DE102007041475A1 - Active ingredient combination of glycyrrhetinic acid and erythrulose and cosmetic or dermatological preparations containing this combination of active ingredients - Google Patents

Abstract

Active ingredient combination of a) glycyrrhetinic acid and / or glycyrrhizin and b) erythrulose and, if desired, c) dihydroxyacetone.

Description

The The present invention relates to drug combinations, in particular such for tanning the human skin, as well as cosmetic and dermatological preparations containing such drug combinations.

The damaging effect of the ultraviolet part of solar radiation on the skin is well known. While blasting with a wavelength less than 290 nm (the so-called UVC range), from the ozone layer in the earth's atmosphere be absorbed, causing rays in the range between 290 nm and 320 nm, the so-called UVB range, an erythema, a simple Sunburn or even more or less severe burns.

When a maximum of the erythema efficiency of sunlight becomes the tighter Range indicated around 308 nm.

To the Protection against UVB radiation, numerous compounds are known which are mostly derivatives of the 3-benzylidene camphor, 4-aminobenzoic acid, cinnamic acid, salicylic acid, benzophenone and 2-phenylbenzimidazole.

Also for the range between about 320 nm and about 400 nm, the so called UVA range, it is important to have filter substances available to have, because even its rays can cause damage. It has been proven that UVA radiation causes damage the elastic and collagen fibers of the connective tissue leads, what makes the skin age prematurely, and that it as the cause of numerous phototoxic and photoallergic shear reactions you can see. The damaging influence of UVB radiation can be amplified by UVA radiation.

UV-A radiation can also cause skin damage by the skin's own Kerstin or Elastin is damaged. This will be Elasticity and water retention capacity of the skin reduced, d. H. The skin becomes less supple and tends to Wrinkling. The strikingly high incidence of skin cancer in areas of strong sunlight, it appears that damage to the genetic information in the cells Sunlight, especially caused by UV-A radiation.

The UV radiation can also lead to photochemical reactions, whereby then the photochemical reaction products in the skin metabolism intervention.

mainly are such photochemical reaction products to radical compounds, eg. B. hydroxyl radicals. Also undefined radical photoproducts that are formed in the skin itself, may be uncontrolled due to their high reactivity Subsequent reactions to the day. But also singlet oxygen, a non-radical excited state of the oxygen molecule can occur with UV irradiation, as well as short-lived epoxides and many other. Singlet oxygen, for example, stands opposite the normally present triplet oxygen (radical Ground state) by increased reactivity. Indeed There are also excited, reactive (radical) triplet states of the oxygen molecule.

Further counts UV radiation as ionizing radiation. It exists So the risk that even ionic species in UV exposure arise, which in turn oxidative in the biochemical Intervene processes.

The Pigmentation of human skin, is essentially through the presence of melanin causes. Melanin and its degradation products (Melanoids), carotene, degree of circulation and the nature and Thickness of the stratum corneum and other skin layers leave skin shades from virtually white (with reduced filling or in the absence of blood vessels) or yellowish over light brown-reddish, bluish to brown different Nuances and finally appear almost black. The individual skin regions show due to different amounts of melanin different depth of coloration. According to recent findings has the distribution of melanin in the skin is at least as great Influence on the color appearance (browning) as the amount of melanin.

The natural melanin protects the skin from penetrating UV radiation. The number of melanin granules produced in the melanocytes, together with the epidermal distribution of the melanin granules, determines whether they are light or dark-skinned. With strong pigmentation (eg with colored, but also with bright membranous after some UV irradiation), melanin is also found in the stratum spinosum and even in the stratum corneum. It attenuates UV radiation by up to about 90% before it reaches the corium.

• Hauttyp I bräunt nie, bekommt immer einen Sonnenbrand.
• Hauttyp II bräunt kaum, bekommt leicht einen Sonnenbrand.
• Hauttyp III bräunt durchschnittlich gut.
• Hauttyp IV bräunt leicht und anhaltend, bekommt fast nie Sonnenbrand.
• Hauttyp V dunkle, oft fast schwarze Haut, bekommt nie Sonnenbrand.

