DE102008059904A1 - Foaming or foamable formulation, useful in cosmetic and/or dermatological formulations, comprises at least one alkyl lactoside, where the alpha or beta glycosidic bond is linked with the lactose residue - Google Patents

Abstract

Foaming or foamable formulation comprises at least one 8-12C alkyl lactoside (I), where the alpha - or beta glycosidic bond is linked with the lactose residue. Foaming or foamable formulation comprises at least one 8-12C alkyl lactoside of formula (I). The alpha - or beta glycosidic bond is linked with the lactose residue. R : 8-12C alkyl. [Image].

Description

The The present invention relates to foaming or foamable Preparations containing one or more alkyl lactosides, and the use of one or more alkyl-lactosides in foam-like or foamable preparations.

foams represent dispersions of gas in a liquid. They are thermodynamic and over very long periods of time considered, unstable. They are often called kinetics stable.

The Instability is caused for example by the phenomenon "drainage", that is, the water in the slats flows due gravity down and / or in the interface the lamella surfactants are pressed together or the Thickness of the slat sinks, so that there are finally two small ones adjoining gas bubbles in a larger one Gas bubble rise.

foams in aqueous systems are stabilized by surfactants. These surfactants are a component of soaps, foams and cosmetics. and shower baths, oil baths, face cleansing products and shaving products.

surfactants are amphiphilic substances that are organic, nonpolar substances in water to be able to solve. They care, conditioned by their specific molecular structure with at least one hydrophilic and a hydrophobic moiety, for a reduction the surface tension of the water, the wetting of the Skin, facilitating soil removal and solution, a light rinse and - as desired - for foam control.

• • anionische Tenside,
• • kationische Tenside,
• • amphotere Tenside und
• • nichtionische Tenside.

The hydrophilic portions of a surfactant molecule are usually polar functional groups, for example -COO ^- , -OSO ₃ ^2- , -SO ₃ ^- , while the hydrophobic parts are usually nonpolar hydrocarbon radicals. Surfactants are generally classified according to the nature and charge of the hydrophilic part of the molecule. Here four groups can be distinguished:

• Anionic surfactants,
• Cationic surfactants,
• • amphoteric surfactants and
• • nonionic surfactants.

When Surfactants are fatty alcohol ethoxylates in cosmetic formulations such as lauryl ether sulfate or lauryl sulfate, fatty acid is histiates, Sulfosuccinic acid esters, betaines, cocoamphoacetates.

The Production of cosmetic detergents shows for years an upward trend. This is mainly due to the increasing health consciousness and hygiene needs of consumers.

surfactants Fabrics - most prominently alkali salts of higher Fatty acids, so the classic "soaps" - are amphiphilic substances, the organic non-polar substances in water can emulsify.

These Substances not only soak up dirt from the skin and hair, they irritate, depending on the choice of surfactant or surfactant mixture, skin and mucous membranes more or less strong. It is true, a large number mild surfactants available, however, are the surfactants of The art either mild, but cleans poorly, or but they cleanse well, but irritate skin or mucous membranes.

Nice in a simple water bath without the addition of surfactants it comes initially to a swelling of the horny layer of the skin, wherein the degree of this swelling, for example, on the duration of the bath and its temperature depends. At the same time become water-soluble Fabrics, e.g. B. water-soluble soil constituents, but also skin-own substances, which are responsible for the water-binding capacity the horny layer are responsible, washed off or washed out. By skin's own surface-active substances also become skin fats to a certain extent solved and washed out. This conditionally after initial swelling a subsequent significant dehydration skin intensified by detergent additives can be.

In healthy skin, these processes are generally irrelevant, as the protective mechanisms of the skin can readily compensate for such minor disorders of the upper layers of the skin. But even in the case of non-pathological deviations from the normal status, eg. B. by environmental wear damage or irritation, photodamage, aging skin, etc., the protective mechanism of the skin surface is disturbed. Under certain circumstances, he is then no longer able to fulfill his task on his own and must be regenerated by external measures. Object of the present invention was thus to remedy this deficiency of the prior art.

It is of course known per se to accomplish foams in aqueous systems. Usually, a surfactant system comprising a fast defoamer and a foam stabilizer is used according to the following scheme: Table 1 Fast foaming agent (primary surfactant) Foam stabilizer (contenside) substance class LES Betaine LES cocoamphoacetate LES Mixtures of 2 cosurfactants

The Stabilization of the foam takes place with lauryl ether sulfate with a other substance class, such as betaines or cocoamphoacetates.

