composition, and the microcapsules have a fracture stress of 50 to 150 μN and a diameter of 5 to 15 μm. Also part of the present invention is the use of the textile according to the invention in the manufacture of clothing and other items to be worn on the body.

Description

FIELD OF THE INVENTION

 The invention relates to textiles for the production of drug-releasing clothing, in particular for the production of sportswear, underwear, stockings or nightwear, and further of textile articles which are applied to the skin of a human, such as bandages, bandages or the like.

STATE OF THE ART

 Textiles that release certain active ingredients on the skin are known.

The DE 20 2013 005 558 U1 discloses a saturated with an active elastic sock. The impregnation can be done by dipping, spraying or rolling up. It is applied by simply wearing the sock an active ingredient on the foot.

The WO 2010/006442 A1 discloses microparticle-loaded textiles wherein the microparticles consist of an organic vehicle impregnated with an active agent and a surfactant and a binder. When rubbed, the microparticles erode and release the active ingredient gradually.

The WO 2005/005712 A2 discloses compositions for applying drug-added microcapsules to fabrics. In the process, the active ingredients are gradually released when the textiles are worn by diffusing through the shells of the microcapsules.

The DE 20 2007 013 384 U1 discloses underwear and corsetry to which different sized skin-tightening active ingredient-containing microcapsules are "pasted". The microcapsules should burst during movement and heat and release the drug.

It is an object of the present invention to provide textiles from which active ingredients can be released over a long period of time and reliably.

ASPECTS AND EMBODIMENTS OF THE INVENTION

 In one aspect, the invention provides a textile loaded with breakable microcapsules of polyurethane, wherein the microcapsules are adapted to break under mechanical force and release their content in the fabric, characterized in that the content of the microcapsules comprises a skin care composition , The microcapsules preferably have a breaking stress of between 50 and 150 μN and a diameter between 5 and 15 μm.

The invention is based on the idea that with the microcapsules described above, a long-term and uniform action of the skin care composition can be achieved. This allows a particularly effective action on and in the skin and the skin sustainably improved. Because of the nature of the microcapsules, it is advantageously achieved that the active ingredient remains present over many wearing and washing operations and is released only gradually to the skin when worn. This allows a long use of the textile according to the invention. The above-described microcapsules according to the invention advantageously enable a stable release rate of the active ingredient, so that the release of the active ingredient can be relatively well established and distributed appropriately over a period of time. By wearing the textile according to the invention as clothing which is in contact with the skin, the elasticity of the skin is advantageously improved. Advantageously, an improvement in skin elasticity is achieved by wearing apparel made of a textile loaded with microcapsules according to embodiments of the present invention containing a skin care composition. Preferably, the content of the microcapsules is lipophilic.

In a preferred embodiment, the microcapsules contain Q-10 and / or menthol. Advantageously, an increase in the skin's own Q10 content is achieved by wearing apparel made from a textile loaded with drug-containing microcapsules according to embodiments of the present invention. Advantageously, a particularly good skin tightening is achieved by the permanent action of Q-10 and / or menthol achieved by the microcapsules. The content Q-10 may be from 1 to 500 ng / cm ² textile, for example from 100 to 500 ng / cm ² textile and / or the menthol content from 0.2 to 2 μg / cm ² textile, for example from 0.5 to 1.5 μg / cm ² textile. In these salary ranges, a particularly good skin tightening has been shown, but the invention is not limited to these ranges.

In a preferred embodiment, the skin care composition is at least one triglyceride. Advantageously, it is achieved that the skin care active ingredients can dissolve particularly well and can penetrate into the skin. The one or more triglycerides may be selected from caprylic and / or capric acid derived triglycerides such as CAS number 65381-09-1 / 73398-61-5.

In a preferred embodiment, the textile according to the invention consists of a mixture of polyamide and elastane. Advantageously, a particularly comfortable carrying is possible. Furthermore, such a mixture supports a mechanical tightening of the skin.

