DE102007032663A1 - Cosmetic or dermatological preparations for skin care, protection and cleaning, containing apiogalacturonan compounds or extracts thereof from seaweed, together with UV light absorbers - Google Patents

Abstract

Preparations containing one or more apiogalacturonans (I) or extract(s) of (I) from Zostera marina and also one or more UV light absorbers.

Description

The The present invention relates to a cosmetic or dermatological Preparations containing apiogalacturonans or a Apiogalacturonane extract from Zostera marina.

The The present invention relates in particular to cosmetic or dermatological Preparations containing active ingredients for care and protection the skin, especially the sensitive skin as well as very special in the foreground by intrinsic and / or extrinsic Factors of aging or aging skin and the use of such Active substances and combinations of such active substances in the field of cosmetic and dermatological skin care.

Under Cosmetic skin care is to be understood in the first place that the natural function of the skin as a barrier against environmental influences (eg dirt, chemicals, microorganisms) and against the loss of endogenous substances (eg water, natural Fats, electrolytes) is strengthened or restored.

Becomes Disturbed by this feature, it can become overstressed Absorption of toxic or allergenic substances or infestation of Microorganisms and as a result to toxic or allergic skin reactions come.

at old skin, for example, the regenerative renewal slows down, in particular, the water-binding capacity of the horny layer subsides. It therefore becomes inflexible, dry and cracked ("physiologically" dry skin). A barrier damage is the consequence. The skin becomes susceptible to negative Environmental influences such as the invasion of microorganisms, toxins and allergens. As a result, it can even become toxic or allergic Skin reactions come.

at Pathologically dry and sensitive skin is a barrier damage a priori. Epidermal intercellular lipids become defective or formed in insufficient quantity or composition. The Consequence is an increased permeability of the Horny layer and inadequate protection of the skin from loss hygroscopic substances and water.

The Barrier action of the skin may be beyond the determination of transepidermal Water loss (TEWL - transepidermal water loss) become. This is the evaporation of water from the Interior of the body without the involvement of water loss Sweat. The determination of the TEWL value has proven to be extraordinary has proved informative and may be more chapped or crippled for diagnosis Skin, for the determination of compatibility chemically diverse built-up surfactants and the like can be used more.

For the beauty and care of the skin is the water content in the uppermost skin layer of paramount importance. It can be cheap to a limited extent by introducing moisture regulators influence.

anionic Surfactants, which are generally components of cleaning preparations are, the pH in the horny layer can be long lasting increase what regenerative processes that restore and renewal of the barrier function of the skin, severely hampered. In this case, in the horny layer arises between regeneration and the loss of essential substances through regular Extraction a new, often very unfavorable Equilibrium state, the external appearance the skin and the physiological functioning of the horny layer crucial impaired.

Nice in a simple water bath without the addition of surfactants it comes initially to a swelling of the horny layer of the skin, wherein the degree of this swelling, for example, on the duration of the bath and its temperature depends. At the same time become water-soluble Fabrics, e.g. B. water-soluble soil constituents, but also skin-own substances, which are responsible for the water-binding capacity the horny layer are responsible, or washed off. By skin's own surface-active substances also become skin fats to a certain extent solved and washed out. This conditionally after initial swelling a subsequent significant dehydration the skin, which is reinforced by detergent additives can be.

In healthy skin, these processes are generally irrelevant, as the protective mechanisms of the skin can readily compensate for such minor disorders of the upper layers of the skin. But even in the case of non-pathological deviations from the normal status, eg. B. by environmental wear damage or irritation, photodamage, aging skin, etc., the protective mechanism of the skin surface is disturbed. Under certain circumstances, he is then unable by his own power to fulfill his task and must by external measures are regenerated.

About that In addition, it is known that lipid composition and amount the horny layer of the pathologically altered, dry and the dry but not diseased skin younger and older people deviates from the normal state in healthy, normal-hydrated skin of the same age group is found. At the same time represent changes in a lipid pattern very dry, non-eczematous skin of patients with atopic eczema an extreme case for the deviations found in the dry skin of healthy people become.