Depending on photosensitivity, the following skin types are usually distinguished:

• Skin type I never tans, always gets a sunburn.
• Skin type II hardly tans, easily gets sunburned.
• Skin type III tans well on average.
• Skin type IV tans easily and persistently, almost never gets sunburned.
• Skin type V Dark, often almost black, skin never gets sunburned.

The natural shielding of harmful UV radiation is a tangible benefit of natural skin tanning. For some decades now, a "healthy" Skin color as a sign of particular sporting activity and is therefore desirable by a broad consumer stratum considered. Representatives of skin types I and II, who are one such Skin tinting, therefore, are anyway on self-tanning Instructed preparations. But also representatives of the skin type III, who are not too exposed to the risks of sunbathing and still want to look brown, are grateful audiences for self-tanning preparations.

Artificial skin tanning can be effected by cosmetic or medical means, whereby essentially the following approaches play a role:
Carotene is stored in the subcutaneous adipose tissue by regular intake of carotene preparations, the skin gradually turns orange to yellow-brown.

With the help of washable make-up preparations a slight skin tone can be achieved (eg extracts of fresh green walnut shells, henna)
The staining can also be done by way of chemical modification of the horny layer of the skin with so-called self-tanning preparations. The most important active ingredient is dihydroxyacetone (DHA). The skin tanning achieved in this way is not washable and is only removed with the normal desquamation of the skin (after approx. 10-15 days). Dihydroxyacetone can be referred to as ketotriose and reacts as reducing sugar with the amino acids of the skin or the free amino and imino groups of Kerstins via a series of intermediates in the sense of a Maillard reaction to brown-colored substances, so-called melanoids, which sometimes melanoidins to be named.

• • häufig ungleichmäßig gebräunt ist
• • keinen natürlichen Hautbräunungsfarbton aufweist
• • nach dem Auftragen auf die Haut unangenehm riecht
• • es zu starken Verfärbungen der Handinnenflächen und der Nägel kommt und
• • im Gegensatze zu „sonnengebräunter" Haut nicht gegen Sonnenbrand geschützt ist.

Disadvantages of tanning with dihydroxyacetone is that the tanned skin with him

• • is often browned unevenly
• • does not have a natural skin tint color
• • smells unpleasant after application to the skin
• • it comes to strong discoloration of the palms and nails and
• • In contrast to "tanned" skin is not protected against sunburn.

Also classic self-tanning products show only very bad skin care properties and lead frequently for discoloration of clothes, bedding and other Textiles.

The Use of glycyrrhetinic acid and glycyrrhizin in cosmetics and Dermatika is known per se.

Glycyrrhetinic acid is characterized by the following structure:

Next the naturally occurring 18β-form There is also an 18 α-form. Made of licorice (Glycyrrhiza glabra, Leguminosae) isolatable glycyrrhetinic acid is the aglycone of glycyrrhizin (which is the 2β-glucuronido-α-glucuronide Glycyrrhetinsäure represents).

Glycyrrhizin is characterized by the following structure:

Glycyrrhetinsäure is used as an anti-inflammatory agent. Glycyrrhetinic acid 3-hemisuccinate serves as an ulcer therapeutic.

glycyrrhizin has an anti-inflammatory effect and serves as licorice juice (Sirupus liquiritiae) as cough medicine and expectorant.

Glycyrrhetinsäure and glycyrrhizin are known to those skilled in the art as agents having a skin-lightening efficacy known.

The To remedy disadvantages of the prior art was therefore the task of the present invention.

• a) Glycyrrhetinsäure und/oder Glycyrrhizin und
• b) Erythrulose sowie gewünschtenfalls
• c) Dihydroxyaceton und kosmetische oder dermatologische Zubereitungen, diese Wirkstoffkombinationen enthaltend, die Probleme des Standes der Technik lösen würden.