In a preferred embodiment, the content is transferred by mechanical force of broken microcapsules to the human skin when used as a skin-fitting clothing so that, for example, the content of skin intrinsic Q-10 is increased by at least 50%. The skin is so effectively toned, resulting in the desirable effect of younger-looking skin.

In a preferred embodiment, after one or more hand or machine washes of the textile continue to release the contents of the microcapsules. Even after several machine washes according to the invention still skin care ingredients on the textile detectable. Advantageously, the microcapsules are so stable embedded in the textile that after repeated hand or machine wash a release of content of the microcapsules on and into the skin can be further observed.

In a further aspect, the present invention relates to a textile manufacturing process comprising the step of loading a textile with microcapsules of polyurethane, wherein the microcapsules are adapted to break under mechanical force and release their content in the fabric, the content a skin care composition, and wherein the microcapsules have a fracture stress of 50 to 150 μN and a diameter of 5 to 15 μm.

In another aspect, the invention relates to clothing and other articles made from the textile of the invention. In particular, aspects of the present invention relate to elastic garments made from a textile which, when worn, exerts a compression of up to 18 mmHg on the skin.

In a further aspect, the invention relates to a use of a textile and / or clothing, which is made of the textile according to the invention, for improving the appearance of the skin.

 The embodiments described above may be combined as desired with one another and with the aspects described above in order to achieve advantages according to the invention.

BRIEF DESCRIPTION OF THE FIGURES

 The invention will now be described by way of example with reference to preferred embodiments thereof with reference to the accompanying figures.

It shows:

1 an electron micrograph of a loaded according to the invention with microcapsules textile;

2 an electron micrograph of a loaded according to the invention with microcapsules textile after 30 washes;

3 an electron micrograph of an intact microcapsule on a textile according to the invention;

4 an electron micrograph of a broken microcapsule on a textile according to the invention after release of the content; and

5 a schematic representation of the head of the probe of a cutometer gauge.

DETAILED DESCRIPTION OF THE INVENTION

According to the present invention, textiles are provided which are loaded with active ingredient-releasing polyurethane microcapsules. 1 shows an electron micrograph of a textile according to the invention, in which the microcapsules are clearly visible.

Preferably, the microcapsules are made of polyurethane prepared by polymerizing toluene-2,4-diisocyanate with polyols. The manufacturing method may be designed to obtain polyurethane microcapsules having a diameter of 5 to 15 μm and a fracture stress of 50 to 150 μN. The preparation of the microcapsules and their loading with ingredients and the application to textile are known to the person skilled in the art. For example, the microcapsules are applied as an aqueous emulsion together with a second polyurethane as a binder to the textile, whereby the binder covalently binds to the microcapsules and the textile fibers, and thus charges the microcapsules on the textile. In such an emulsion are, for example, 30 to 40 wt .-% of caprylic and / or capric acid derived triglycerides, 0.01 to 0.1 wt .-% of an active ingredient, and water, polymer and preservative. 3 and 4 show a present in the textile according to the invention microcapsule before and after their breakage.

Preferably, the capsule contents coenzyme Q-10 (ubiquinone-10). Q-10 is a substance of the body, which is partly absorbed through the diet, but also produced in the body itself. Q-10 is present in and on human skin and is involved in, among other things, the elimination of harmful free radicals. Optionally, the capsule contents may also contain menthol.

The microcapsules further contain a skin care composition, such as one or more triglycerides, such as caprylic and / or capric acid-derived triglycerides (CAS Nos. 65381-09-1 / 73398-61-5).

It has been shown that 15 to 25% of the initial concentration of active ingredients can be released from the textile by wearing garments lying on the skin for 6 to 8 hours, such as panties, for example. By transferring to the skin, for example, the content of the skin's own Q-10 can be increased by more than 50% and / or the content of caprylic and / or capric acid-derived triglycerides increased by 200% to 300%.