These Deviations particularly concern the ceramides which in their amount greatly reduced and additionally composed differently are. A striking feature is the deficit of the Ceramides 1 and 3, wherein in particular for the ceramide 1 It is known that the order of the Lipids in the intercellular membrane systems increases.

Adverse Changes in the lipid membranes of the previously described Species may be due to aberrant lipid biosynthesis and also, in effect, increase transepidermal Water loss. A long-standing barrier barrier again makes the skin, which is healthy in itself, more sensitive and can in a single case to the emergence of eczematous processes in the sick Contribute to the skin.

The Effect of ointments and creams on barrier function and hydration The horny layer is usually not in a recovery or strengthening the physico-chemical properties of lamellae from intercellular lipids. An essential partial effect is based on the mere coverage of the treated skin areas and the resulting water retention in the underlying Stratum corneum. Co-applied hygroscopic substances bind this Water, causing a measurable increase in water content comes in the horny layer. This purely physical barrier can however, be relatively easily removed. After weaning of the product, the skin then returns very quickly to the condition back before treatment. In addition, can the skin care effect with regular treatment subside, so eventually even during the treatment of the status quo is achieved again. For certain Products, the condition of the skin worsens after weaning may be temporary. A sustainable one Product effect is usually not or only in a limited Dimensions achieved.

Around the deficient skin in its natural regeneration to support and strengthen their physiological function, In recent years, topical preparations are increasingly becoming intercellular lipid mixtures added by the skin to rebuild the natural Barrier should be used. However, it is these lipids, but especially the ceramides, very expensive raw materials. In addition, their effect is usually much less than hoped.

aim Thus, it has been the object of the present invention to find ways to overcome the disadvantages of the prior art. In particular, the effect should be the skin care products are physiological, fast and sustainable.

Under Skin care in the sense of the present invention is primarily to understand that the natural function of Skin as a barrier against environmental influences (eg dirt, Chemicals, microorganisms) and against the loss of the body's own Strengthened substances (eg water, lipids, electrolytes) or is restored.

Products for the care, treatment and cleaning of dry and stressed Skin is known. However, their contribution to regeneration a physiologically intact, hydrated and smooth horny layer extensive and limited in time.

The Effect of ointments and creams on barrier function and hydration the horny layer is based essentially on the cover (occlusion) of the treated dermal districts. The ointment or cream poses, so to speak a (second) artificial barrier that reduces water loss to prevent the skin. Accordingly, this physical Barrier - for example with cleaning agents - again be removed, causing the original, impaired State is reached again. In addition, the skin care effect relax with regular treatment. After this Discontinuing the product application, the skin returns very quickly back to the state before treatment. For certain Products may deteriorate the condition of the skin under certain circumstances even temporarily. A sustainable product effect becomes usually not or only in a limited Dimensions achieved.

The Effect of some pharmaceutical preparations on the barrier function the skin is even in a selective barrier damage, which should allow the active ingredients in or through the skin can invade the body. One Disturbed appearance of the skin is thereby as a side effect partially accepted.

The Effect of nourishing cleaning products consists essentially in an efficient refatting with sebum lipid-like Substances. By the simultaneous reduction of the surfactant content Such preparations can damage the horny layer barrier further limit.

the The prior art, however, lacks preparations which the barrier function and the hydration of the horny layer are positive affect and the physicochemical properties of the horny layer and in particular strengthen the lamellae from intercellular lipids or even restore.

task It was therefore the object of the present invention to overcome the disadvantages of the prior art to eliminate the technology. In particular, skin-care preparations should and preparations provided for cleansing the skin which preserve the barrier properties of the skin or restore, especially when natural regeneration the skin is insufficient. They should also be used for treatment and prophylaxis consequential damage of skin drying, such as fissures or inflammatory or allergic processes or even the Eczema, be suitable. Object of the present invention It was also, stable skin-care cosmetic and / or dermatological To provide means that protect the skin from environmental influences how to protect sun and wind. In particular, the effect should be the preparations are physiological, fast and sustainable.

The Plant genus Zostera belongs to the family of seagrass plants (Zosteraceae) and includes several submerged living species of the Sea grass in the seas. You can up to one Depth of 15m grow and include some of the few submerged ones Flowering plants.