It was, however, surprising and not foreseeable for the expert that drug combinations from

• a) Glycyrrhetinsäure and / or Glycyrrhizin and
• b) erythrulose and if desired
• c) Dihydroxyacetone and cosmetic or dermatological preparations, containing these combinations of active ingredients, which would solve problems of the prior art.

• • die Bräunung der Haut steigern,
• • eine gleichmäßigere und natürlichere Bräunung der Haut ermöglichen,
• • keine unerwünschten Gerüche beim Auftragen auf die Haut entwickeln
• • kein unerwünschtes Austrocknen der Haut mit sich bringen,
• • keine unerwünschte Verfärbung bestimmter Hautareale, wie z. B. der Handinnenflächen, und der Nägel aufweisen und
• • eine Verfärbung von Textilien nach Auftragen auf die Haut vermeiden.

In particular, it had not been foreseen for the skilled person that the preparations according to the invention

• • increase the tanning of the skin,
• • enable a more even and natural tanning of the skin,
• • do not develop unwanted odors when applied to the skin
• • do not cause unwanted drying of the skin,
• • no unwanted discoloration of certain skin areas, such as B. the palms, and the nails and
• • avoid discolouring textiles after application to the skin.

in the In general, the Glycyrrhetinsäure according to the invention Glycyrrhizin preferred, but may also be advantageous be replaced by this partially or completely.

in the In general, the erythrulose according to the invention is Dihydroxyacetone preferred, but may also be advantageous be replaced by this partially or completely.

According to the invention advantageous are in the drug combinations or the preparations containing them Weight ratios of glycyrrhetinic acid and / or Glycyrrhizin on the one hand and erythrulose on the other hand from the field chosen from 10: 1 to 1: 100.

Especially preferred weight ratios of glycyrrhetinic acid and / or glycyrrhizin on the one hand and erythrulose on the other hand in the active substance combinations or the preparations containing them are most preferred from the range of 1:30 to 1: 7.5 chosen from the range of 1:20 and 1:10.

Prefers contain cosmetic or dermatological preparations according to the Invention 0.001-10% by weight of glycyrrhetinic acid and / or glycyrrhizin.

Further preferably contain cosmetic or dermatological preparations according to the invention 0.1-3 wt .-% of erythrulose.

Further According to the invention advantageously contain cosmetic or dermatological preparations according to the invention 0.1-3 wt .-% of dihydroxyacetone.

A preferred embodiment of the present invention Preparations containing 0.001-10% by weight of glycyrrhetinic acid and / or glycyrrhizin and 0.1-3 wt .-% dihydroxyacetone and / or 0.1-3 erythrulose.

preferred Ratios of glycyrrhetinic acid and dihydroxyacetone are between 10: 1 to 1: 100, more preferably between 1:30 and 1: 7.5, most preferably between 1:20 and 1:10.

Especially preferably contain cosmetic or dermatological preparations according to the invention 0.01-1 wt .-% of Glycyrrhetinic acid and / or glycyrrhizin and 0.5-2 Wt .-% dihydroxyacetone and / or erythrulose, wherein a combination from dihydroxyacetone and erythrulose in a ratio of 1: 5 to 5: 1, based on the total composition of the preparations.

All particularly preferably contain cosmetic or dermatological preparations 0.05-0.25% by weight according to the invention Glycyrrhetinsäure and 0.75-1.75 Gew.-Erythrulose, based on the total composition of the preparations.

• a) die Hautbarriere gestärkt wird
• b) die Hautfeuchtigkeit gesteigert wird
• c) insbesondere unerwünschte Pigmentierungsstörungen wie Melasma, verschiedene Formen der postinflammatorischen Hyperpigmentierung beispielsweise infolge von Narben oder nach Sonnenbränden, Altersflecken, Sommersprossen, Leberflecken, Vitiligo usw. gemildert oder beseitigt werden,.
• d) Hautfalten vermindert werden.

