DE102012220494A1 - Use of lanolin comprising a proportion of cholesterol, steranes and/or wool wax acids increased in relation to natural proportion, for producing cosmetic and/or dermatological products - Google Patents

Use of lanolin comprising a proportion of cholesterol, steranes and/or wool wax acids increased in relation to natural proportion, for producing cosmetic and/or dermatological products Download PDF

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Publication number
DE102012220494A1
DE102012220494A1 DE201210220494 DE102012220494A DE102012220494A1 DE 102012220494 A1 DE102012220494 A1 DE 102012220494A1 DE 201210220494 DE201210220494 DE 201210220494 DE 102012220494 A DE102012220494 A DE 102012220494A DE 102012220494 A1 DE102012220494 A1 DE 102012220494A1
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DE
Germany
Prior art keywords
lanolin
proportion
cholesterol
wool wax
relation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE201210220494
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German (de)
Inventor
Herbert Wildling
Volker Setzke
Aage Reichensperger
Rainer Kröpke
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Beiersdorf AG
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Beiersdorf AG
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Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Priority to DE201210220494 priority Critical patent/DE102012220494A1/en
Publication of DE102012220494A1 publication Critical patent/DE102012220494A1/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B11/00—Recovery or refining of other fatty substances, e.g. lanolin or waxes
    • C11B11/005—Lanolin; Woolfat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Abstract

Use of lanolin comprising a proportion of cholesterol, steranes and/or wool wax acids increased in relation to natural proportion, for producing cosmetic and/or dermatological products, is claimed. Independent claims are included for: (1) the preparation comprising, in addition to lanolin and/or woolwax, other components; (2) a woolwax- or lanolin product; (3) producing the lanolin or woolwax with consistently high quality, where the proportional increase in cholesterol, steranes and/or wool wax acids takes place by concentration; and (4) producing the lanolin or woolwax with the proportion of cholesterol, steranes and/or wool wax acids increased in relation to natural proportion, where the proportional increase takes place by concentration.

Description

Lanolin ist die INCI-Bezeichnung von Wollwachs und auch die international gebräuchlichere. Da im Deutschen Arzneibuch (DAB) eine (traditionelle) Mischung von Wollwachs (65 Teile) mit Paraffinöl (15 Teile) und Wasser (20 Teile) ebenfalls als Lanolin bezeichnet wird, ist eine Verwechslung möglich. Deshalb ist im pharmazeutischen Bereich mehr der Begriff Wollwachs (Adeps lanae) und in allen anderen Bereichen mehr der Begriff Lanolin (Lanolinum) gebräuchlich. Lanolin is the INCI name of wool wax and also the more internationally used. As in the German Pharmacopoeia (DAB) a (traditional) mixture of wool wax (65 parts) with paraffin oil (15 parts) and water (20 parts) is also referred to as lanolin, a confusion is possible. Therefore, in the pharmaceutical field more the term wool wax (Adeps lanae) and in all other areas more the term lanolin (Lanolinum) is used.

Lanolin stellt den Haar- und Hautschutz der Schafe dar. Lanolin represents the hair and skin protection of sheep.

Auf Grund der bi-funktionellen Gruppen der vorkommenden Hydroxysäuren (ca. 32 % der Fettsäurefraktion) und der Dihydroxy-Alkohole (ca. 7 % der Alkoholfraktion) besteht Lanolin aus einem Gemisch von überwiegend langkettigen Estern, Di-Estern und Hydroxy-Estern. Bei deren Hydrolyse wurden bis jetzt 69 aliphatische Alkohole (C14–C36) und 6 Sterole (Cholesterol, Dihydrocholesterol, Lanosterol, Dihydrolanosterol, Agnosterol, Dihydroagnosterol) sowie 138 Fettsäuren (C8–C41), die Wollwachssäuren, isoliert. Nimmt man vereinfachend an, dass nur Monoesterverbindungen vorliegen, ergeben sich daraus schon über zehntausend mögliche Esterverbindungen. Die wirkliche Zahl ist nicht bekannt. In pharmazeutischem Wollwachs dürfen bis 0,5 % freie Fettsäuren enthalten sein (z.B. Europäisches Arzneibuch, Säurezahl < 1). Der Gehalt an freie Alkoholen (bis 12 %) ist nicht begrenzt. Due to the bi-functional groups of the occurring hydroxy acids (about 32% of the fatty acid fraction) and the dihydroxy alcohols (about 7% of the alcohol fraction) lanolin consists of a mixture of predominantly long-chain esters, diesters and hydroxy esters. In their hydrolysis, 69 aliphatic alcohols (C 14 -C 36 ) and 6 sterols (cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, agnosterol, dihydroagnosterol) and 138 fatty acids (C 8 -C 41 ), the wool-wax acids, have been isolated so far. Assuming, for simplicity, that only monoester compounds are present, there are already more than ten thousand possible ester compounds. The real number is unknown. In pharmaceutical wool wax may be up to 0.5% free fatty acids contained (eg European Pharmacopoeia, acid number <1). The content of free alcohols (up to 12%) is not limited.