Of the Name Zostera is the Greek "zoster" (Zωστηἡρ) ajar, which means "belt" and to the should remember flat ribbon-shaped leaves. Worldwide There are twelve recognized species, all of them only in the Oceans occur and grow mostly in seagrass meadows.

The Common seagrass (Zostera marina) grows submerged (submers) on the sea shores and form there together with other marine angiosperms flowering plants undersea Seagrass beds.

From Zostera marina, polysaccharide zosteran extractable, a apio-rich polysaccharide consisting of an α-1,4-D-galactopyranosyluronan backbone substituted with 1,2-linked apiofuranose oligosaccharides and single apioseric residues, is extractable using standard extraction techniques.

According to the invention Preparations containing apiogalacturonans or a Apiogalacturonane extract containing Zostera marina as well proposed one or more UV light absorbing substances. They are in all respects extremely satisfactory preparations.

• – besser die Barriereeigenschaften der Haut erhalten oder wiederherstellen,
• – besser der Hautaustrocknung entgegenwirken,
• – besser gegen Pigmentstörungen wirken,
• – besser gegen entzündliche Hautzustände wirken
• – besser gegen die Hautalterung wirken und
• – die Haut besser vor Umwelteinflüssen schützen

als die Zubereitungen des Standes der Technik.It was not foreseeable for the skilled person that such preparations

• - better maintain or restore the barrier properties of the skin,
• - better counteract skin dehydration,
• - better against pigment disorders,
• - work better against inflammatory skin conditions
• - Act better against aging skin and
• - Protect the skin better from environmental influences

as the preparations of the prior art.

• – von defizitären, sensitiven oder hypoaktiven Hautzuständen oder defizitären, sensitiven oder hypoaktiven Zustände von Hautanhangsgebilden
• – von Erscheinungen vorzeitiger Alterung der Haut (z. B. Falten, Altersflecken, Teleangiektasien) und/oder der Hautanhangsgebilde,
• – von umweltbedingten (Rauchen, Smog, reaktive Sauerstoffspecies, freie Radikale) und insbesondere lichtbedingten negativen Veränderungen der Haut und der Hautanhangsgebilde.
• – von lichtbedingten Hautschäden
• – von Pigmentierungsstörungen,
• – von empfindlicher, gereizter und juckender Haut,
• – von trockenen Hautzuständen und Hornschichtbarrierestörungen,
• – von Haarausfall und für verbessertes Haarwachstum
• – von entzündlichen Hautzuständen sowie atopischem Ekzem, seborrhoischem Ekzem, polymorpher Lichtdermatose, Psoriasis, Vitiligo

möglich. Der erfindungsgemäße Wirkstoffes bzw. kosmetischer oder topischer dermatologischer Zubereitungen mit einem wirksamen Gehalt an erfindungsgemäßem Wirkstoff dient aber auch in überraschender Weise

• – zur Beruhigung von empfindlicher oder gereizter Haut
• – zur Stimulation der Kollagen-, Hyaluronsäure-, Elastinsynthese
• – zur Stimulation der Ceramidsynthese der Haut
• – zur Stimulation der intrazellulären DNA-Synthese, insbesondere bei defizitären oder hypoaktiven Hautzuständen.
• – zur Steigerung der Zellerneuerung und Regeneration der Haut
• – zur Steigerung der hauteigenen Schutz- und Reparaturmechanismen (beispielsweise für dysfunktionelle Enzyme, DNA, Lipide, Proteine)
• – zur Vor- und Nachbehandlung bei topischer Anwendung von Laser- und Abschleifbehandlungen, die z. B. der Reduzierung von Hautfalten und Narben dienen, um den resultierenden Hautreizungen entgegenzuwirken und die Regenerationsprozesse in der verletzten Haut zu fördern.