In addition to the above-described positive properties on the tanning of the skin, the formulations of the invention showed that

• a) the skin barrier is strengthened
• b) the skin moisture is increased
• c) in particular, alleviates or eliminates undesirable pigmentation disorders such as melasma, various forms of post-inflammatory hyperpigmentation due to, for example, scars or sunburn, age spots, freckles, liver spots, vitiligo, etc.
• d) skin wrinkles are reduced.

The Application of inventive preparations led Furthermore, astonishingly also to an improvement of the skin contours and to increased elasticity, in particular at the connective tissue weak areas of the body such. B. on the legs, abdomen and buttocks. These Skin tightening and firming effects go beyond one Improvement of cell metabolism with the reduction of orange peel accompanied, for example, with the reduction of skin dents on the thigh area ("rider trousers").

invention Emulsions in the context of the present invention, for. B. in the form of a Cream, a lotion, a cosmetic milk are beneficial and contain z. Fats, oils, waxes and / or other fatty substances, and water and one or more emulsifiers, as is customary be used for such a type of formulation.

It is also possible and advantageous in the sense of the present Invention, the active ingredient used in the invention in aqueous systems or surfactant preparations for To cleanse the skin and hair.

It Of course, it is known to the person skilled in the art that sophisticated Cosmetic compositions usually not without the usual Auxiliaries and additives are conceivable. These include, for example Bodying agents, fillers, perfume, dyes, emulsifiers, additional active ingredients such as vitamins or proteins, light stabilizers, Stabilizers, insect repellents, alcohol, water, salts, antimicrobial, proteolytic or keratolytic substances, etc.

mutatis Mutandis are subject to appropriate formulation requirements medical preparations.

medical containing topical compositions within the meaning of the present invention usually one or more drugs in effective concentration. For the sake of simplicity, a clear distinction is made between cosmetic and medical use and corresponding products to the statutory provisions of the Federal Republic of Germany referenced (eg Kosmetikverordnung, food and drug law).

The cosmetic and / or dermatological according to the invention Formulations can be composed as usual and for the treatment of the skin and / or the hair in the sense of dermatological treatment or a treatment in terms of nourishing cosmetics. she But also in make-up products in the decorative Cosmetics are used or in the cosmetic and dermatological Cleaning products.

For the purposes of the present invention, the moisturizer (s) selected from the group: glycerol, lactic acid and / or lactates, in particular sodium lactate, butylene glycol, propylene glycol, biosaccharide gum-1, glycine soybean, ethylhexyloxyglycerol, pyrrolidonecarboxylic acid and urea are very particularly advantageous. Furthermore, it is particularly advantageous to use polymeric moisturizers from the group of water-soluble, water-swellable or water-gellable polysaccharides. For example, hyaluronic acid, chitosan and a fucose-rich polysaccharide are particularly advantageous Chemical Abstracts under the registry number 178463-23-5 filed and z. B. under the name Fucogel ^® 1000 of the company SOLABIA SA is available. Moisturizers can also be used advantageously as anti-wrinkle active ingredients for the prophylaxis and treatment of cosmetic or dermatological skin changes, as described, for example, in US Pat. B. occur during skin aging, can be used. It is particularly advantageous for the purposes of the present invention to use glycerol as a moisturizer, preferably in a concentration of 0.05 to 30 wt .-%, particularly preferably 1 to 10 wt .-%, each based on the total weight of the preparation.

If the cosmetic or dermatological preparation is a solution or lotion, the solvents used can be: water or aqueous solutions, furthermore oils, such as triglycerides of capric or caprylic acid, but preferably castor oil, fats, waxes and other natural and synthetic fatty substances, preferably Esters of fatty acids with lower C-number alcohols, e.g. With isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with alkanoic acids of low C number or with fatty acids, but also alcohols, diols or polyols of low C number, and their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products ,

Especially are mixtures of the abovementioned solvents used, as with alcoholic solvents water may be an advantageous further component.

cosmetic and dermatological preparations according to the invention, also z. B. to protect the skin from UV rays exist in various forms, such as. B. usually be used for this type of preparations. So can you z. B. a solu tion, an emulsion of Type water-in-oil (W / O) or oil-in-water type (O / W), or a multiple emulsions, for example of the water-in-oil-in-water type (W / O / W), oil-in-water-in-oil (O / W / O), a gel, a hydrodispersion, a lamellar phase, a liquid isotropic solution phase, a micellar phase, a solid or dispersed single or multiple hexagonal phase, a solid or dispersed one or more cubic phase, a lyotropic Phase, a crystalline phase, a solid pin or a Represent aerosol.

