DE102010021345A1 - Occlusions instrument for closing left atrial auricle of patient, has occluder provided with region that is located from central region to retention region for forming actuated connection between nub region of occluder and auricle wall - Google Patents
Occlusions instrument for closing left atrial auricle of patient, has occluder provided with region that is located from central region to retention region for forming actuated connection between nub region of occluder and auricle wall Download PDFInfo
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- DE102010021345A1 DE102010021345A1 DE201010021345 DE102010021345A DE102010021345A1 DE 102010021345 A1 DE102010021345 A1 DE 102010021345A1 DE 201010021345 DE201010021345 DE 201010021345 DE 102010021345 A DE102010021345 A DE 102010021345A DE 102010021345 A1 DE102010021345 A1 DE 102010021345A1
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- occluder
- region
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- retention area
- auricle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12122—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder within the heart
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12168—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
- A61B17/12172—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00526—Methods of manufacturing
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- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
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- Surgical Instruments (AREA)
Abstract
Description
Die vorliegende Erfindung betrifft ein Occlusionsinstrument zum Verschluss des linken Herzohrs. Ein solches Occlusionsinstrument besteht aus einem selbstexpandierbaren Occlusionskörper, welcher aus einem Metallrohr gelasert wird und dessen Gestalt mittels eines Umformungs- und Wärmebehandlungsverfahrens eine geeignete Formgebung erhält. Der Occlusionskörper hat die Grundform eines abgesetzten Zylinders mit einem im Durchmesser größeren vorderseitigen proximalen Retentionsbereich und einem im Durchmesser kleineren rückseitigen distalen Retentionsbereich, wobei im Übergang des distalen Retentionsbereichs zum proximalen Retentionsbereich hin sich auf dem äußeren Umfang des Occlusionskörper Noppen befinden, welche der festen Verankerung des Occlusionsinstruments im Herzohr dienlich sind. Diese intravaskuläre Verschlußvorrichtung ist so ausgelegt, dass der Occluionskörper im zusammengefalteten Zustand mittels eines Katheters in den Körper eines Patienten minimalinvasiv einführbar und in dem Herzohr des Patienten positionierbar ist.The present invention relates to an occlusion device for closing the left atrial appendage. Such an occlusion device consists of a self-expandable occlusion body, which is lasered from a metal tube and whose shape is given a suitable shape by means of a deformation and heat treatment process. The occlusion body has the basic shape of a stepped cylinder with a larger diameter front proximal retention area and a smaller diameter rear distal retention area, wherein in the transition of the distal retention area to the proximal retention area there are nubs on the outer circumference of the occlusion body, which are the solid anchorage of the occlusion site Occlusionsinstruments in the auricle are useful. This intravascular closure device is designed so that the occlusion body in the folded state by means of a catheter in the body of a patient is minimally invasive insertable and positionable in the atrial appendage of the patient.
Hintergrund der ErfindungBackground of the invention
Das linke Herzohr ist bei Vorhofflimmern der häufigste Entstehungsort für Blutgerinnsel, die zu einem Schlaganfall führen können. Sowohl durch den operativen als auch durch den interventionellen Verschluss des linken Herzohrs reduziert man das Risiko der Thromboembolie.The left ear of the heart is the most frequent source of blood clots in atrial fibrillation, which can lead to a stroke. Both surgical and interventional closure of the left atrial appendage reduce the risk of thromboembolism.
Stand der TechnikState of the art
Mit dem PLAATO-Device, Patent
Bei einem nachfolgenden LAA-Verschlußsytem, dem Watchman-Occluder der Firma Atritech, sind solche Perforationen nicht auszuschließen. Hinzu kommt das Problem der unzureichenden Lokalisation. Der Watchman-Occluder neigt dazu, zu tief in das Herzohr abzugleiten.In a subsequent LAA closure system, the Watchman Occluder from Atritech, such perforations can not be ruled out. Added to this is the problem of inadequate localization. The Watchman Occluder tends to slide too deep into the heart ear.
Von AGA Medical Corp. wurde Ende 2008 ein LAA-Occluder für Europa zugelassen.From AGA Medical Corp. At the end of 2008, an LAA occluder was approved for Europe.