The use of cosmetic or zostera marina extract containing apiogalacturonans or an apiogalacturonane surprisingly offers an effective treatment, but also a prophylaxis

• - of deficient, sensitive or hypoactive skin conditions or deficient, sensitive or hypoactive states of skin appendages
• - signs of premature aging of the skin (eg wrinkles, age spots, telangiectasias) and / or the appendages of the skin,
• - of environmental factors (smoking, smog, reactive oxygen species, free radicals) and in particular light-induced negative changes in the skin and the appendages.
• - of light-induced skin damage
• - pigmentation disorders,
• - of sensitive, irritated and itchy skin,
• Dry skin conditions and corneal barrier disorders,
• - from hair loss and for improved hair growth
• - of inflammatory skin conditions as well as atopic eczema, seborrheic eczema, polymorphic photodermatosis, psoriasis, vitiligo

possible. The active ingredient according to the invention or cosmetic or topical dermatological preparations with an effective content of the active ingredient according to the invention, however, also serves in a surprising manner

• - to soothe sensitive or irritated skin
• - To stimulate collagen, hyaluronic acid, elastin synthesis
• - to stimulate the ceramide synthesis of the skin
• - To stimulate intracellular DNA synthesis, especially in deficient or hypoactive skin conditions.
• - to increase the cell renewal and regeneration of the skin
• - to increase the skin's own protective and repair mechanisms (eg for dysfunctional enzymes, DNA, lipids, proteins)
• - For pre- and post-treatment in topical application of laser and Abschleifbehandlungen z. As the reduction of skin wrinkles and scars serve to counteract the resulting skin irritation and promote the regeneration processes in the injured skin.

gekennzeichnet ist und unter der Handelsbezeichnung Tinosorb^® M bei der CIBA-Chemikalien GmbH erhältlich ist.Advantageous organic pigment in the context of the present invention is the 2,2'-methylenebis (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) -phenol) [INCI : Bisoctyltriazole], which is represented by the chemical structural formula

characterized and CIBA-Chemikalien GmbH available under the trade name Tinosorb M ^® in.

Advantageously, preparations according to the invention contain substances which absorb UV radiation in the UV-A and / or UV-B range, the total amount of the filter substances being e.g. B. 0.1 wt .-% to 30 wt .-%, preferably 0.5 to 20 wt .-%, in particular 1.0 to 15.0 wt .-%, based on the total weight of the preparations to cosmeti make preparations available that protect the hair or the skin from the entire range of ultraviolet radiation. They can also be used as sunscreen medium for hair or skin.

Advantageous UV-A filter substances for the purposes of the present invention are dibenzoylmethane derivatives, in particular 4- (tert-butyl) -4'-methoxydibenzoylmethane (CAS-Nr. 70356-09-1), marketed by Givaudan under the trade name Parsol ^® 1789 and is sold by Merck under the trade name Eusolex ^® 9020th

und ihre Salze, besonders die entsprechenden Natrium-, Kalium- oder Triethanolammonium-Salze, insbesondere das Phenylen-1,4-bis-(2-benzimidazyl)-3,3'-5,5'-tetrasulfonsäure-bis-natriumsalz

mit der INCI-Bezeichnung Bisimidazylate, welches beispielsweise unter der Handelsbezeichnung Neo Heliopan AP bei Haarmann & Reimer erhältlich ist.Further advantageous UV-A filter substances are the phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid

and their salts, especially the corresponding sodium, potassium or triethanolammonium salts, especially the phenylene-1,4-bis (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid bis-sodium salt

with the INCI name bisimidazylate, which is available, for example, under the trade name Neo Heliopan AP from Haarmann & Reimer.

Also advantageous are the 1,4-di (2-oxo-10-sulfo-3-bomylidenemethyl) benzene and its salts (especially the corresponding 10-sulfato compounds, in particular the corresponding sodium, potassium or triethanolammonium salt) which is also referred to as benzene-1,4-di (2-oxo-3-bomylidenemethyl-10-sulfonic acid) and is characterized by the following structure:

advantageous UV filter substances in the context of the present invention are further so-called broadband filters, d. H. Filter substances containing both UV-A as well as absorb UV-B radiation.