The active compounds according to the invention can also be used particularly advantageously in microemulsions, for example as in the German Offenlegungsschrift DE-195 9 079 described, are used.

The oil phase The preparations according to the invention will be advantageous selected from the group of saturated esters and / or unsaturated, branched and / or unbranched Alkanecarboxylic acids of a chain length of 3 to 30 C atoms and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length from 3 to 30 carbon atoms, from the group of aromatic esters Carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 3 to 30 carbon atoms. Such ester oils can then are advantageously selected from the group isopropyl myristate, Isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyl dodecyl palmitate, Oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate and synthetic, semi-synthetic and natural mixtures of such esters, z. B. jojoba oil.

Further the oil phase can be chosen advantageously from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ethers, the group the saturated or unsaturated, branched or unbranched alcohols, and the fatty acid triglycerides, namely the triglycerol esters of saturated and / or unsaturated branched and / or unbranched alkanecarboxylic acids of a Chain length of 8 to 24, in particular 12-18 C atoms. The fatty acid triglycerides may be, for example be chosen advantageously from the group of synthetic, semisynthetic and natural oils, e.g. Olive oil, sunflower oil, Soybean oil, peanut oil, rapeseed oil, almond oil, Palm oil, coconut oil, palm kernel oil and the like more.

Also any mixtures of such oil and wax components are advantageous to use in the context of the present invention.

Advantageously, the oil phase is selected from the group consisting of 2-ethylhexyl isostearate, octyldodecanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C _12-15 alkyl benzoate, caprylic capric acid triglyceride, dicaprylyl ether.

Particularly advantageous are mixtures of C _12-15 -alkyl benzoate and 2-ethylhexyl isostearate, mixtures of C _12-15 -alkyl benzoate and isotridecyl isononanoate and mixtures of C _12-15 -alkyl benzoate, 2-ethylhexyl isostearate and isotridecyl isononanoate.

From The hydrocarbons are paraffin oil, squalane and squalene advantageous to use in the context of the present invention.

Advantageous the oil phase may also contain a content of cyclic or have linear silicone oils or completely consist of such oils, although it is preferred except the silicone oil or silicone oils an additional content of other oil phase components to use.

Advantageous Cyclomethicone (Octamethylcyclotetrasiloxan) as according to the invention to used silicone oil. But also other silicone oils are advantageous for the purposes of the present invention to use for example, hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).

Especially also advantageous are mixtures of cyclomethicone and isotridecyl isononanoate, from cyclomethicone and 2-ethylhexyl isostearate.

Advantageous the content of the oil phase is between 1 and 50 wt .-%, based on the total weight of the preparations, is preferred 2.5-30 wt .-%, particularly preferably 5-15 wt .-%.

to Application are the cosmetic according to the invention and / or dermatological formulations in the for cosmetics and dermatological usual way to the skin and / or the Hair applied in sufficient quantity.

Further advantageous for the purposes of the present invention to be used active ingredients are those that improve the condition of the skin, in particular Active ingredients for the treatment and / or care of aging skin, for example those that cause the appearance of wrinkles or even existing wrinkles Reduce.

Especially Biochinones, in particular ubiquinone, are particularly advantageous (Q10), folic acid and its derivatives (especially tetrahydrofolic acid and dihydrofolic acid), niacin and its derivatives (in particular Niacinamide), creatine and creatinine, carnitine, biotin, isoflavone, Hop and hops malt extracts. Also means the restructuring of connective tissue, such as natural and synthetic Isoflavonoids and isoflavonoid-containing plant extracts - such as z. B. soy and clover extracts - can in the formulations of the invention very well used become. It also shows that the formulations are special Way, agents to support the skin functions dry skin (such as vitamin C, biotin, carnitine, Green Tea Extracts, Eucalyptus Oil, Urea and Mineral salts (such as eg NaCl, marine minerals) as well as osmolytes (like Eg inositol, betaine, quaternary ammonium compounds)) to use. Especially advantageous are the following active ingredients, these can be used individually or in combination: Ubiquinone. Folic acid, creatine, carnitine and isoflavone.