Aus
Die Anwendung eines Fixiermittels in
Aufgabenstellungtask
Aufgabe der Erfindung ist es, die zum Stand der Technik beschriebenen Nachteile zu vermeiden und insbesondere durch einen leicht handhabbaren Implantationsvorgang eine sichere Implantation eines solchen LAA-Occluders zu erreichen.The object of the invention is to avoid the disadvantages described in the prior art and in particular to achieve a safe implantation of such an LAA occluder by means of an easily manageable implantation process.
Bei der vorliegenden Erfindung kommt ein Occlusionsinstrument zum Einsatz, welches selbstzentrierend ist und in jeder beliebigen Ausführungsform eine optimale Lage nach dem Implantationsvorgang einnimmt. Die Grundform eines solchen Herzohr-Occluders ähnelt der eines abgesetzten Zylinders. Das kreisrunde Ende mit dem größeren Durchmesser befindet sich am Übergang vom linken Vorhof zum Eingang des linken Herzohrs. Der längliche, kreisrunde Stiel befindet sich im Hauptkanal des Herzohrs. Aus den Abmessungen des Herzohrs, mit einem Durchmesser des Herzohreingangs von 10 bis 26,5 mm und einer nutzbaren Tiefe des Hauptkanals des Herzohrs von 14 bis 30 mm ergeben sich entsprechend abgestufte Baugrößen geeigneter Herzohr-Occluder, wobei zu berücksichtigen ist, dass sich ein solcher aus einem beispielsweise geeigneten metallischen Nitinolrohr gelaserten Occluder im komprimierten Zustand ca. 10% verkleinert.In the present invention, an occlusion device is used which is self-centering and, in any embodiment, occupies an optimal position after the implantation procedure. The basic form of such a heart ear occluder resembles that of a stepped cylinder. The circular end with the larger diameter is located at the transition from the left atrium to the entrance of the left atrial appendage. The elongated, circular stem is located in the main canal of the auricle. From the dimensions of the atrial appendage, with a diameter of the heart tube entrance of 10 to 26.5 mm and a usable depth of the main channel of the auricular tube of 14 to 30 mm, suitably graduated sizes of suitable Herzohr Occluder arise, whereby it is to be considered that such From an example suitable metallic Nitinolrohr lasaserten Occluder reduced in compressed state about 10%.
Solche superelastischen Metalllegierungen wie Nitinol, eine Titan-Nickellegierung, mit einer Elastizität von 7% maximaler Dehnung zur Ausgangslänge sind besonders gut geeignet, einen derartig geformten Körper herzustellen. Ausgangsseitig wird ein dünnwandiges Nitinolrohr von maximal 2,5 mm Durchmesser verwendet. Durch Einsatz eines geeigneten Lasers werden verschiedene Schlitze in das Metallrohr eingebracht. Im Anschluß an das Lasern wird das Metallrohr mit einer mechanischen Vorrichtung aufgeweitet und durch Warmbehandlung in Form gebracht. Die Warmbehandlungsdauer ist bei Temperaturen von 350 bis 600°C und einer Haltezeit von einer halben Stunde bis 2 Minuten (die kürzeren Zeiten bei höheren Temperaturen) durchführbar. Die Verfahrensschritte Lasern, Aufdehnen und Warmbehandlung werden mehrmals hintereinander durchgeführt, bis die Endform des Occlusionsinstrumentes erreicht ist. Durch eine mögliche Laserschnittbreite von bis zu 15 μm können auf dem Umfang eines solchen Metallrohrs mehr als 150 Schnitte parallel zur Längsachse durchgeführt werden.Such superelastic metal alloys such as Nitinol, a titanium-nickel alloy, having an elasticity of 7% maximum elongation to the initial length are particularly well suited to make such a shaped body. On the output side, a thin-walled nitinol tube of maximum 2.5 mm diameter is used. By using a suitable laser different slots are introduced into the metal tube. Following lasering, the metal tube is widened with a mechanical device and shaped by heat treatment. The heat treatment time is feasible at temperatures of 350 to 600 ° C and a holding time of half an hour to 2 minutes (the shorter times at higher temperatures). The laser, stretching and heat treatment steps are carried out several times in succession until the final shape of the occlusion device has been reached. By a possible laser cutting width of up to 15 microns can be performed on the circumference of such a metal tube more than 150 cuts parallel to the longitudinal axis.