The Requirements for the properties of cosmetic cleansing preparations have changed significantly in recent years. Earlier The focus was on effects such as cleaning and foaming the consumer's wishes. At present, the ecological, economic and in particular the dermatological properties of the products, although the foaming power is still a crucial one The role is played, for example as an indicator, by residual amounts of surfactants remove after cleansing of skin and hair or overdoses to avoid during use.

Indeed stands for cosmetic products - unlike the most technical cleaning agents - the skin and mucous membrane compatibility absolutely in the foreground; the products should be "mild".

It is also known, the sodium lauryl sulfate as a foaming Surfactant used for toothpaste. For safety reasons It is recommended not to use more than 2%.

For the field of cosmetics, dermatology is used as a surfactant for foaming preparations often lauryl ether sulfate (LES) and lauryl sulfate (LS) used. This surfactant foams in water well, but the foam is not long-term stable. Therefore cosurfactants are added, such as betaines, cocoamphoacetates. additionally Common salt and / or a polymer is often added to to obtain gelatinous preparations.

bei der R einen verzweigten oder unverzweigten Alkylrest mit 8 bis 12 Kohlenstoffatomen bedeutet, der α- oder β-glycosidisch mit dem Lactoserest verknüpft ist.According to the invention, these problems are solved by foaming or foamable preparations containing one or more C _8-12 -alkyl-lactosides of the general structure

where R is a branched or unbranched alkyl radical having 8 to 12 carbon atoms, which is linked to the lactoserest α- or β-glycosidic.

Preferred according to the invention are those preparations which are characterized in that the alkyl lactoside (s) is or are selected from the group
Octyl-4-O- (β-D-galactopyranosyl) -β-D-glucopyranoside
Octyl-4-O- (β-D-galactopyranosyl) -α-D-glucopyranoside
Decyl-4-O- (β-D-galactopyranosyl) -β-D-glucopyranoside
Decyl-4-O- (β-D-galactopyranosyl) -α-D-glucopyranoside
Dodecyl-4-O- (β-D-galactopyranosyl) -β-D-glucopyranoside
Dodecyl-4-O- (β-D-galactopyranosyl) -α-D-glucopyranoside

In an advantageous embodiment, the invention relates to preparations for oral and dental care. Frequently, there is a lack of mucous membrane-compatible and foaming surfactants / emulsifiers to substances that thicken the intended preparation. Often methylhydroxypropylcellulose or hypromellose is used as thickener for fluoride gels

The synthesis of the alkyl lactosides can be carried out, for example, according to the following reaction scheme:

The production processes for components according to the invention are basically known ( Vill, V., Böcker, T., Thiem, J., Fischer, F., Liq. Cryst., 6, 1989, 349 et seq. ; v. Minden, HM, Brandenburg, K., Seydel, U., Koch, MHJ, Garamus, VM, Willumeit, R., Vill, V., Chem. Phys. Lipids, 106, 2000, 157 et seq. ; Schreiber, Joerg; Milkereit, Goetz; Gerber, Sven; Vill, Volkmar, PCT Int. Appl., (2006), 67 pp ). These provide the product in the highest purity and only one anomer after purification by column chromatography.

at The lactosides obtainable in this way are α / β mixtures. These are advantageous according to the invention but also, if desired, by anomerically pure substances be replaced.

The Preparation of the following alkyl lactosides is briefly outlined below:

LacC8:

• Octyl-4-O- (β-D-galactopyranosyl) -β-D-glucopyranoside
• Octyl-4-O- (β-D-galactopyranosyl) -α-D-glucopyranoside

LacC10:

• Decyl-4-O- (β-D-galactopyranosyl) -β-D-glucopyranoside
• Decyl-4-O- (β-D-galactopyranosyl) -α-D-glucopyranoside

LacC12:

• Dodecyl-4-O- (β-D-galactopyranosyl) -β-D-glucopyranoside
• Dodecyl-4-O- (β-D-galactopyranosyl) -α-D-glucopyranoside

Preparation of 1,2,3,6-tetra-O-acetyl-4-O- (2 ', 3', 4 ', 6'-tetra-O-acetyl-β-D-galactopyranosyl) -β-D glucopyranose (Octaacetyl-β-lactose)

