DE102010048899B8 - Verfahren zum Diagnostizieren aneuploider kolorektaler Tumore - Google Patents

Verfahren zum Diagnostizieren aneuploider kolorektaler Tumore Download PDF

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Publication number
DE102010048899B8
DE102010048899B8 DE201010048899 DE102010048899A DE102010048899B8 DE 102010048899 B8 DE102010048899 B8 DE 102010048899B8 DE 201010048899 DE201010048899 DE 201010048899 DE 102010048899 A DE102010048899 A DE 102010048899A DE 102010048899 B8 DE102010048899 B8 DE 102010048899B8
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DE
Germany
Prior art keywords
aneuploid
diagnosing
colorectal tumors
colorectal
tumors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE201010048899
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English (en)
Other versions
DE102010048899B3 (de
Inventor
PD Dr. Dr. Habermann Jens
PD Dr. Dr. Roblick Uwe
Timo Gemoll
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNIVERSITAETSKLINIKUM SCHLESWIG HOLSTEIN CAMPUS LUEBECK
Universitatsklinikum Schleswig-Holstein Campus Luebeck
Original Assignee
UNIVERSITAETSKLINIKUM SCHLESWIG HOLSTEIN CAMPUS LUEBECK
Universitatsklinikum Schleswig-Holstein Campus Luebeck
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by UNIVERSITAETSKLINIKUM SCHLESWIG HOLSTEIN CAMPUS LUEBECK, Universitatsklinikum Schleswig-Holstein Campus Luebeck filed Critical UNIVERSITAETSKLINIKUM SCHLESWIG HOLSTEIN CAMPUS LUEBECK
Priority to DE201010048899 priority Critical patent/DE102010048899B8/de
Priority to PCT/EP2011/068244 priority patent/WO2012052473A1/de
Priority to EP11776144.5A priority patent/EP2630496A1/de
Publication of DE102010048899B3 publication Critical patent/DE102010048899B3/de
Application granted granted Critical
Publication of DE102010048899B8 publication Critical patent/DE102010048899B8/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • G01N2333/98—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE201010048899 2010-10-19 2010-10-19 Verfahren zum Diagnostizieren aneuploider kolorektaler Tumore Expired - Fee Related DE102010048899B8 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE201010048899 DE102010048899B8 (de) 2010-10-19 2010-10-19 Verfahren zum Diagnostizieren aneuploider kolorektaler Tumore
PCT/EP2011/068244 WO2012052473A1 (de) 2010-10-19 2011-10-19 Verfahren zum diagnostizieren aneuploider kolorektaler tumore
EP11776144.5A EP2630496A1 (de) 2010-10-19 2011-10-19 Verfahren zum diagnostizieren aneuploider kolorektaler tumore

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE201010048899 DE102010048899B8 (de) 2010-10-19 2010-10-19 Verfahren zum Diagnostizieren aneuploider kolorektaler Tumore

Publications (2)

Publication Number Publication Date
DE102010048899B3 DE102010048899B3 (de) 2012-03-01
DE102010048899B8 true DE102010048899B8 (de) 2012-06-14

Family

ID=44883229

Family Applications (1)

Application Number Title Priority Date Filing Date
DE201010048899 Expired - Fee Related DE102010048899B8 (de) 2010-10-19 2010-10-19 Verfahren zum Diagnostizieren aneuploider kolorektaler Tumore

Country Status (3)

Country Link
EP (1) EP2630496A1 (de)
DE (1) DE102010048899B8 (de)
WO (1) WO2012052473A1 (de)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5919657A (en) * 1997-04-09 1999-07-06 Incyte Pharmaceuticals, Inc. Nucleic acids encoding human thioredoxin protein; related reagents
DE60138321D1 (de) * 2000-06-16 2009-05-20 Rudel Thomas Verfahren zur Identifizierung während der Apoptose modifizierter Proteine
WO2008099972A1 (ja) * 2007-02-16 2008-08-21 Shimadzu Corporation 上皮性卵巣癌の組織型識別マーカー、及びそれを用いた組織型に基づく上皮性卵巣癌の罹患の識別法

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ASHKTORAB, H. u.a.: Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma. Dig. Dis. Sci. (2009) 54 (10) 2109-2117 *
ASHKTORAB, H. u.a.: Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma. Dig. Dis. Sci. (2009) 54 (10) 2109–2117
GEMOLL, T. u.a.: HDAC2 and TXNL1 characterize aneuploid subtypes of colorectal cancer. Tagung der Vereinigung nordwestdeutscher Chirurgen, 2.6.-4.6.2011, Stralsund, Poster 3.2 (gutachtlich) *
GEMOLL, T. u.a.: HDAC2 and TXNL1 distinguish aneuploid from diploid colorectal cancers. Cell. Mol. Life Sci. (3.2.2011) DOI: 10.1007/s00018-011-0628-3 (gutachtlich) *
WEICHERT, W. u.a.: Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. Clin. Cancer Res. (2008) 14 (6) 1669-77 *
ZHU, P. u.a.: Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis. Cancer Cell. (2004) 5 (5) 455-63 *

Also Published As

Publication number Publication date
DE102010048899B3 (de) 2012-03-01
EP2630496A1 (de) 2013-08-28
WO2012052473A1 (de) 2012-04-26

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