DE102008014224A1 - Remineralizing chew toy, useful e.g. for obtaining a jaw-training, tooth-cleaning and/or gum massage in animals and to prevent periodontitis, comprises a polymer and/or an elastomer, which contain a matrix supported salt hydrate melt - Google Patents

Abstract

Remineralizing chew toy comprises a polymer and/or an elastomer, which contain a matrix supported salt hydrate melt (up to 30 (preferably 10) wt.%), which is produced by: completely dissolving an organic calcium salt, consisting of organic acids, in warm water; concentrating the solution under reduced pressure; cooling at normal pressure and subsequently adding an organic acid; concentrating the solution under reduced pressure at a heating bath temperature of 50-150[deg] C; cooling the hot, pourable calcium salt hydrate melt at normal pressure; and supplying liquid into the matrix. Remineralizing chew toy comprises a polymer and/or an elastomer, which contain a matrix supported salt hydrate melt (up to 30 (preferably 10) wt.%), which is produced by: completely dissolving an organic calcium salt, consisting of organic acids, in warm water at 35-80[deg] C; concentrating the solution under reduced pressure at a heating bath temperature of 50-150[deg] C; cooling at normal pressure and subsequently adding an organic acid at constant temperature; concentrating the solution under reduced pressure at a heating bath temperature of 50-150[deg] C; cooling the hot, pourable calcium salt hydrate melt at normal pressure; and supplying liquid into the matrix or solid calcium salt hydrate melt in granulate form into the matrix. ACTIVITY : Antiinflammatory; Antibacterial. MECHANISM OF ACTION : None given.

Description

The The present application relates to a pet toy for entertaining an animal and achieving a jaw training, a tooth cleaning and / or a gum massage in the animal.

A toy of the aforementioned kind is from the DE 699 04 921 T2 known. In this case, the toy is improved by two balloon-like sections, which are connected via a hollow body, that over a number of spaced ribs with narrow grooves, the cleaning effect of the toy and the fun of the animal in the tactile perception of the bite toy is to be improved.

Problematic is in the above-described toy just with pets pronounced elongated dentition that this the toy with the help of the lying behind molars with high biting pressure can shred and destroy without difficulty.

Farther problematic is that just in the area of the molars, which closely can be staggered, a cleaning effect is given inadequately, since the toy does not require cleaning Provides area of interdental spaces.

in view of the known state of the art, the task was a To offer biting toys for animals, with which the Overcome disadvantages and improved care of the teeth can be provided.

The Solution of this task is carried out according to Features of the independent claims.

Further Benefits will become apparent from the following description and the dependent claims.

Problematic is the onset of periodontal disease, periodontal disease and the concomitant halitosis. Cause for that is the Eating habit that domesticated animals fed food devour instead of chewing and because of the insufficient Strain on the jawbone, the development of diseases of the periodontium mitverursachen.

Surprisingly It has just been found that periodontal disease is caused by a toy with the addition of a calcium-containing salt hydrate melt, in particular in connection with circulation stimulating minerals, prophylactic is prevented.

Farther The problem with pets is in particular the decay of the teeth due to tooth decay. The high concentration of germ-promoting carbohydrate components is one when you consume commercial feed the main causes of occurrence and spread of tooth decay. The carbohydrates contained in feeds serve bacteria of the mouth and throat as a nutrient, on the one hand bacterial degradation products such as organic acids, in the form of lemons, ants or even acetic acid, in particular however lactic acid and on the other hand an increased plaque formation with their acid-forming germs for formation of caries are responsible.

surprisingly Way can with a biting toy according to the invention based on polymer and / or elastomer according to independent claims a toy for Pets are provided, which reliably the Disadvantages of the prior art overcome and improved dental care provided by remineralization of the teeth.

at The attempts to remineralizing effect was surprisingly found that a biting toy with matrix-supported, acidic, freshly prepared, dehydrated under reduced pressure Calcium salt hydrate melt with a residual water content in the range from 5% by weight to 25% by weight, preferably from 10% by weight to 20% Wt .-%, a remineralization of the teeth provides.