40.0 g of lactose (0.117 mol, contained 5% H ₂ O) was dissolved in 110 ml (1.17 mol, 10.5 eq) of acetic anhydride. The mixture was cooled to -5 ° C and a mixture of four drops of concentrated sulfuric acid in 1 ml of acetic anhydride was added slowly and dropwise. After completion of the addition, the reaction mixture stirred for 10 minutes at -5 ° C, then 2 hours at 60 ° C. The solution was poured onto ice and treated with dichloromethane. The phases were separated and the aqueous phase was extracted with 50 ml CH ₂ Cl ₂ (2x). The combined organic phases were added dropwise in 600 ml of saturated sodium bicarbonate solution. The mixture was filtered and then separated. The aqueous phase was extracted with 50 ml of CH ₂ Cl ₂ (2 ×). The combined organic phases were washed with 100 ml H ₂ O, dried over MgSO ₄ and the solvent was removed under reduced pressure.

The product was recrystallized in freshly distilled ethanol.
Yield: 80% LacOAc white solid.

Production Example 1

Preparation of octyl-4-O- (β-D-galactopyranosyl) -β-D-glucopyranoside decyl-4-O- (β-D-galactopyranosyl) -β-D-glucopyranoside Dodecyl-4-O- (β-D-galactopyranosyl) -β-D-glucopyranoside as pure substance (β-anomer)

(10 mmol) 1,2,3,4-tetra-O-acetyl-4-O- (2 ', 3', 4 ', 5'-tetra-O-acetyl-β-D-galactopyranosyl) -β-D- glucopyranoside and (14 mmol) of the respective alcohol (here 1-dodecanol, 1-decanol and 1-octanol) in 100 ml abs. Dichloromethane were stirred solved. To this was added (14 mmol) boron trifluoride etherate slowly dropwise. Subsequently, the reaction mixture was over Stirred at room temperature overnight. For working up the product 100 ml were saturated. Sodium bicarbonate solution added and for another 30 min. touched. The aqueous phase was washed twice with 30 ml of dichloromethane extracted, the combined organic phases were washed twice 60 ml of saturated sodium bicarbonate solution and washed once with 60 ml of distilled water. After subsequent Drying over magnesium sulfate became the solvent removed under reduced pressure. The product was purified by column chromatography purified (petroleum ether (50-70), ethyl acetate 2: 1).

The peracetylated lactosides Lac-C8 and Lac-C10 were each stirred with about 80 ml of anhydrous methanol and 3 spatula tips Natiummethylat three hours. The solutions were stirred for about 15 minutes after addition of ion exchanger Dowex 50 WX 4. After a subsequent pH test (pH: 4), the ion exchanger was filtered off and the solvent was removed under reduced pressure. The products Lac-C8 and Lac-C10 were purified by column chromatography (chloroform, methanol 3: 1).
Yield: 56% LacC8 white solids
61% LacC10 white solids
58% LacC12 white solids

Production Example 2

Preparation of Lac810z: Octyl-4-O- (β-D-galactopyranosyl) -α / β-D-glucopyranoside Decyl-4-O- (β-D-galactopyranosyl) -α / β-D-glucopyranoside as product mixture by means of a Fatty alcohol mixtures (Sasol, Nafol 810 z, 15% C ₈ and 85% C ₁₀ ). The α / β anomers were not separated.

(10 mmol) 1,2,3,4-tetra-O-acetyl-4-O- (2 ', 3', 4 ', 5'-tetra-O-acetyl-β-D-galactopyranosyl) -β- D-glucopyranoside and (14 mmol) of the respective alcohol (here Sasol, Nafol 810 z, 15% C ₈ and 85% C ₁₀ ) in 100 ml abs. Dichloromethane was dissolved with stirring. To this was added dropwise (14 mmol) boron trifluoride etherate slowly. Subsequently, the reaction mixture was stirred overnight at room temperature. For working up the product 100 ml of saturated sodium bicarbonate solution were added and for a further 30 min. touched. The aqueous phase was extracted twice with 30 ml of dichloromethane each time, and the combined organic phases were washed twice with 60 ml of saturated sodium bicarbonate solution and once with 60 ml of distilled water. After subsequent drying over magnesium sulfate, the solvent was removed under reduced pressure. The product was purified by column chromatography (petroleum ether (50-70), ethyl acetate 2: 1).

