DE102007040177A1 - Lung tissue aeration measuring method, involves calculating residual air from highest signal of voxels of measuring object after expiration, where object has change between inhalation and exhalation in comparison with preset region - Google Patents

Lung tissue aeration measuring method, involves calculating residual air from highest signal of voxels of measuring object after expiration, where object has change between inhalation and exhalation in comparison with preset region Download PDF

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DE102007040177A1
DE102007040177A1 DE102007040177A DE102007040177A DE102007040177A1 DE 102007040177 A1 DE102007040177 A1 DE 102007040177A1 DE 102007040177 A DE102007040177 A DE 102007040177A DE 102007040177 A DE102007040177 A DE 102007040177A DE 102007040177 A1 DE102007040177 A1 DE 102007040177A1
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signal
exhalation
measurement
voxels
residual air
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves

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Abstract

The method involves calculating residual air from a highest signal of voxels of a measuring object after expiration, where the measuring object has a change between inhalation and exhalation in comparison to a preset region for calculating a ventilation value. Measurement of a total signal is performed by automatic segmenting of an entire lung. The total signal of an examined patient and maximum intensity pixels are calculated by signal change during the respiration. An automatic size correction of the lung is provided by a computer-based registration algorithm. An independent claim is also included for a device for accurate aeration measurement of a tissue.

Description

Grundlagen (Stand der Technik)Basics (prior art)

Gemäß der Anmeldung PCT/EP2004/005300 kann aufgrund folgender Überlegungen die Lungenventilation lokal nicht invasiv berechnet werden.

  • • Die Lunge kann als Summe gasgefüllter Volumenelemente (Voxel) betrachtet werden
  • • Es besteht ein dreidimensionales Koordinatensystem
  • • Veränderung in Große und Form während der Ventilation
  • • Es ist nicht möglich ein Volumenelement während des Atemzyklus exakt zu lokalisieren
  • • Als Vereinfachung Koppelung einer "Region of Interest" (ROI) an anatomische Strukturen (z. B. Lungenvenen)
  • • Mathematischer Algorithmus zur Erfassung der Volumen und Dichteänderung
According to the application PCT / EP2004 / 005300 Due to the following considerations, lung ventilation can be calculated locally non-invasively.
  • • The lungs can be considered as the sum of gas-filled volume elements (voxels)
  • • There is a three-dimensional coordinate system
  • • Change in size and shape during ventilation
  • • It is not possible to accurately locate a volume element during the breathing cycle
  • • Simplification linking a "Region of Interest" (ROI) to anatomical structures (eg pulmonary veins)
  • • Mathematical algorithm for volume and density change

Wenn erkannt ist, dass die Dichteänderungen und die Ventilations (Belüftungswerte) direkt voneinander abhängen, lässt sich aus den Dichteänderungen direkt die lokale Belüftung berechnen (erfinderischer Inhalt der zitierten Anmeldung). Die Ventilationswerte sind dann durch folgende Gleichungen gegeben:
Berechnung der Ventilation in ml Luft/ml Lungengewebe
(theoretische Annahme: homogene Verteilung des signalgebenden Lungenparenchyms im Messvolumen) Vabs = (Sexp-Sinsp)/(Sexy-Snoise) If it is recognized that the density changes and the ventilation values are directly dependent on each other, it is possible to calculate the local aeration directly from the density changes (inventive content of the cited application). The ventilation values are then given by the following equations:
Calculation of ventilation in ml air / ml lung tissue
(theoretical assumption: homogeneous distribution of the signaling lung parenchyma in the measurement volume) Vabs = (Sexp-Sinsp) / (Sexy-Snoise)

Die Ventilation zu einem bestimmten Zeitpunkt während des Atemzyklus (Vact) ergibt sich demzufolge aus Vact = (Sexp-Sact)/(Sexp-Snoise) The ventilation at a certain time during the respiratory cycle (Vact) results accordingly Vact = (Sexp-Sact) / (Sexp-Snoise)

Methode zur Verbesserung der Messung(Erfindungsbeschreibung)Method for improving the measurement (description of the invention)