With other, matrix-supported agents and shares could this effect advantageous as described in detail below be improved.

matrix in the sense of the present invention means the structural composition of the polymer and elastomer.

supported means in the sense of the present application that the concerned Substance in the cavities, caverns or polymer spaces the polymer and elastomer disposed or even during the production in the polymer / elastomer in liquid or particulate form has been introduced.

The Preparation of the salt hydrate melt was carried out on the basis of Calcium salts of animal physiologically acceptable, organic acids, although mixtures of different acids are used could.

Preferably, the melt was prepared with at least one organic acid selected from the group consisting of lactic acid, citric acid and gluconic acid, said composition One provides an improved distribution and wetting of all teeth in the oral cavity. It has surprisingly been found that the use of citric acid does not adversely affect the efficacy of the enamel remineralization compositions despite the known calcium complexing properties.

Especially preferred is a salt hydrate melt containing a combination made from lactic acid and citric acid. at These compositions will have a rapid viscosity decrease after release in combination with a significantly prolonged Biting game of the pet scored.

Prefers As calcium salt, calcium lactate, calcium citrate and calcium gluconate are used used. As further acid are preferred lactic acid or citric acid and gluconic acid, wherein particularly preferably the acid added to the Säureanion corresponding acid.

The Inventors assume that the representation of the Melt at reduced pressure in the freshly prepared calcium salt melt also proportionate dimers and oligomers (anhydrides) of the added acids can be formed, wherein also mixed anhydrides can be present.

With the while releasing from the biting toy at the same time expired rehydration reaction can also surprise Advantages of biting toys made with fresh melt be explained, such. B. the dispersive distribution of Ingredients during the biting game, the low tendency to exit in the biting toy during storage, the higher Efficacy in terms of teeth cleaning and consistent elastic consistency of the elastomer and polymer.

According to the invention the calcium salt hydrate melts from a hydrous mixture at least one organic calcium salt and one or more Organic acids by dehydration under reduced Pressure and elevated temperature and subsequent Cooling won. The molten salt is falling as a ductile, macroscopically homogeneous mass. Here, the melt points in Domains a Nahordnung on. The domains are arranged in turn distributed chaotically, so that in the X-ray diffraction only uncharacteristic, extremely wide and diffuse diffraction signals are visible become. This is evidenced by a X-ray amorphous, non-crystalline Arrangement of the above-described short order having domains in the solid.

• a) vollständiges Lösen von mindestens einem organischen Calciumsalz in warmen Wasser (T = 35–80°C);
• b) Einengen der Lösung unter vermindertem Druck und erhöhter Temperatur (Heizbad 50–150°C);
• c) Entspannen auf Normaldruck und anschließende Zugabe der mindestens einen organischen Säure bei konstanter Temperatur;
• d) Einengen der Lösung unter vermindertem Druck und erhöhter Temperatur (Heizbad 50–150°C);
• e) Entspannen auf Normaldruck der heißen, fließfähigen Schmelze.

The preparation of such a melt on a laboratory scale comprises the steps:

• a) complete dissolution of at least one organic calcium salt in warm water (T = 35-80 ° C);
• b) concentration of the solution under reduced pressure and elevated temperature (heating bath 50-150 ° C);
• c) depressurization to normal pressure and subsequent addition of the at least one organic acid at a constant temperature;
• d) concentration of the solution under reduced pressure and elevated temperature (heating bath 50-150 ° C);
• e) depressurization to normal pressure of the hot, flowable melt.

The Flowability offers the advantage that the melt directly in the further production process of the biting toy can be processed by stirring into the matrix or can be poured into thin slices, which after Solidified granulated or ground so that a high surface-to-volume ratio of the particles is achieved what the further processing, in particular the introduction into the matrix of the biting toy, relieved.

So can in the case of matrix-supported, granulated calcium salt hydrate melt with multilayer structure with at least two consecutive layers particularly advantageous by a first, outer Layer in which a salivation stimulating Scharfstoff is included, a preparatory, even Rinsing the mouth can be effected. It is preferred Hereby a sharp substance with at the same time the blood circulation increasing Effect uses, what a more even and causes elevated temperature of the surrounding tissue. This will increases the rate of remineralization reaction and remineralization improves. Proved to be particularly advantageous This is a combination of Scharfstoffund natural, gentle Biocide, preferably a slightly astringent tannin. The biocide lowers the germ count, especially in the area of carious Primary lesions and thus provides a cleaner and better tooth surface ready. Due to the weakly astringent effect of a tannin could here a much more constant, uniform Salivary flow can be achieved, giving a more accurate adjustment of the concentration gradients during the biting game.