The peracetylated lactoside Lac810z was stirred for three hours with about 80 ml of anhydrous methanol and 3 spatula tips of sodium methoxide. The solutions were stirred for about 15 minutes after addition of ion exchanger Dowex 50 WX 4. After a subsequent pH test (pH: 4), the ion exchanger was filtered off and the solvent was removed under reduced pressure. The products Lac810z were purified by column chromatography (chloroform, methanol 3: 1).
Yield: 55% Lac810z white solid

Tab. 2

Other fatty alcohol mixtures are possible: Abbreviations Sasol Content in wt.%: yield lactoside Fatty alcohol trade name n-C8-OH n-C10-OH n-C12-OH Lac810d Nafol 810 d 46.0 53.6 - 49% Lac810 f Nafol 810 f 70.1 29.8 - 59% Lac810z Nafol 810 z 15.0 84.8 - 55% Lac1012b Lincol 1012 b - 80.3 19.7 61%

The Lactosides were named according to the fatty alcohols. Pure fatty alcohols are also available from Fluka / Sigma. Fatty alcohol mixtures from Sasol.

Lac810z, for example, is a C8 / C10 lactoside prepared by chemical synthesis from lactose (monohydrate) and the fatty alcohol mixture Nafol 810 z from Sasol. Tab. 3 Abbreviations Sasol Content in wt.%: lactoside Fatty alcohol trade name n-C8-OH n-C10-OH n-C12-OH Lac-810d Nafol 810 d 46.0 53.6 - Lac-810 f Nafol 810 f 70.1 29.8 - Lac-810z Nafol 810 z 15.0 84.8 - Lac-1012b Lincol 1012 b - 80.3 19.7 - Fluka / Sigma - - - - trade name - - - Lac-C8 1-octanol 96 - - Lac-C10 1-decanol - 95 - Lac-C12 1-dodecanol - - 96

The Preparations according to the invention are particular preferably characterized in that the total amount one or more alkyl-lactosides according to the invention in the finished cosmetic or dermatological preparations, characterized in that it is 0.05 to 5 wt .-%, preferably 0.1-3% wt% of one or more C8-12 alkyl lactosides contained, based on the total weight of the aqueous Phase.

The according to the invention - advantageous cosmetic and / or dermatological preparations contain cosmetic excipients, as they usually do be used in such preparations, for. B. preservatives, Perfumes, substances for preventing foaming, Dyes, pigments that have a coloring effect, Thickeners, moisturizing and / or moisturizing substances, oils, waxes or other common ingredients of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, Electrolytes, organic solvents or silicone derivatives.

Especially Advantageously, the inventive feature Cosmetic and dermatological preparations by a content on other surfactants.

• 1. Acylglutamate, beispielsweise Natriumacylglutamat, Di-TEA-palmitoylaspartat und Natrium Caprylic/Capric Glutamat,
• 2. Acylpeptide, beispielsweise Palmitoyl-hydrolysiertes Milchprotein, Natrium Cocoyl-hydrolysiertes Soja Protein und Natrium-/Kalium-Cocoyl-hydrolysiertes Kollagen,
• 3. Sarcosinate, beispielsweise Myristoyl Sarcosin, TEA-lauroyl Sarcosinat, Natriumlauroylsarcosinat und Natriumcocoylsarkosinat,
• 4. Taurate, beispielsweise Natriumlauroyltaurat und Natriummethylcocoyltaurat,
• 5. Acyllactylate, Lauroyllactylat, Caproyllactylat
• 6. Alaninate

Carbonsäuren und Derivate, wie

• 1. Carbonsäuren, beispielsweise Laurinsäure, Aluminiumstearat, Magnesiumalkanolat und Zinkundecylenat,
• 2. Ester-Carbonsäuren, beispielsweise Calciumstearoyllactylat, Laureth-6-Citrat und Natrium PEG-4-Lauramidcarboxylat,
• 3. Ether-Carbonsäuren, beispielsweise Natriumlaureth-13-Carboxylat und Natrium PEG-6-Cocamide Carboxylat,

Phosphorsäureester und Salze, wie beispielsweise DEA-Oleth-10-Phosphat und Dilaureth-4 Phosphat,
Sulfonsäuren und Salze, wie

