DE102010050299A1 - New organisms, e.g. bacteria, which live in the human body and produce substances, e.g. as waste product, which blocks the receptor molecules from the HIV virus, and no longer docks the HIV virus, useful e.g. for the production of insulin - Google Patents

Abstract

Organisms, e.g. bacteria, which live in the human body and produce substances, e.g. as waste product, which blocks the receptor molecules from the HIV virus, and no longer docks the HIV virus, are new. The organisms are genetically modified organisms (including generic cells, bacteria and viruses) e.g. organisms, which produce other useful substances, e.g. fun-promoting substances such as tadalafil in the body, and substances that kill sperm or produce other beneficial substances in the body. Organisms, e.g. bacteria, which live in the human body and produce substances, e.g. as waste product, which blocks the receptor molecules from the HIV virus, and no longer docks the HIV virus, are new. The organisms are genetically modified organisms (including generic cells, bacteria and viruses) e.g. organisms, which produce other useful substances, e.g. fun-promoting substances such as tadalafil in the body, and substances that kill sperm or produce other beneficial substances in the body. The genetically modified organisms (including bacteria, viruses, normal body cells, e.g. cluster of differentiation (CD)8 T cells) feed through the genetic modification of undesirable bacteria/viruses, e.g. HIV virus. Substances such as enzymes, control the HIV virus, e.g. if these enzymes/substances produced by the body itself. These organisms live independently in the human body and make the production of functional substances. A production in tanks is not covered if the modified organism/the substance in the body does not make production themselves. The organisms that make the production in the body itself and/or outside of the body (for a higher efficiency) are detected, and the substances/organisms make HIV in monkeys as harmless as athlete's foot for humans. ACTIVITY : Anti-HIV. MECHANISM OF ACTION : None given.

Description

Technical Field: Biotechnology

State of the art:

One way to get a long life out of HIV infection is to take antiretroviral drugs. These usually have to be taken almost or exclusively daily. This makes the treatment expensive and priceless in an economic crisis in many countries where drugs are donated by the US. HIV would then spread quickly. Technically there is a possibility against the HIV virus to block molecules used in docking the HIV virus on other molecules with other molecules (by the medications). These "other molecules" must of course always be replenished.

For many years it has been state of the art to produce substances, for example in insulin production, by genetically modified bacteria. It is also state of the art (the drug perenterol for intestinal diseases as an example) to introduce living bacteria into the human body. These living bacteria can colonize the whole body in unwanted circumstances (as per leaflet). The peaceful coexistence of bacteria in the body, which by default are not part of the human body system, is thus technically proven.

Solution:

It is thus proposed to combine all three aspects in a new genetically modified organism (bacterium, virus, human or other cell, etc.) in such a way that this new organism excretes / generates such molecules as a by - product floating in the blood, then the receptor molecules of the / block for the HIV virus.

So it is the mechanism, such as insulin production, that needs to be explored (and that of other bacteria as well) to target molecules that are (a) produced by the bacteria and (b) the receptor molecules can block.

The invention sought after for protection is organisms (eg bacteria) that live in the human body and produce molecules that block the receptor molecules of / for HIV viruses and, linked to this principle, organisms that are also HIV Nourish viruses.

Industrial Applicability: The HIV virus has so far caused very high costs due to the costs of medicines. Also, it reduces the flirt-induced fun.

If the drug is actually produced in the body itself, the HIV virus is no longer a problem in many parts of the world. An appropriate drug can then be given by UN programs for free for single use. In conjunction with fun-promoting other substances (Taladafil etc.), which may possibly also be produced in the body for a kind of "basic level", also creates a new market for new lifestyle products. Are then still introduced, according to the same principle, bacteria that feed on sperm or kill them, so the hormone level does not adversely affect (vividly: Viagra plus and Viagra plus plus (the first plus against HIV, the second against the sperm) ) creates a market, which is a motive for the development of the content of the patent specification for a product.

Claims (1)

Organisms, for example, but not limited to, bacteria, which are characterized by being able to (a) live in the human body and (b) produce substances, for example as a waste product, which are designed to bind the receptor molecules of (= on the HIV virus) or for (= in other places, ie the ones where the HIV virus docks) so block HIV viruses that can no longer dock the HIV virus. Subclaim 1: The claim also relates to genetically modified organisms (including "common" cells, bacteria, viruses), for example organisms which produce other useful substances, for example fun-loving substances such as taladafil in the body, produce substances that kill sperm or produce other beneficial substances in the body. Unteranspruch 2: The claims also relate to genetically modified organisms (including bacteria, viruses, "normal" body cells, for example CD 8 T cells), which feed on the genetic modification of unwanted bacteria / virus, ie z. B. Feeding HIV viruses. Subclaim 3: The claims also relate to substances such as enzymes which silence HIV viruses, for example when these enzymes / substances are produced in the body itself. Delineation: It is important for the claims that these organisms can live in the human body itself and can there carry out the production of the functional substance (s). Production in tanks is not covered by the claims if the modified organisms do not produce the substance in the body itself can make. However, organisms which (a) are able to carry out their own production in the body and / or (b) outside the body (for example for higher efficiency) are covered by the claims. The claims relate only to organisms for which patent protection is even possible. So if in the future an organism is discovered that feeds on HIV viruses (eg in monkeys) then this organism will be covered by the claims if it is patentable (although such a thing would actually be a discovery and not an invention) , Of course, if this discovered organism is not patentable (that is, can not be patented by anyone), this discovery should be generally available - for example, if, as suggested by this patent, substances / organisms are sought that make HIV as harmless to monkeys as athlete's foot People. Technical realization: Send to a company / institute experienced in the production of genetically modified organisms, for example for insulin production, in geology (projects in the sub-region "Deep Biosphere" of the Integrated Ocean Drilling Program IODP) etc.