A subsequent, inner layer in the matrix-supported granules releases the remineralizing calcium salt from the calcium salt hydrate melt in the previously optimally prepared oral cavity of the animal. Advantageously, the calcium salt hydrate melt is incorporated with a xylitol content in the granules. The xylitol content causes a cooling, pleasant dissolution of the granule layer, which in the animal to This is due to the intention to achieve the pleasant, cooling effect as completely as possible over the entire area.

Just in combination with the freshly made and in the biting toy supported calcium salt hydrate melts, the remineralization of To achieve teeth with constant reliability.

advantageously, be in the preparation of the Salzhydratschmelze the first concentration in Step b) 10-88%, preferably 25-85%, more preferably 45-80% and most preferably 80% of the amount of water charged away.

advantageously, is the organic acid before step c) up to 25 wt .-%. preferably 2-20% by weight, more preferably 3-10 Wt .-% and most preferably 4.6 wt .-% water based on the submitted total mass of the calcium salts added.

Especially preferably, the acid is added to the temperature before addition heated the submitted salt solution.

advantageously, when narrowing down in step d), a further 5-12% of the in Step a introduced amount of water, preferably 7-10%, especially preferably 8.5%, removed.

advantageously, the melt contains a calcium content of 1.5-3 Mol to 1 kg of melt based on elemental calcium, giving a Proportion of 6 wt .-% to 12 wt .-% corresponds. In a special preferred embodiment is at least the calcium salt component in microencapsulated or nano-encapsulated form before release the salt is delayed during consumption, so that initially the oral cavity as described above also in granular supported Salzhydratschmelze advantageous is rinsed preparatory before the calcium is released becomes. In this way, the precipitation of calcium salt compounds optimized and achieved an optimized, reliable remineralization.

surprisingly It has been shown that by the addition of sodium fluoride in the basic composition of the calcium-containing melt the Remineralisierungswirkung contrary to expectations, not inhibited, but significantly increased becomes. The maximum amount of fluoride in the overall composition the salt hydrate melt is 1500 ppm (1.5 g / kg), preferably the proportion of fluoride is 1500 to 1000 ppm, especially preferably 1400 ppm.

In a further embodiment is also the Scharfstoffkomponente, preferably in combination with other and / or separately encapsulated, further Active ingredients, encapsulated, so depending on the particular Encapsulation delayed a long-term remineralization due to temporal Released active ingredients in conjunction with the controlled salivation is brought about.

A another preferred embodiment provides a layered one Encapsulation of calcium salt hydrate melt and other active ingredients so that they alternate in at least three sequential Steps are released to optimal remineralization to ensure.

A another embodiment comprises a microencapsulated Acid or an acid anhydride, which is time-delayed be released so that over a longer Period of low required for remineralization pH in the oral cavity is maintained. Preferably, the microcapsules For this mucoadhesive properties, so that too is maintained after consumption an optimal pH range.

In an embodiment which is particularly pressure-stable proved, the biting toy showed a spherical, external Basic shape, in which along a vertically extending, tubular body Slats with a thickness relative to the diameter of the main body from 0.1 to 0.3 to 1.

Prefers the biting toy still has matrix-supported Cleaning body on, as a powder, consisting of particles of at least one substance selected from the group consisting of titanium dioxide, Alumina, alkali carbonate, disperse silica, dicalcium phosphate (DCP), dicalcium phosphate dihydrate (DCPD), sodium metaphosphate, silica gels and alumina hydrates and hydrated silica are.

Advantageous the biting toy furthermore has a polymer and / or Elastomer-based color indicator on which increase of the pH value in the biting toy over a limit value in the range of 5 to 7, preferably 5.5 to 6.5, more preferably 6, showing a color change. As a result, the owner side clearly recognized be that the inventive, acid salt hydrate melt almost completely released from the biting toy and that the biting toy is to be replaced. So is a permanent and user-side easily controllable, Improved dental care in the respective pet reliably provided.