Im Bereich des proximalen Ende des Occluders im Übergang zum Zylinderschaft befinden sich durch spezielle Laserschnitte hergestellte Noppen, bzw. Stollen, welche in mehreren Reihen auf dem Umfang einen festen Halt im Herzohr garantieren. Oberhalb dieses Bereiches zum proximalen Ende hin befinden sich im Bereich des Herzohreingangs ein oder mehrere Lagen medizinisch geeigneter Materialien als Patches zur Abdichtung des Blutstroms, damit dieser das Herzohr nicht mehr in Richtung des linken Vorhofs passieren kann. Als Material wäre z. B. Dacron, unter der chemischen Bezeichnung PET (Polyethylenterephthalat), geeignet.In the area of the proximal end of the occluder in the transition to the cylindrical shaft are pimples or studs produced by special laser cuts, which guarantee a firm hold in the atrial appendage in several rows on the circumference. Above this area towards the proximal end, one or more layers of medically suitable materials are located in the region of the atrial appendage as patches for sealing off the blood stream, so that it can no longer pass through the atrial appendage in the direction of the left atrium. As a material z. As Dacron, under the chemical name PET (polyethylene terephthalate), suitable.
Ein bevorzugtes Ausführungsbeispiel des Occlusionsinstrumentes ist dadurch gekennzeichnet, dass das Befestigungselement für den Einführkatheter am proximalen Ende in axialer Richtung eine Durchgangsbohrung aufweist, sodass ein Einführkatheter mit dem Occluder über einen bereits im Herzohr befindlichen Führungsdraht geschoben werden kann.A preferred embodiment of the occlusion device is characterized in that the fastening element for the insertion catheter has a through hole in the axial direction at the proximal end, so that an insertion catheter with the occluder can be pushed over a guide wire already in the atrial appendage.
Ein weiteres bevorzugtes Ausführungsbeispiel des Occluders ist dadurch gekennzeichnet, dass derselbige aus zwei Teilen besteht, und zwar aus einem proximalen Teil, ein kreisrunder Deckel und ein kurzes Zylinderstück mit umlaufenden Noppen und ein distales Teilstück, welches einen ovalen Querschnitt aufweist und sich zum Ende hin stetig verjüngt. Das distale Teilstück ist dreh- und schwenkbar zum proximalen Teil des Occluders durch eine entsprechende Kupplung. Das distale Teilstück ist somit in der Lage sich selbstzentrierend in eine optimale Lageposition auszurichten. Eine solche Ausführungsform kann erforderlich sein, wenn der Hauptkanal des Herzohrs etwas kürzer ist als für die bereits beschriebenen Ausführungsbeispiele.Another preferred embodiment of the Occluder is characterized in that it consists of two parts, namely a proximal part, a circular cover and a short cylinder piece with circumferential knobs and a distal portion which has an oval cross section and is continuous towards the end rejuvenated. The distal portion is rotatable and pivotable to the proximal portion of the Occluder by a corresponding coupling. The distal portion is thus able to align itself in an optimal position of self-centering. Such an embodiment may be required if the main canal of the atrial appendage is slightly shorter than for the previously described embodiments.