Furthermore, it has been shown that the release of the active substances contained in the microcapsules also stops after manual or machine washing of a garment made from the textile according to the invention. In particular, as shown in Table I, even after 25 to 30 washes, a release could still be detected. TABLE I sample Q-10 content after 25 washes (ng / cm ² ) Q-10 content after 30 washes (ng / cm ² ) 1 0.9 0.8 2 0.9 1.0 3 0.7 0.7 4 0.8 0.6 5 1.1 0.9

The data shown in Table I relate to textile samples of embodiments according to the invention having an original Q-10 content of 10 ng / cm ² textile. The samples had an average weight of 1.280 g at a size of about 50 cm ² (Karl Schröder KG) and were washed in a commercial washing machine with commercial detergent with standard washes and then extracted with acetone, centrifuged and analyzed by HPLC MS / MS analyzed. 2 shows correspondingly an electron micrograph of a microcapsules loaded according to the invention textile after 30 washes, wherein the remaining on the textile drug can be seen.

The textiles according to the invention are also suitable for improving the elastic and plastic properties of human skin. Textiles according to the invention with a compression of up to 18 mmHg (eg textiles made of a polyamide / elastane mixture) show a positive effect on measurements of skin elasticity by means of a cutometer / torsion method, which measurably sets within a two-week wearing period (daily approx. 8 hours). With the Cutometer, the uniaxial shear stress of human skin can be traceably measured. The measurement principle of the cutometer is based on the fact that a negative pressure is generated in a cylindrical measuring head, whereby a few millimeters of the uppermost skin layers of the skin area to be measured are pulled into the opening of a measuring probe. The penetration depth is detected by an optical measuring system. The optical measuring system consists of an infrared light transmitter and a light receiver as well as two opposite glass prisms, which guide the light from the transmitter to the receiver. The optical system measures the decrease in the light intensity as a function of the suction height of the skin. The suction height is proportional to the elasticity of the skin. At the end of the measuring time, the negative pressure is switched off and the skin can return to its original shape, whereby the speed of the regression is also measured. The more elastic a skin is, the faster it can be absorbed and the faster it returns to its original shape. The curve taken during the measurement can be used to evaluate the viscoelastic nature of the skin. 5 shows the measuring method accordingly. Preferred embodiments of the present invention relate to apparel and other skin-wearing textile articles having a compression pressure of up to 18 mmHg for improving skin elasticity. These clothing or articles may consist of the textile according to the invention described above, for example of a polyamide / elastane mixture, for example with a polyamide content of about 92% and an elastane content of about 8%. Such compression textiles or "cosmetotextiles" show a measurable positive effect on the viscoelastic properties of the skin, measured by the above-described cutometer procedure, from about 2 weeks onwards daily wear. This improvement in the elastic and plastic properties of the skin is triggered by the compression textiles when worn.

Possible garments of the textile according to the invention include trousers, long and short underpants, briefs, panties, undershirts, camisole, sports bras, tops, bodysuits, bathing suits and pants, sports jerseys, biker pants, leotards, muscle shirts, socks, stockings, tights, trousers , Leggings, t-shirts, thermal shirts, thermal underwear, corsetry, armwarmers, leg warmers, leg warmers, leggings, gauntlets, pajamas, corsets and the like. Other textile articles of the textile according to the invention include dressings, support bandages, protective bandages, envelopes, bandages, support bandages, sweatbands and diaper wraps.

When wearing the garments or applying the textile articles so an application pressure of up to 18 mmHg is applied to the human skin, through which the measurable improvements described above are achieved. By using the active substance-releasing textile according to the invention additional effects can be achieved, in particular if the released active ingredients contain a skin care component and / or Q-10 and / or menthol. The clothing or textile articles may be wholly or partly made of the textile according to the invention.