• 1. Acyl-isethionate, z. B. Natrium-/Ammoniumcocoyl-isethionat,
• 2. Alkylarylsulfonate,
• 3. Alkylsulfonate, beispielsweise Natriumcocosmonoglyceridsulfat, Natrium C_12-14 Olefinsulfonat, Natriumlaurylsulfoacetat und Magnesium PEG-3 Cocamidsulfat,
• 4. Sulfosuccinate, beispielsweise Dioctylnatriumsulfosuccinat, Dinatriumlaurethsulfosuccinat, Dinatriumlaurylsulfosuccinat und Dinatriumundecylenamido-MEA-Sulfosuccinat

sowie
Schwefelsäureester, wie

• 1. Alkylethersulfat, beispielsweise Natrium-, Ammonium-, Magnesium-, MIPA-, TIPA-Laurethsulfat, Natriummyrethsulfat und Natrium C_12-13-Parethsulfat,
• 2. Alkylsulfate, beispielsweise Natrium-, Ammonium- und TEA-Laurylsulfat.

Advantageously used according to the invention further surfactants are anionic surfactants, for example selected from the group of
Acylamino acids (and their salts), such as

• 1. acylglutamates, for example sodium acylglutamate, di-TEA-palmitoylaspartate and sodium caprylic / capric glutamate,
• 2. acyl peptides, for example palmitoyl-hydrolyzed milk protein, sodium cocoyl-hydrolyzed soy protein and sodium / potassium cocoyl-hydrolyzed collagen,
• 3. sarcosinates, for example myristoyl sarcosine, TEA lauroyl sarcosinate, sodium lauroyl sarcosinate and sodium cocoyl sarcosinate,
• 4. taurates, for example sodium lauroyl taurate and sodium methyl cocoyl taurate,
• 5. Acyl lactylates, lauroyl lactylate, caproyl lactylate
• 6. Alaninates

Carboxylic acids and derivatives, such as

• 1. carboxylic acids, for example lauric acid, aluminum stearate, magnesium alkoxide and zinc undecylenate,
• 2. Ester carboxylic acids, for example calcium stearoyl lactylate, laureth-6-citrate and sodium PEG-4-lauramide carboxylate,
• 3. Ether carboxylic acids, for example sodium laureth-13-carboxylate and sodium PEG-6-cocamide carboxylate,

Phosphoric acid esters and salts such as DEA-oleth-10-phosphate and dilaureth-4-phosphate,
Sulfonic acids and salts, such as

• 1. Acyl-isethionates, z. B. sodium / ammonium cocoyl isethionate,
• 2. alkylaryl sulphonates,
• 3. Alkyl sulfonates, for example sodium coconut monoglyceride sulfate, sodium C _12-14 olefinsulfonate, sodium lauryl sulfoacetate and magnesium PEG-3 cocamide sulfate,
• 4. Sulfosuccinates, for example dioctyl sodium sulfosuccinate, disodium laureth sulfosuccinate, disodium lauryl sulfosuccinate and disodium undecylenamido MEA sulfosuccinate

such as
Sulfuric acid esters, such as

• 1. alkyl ether sulfate, for example sodium, ammonium, magnesium, MIPA, TIPA laureth sulfate, sodium myreth sulfate and sodium C _12-13 pareth sulfate,
• 2. Alkyl sulfates, for example sodium, ammonium and TEA lauryl sulfate.

• 1. Alkylamine,
• 2. Alkylimidazole,
• 3. Ethoxylierte Amine und
• 4. Quaternäre Tenside.
• 5. Esterquats

Further surfactants to be advantageously used according to the invention are cationic surfactants, for example selected from the group of

• 1. alkylamines,
• 2. alkylimidazoles,
• 3. Ethoxylated amines and
• 4. Quaternary surfactants.
• 5. Esterquats

quaternary Surfactants contain at least one N-atom, with 4 alkyl and / or Aryl groups is covalently linked. This leads, independently from pH, to a positive charge. Advantageous quaternary Surfactants are alkylbetaine, alkylamidopropyl betaine and alkyl amidopropyl hydroxysulfine. Cationic surfactants may further preferably in the sense of be selected from the group of quaternary ammonium compounds, in particular Benzyltrialkylammoniumchloride or bromides, such as benzyldimethylstearylammonium chloride, furthermore alkyltrialkylammonium salts, for example cetyltrimethylammonium chloride, for example or bromide, alkyldimethylhydroxyethylammonium chlorides or bromides, dialkyldimethylammonium chlorides or bromides, alkylamidoethyltrimethylammonium ether sulfates, alkylpyridinium salts, for example, lauryl or cetylpyrimidinium chloride, imidazoline derivatives and cationic compounds such as amine oxides, for example Alkyldimethylamine oxides or alkylaminoethyldimethylamine oxides. Advantageous In particular, cetyltrimethylammonium salts are to be used.