Ausführungsbeispielembodiment
Im folgenden werden bevorzugte Ausführungsbeispiele des erfindungsgemäßen LAA-Occluders anhand der Zeichnungen näher erläutert. Dabei können die in den Ansprüchen und in der Beschreibung erwähnten Merkmale jeweils einzeln für sich oder in beliebiger Kombination erfindungswesentlich sein. Es zeigen:In the following preferred embodiments of the invention LAA Occluders are explained in detail with reference to the drawings. The features mentioned in the claims and in the description may each be essential to the invention individually or in any desired combination. Show it:
In den
In der
In der
In der
BezugszeichenlisteLIST OF REFERENCE NUMBERS
- 11
- Herzohr-Occluder, Occlusionselement, OccluderHeart ear occluder, occlusion element, occluder
- 22
- Vorderansichtfront view
- 33
- Seitenansicht von rechtsSide view from the right
- 44
- DraufsichtTop view
- 55
- Unteransichtbottom view
- 66
- Vorderansicht mit Teilschnitt rechtsFront view with partial section on the right
- 77
- Proximales EndeProximal end
- 88th
- Distales EndeDistal end
- 99
- Proximaler RetentionsbereichProximal retention area
- 1010
- Distaler RetentionsbereichDistal retention area
- 1111
- Befestigungselementfastener
- 1212
- Kupplungselementcoupling member
- 1313
- Linker VorhofLeft atrium
- 1414
- Linkes HerzohrLeft ear of the heart
- 1515
- Längsachselongitudinal axis
- 1616
- Abdeckungcover
- 1717
- Ankeranchor
- 1818
- Noppen (Stollen)Pimples
- 1919
-
Bereich Occluder mit Noppen
18 Occluder area withpimples 18 - 2020
-
Befestigungselement
11 mit axialem Durchgangfastener 11 with axial passage - 2121
- Einschnürungconstriction
- 2222
- Räumliche AnsichtSpatial view
- 2323
- Gelaserte StegeLasered bars
ZITATE ENTHALTEN IN DER BESCHREIBUNG QUOTES INCLUDE IN THE DESCRIPTION
Diese Liste der vom Anmelder aufgeführten Dokumente wurde automatisiert erzeugt und ist ausschließlich zur besseren Information des Lesers aufgenommen. Die Liste ist nicht Bestandteil der deutschen Patent- bzw. Gebrauchsmusteranmeldung. Das DPMA übernimmt keinerlei Haftung für etwaige Fehler oder Auslassungen.This list of the documents listed by the applicant has been generated automatically and is included solely for the better information of the reader. The list is not part of the German patent or utility model application. The DPMA assumes no liability for any errors or omissions.
Zitierte PatentliteraturCited patent literature
- EP 1852141 A2 [0003] EP 1852141 A2 [0003]
- WO 2007/140797 A1 [0006, 0006, 0007] WO 2007/140797 A1 [0006, 0006, 0007]
- DE 102005053906 A1 [0006, 0006] DE 102005053906 A1 [0006, 0006]
- WO 2008/125689 A1 [0006, 0006] WO 2008/125689 A1 [0006, 0006]
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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DE201010021345 DE102010021345A1 (en) | 2010-05-22 | 2010-05-22 | Occlusions instrument for closing left atrial auricle of patient, has occluder provided with region that is located from central region to retention region for forming actuated connection between nub region of occluder and auricle wall |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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DE201010021345 DE102010021345A1 (en) | 2010-05-22 | 2010-05-22 | Occlusions instrument for closing left atrial auricle of patient, has occluder provided with region that is located from central region to retention region for forming actuated connection between nub region of occluder and auricle wall |
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Publication Number | Publication Date |
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DE102010021345A1 true DE102010021345A1 (en) | 2011-11-24 |
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DE201010021345 Ceased DE102010021345A1 (en) | 2010-05-22 | 2010-05-22 | Occlusions instrument for closing left atrial auricle of patient, has occluder provided with region that is located from central region to retention region for forming actuated connection between nub region of occluder and auricle wall |
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Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102015104785A1 (en) | 2015-03-27 | 2016-09-29 | Pfm Medical Ag | Device for closing a cardiac ear |