Entsprechend der theoretischen Grundlagen kann aus einer kernspintomografischen Untersuchung eines Schwammes (als Phantom der Lunge) in verschiedenen Stadien der Kompression kernspintomografisch die Belüftung des Schwammes berechnet werden. Dieses Vorgehen ist z. B. in der Schrift:
Zapke M, Topf HG, Zenker M, Kuth R, Deimling M, Kreisler P, Rauh M, Chefd'hotel C, Geiger B, Rupprecht T. Magnetic resonance lung function – a breakthrough for lung imaging and functional assessment? A phantom study and clinical trial. Respir Res. 2006 Aug 6;7:106 .
beschrieben. Die Restluft nach voltständigem Ausatmen lässt sich allerdings durch das beschriebene Verfahren nicht ermitteln.According to the theoretical principles, a magnetic resonance tomography examination of a sponge (as a phantom of the lung) at different stages of compression can be used to calculate the aeration of the sponge using magnetic resonance tomography. This procedure is z. In writing:
Zapke M, Topf HG, Zenker M, Kuth R, Deimling M, Kreisler P, Rauh M, Chef D 'hotel C, Geiger B, Rupprecht T. Magnetic resonance function - a breakthrough for lung imaging and functional assessment? A phantom study and clinical trial. Respir Res. 2006 Aug 6; 7: 106 ,
described. However, the residual air after volatilized exhalation can not be determined by the method described.

Verbesserungsverfahrenenhancement procedures

Zusätzlich zu dem geschilderten Verfahren wird durch Vergleich aller voxel in ein und ausgeatmetem Bild der höchste Intensitätswert (Signalwert) aller ventilierten Voxel berechnet und unterstellt dass diese nach Ausatmung praktisch keine oder nur noch sehr geringe Luftmengen enthalten.additionally to the described method is by comparison of all voxels in an exhaled and breathed image the highest intensity value (Signal value) of all ventilated voxels calculated and assumed that after exhalation, these are practically no or only very small Air volumes included.

Dann werden die so selektionierten maximalen Signalwerte als Referenz zur Berechnung der Ventilation nach der geschilderten Methode verwendet.Then the thus selected maximum signal values are used as reference used to calculate the ventilation according to the described method.

Das Restluftvolumen pro voxel (Vrest) ergibt sich dann im ausgeatmeten Bild als: Vrest = (Smax-Sexp)/(smax-Snoise) (1) The residual air volume per voxel (Vrest) then results in the exhaled picture as: Vrest = (Smax-Sexp) / (Smax-Snoise) (1)

Dabei sind:

Smax:
maximales Signal eines ventilierten Voxels
Sexp:
Signal eines Vergleichsvoxels in der Exspiration
Snoise:
Rauschen
Here are:
Smax:
maximum signal of a ventilated voxel
sexp:
Signal of a comparison voxel in expiration
Snoise:
sough

Der gesamte Luftgehalt im eingeatmeten Bild pro voxel Vtot ergibt sich als: Vtot = Vrest + Vinsp (2) The total air content in the inspired image per voxel Vtot is given as: Vtot = Vrest + Vinsp (2)

Dabei sind:

Vtot:
totale Ventilation
Vinsp:
Ventilation berechnet gemäß der bekannten Methode
Here are:
Vtot:
total ventilation
Vinsp:
Ventilation calculated according to the known method

ZITATE ENTHALTEN IN DER BESCHREIBUNGQUOTES INCLUDE IN THE DESCRIPTION

Diese Liste der vom Anmelder aufgeführten Dokumente wurde automatisiert erzeugt und ist ausschließlich zur besseren Information des Lesers aufgenommen. Die Liste ist nicht Bestandteil der deutschen Patent- bzw. Gebrauchsmusteranmeldung. Das DPMA übernimmt keinerlei Haftung für etwaige Fehler oder Auslassungen.This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.

Zitierte PatentliteraturCited patent literature

  • - EP 2004/005300 [0001] - EP 2004/005300 [0001]

Zitierte Nicht-PatentliteraturCited non-patent literature

  • - Zapke M, Topf HG, Zenker M, Kuth R, Deimling M, Kreisler P, Rauh M, Chefd'hotel C, Geiger B, Rupprecht T. Magnetic resonance lung function – a breakthrough for lung imaging and functional assessment? A phantom study and clinical trial. Respir Res. 2006 Aug 6;7:106 [0004] - Zapke M, Topf HG, Zenker M, Kuth R, Deimling M, Kreisler P, Rauh M, Chef D 'hotel C, Geiger B, Rupprecht T. Magnetic resonance function - a breakthrough for lung imaging and functional assessment? A phantom study and clinical trial. Respir Res. 2006 Aug 6; 7: 106 [0004]

Claims (11)