EXAMPLES

Six subjects have worn from the textile according to the invention elastic tight-fitting panties (panties) during each 6 to 8 hours during the day with normal physical activity. The fabric was mixed with Q10-containing microcapsules in a concentration yielding approximately 2 μg Q-10 per cm ^{2 of} fabric. The average Q-10 content of the panties was measured before and after wearing. From the results, the effectiveness of the textiles of the invention is derived. The results are listed in Table II. For this purpose, the Q-10 content of 50 cm ² textile samples of the panties before and after wearing was analyzed as already described above. TABLE II subject Content Q-10 before exposure (μg / cm ² ) Content Q-10 after exposure (μg / cm ² ) Recovery (%) 1 2.1 1.7 82 2 1.8 1.4 79 3 1.7 1.4 83 4 2,4 1.8 74 5 2.2 1.8 79 6 2.3 1.9 84

 It is consistently noted that the garment's Q-10 content has decreased by about 15% to 25%. This shows that part of the Q-10 is released from the microcapsules present in the textile according to the invention.

In addition, test subjects were subjected to dermal (D-Squame) measurements before and after wearing the panties so as to determine the amount of Q-10 on the skin surface before and after wear. The results are listed in Table III. To determine the Q-10 content at the skin surface, D-Squame skin tears (stripping study) were taken from different parts of the skin, before and after wearing the underpants. Every skin tear has a surface of approx. 3.8 cm ² . For analysis, the D-squame cut-offs were extracted with acetone (1 mL) and the aliquot was then filtered from the extract and analyzed for the presence of Q-10 by HPLC-MS / MS. TABLE III subject Previously later 1 sample ng / D-Squame sample ng / D-Squame 1-1 2.7 1-11 6.0 1-2 3.5 1-12 7.9 1-3 4.1 1-13 11.0 1-4 3.8 1-14 14.9 1-5 2,4 1-15 11.5 1-6 1.7 1-16 10.3 2 2-1 2,4 2-11 10.0 2-2 2.7 2-12 8.3 2-3 2.8 2-13 8.1 2-4 3.3 2-14 7.6 2-5 2.8 2-15 8.1 2-6 3.3 2-16 14.8 3 3-1 4.1 3-11 9.4 3-2 5.8 3-12 11.5 3-3 7.1 3-13 13.1 3-4 5.4 3-14 10.7 3-5 5.5 3-15 13.1 3-6 5.6 3-16 13.3 4 4-1 6.9 4-11 10.8 4-2 6.5 4-12 10.4 4-3 5.0 4-13 13.3 4-4 5.7 4-14 9.3 4-5 6.6 4-15 11.6 4-6 9.9 4-16 11.5 5 5-1 4.0 5-11 9.2 5-2 4.6 5-12 8.3 5-3 4.5 5-13 8.1 5-4 3.2 5-14 9.7 5-5 2.7 5-15 4.0 5-6 4.4 5-16 4.6 6 6-1 3.7 6-11 13.5 6-2 2.6 6-12 16.6 6-3 3.8 6-13 15.8 6-4 2.5 6-14 17.4 6-5 2.9 6-15 13.5 6-6 2.3 6-16 13.6

 It is consistently noted that the concentration of Q-10 on the skin surface of subjects has increased by at least 50%, often significantly more.