Especially The incorporation of active ingredients proved to be advantageous for alleviation irritative skin conditions, be it with sensitive skin in general or noxious skin (UV light, chemicals), as advantageous. Here are agents such as sericosides, various extracts of licorice, Licochalcone, especially licochalcone A, silymarin, silyphos, dexpanthenol, inhibitors of prostaglandin metabolism, especially cyclooxygenase and leukotriene metabolism, especially 5-lipoxygenase, but also the 5-lipoxevase inhibitor protein, FLAP. The before mentioned active ingredients are also particularly suitable to a (energy) depot create or renew as well as repair (repair) different cellular structures, in particular the DNA to activate. Very particularly advantageous in this case are licochalcones, in particular Licochalcone A, and dexpanthenol, these being used individually or in combination can be used.

Especially advantageous preparations are also obtained if, as additional or agents used antioxidants. Included in the invention the preparations advantageously one or more antioxidants. As cheap, but nevertheless optional to use antioxidants can all for cosmetic and dermatological Applications suitable or common antioxidants be used.

All particularly advantageous in the context of the present invention water-soluble antioxidants are used, such as Vitamins, eg. As ascorbic acid and its derivatives - in particular Ascorbyl palmitate, Na and Mg ascorbyl phosphate and ascorbyl acetate - as well as Rutinic acid and its derivatives, in particular alpha glucosylrutin, Quercetin and isoquercetin.

Especially preferred antioxidants are also vitamin E and its derivatives (especially vitamin E acetate), vitamin A and its derivatives (in particular Vitamin A palmitate) as well as carnosine, butylhydroxytoluene, butylhydroxyanisole, beta-alanine and carotenoids (especially beta-carotene) and phytoene.

The Amount of antioxidants (one or more compounds) in the Preparations is preferably from 0.001 to 30% by weight, particularly preferably 0.05 to 20 wt .-%, in particular 0.1 to 10 Wt .-%, based on the total weight of the preparation.