• 1. Acyl-/dialkylethylendiamin, beispielsweise Natriumacylamphoacetat, Dinatriumacylamphodipropionat, Dinatriumalkylamphodiacetat, Natriumacylamphohydroxypropylsulfonat, Dinatriumacylamphodiacetat und Natriumacylamphopropionat,
• 2. N-Alkylaminosäuren, beispielsweise Aminopropylalkylglutamid, Alkylaminopropionsäure, Natriumalkylimidodipropionat und Lauroamphocarboxyglycinat.

Advantageously used according to the invention further surfactants are amphoteric surfactants, for example selected from the group

• 1. acyl / dialkylethylenediamine, for example sodium acylamphoacetate, disodium acylamphodipropionate, disodium alkylamphodiacetate, sodium acylamphohydroxypropylsulfonate, disodium acylamphodiacetate and sodium acylamphopropionate,
• 2. N-alkylamino acids, for example aminopropylalkylglutamide, alkylaminopropionic acid, sodium alkylimidodipropionate and lauroamphocarboxyglycinate.

• 1. Alkohole,
• 2. Alkanolamide, wie Cocamide MEA/DEA/MIPA,
• 3. Aminoxide, wie Cocoamidopropylaminoxid,
• 4. Ester, die durch Veresterung von Carbonsäuren mit Ethylenoxid, Glycerin, Sorbitan oder anderen Alkoholen entstehen,
• 5. Ether, beispielsweise ethoxylierte/propoxylierte Alkohole, ethoxylierte/propoxylierte Ester, ethoxylierte/propoxylierte Glycerinester, ethoxylierte/propoxylierte Cholesterine, ethoxylierte/propoxylierte Triglyceridester, ethoxyliertes propoxyliertes Lanolin, ethoxylierte/propoxylierte Polysiloxane, propoxylierte POE-Ether und Alkylpolyglycoside wie beispielsweise Laurylglucosid, Decylglycosid und Cocoglycosid.
• 6. Sucroseester, -Ether
• 7 Polyglycerinester, Diglycerinester, Monoglycerinester
• 8. Methylglucosester, Ester von Hydroxysäuren

Further surfactants to be used advantageously according to the invention are nonionic surfactants, for example those selected from the group of

• 1. Alcohols,
• 2. alkanolamides, such as cocamide MEA / DEA / MIPA,
• 3. amine oxides, such as cocoamidopropylamine oxide,
• 4. Esters formed by esterification of carboxylic acids with ethylene oxide, glycerol, sorbitan or other alcohols,
• 5. Ethers, for example ethoxylated / propoxylated alcohols, ethoxylated / propoxylated esters, ethoxylated / propoxylated glycerol esters, ethoxylated / propoxylated cholesterols, ethoxylated / propoxylated triglyceride esters, ethoxylated propoxylated lanolin, ethoxylated / propoxylated polysiloxanes, propoxylated POE ethers and alkylpolyglycosides such as lauryl glucoside, decyl glycoside and cocoglycoside.
• 6. sucrose ester, ether
• 7 polyglycerol esters, diglycerol esters, monoglycerol esters
• 8. Methyl glucose esters, esters of hydroxy acids

Advantageous is also the use of a combination of anionic and / or amphoteric surfactants with one or more alkyl lactosides.

It is inventively possible and advantageous to obtain foams according to the following overview: Tab. 4 Fast foaming agent (primary surfactant) Foam stabilizer (contenside) substance class Alkyl-lactoside (e) Alkyl-lactoside (e)

To For example, one chooses a C8 lactoside as the primary surfactant and a C10 and / or C12 lactoside as cosurfactant. The shorter-chain C8 alkyl lactosides are more concentrated than the longer chain ones C10 / C12 alkyl-alkyl-lactosides, if you use clear formulations would like to receive.

Tab. 5

It is also possible and advantageous according to the invention to obtain foams according to the following overview: Fast foaming agent (primary surfactant) Foam stabilizer (contenside) substance class LES Alkyl-lactoside (e) LS Alkyl-lactoside (e)

Tab. 6

It is also possible and advantageous according to the invention to obtain foams according to the following overview: Fast foaming agent (primary surfactant) Foam stabilizer (contenside) substance class Alkyl-lactoside (e) betaine Alkyl-lactoside (e) cocoamphoacetate

Determination of foamability I

Foaming power and foam stability were tested with the lactoside mixtures according to a following procedure:
Of the individual samples, 10 ml of a 5% by weight aqueous solution was transferred to a 100 ml mixing cylinder and swirled vigorously 20 times within 1 minute and then observed for 2 hours. As a comparison, LES 5% by weight and Plantaren 818 UP 5% by weight were used.

