DE102010008417A8 - Hochaffine multivalente Chelatorverbindungen (MCHs) und deren Verwendung zur Struktur- und Funktionsanalyse von Zielmolekülen - Google Patents

Hochaffine multivalente Chelatorverbindungen (MCHs) und deren Verwendung zur Struktur- und Funktionsanalyse von Zielmolekülen Download PDF

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Publication number
DE102010008417A8
DE102010008417A8 DE102010008417A DE102010008417A DE102010008417A8 DE 102010008417 A8 DE102010008417 A8 DE 102010008417A8 DE 102010008417 A DE102010008417 A DE 102010008417A DE 102010008417 A DE102010008417 A DE 102010008417A DE 102010008417 A8 DE102010008417 A8 DE 102010008417A8
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DE
Germany
Prior art keywords
mchs
structural
high affinity
target molecules
functional analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102010008417A
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English (en)
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DE102010008417A1 (de
Inventor
Robert Tampé
Christoph Baldauf
Enrica Bordignon
Katrin Schulze
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goethe Universitaet Frankfurt am Main
Original Assignee
Goethe Universitaet Frankfurt am Main
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Goethe Universitaet Frankfurt am Main filed Critical Goethe Universitaet Frankfurt am Main
Priority to DE102010008417A priority Critical patent/DE102010008417A1/de
Priority to PCT/EP2011/052451 priority patent/WO2011101445A1/de
Publication of DE102010008417A1 publication Critical patent/DE102010008417A1/de
Publication of DE102010008417A8 publication Critical patent/DE102010008417A8/de
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/03—Free radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
DE102010008417A 2010-02-18 2010-02-18 Hochaffine multivalente Chelatorverbindungen (MCHs) und deren Verwendung zur Struktur- und Funktionsanalyse von Zielmolekülen Withdrawn DE102010008417A1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE102010008417A DE102010008417A1 (de) 2010-02-18 2010-02-18 Hochaffine multivalente Chelatorverbindungen (MCHs) und deren Verwendung zur Struktur- und Funktionsanalyse von Zielmolekülen
PCT/EP2011/052451 WO2011101445A1 (de) 2010-02-18 2011-02-18 HOCHAFFINE MULTIVALENTE CHELATORVERBINDUNGEN (MCHs) UND DEREN VERWENDUNG ZUR STRUKTUR- UND FUNKTIONSANALYSE VON ZIELMOLEKÜLEN

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102010008417A DE102010008417A1 (de) 2010-02-18 2010-02-18 Hochaffine multivalente Chelatorverbindungen (MCHs) und deren Verwendung zur Struktur- und Funktionsanalyse von Zielmolekülen

Publications (2)

Publication Number Publication Date
DE102010008417A1 DE102010008417A1 (de) 2011-08-18
DE102010008417A8 true DE102010008417A8 (de) 2011-12-15

Family

ID=43795428

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102010008417A Withdrawn DE102010008417A1 (de) 2010-02-18 2010-02-18 Hochaffine multivalente Chelatorverbindungen (MCHs) und deren Verwendung zur Struktur- und Funktionsanalyse von Zielmolekülen

Country Status (2)

Country Link
DE (1) DE102010008417A1 (de)
WO (1) WO2011101445A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2841446A2 (de) 2012-04-26 2015-03-04 IBA GmbH Adaptermolekül zur reversiblen ausrüstung eines fusionsproteins mit einem oligohistidinaffinitätsmarker mit einem weiteren affinitätsmarker und verfahren zur verwendung davon
CN106732464B (zh) * 2017-02-02 2020-11-20 复旦大学 一种亲水树枝和c18修饰的磁性石墨烯材料及其制备方法和应用
WO2021100042A1 (en) * 2019-11-18 2021-05-27 Technion Research & Development Foundation Limited Minimally-invasive continuous clinical monitoring of small molecules with analytical accuracy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006013042A2 (en) * 2004-08-05 2006-02-09 Johann Wolfgang Goethe-Universität Frankfurt am Main Multivalent chelators for modifying and organizing of target molecules

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPP856399A0 (en) * 1999-02-08 1999-03-04 Australian Membrane And Biotechnology Research Institute Improved compounds for protein binding
DK1850832T3 (en) * 2005-02-07 2015-04-13 Lipotek Pty Ltd adjuvanting
JP2008539252A (ja) * 2005-04-25 2008-11-13 スリーエム イノベイティブ プロパティズ カンパニー 免疫活性化組成物
WO2008145609A1 (en) * 2007-05-25 2008-12-04 Novartis Ag Method of making covalent conjugates with his-tagged proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006013042A2 (en) * 2004-08-05 2006-02-09 Johann Wolfgang Goethe-Universität Frankfurt am Main Multivalent chelators for modifying and organizing of target molecules
DE102004038134A1 (de) * 2004-08-05 2006-03-16 Johann Wolfgang Goethe-Universität Frankfurt am Main Multivalente Chelatoren zum Modifizieren und Organisieren von Zielmolekülen

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Lata, S. et al.: High-Affinity Adaptors for Switchable Recognition of Histidine-TaggedProteins. In: J. Am. Chem. Soc., 2005, 127, S. 10205-10215 *
Lee, H.-S. et al.: Use of the quartz crystal microbalance to monitor ligand-induced conformational rearrangements in HIV-1 envelope protein gp120. In: Analytical and Bionanlytical Chemistry (2010), 396(3), S. 1142-1152. - ISSN: 1618-2642 *
Tinazli, A. et al.: High-Affinity Chelator Thiols for Switchable and Oriented Immobilization of Histidine-Tagged Proteins: A Generic Platform for Protein Chip Technologies. In: Chemistry-A European Journal, 2005, 11, S. 5249-5259. - ISSN: 1521-3765 *

Also Published As

Publication number Publication date
WO2011101445A1 (de) 2011-08-25
DE102010008417A1 (de) 2011-08-18

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Legal Events

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R016 Response to examination communication
R082 Change of representative

Representative=s name: BOEHMERT & BOEHMERT ANWALTSPARTNERSCHAFT MBB -, DE

Representative=s name: BOEHMERT & BOEHMERT, DE

Representative=s name: BOEHMERT & BOEHMERT, 80336 MUENCHEN, DE

R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Effective date: 20130903