To demonstrate the general efficacy of the invention for transferring contents of the microcapsules to the human skin, elastic tight-fitting panties were worn for six to eight hours during normal physical activity, according to the first series of experiments of the textile according to the invention , The fabric was mixed with microcapsules in an amount yielding about 2 μg each of skin care composition (caprylic and / or capric acid-derived triglycerides, CAS number 65381-09-1 / 73398-61-5) per cm ^{2 of} fabric. Again, test subjects were subjected to dermal (D-squame) measurements before and after wearing the panties so as to determine the amount of skin care composition on the skin surface before and after wear. The results are listed in Table IV. The analysis was again performed by D-Squame analysis and extraction techniques. TABLE IV subject Previously later sample ng / D-Squame sample ng / D-Squame 7 7-1 59.9 7-11 373.9 7-2 88.6 7-12 378.7 7-3 116.2 7-13 542.7 7-4 82.7 7-14 538.5 7-5 31.9 7-15 462.8 7-6 27.7 7-16 436.2 8th 8-1 518.5 8-11 997.9 8-2 653.5 8-12 1,277.1 8-3 857.6 8-13 920.5 8-4 626.2 8-14 1,475.6 8-5 900.0 8-15 964.0 8-6 588.2 8-16 1,250.5 9 9-1 37.0 9-11 97.8 9-2 55.0 9-12 110.5 9-3 59.2 9-13 130.4 9-4 56.2 9-14 83.1 9-5 42.7 9-15 106.6 9-6 42.2 9-16 103.3 10 10-1 21.9 10-11 62.1 10-2 23.5 10-12 40.3 10-3 22.4 10-13 49.9 10-4 22.2 10-14 57.3 10-5 23.2 10-15 47.5 10-6 24.5 10-16 83.5 11 11-1 21.0 11-11 81.0 11-2 21.1 11-12 86.7 11-3 20.3 11-13 88.4 11-4 18.2 11-14 74.3 11-5 18.2 11-15 64.1 11-6 25.9 11-16 78.2 12 12-1 18.6 12-11 168.8 12-2 17.2 12-12 175.3 12-3 22.7 12-13 178.1 12-4 23.6 12-14 125.2 12-5 20.6 12-15 97.9 12-6 16.1 12-16 109.8

 Here, too, it has been consistently established that the concentration of triglycerides on the skin surface of the test persons has increased by at least 50%, often even significantly more.

In addition, part of the present innovation are any combinations of features and / or demarcations described herein, insofar as they are not mutually exclusive. The description of the invention relates to certain embodiments of the invention with the aim of illustrating them. The person skilled in the art will recognize that further modifications and equivalents of the embodiments described herein are possible. Such modifications and equivalents also form part of the full scope of the invention described.

QUOTES INCLUDE IN THE DESCRIPTION

This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.

Cited patent literature

• DE 202013005558 U1 [0003]
• WO 2010/006442 Al [0004]
• WO 2005/005712 A2 [0005]
• DE 202007013384 U1 [0006]

Claims (10)

Textile for the manufacture of clothing loaded with breakable microcapsules of polyurethane, the microcapsules being such that they break under mechanical force and release their content in the textile, the content comprising a skin care composition, characterized in that the microcapsules have a breaking stress of 50 to 150 μN and have a diameter of 5 to 15 microns.  The textile according to claim 1, wherein the content of the microcapsules is lipophilic.  The textile according to claim 1 or 2, wherein the content of the microcapsules comprises Q-10 and / or menthol. The textile according to claim 3, wherein the amount Q-10 is from 1 to 500 ng / cm ^{2 of} textile and / or the amount of menthol is from 0.2 to 2 μg / cm ^{2 of} textile.  A textile according to any one of the preceding claims, wherein the skin care composition comprises one or more triglycerides.  The textile according to claim 5, wherein the triglycerides are selected from caprylic and / or capric acid derived triglycerides, such as CAS number 65381-09-1 / 73398-61-5.  The textile according to any of the preceding claims, wherein when used as a skin-clad garment, the contents are transferred to the human skin by mechanical action of broken microcapsules such that the level of intrinsic Q-10 is increased by at least 50%.  A textile according to any one of the preceding claims for use as compression textile in clothing or other skin-engaging articles.  A fabric manufacturing method comprising loading a fabric with microcapsules of polyurethane, the microcapsules being adapted to break under mechanical force and release their content in the fabric, the content comprising a skin care composition, and wherein the microcapsules have a breaking stress of 50 to 150 μN and have a diameter of 5 to 15 microns  Clothing made from a textile according to any one of claims 1 to 8.

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