Verfahren zur genaueren Belüftungsmessung eines Gewebes gekennzeichnet durch die Berechnung der Restluft nach Ausatmung aus dem höchsten Signal des voxels des Messobjektes das zwischen Ein- und Ausatmung eine Änderung aufweist im Vergleich zu einer zweiten Region zur Berechnung eines Ventilationswertes.Method for more accurate aeration measurement of a Tissue characterized by the calculation of the residual air after exhalation from the highest signal of the voxel of the object to be measured between inhalation and exhalation has a change in comparison to a second region for calculating a ventilation value. Verfahren nach Anspruch 1 bei dem zusätzlich eine kardiale Triggerung durchgeführt wird.The method of claim 1 further comprising Cardiac triggering is performed. Verfahren nach Anspruch 1 bei dem die Messung des Gesamtsignals durch eine automatische Segmentierung (Erkennung) der gesamten Lunge erfolgt.Method according to claim 1, wherein the measurement of the Total signal through automatic segmentation (detection) the entire lung is done. Verfahren nach Anspruch 1 bei dem das gesamte Signal des untersuchten Patienten gemessen wird (whole body scanning) und hieraus die maximal intensen Pixel mit Signaländerung während der Atmung berechnet werden.Method according to Claim 1, in which the entire signal of the examined patient is measured (whole body scanning) and from this the maximum intensen pixels with signal change during of breathing. Verfahren nach Anspruch 1 bei dem zusätzlich zu der automatische Segmentierung noch eine automatische Größekorrektur der Lunge mittels eines computergestützten Registrierungsalgorithmus durchgeführt wird.The method of claim 1 further comprising the automatic segmentation is still an automatic size correction the lung is performed by means of a computer-aided registration algorithm becomes. Gerät und Einrichtung die das Verfahren nach Anspruch 1–5 automatisiert (computerunterstützt) durchführt.Device and device the procedure according to claim 1-5 automated (computer-aided) performs. Gerät und Verfahren nach Anspruch 1) das aus der Restluft und der bekannten Ventilationsberechnung den totalen Luftgehalt eines Lungenabschnittes berechnet und darstellt.Apparatus and method according to claim 1) the residual air and the known ventilation calculation the total Calculates and represents the air content of a lung section. Gerät und Verfahren nach Anspruch 1 und/oder einem der Ansprüche 2–7 bei dem eine Gruppe von Voxeln (z. B. Mittelwert oder Median des Signals) mit sehr hohem Signal als Referenz verwendet wird.Apparatus and method according to claim 1 and / or one of claims 2-7 wherein a group of Voxels (eg mean or median of the signal) with very high Signal is used as a reference. Gerät und Verfahren nach Anspruch 1 und/oder einem der Ansprüche 2–7 bei dem ein Kernspintomographiegerät zur Signalmessung verwendet wird.Apparatus and method according to claim 1 and / or one of claims 2-7 in which a magnetic resonance imaging apparatus is used for signal measurement. Gerät und Verfahren nach Anspruch 1 und/oder einem der Ansprüche 2–7 bei dem ein Computertomographiegerät oder ein anderes Röntgengerät zur Signalmessung verwendet wird.Apparatus and method according to claim 1 and / or one of claims 2-7 in which a computed tomography device or another X-ray device for signal measurement is used. Gerät und Verfahren nach Anspruch 1 und/oder einem der Ansprüche 2–7 bei dem ein Ultraschallgerät zur Signalmessung verwendet wird.Apparatus and method according to claim 1 and / or any one of claims 2-7 in which an ultrasonic device is used for signal measurement.
DE102007040177A 2007-08-25 2007-08-25 Lung tissue aeration measuring method, involves calculating residual air from highest signal of voxels of measuring object after expiration, where object has change between inhalation and exhalation in comparison with preset region Withdrawn DE102007040177A1 (en)

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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004005300A1 (en) 2002-07-09 2004-01-15 Pure Pharmaceuticals, Inc. Microfine zinc-glycerol complexes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004005300A1 (en) 2002-07-09 2004-01-15 Pure Pharmaceuticals, Inc. Microfine zinc-glycerol complexes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Zapke M, Topf HG, Zenker M, Kuth R, Deimling M, Kreisler P, Rauh M, Chefd'hotel C, Geiger B, Rupprecht T. Magnetic resonance lung function - a breakthrough for lung imaging and functional assessment? A phantom study and clinical trial. Respir Res. 2006 Aug 6;7:106

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