WO2016155847A1 (en) * | 2015-04-02 | 2016-10-06 | Acoredis Gmbh | Modular occlusion device for closing the left atrial appendage (laa) and production thereof |
WO2016192781A1 (en) * | 2015-06-02 | 2016-12-08 | Acoredis Gmbh | Occlusion instrument, or occluder (closure device) for heart defects and production of same |
WO2018069523A1 (en) | 2016-10-13 | 2018-04-19 | Cormos Medical Gmbh | Laa occluder for closing the left atrial appendage |
US10383725B2 (en) | 2016-08-11 | 2019-08-20 | 4C Medical Technologies, Inc. | Heart chamber prosthetic valve implant with base, mesh and dome sections with single chamber anchoring for preservation, supplementation and/or replacement of native valve function |
EP3698729A4 (en) * | 2017-10-17 | 2020-10-28 | Shanghai MicroPort Medical (Group) Co., Ltd. | Left atrial appendage occlusion device and left atrial appendage occlusion system |
US11857441B2 (en) | 2018-09-04 | 2024-01-02 | 4C Medical Technologies, Inc. | Stent loading device |
US11931253B2 (en) | 2020-01-31 | 2024-03-19 | 4C Medical Technologies, Inc. | Prosthetic heart valve delivery system: ball-slide attachment |
US11944537B2 (en) | 2017-01-24 | 2024-04-02 | 4C Medical Technologies, Inc. | Systems, methods and devices for two-step delivery and implantation of prosthetic heart valve |
US11957577B2 (en) | 2017-01-19 | 2024-04-16 | 4C Medical Technologies, Inc. | Systems, methods and devices for delivery systems, methods and devices for implanting prosthetic heart valves |
US11992403B2 (en) | 2020-03-06 | 2024-05-28 | 4C Medical Technologies, Inc. | Devices, systems and methods for improving recapture of prosthetic heart valve device with stent frame having valve support with inwardly stent cells |
US12029647B2 (en) | 2017-03-07 | 2024-07-09 | 4C Medical Technologies, Inc. | Systems, methods and devices for prosthetic heart valve with single valve leaflet |
US12036113B2 (en) | 2017-06-14 | 2024-07-16 | 4C Medical Technologies, Inc. | Delivery of heart chamber prosthetic valve implant |
US12053375B2 (en) | 2020-03-05 | 2024-08-06 | 4C Medical Technologies, Inc. | Prosthetic mitral valve with improved atrial and/or annular apposition and paravalvular leakage mitigation |
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DE10004979A1 (en) * | 1999-02-18 | 2000-08-24 | Tokendo S A R L La Ciotat | Bronchial prosthesis insertion system with endoscope dimensions prosthesis pusher channel to accept endoscope end for monitoring prosthesis insertion by inter-tube pressure applied by emerging prosthesis. |
US20040215230A1 (en) * | 2003-04-28 | 2004-10-28 | Frazier Andrew G. C. | Left atrial appendage occlusion device with active expansion |
DE102005053906A1 (en) | 2005-11-11 | 2007-05-24 | Occlutech Gmbh | Occlusion device e.g. for septal defects in medical technology, has interlaced structure of thin wires or threads whereby holder, on its free end, has top section with eyelet in form of cross bore |
EP1852141A2 (en) | 1999-09-20 | 2007-11-07 | ev3 Endovascular, Inc. | Method and apparatus for closing a body lumen |
WO2007140797A1 (en) | 2006-06-02 | 2007-12-13 | Occlutech Gmbh | Occlusion instrument for closing a cardiac auricle |
WO2008125689A1 (en) | 2007-04-16 | 2008-10-23 | Occlutech Gmbh | Occluder for occluding an atrial appendage and production process therefor |
DE60225494T2 (en) * | 2001-01-12 | 2009-04-23 | ev3 Endovascular, Inc., Plymouth | Closure device of a septal defect |
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2010
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DE10004979A1 (en) * | 1999-02-18 | 2000-08-24 | Tokendo S A R L La Ciotat | Bronchial prosthesis insertion system with endoscope dimensions prosthesis pusher channel to accept endoscope end for monitoring prosthesis insertion by inter-tube pressure applied by emerging prosthesis. |
EP1852141A2 (en) | 1999-09-20 | 2007-11-07 | ev3 Endovascular, Inc. | Method and apparatus for closing a body lumen |
DE60225494T2 (en) * | 2001-01-12 | 2009-04-23 | ev3 Endovascular, Inc., Plymouth | Closure device of a septal defect |
US20040215230A1 (en) * | 2003-04-28 | 2004-10-28 | Frazier Andrew G. C. | Left atrial appendage occlusion device with active expansion |