Bedingt durch die Schafrasse, deren Futtermittel, den Umwelteinflüssen denen die Schafe ausgesetzt sind und dem Waschverfahren der Schafwolle, werden Lanoline mit sehr unterschiedlichen Qualitäten angeboten. Due to the sheep breed, their feed, the environmental influences which the sheep are exposed to and the washing process of the sheep's wool, lanolins with very different qualities are offered.

Durch die Aufkonzentration der Bestandteile Cholesterin und/oder Stearane und/oder Wollwachssäure erhält man Lanolinprodukte in gleichbleibend hoher Qualität. Solche Produkte homogener Zusammensetzung sind als Wirkstoffe in der Kosmetik und Pharmazie einsetzbar, ohne dass Konzentrationsanpassungen notwendig würden. The concentration of the components cholesterol and / or stearanes and / or wool wax acid gives lanolin products in consistently high quality. Such products of homogeneous composition can be used as active ingredients in cosmetics and pharmaceutics without the need for concentration adjustments.

Das Cholesterin (auch Cholesterol) ist ein in allen tierischen Zellen vorkommender Naturstoff. Der Name leitet sich vom griechischen chole ‚Galle‘ und stereos ‚fest‘ ab, da es – bereits im 18. Jahrhundert – in Gallensteinen gefunden wurde. Cholesterol (also known as cholesterol) is a natural substance found in all animal cells. The name derives from the Greek chole, bile 'and stereos' firm', since it was found - already in the 18th century - in gallstones.

Als Sterane werden organische Kohlenwasserstoff-Moleküle bezeichnet, welche mit dem Steran die Grundstruktur für die Stoffgruppe der Steroide enthalten. Die chemische Bezeichnung für Steran ist Hexadecahydro-cyclopenta[a]phenanthren. Es setzt sich aus drei sechsgliedrigen und einem fünfgliedrigen Ring zusammen, die mit Buchstaben A, B, C und D gekennzeichnet werden. Das Molekül besitzt sechs Stereozentren, jeweils an den Kohlenstoffatomen, die zu zwei Ringen gehören (5, 10, 8, 9, 13, 14). Steran ist der Oberbegriff für sämtliche Stereoisomere, ungeachtet der Konfiguration an den Stereozentren. Steranes are organic hydrocarbon molecules which, together with steran, contain the basic structure for the substance group of steroids. The chemical name for sterane is hexadecahydro-cyclopenta [a] phenanthrene. It consists of three six-membered and one five-membered ring, which are identified by letters A, B, C and D. The molecule has six stereocenters, each on the carbon atoms that belong to two rings (5, 10, 8, 9, 13, 14). Steran is the generic term for all stereoisomers, regardless of the configuration at the stereocenters.

Wollwachssäure ist das im Lanolin enthaltene Gemisch an Fettsäuren. Wool wax acid is the lanolin-containing mixture of fatty acids.