The following examples are intended to illustrate the embodiments of the present inventions. example 1 INCI Wt .-% Wt .-% stearic acid 2 2 dicaprylyl 3 3 octyldodecanol 2 2 C12-15 alkyl benzoates 4 4 cetyl alcohol 2 2 Cetearyl ethyl hexanoate + isopropyl myristate 2 2 glycerin 5 5 ethylhexylmethoxycinnamate 2 2 TiO2 1 1 cetyl palmitate 1 1 glyceryl stearate 1 1 phenoxyethanol 0.4 0.4 Butyl_Methoxydibenzoxylmethan 2 2 Perfume qs qs EDTA 0.2 0.2 Glycyrrhetinsäure 0.1 0.1 erythrulose 1.5 0.5 DHA - 1 Carbomer 0.2 0.2 folic acid 0.05 - Magnesium aluminum silicate 0.2 0.2 methylparaben 0.1 0.1 Vitamin E acetate 0.1 0.1 Propylparaben 12:05 12:05 BHT 12:05 12:05 water ad 100 ad 100 Example 2 INCI Wt .-% glyceryl stearate 2 ricinoleate 1 stearyl 2 cetyl alcohol 2 Hydrogenated coconut fat glycerides 1 Caprylic / capric 3 Ethylhexylkokosfettsäureester 2 dicaprylyl 2 C12-15 alkyl benzoates 3 tocopheryl acetate 1 Ubiquinone (Coenzyme Q10) 0.05 sodium ascorbyl 0.1 Glycyrrhetinsäure 0.1 erythrulose 1.75 p-Hydroxybenzoic acid alkyl ester (paraben) 0.4 methyl propanediol 1 carrageenan 0.1 Carbomer 0.2 EDTA 0.2 glycerin 7 Water and / or oil soluble dyes 0.05 Fillers / Additives (Nylon, BHT) 0.5 Perfume qs water ad 100 Example 3 INCI Wt .-% PEG-40 Stearate 1 glyceryl stearate 3 cetearyl 2 dimeticones 1 Hydrogenated coconut fat glycerides 2 Caprylic / capric 2 octyldodecanol 2 dicaprylyl 2 C12-15 alkyl benzoates 3 ethylhexylmethoxycinnamate 4 butylmethoxydibenzoylmethane 2 tocopheryl acetate 1 panthenol 0.5 sodium ascorbyl 0.1 Glycyrrhetinsäure 0.1 erythrulose 1.5 p-Hydroxybenzoic acid alkyl ester (paraben) 0.4 methyl propanediol 1 Carbomer 0.2 Xanthan gum 0.1 EDTA 0.2 glycerin 8th tapioca 0.05 Fillers / additives, 0.3 Perfume qs water ad 100 Example 4-6 INCI Wt .-% Polyglyceryl-3 methylglucose 2 2 2 sorbitan 3 3 3 cetyl alcohol 2 2 2 myristate 1 1 1 dicaprylyl 3 3 3 octyldodecanol 2 2 2 C12-15 alkyl benzoates 3 3 3 Cetearyl ethylhexanoate + isopropyl myristate 2 2 2 ethylhexylmethoxycinnamate 2 2 2 ethylhexyl triazone 1 1 1 Butylmethoxydibenzoxylmethan 2 2 2 creatine 0.2 - - Magnesium aluminum silicate 0.2 0.2 0.2 glycerin 5 5 5 phenoxyethanol 0.4 0.4 0.4 parabens 0.3 0.3 0.3 Vitamin E acetate 0.1 0.1 0.1 Glycyrrhetinsäure 0.1 0.1 0.1 erythrulose 2.0 1 1.5 BHT 0.05 0.05 0.05 EDTA 0.2 0.2 0.2 Carbomer 0.2 0.2 0.2 Perfume qs qs qs water ad 100 ad 100 ad 100

QUOTES INCLUDE IN THE DESCRIPTION

This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.

Cited patent literature

• - DE 1959079 A [0051]

Cited non-patent literature

• - Chemical Abstracts under the registry number 178463-23-5 [0047]

Claims (9)

Drug combinations from a) glycyrrhetinic acid and / or glycyrrhizin and b) Erythrulose as well as desired c) Dihydroxyacetone. Active substance combinations according to Claim 1, characterized that the weight ratios of glycyrrhetinic acid and / or glycyrrhizin on the one hand, and erythrulose on the other hand range from 10: 1 to 1: 100 Active substance combinations according to claim 1 or 2, characterized characterized in that weight ratios of glycyrrhetinic acid and / or glycyrrhizin on the one hand, and erythrulose on the other hand the range of 1:30 to 1: 7.5, most preferably from the Range of 1:20 and 1:10 are chosen. Cosmetic or dermatological preparations with a content of drug combinations according to one of the preceding Claims. Preparations containing active substance combinations according to one of the preceding claims, containing 0.001-10 % By weight of glycyrrhetinic acid and / or glycyrrhizin on the total weight of the preparations. Preparations containing active substance combinations according to one of the preceding claims, containing 0,1-3 Wt .-% of erythrulose, based on the total weight of the preparations. Preparations containing active substance combinations according to one of the preceding claims, containing 0,1-3 Wt .-% of dihydroxyacetone, based on the total weight of the preparations. Preparations containing active substance combinations according to one of the preceding claims, containing 0.001-10 Wt% of glycyrrhetinic acid and / or glycyrrhizin and 0.1-3 Erythrulose and 0.1-3 wt .-% dihydroxyacetone. Use of active ingredient combinations or preparations containing them according to one of the preceding claims for tanning the skin.