DE102005053906A1 (en) | 2005-11-11 | 2007-05-24 | Occlutech Gmbh | Occlusion device e.g. for septal defects in medical technology, has interlaced structure of thin wires or threads whereby holder, on its free end, has top section with eyelet in form of cross bore |
WO2007140797A1 (en) | 2006-06-02 | 2007-12-13 | Occlutech Gmbh | Occlusion instrument for closing a cardiac auricle |
WO2008125689A1 (en) | 2007-04-16 | 2008-10-23 | Occlutech Gmbh | Occluder for occluding an atrial appendage and production process therefor |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016155941A1 (en) | 2015-03-27 | 2016-10-06 | Pfm Medical Ag | Device for closing an atrial appendage |
DE102015104785A1 (en) | 2015-03-27 | 2016-09-29 | Pfm Medical Ag | Device for closing a cardiac ear |
US10813649B2 (en) | 2015-03-27 | 2020-10-27 | Pfm Medical Ag | Device for closing an atrial appendage |
WO2016155847A1 (en) * | 2015-04-02 | 2016-10-06 | Acoredis Gmbh | Modular occlusion device for closing the left atrial appendage (laa) and production thereof |
WO2016192781A1 (en) * | 2015-06-02 | 2016-12-08 | Acoredis Gmbh | Occlusion instrument, or occluder (closure device) for heart defects and production of same |
US10828152B2 (en) | 2016-08-11 | 2020-11-10 | 4C Medical Technologies, Inc. | Heart chamber prosthetic valve implant with base, spring and dome sections with single chamber anchoring for preservation, supplementation and/or replacement of native valve function |
US11026782B2 (en) | 2016-08-11 | 2021-06-08 | 4C Medical Technologies, Inc. | Heart chamber prosthetic valve implant with elevated valve section and single chamber anchoring for preservation, supplementation and/or replacement of native valve function |
US10383725B2 (en) | 2016-08-11 | 2019-08-20 | 4C Medical Technologies, Inc. | Heart chamber prosthetic valve implant with base, mesh and dome sections with single chamber anchoring for preservation, supplementation and/or replacement of native valve function |
US10751169B2 (en) | 2016-08-11 | 2020-08-25 | 4C Medical Technologies, Inc. | Heart chamber prosthetic valve implant with base, mesh and dome sections with single chamber anchoring for preservation, supplementation and/or replacement of native valve function |
DE102016012395A1 (en) | 2016-10-13 | 2018-05-03 | Cormos Medical Gmbh | LAA occluder for closing the left atrial appendage |
WO2018069523A1 (en) | 2016-10-13 | 2018-04-19 | Cormos Medical Gmbh | Laa occluder for closing the left atrial appendage |
US11957577B2 (en) | 2017-01-19 | 2024-04-16 | 4C Medical Technologies, Inc. | Systems, methods and devices for delivery systems, methods and devices for implanting prosthetic heart valves |
US11944537B2 (en) | 2017-01-24 | 2024-04-02 | 4C Medical Technologies, Inc. | Systems, methods and devices for two-step delivery and implantation of prosthetic heart valve |
US12029647B2 (en) | 2017-03-07 | 2024-07-09 | 4C Medical Technologies, Inc. | Systems, methods and devices for prosthetic heart valve with single valve leaflet |
US12036113B2 (en) | 2017-06-14 | 2024-07-16 | 4C Medical Technologies, Inc. | Delivery of heart chamber prosthetic valve implant |
EP3698729A4 (en) * | 2017-10-17 | 2020-10-28 | Shanghai MicroPort Medical (Group) Co., Ltd. | Left atrial appendage occlusion device and left atrial appendage occlusion system |
US11857441B2 (en) | 2018-09-04 | 2024-01-02 | 4C Medical Technologies, Inc. | Stent loading device |
US11931253B2 (en) | 2020-01-31 | 2024-03-19 | 4C Medical Technologies, Inc. | Prosthetic heart valve delivery system: ball-slide attachment |
US12053375B2 (en) | 2020-03-05 | 2024-08-06 | 4C Medical Technologies, Inc. | Prosthetic mitral valve with improved atrial and/or annular apposition and paravalvular leakage mitigation |
US11992403B2 (en) | 2020-03-06 | 2024-05-28 | 4C Medical Technologies, Inc. | Devices, systems and methods for improving recapture of prosthetic heart valve device with stent frame having valve support with inwardly stent cells |
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Representative=s name: PATENT- UND RECHTSANWAELTE BARDEHLE PAGENBERG, 816 Representative=s name: PATENT- UND RECHTSANWAELTE BARDEHLE PAGENBERG, DE Representative=s name: BARDEHLE PAGENBERG PARTNERSCHAFT PATENTANWAELT, DE Representative=s name: BARDEHLE PAGENBERG PARTNERSCHAFT MBB PATENTANW, DE |
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Effective date: 20120720 |