Claims (5)

Verwendung von Lanolin zur Herstellung kosmetischer und/oder dermatologischer Produkte, wobei das Lanolin einen gegenüber dem natürlichen Anteil erhöhten Anteil an Cholesterin und/oder Sterane und/oder Wollwachssäuren aufweist. Use of lanolin for the production of cosmetic and / or dermatological products, wherein the lanolin has a proportion of cholesterol and / or sterols and / or wool wax acids which is elevated in relation to the natural proportion. Zubereitung zu Verwendung für dermatologische und/oder kosmetische Zwecke, dadurch gekennzeichnet, dass die Zubereitung neben weiterer Bestandteile Wollwachs und/oder Lanolin enthält, welches einen gegenüber dem natürlichen Anteil erhöhten Anteil an Cholesterin und/oder Sterane und/oder Wollwachsäuren aufweist. Preparation for use for dermatological and / or cosmetic purposes, characterized in that the preparation contains, in addition to other constituents wool wax and / or lanolin, which has a relation to the natural portion of increased content of cholesterol and / or sterols and / or woolly waxes. Wollwachs- oder Lanolinprodukt, dadurch gekennzeichnet, dass es einen gegenüber dem natürlichen Anteil erhöhten Anteil an Cholesterin und/oder Sterane und/oder Wollwachssäuren aufweist. Wool wax or lanolin product, characterized in that it has a relation to the natural portion of increased content of cholesterol and / or sterols and / or wool wax acids. Verfahren zur Herstellung von Lanolin oder Wollwachs mit gelichbleibend hoher Qualität, dadurch gekennzeichnet, dass Anteilserhöhung an Cholesterin und/oder Sterane und/oder Wollwachsäuren durch Aufkonzentrieren erfolgt. Process for the preparation of lanolin or wool wax with persistently high quality, characterized in that an increase in the content of cholesterol and / or sterols and / or woolly wax acids takes place by concentration. Verfahren zur Herstellung von Lanolin oder Wollwachs mit einen gegenüber dem natürlichen Anteil erhöhten Anteil an Cholesterin und/oder Sterane und/oder Wollwachsäuren, dadurch gekennzeichnet, dass Anteilserhöhung durch Aufkonzentrieren erfolgt. Process for the preparation of lanolin or wool wax with a proportion of cholesterol and / or sterols and / or wool wax acids which is increased in relation to the natural proportion, characterized in that an increase in the proportion takes place by concentration.
DE201210220494 2012-11-09 2012-11-09 Use of lanolin comprising a proportion of cholesterol, steranes and/or wool wax acids increased in relation to natural proportion, for producing cosmetic and/or dermatological products Ceased DE102012220494A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE201210220494 DE102012220494A1 (en) 2012-11-09 2012-11-09 Use of lanolin comprising a proportion of cholesterol, steranes and/or wool wax acids increased in relation to natural proportion, for producing cosmetic and/or dermatological products

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DE201210220494 DE102012220494A1 (en) 2012-11-09 2012-11-09 Use of lanolin comprising a proportion of cholesterol, steranes and/or wool wax acids increased in relation to natural proportion, for producing cosmetic and/or dermatological products

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DE102012220494A1 true DE102012220494A1 (en) 2014-05-15

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2649906A1 (en) * 1975-11-25 1977-06-08 Blanarie Vidra Orastie Intrepr METHOD AND DEVICE FOR LANOLIN CLEANING
EP0632267A1 (en) * 1993-01-12 1995-01-04 Nippon Fine Chemical Co., Ltd. Method of measuring content of polycyclic aromatic compound in lanolin and removal thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2649906A1 (en) * 1975-11-25 1977-06-08 Blanarie Vidra Orastie Intrepr METHOD AND DEVICE FOR LANOLIN CLEANING
EP0632267A1 (en) * 1993-01-12 1995-01-04 Nippon Fine Chemical Co., Ltd. Method of measuring content of polycyclic aromatic compound in lanolin and removal thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Derwent-abstract zu CN 1 02 010 791 A; AN_WPI: 2011F51858 *
RÖMPP Online, Stichwort "Lanolin", Version 3.35, URL: http://www.roempp.com/prod/, Dokumentkennung: RD-23-01064, letzte Aktualisierung April 2007 [recherchiert am 26.07.2013] *
RÖMPP Online, Stichwort „Lanolin", Version 3.35, URL: http://www.roempp.com/prod/, Dokumentkennung: RD-23-01064, letzte Aktualisierung April 2007 [recherchiert am 26.07.2013]

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Effective date: 20140701