Of the pH was adjusted with citric acid and was included about pH 5.5.

The following table summarizes the individual results of the lactoside mixtures.

All test samples show good foaming power in the initial phase (0 min). Also the Foam stability is almost identical for all samples. The exception is the Lac-810f, in which the foam completely disintegrates after about 30 minutes, which is probably due to the very high proportion of Lac-C8 in the mixture. Another special feature is the Lac-C810z, where foam is very stable. This can probably be explained by the high proportion of Lac-C10 in the mixture.

Determination of foamability II

In The experiments examined the pure substances of LacC10 and LacC8.

In a 100 ml mixing cylinder, the individual samples (10 ml of a aqueous solution) 20 times within 1 min panned and then the foam height and foam stability over Observed for 120 min.

from Primary surfactant was always 5 wt% and always from cosurfactant Taken 4.23 wt .-%, which a ratio of 6.5 / 5.5 equivalent. In addition, a 50:50 mixture was LacC10 and LacC8 used. The pH was adjusted with citric acid adjusted and was at about pH 5.5.

The following table summarizes the results of each sample.

The Tests show that the mixtures of lactosides and the cosurfactants (sodium acylglutamate, cocoamphoacetate) and / or Primary surfactant (LES) have a good foaming power. A particularly good foam stability show the sample (primary surfactant: LacC10, cosurfactant: cocoamphoacetate). The foam was also after 2 hours still stable. But also the attempt in which the primary surfactant: LES and cosurfactant: LacC10 were still showing after 2 hours good foam stability.

In vivo test for foaming behavior in the hand

Around also to test the foaming behavior of the acyl-lactosides in vivo carried out a series of experiments. It was 1 ml of a 5 % By weight of lactoside solution on an open palm applied and evenly with the other palm Triturated 10 times in circular motions. The foaming is documented in Table 9.

Of the pH was adjusted with citric acid and was included about pH 5.5.

When Comparative substance was a 5 wt .-% LES solution, pH = 5.5 chosen.

The following table summarizes the individual results of the individual samples.

QUOTES INCLUDE IN THE DESCRIPTION

This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.

Cited non-patent literature

• Vill, V., Böcker, T., Thiem, J., Fischer, F., Liq. Cryst., 6, 1989, 349 et seq. [0023]
• - v. Minden, HM, Brandenburg, K., Seydel, U., Koch, MHJ, Garamus, VM, Willumeit, R., Vill, V., Chem. Phys. Lipids, 106, 2000, 157 et seq. [0023]
• - Schreiber, Joerg; Milkereit, Goetz; Gerber, Sven; Vill, Volkmar, PCT Int. Appl., (2006), 67 pp. [0023]

Claims (5)

Foaming or foamable preparations containing one or more C _8-12 alkyl lactosides of the general structure

where R is a branched or unbranched alkyl radical having 8 to 12 carbon atoms, which is linked to the lactoserest α- or β-glycosidic. Foaming or foamable preparations Claim 1, characterized in that the one or more alkyl lactosides is elected or will be from the group Octyl-4-O- (β-D-galactopyranosyl) -β-D-glucopyranoside Octyl-4-O- (β-D-galactopyranosyl) -α-D-glucopyranoside Decyl-4-O- (β-D-galactopyranosyl) -β-D-glucopyranoside Decyl-4-O- (β-D-galactopyranosyl) -α-D-glucopyranoside Dodecyl-4-O- (β-D-galactopyranosyl) -β-D-glucopyranoside Dodecyl-4-O- (β-D-galactopyranosyl) -α-D-glucopyranoside Foaming or foamable preparations according to Claim 1 or 2, characterized in that they contain 0.05-5% by weight of one or more C _8-12 -alkyl lactosides, based on the total weight of the aqueous phase. Foaming or foamable preparations according to one of the preceding claims, characterized in that they contain 0.1-3% by weight of one or more C _8-12 -alkyl lactosides, based on the total weight of the aqueous phase. Foaming or foamable preparations according to one of the preceding claims, characterized that they contain one or more other surfactants.