QUOTES INCLUDE IN THE DESCRIPTION

This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.

Cited patent literature

• - DE 69904921 T2 [0002]

Claims (12)

A pet toy for entertaining an animal and providing a tray training, tooth cleaning and / or gum massage to the animal, characterized in that the remineralizing bite toy is made of a polymer and / or elastomer containing a matrix-supported salt hydrate melt prepared by a) complete dissolution of at least one organic calcium salt selected from the group of physiologically acceptable organic acids in warm water at 35-80 ° C, b) concentration of the solution under reduced pressure at a heating bath temperature of 50-150 ° C, c) Depressurization to atmospheric pressure and subsequent addition of at least one organic acid at constant temperature, d) concentration of the solution under reduced pressure at a heating bath temperature of 50-150 ° C. e) depressurizing the hot, flowable calcium salt hydrate melt to atmospheric pressure and subsequently introducing it into the matrix in liquid form which has been introduced as a solid calcium salt hydrate particulate in granulated Forml in the matrix, wherein the toy has a proportion of salt hydrate melt of up to 30, preferably 5 to 20, particularly preferably 10% by weight. Toy according to the preceding claim, characterized characterized in that the produced Cacliumsalzhydratschmelze a residual water content in the range of 5-25 wt .-%, preferably 10-20% by weight. Toy according to one of the preceding claims, characterized in that the melt is produced with at least an organic acid selected from the group consisting of lactic acid, citric acid and gluconic acid, being a combination of lactic acid and citric acid is particularly preferred. Toy according to one of the preceding claims, characterized in that the calcium salt is selected from the group consisting of calcium lactate, calcium citrate and calcium gluconate, particularly preferred that the calcium salt with the added Acid-corresponding acid anions selected is. Toy according to one of the preceding claims, characterized in that the melt comprises a calcium content of 1.5-3 mol based on 1 kg of melt based on elemental calcium contains. Toy according to one of the preceding claims, wherein the salt hydrate melt was prepared according to the following Steps: a) it is heated to 60 ° water and with stirring and further heating gradually calcium lactate pentahydrate calcium gluconate is added and stirred at the same time, the weight ratio being water: calcium lactate pentahydrate: calcium gluconate 500: 172: 44 is; b) the clear solution is in the Transfered distillation flask and and a volume fraction of water 0.4 / 0.5 based on the original amount of water a heating bath temperature of 130 ° C under reduced pressure distilled; c) in a container become lactic acid (80%) with water heated to 60 ° C and stirring added with citric acid, wherein the weight ratio of Lactic Acid: Water: Citric Acid 22:10:19, and then added to the mixture obtained in b); d) the distillation is continued under reduced pressure at 0.4 bar, up to a total of all distillation steps, an amount of water equal the amount of water submitted under (a) has been transferred. Toy according to one of the preceding claims, characterized in that the toy at least one further Active substance selected from the group consisting of pungent, germicidal Biocide, astringent and acid anhydride. Toy according to the preceding claim, characterized in that the remineralizing additive and / or at least an active ingredient and / or acid in at least partially encapsulated form is present. Toy according to the preceding claim, characterized characterized in that the encapsulation at least partially mucoadhesive is performed. Toy according to one of the preceding claims, characterized in that it matrix-supported cleaning body comprising, as a powder consisting of particles of at least a substance from the group consisting of titanium dioxide, aluminum oxide, Alkaline carbonate, disperse silica, dicalcium phosphate (DCP), dicalcium phosphate dihydrate (DCPD), sodium metaphosphate, silica gels and alumina hydrates and hydrated silica are. Toy according to one of the preceding claims, characterized in that it is a matrix-supported Color indicator, which an increase in the pH in the biting toy on a limit in the range of 5 to 7, preferably 5.5 to 6.5, especially preferably 6, indicated by a color change. Toy after one of the previous ones Claims, having a spherical, outer basic shape in which are arranged along a vertically extending, tubular base body fins having a thickness relative to the diameter of the base body of 0.1 to 0.3 to 1.