wobei R¹, R² und R³ unabhängig voneinander gewählt werden aus der Gruppe der verzweigten und unverzweigten Alkylgruppen mit 1 bis 10 Kohlenstoffatomen bzw. ein einzelnes Wasserstoffatom darstellen. Insbesondere bevorzugt sind das 2,4-Bis-{[4-(2-Ethylhexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazin (INCI: Aniso Triazin), welches unter der Handelsbezeichnung Tinosorb^® S bei der CIBA-Chemikalien GmbH erhältlich ist, und das 4,4',4''-(1,3,5-Triazin-2,4,6-triyltriimino)-tris-benzoesäure-tris(2-ethylhexylester), synonym: 2,4,6-Tris-[anilino-(p-carbo-2'-ethyl-1'-hexyloxy)]-1,3,5-triazin (INCI: Octyl Triazone), welches von der BASF Aktiengesellschaft unter der Warenbezeichnung UVINUL^® T 150 vertrieben wird.Advantageous broadband filters or UV-B filter substances are, for example, bis-resorcinyl triazine derivatives having the following structure:

wherein R ¹ , R ² and R ^{3 are} independently selected from the group of branched and unbranched alkyl groups having 1 to 10 carbon atoms or represent a single hydrogen atom. Especially preferred are 2,4-bis - {[4- (2-ethylhexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine (INCI: aniso triazine), which is available under the trade name Tinosorb ^® S from CIBA-Chemikalien GmbH, and the 4,4 ', 4''- (1,3,5-triazine-2,4,6-triyltriimino) tris-benzoic acid tris (2-ethylhexyl ester), synonymous: 2,4,6-tris [anilino (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine (INCI: Octyl Triazone), which is marketed by BASF Aktiengesellschaft under the trade name Uvinul ^® T 150th

aufweisen, sind vorteilhafte UV-Filtersubstanzen im Sinne der vorliegenden Erfindung, beispielsweise die in der Europäischen Offenlegungsschrift EP 570 838 A1 beschriebenen s-Triazinderivate, deren chemische Struktur durch die generische Formel

wiedergegeben wird, wobei
R einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkylrest, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄-Alkylgruppen, darstellt,
X ein Sauerstoffatom oder eine NH-Gruppe darstellt,
R₁ einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkylrest, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄-Alkylgruppen, oder ein Wasserstoffatom, ein Alkalimetallatom, eine Ammoniumgruppe oder eine Gruppe der Formel

bedeutet, in welcher
A einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkyl- oder Arylrest darstellt, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄-Alkylgruppen,
R₃ ein Wasserstoffatom oder eine Methylgruppe darstellt,
n eine Zahl von 1 bis 10 darstellt,
R₂ einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkylrest, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄-Alkylgruppen, darstellt, wenn X die NH-Gruppe darstellt, und
einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkylrest, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄-Alkylgruppen, oder ein Wasserstoffatom, ein Alkalimetallatom, eine Ammoniumgruppe oder eine Gruppe der Formel

bedeutet, in welcher
A einen verzweigten oder unverzweigten C₁-C₁₈-Alkylrest, einen C₅-C₁₂-Cycloalkyl- oder Arylrest darstellt, gegebenenfalls substituiert mit einer oder mehreren C₁-C₄-Alkylgruppen,
R₃ ein Wasserstoffatom oder eine Methylgruppe darstellt,
n eine Zahl von 1 bis 10 darstellt,
wenn X ein Sauerstoffatom darstellt.Other UV filter substances, which are the structural motif

have advantageous UV filter substances in the sense of the present invention, for example, those in the European published patent application EP 570 838 A1 described s-triazine derivatives, their chemical structure by the generic formula

is reproduced, wherein
R is a branched or unbranched C ₁ -C ₁₈ -alkyl radical, a C ₅ -C ₁₂ -cycloalkyl radical, optionally substi tuiert with one or more C ₁ -C ₄ alkyl groups, represents,
X represents an oxygen atom or an NH group,
R _{1 is} a branched or unbranched C ₁ -C ₁₈ alkyl radical, a C ₅ -C ₁₂ cycloalkyl radical optionally substituted with one or more C ₁ -C ₄ alkyl groups, or a hydrogen atom, an alkali metal atom, an ammonium group or a group of formula

means in which
A is a branched or unbranched C ₁ -C ₁₈ -alkyl radical, a C ₅ -C ₁₂ -cycloalkyl or aryl radical, optionally substituted by one or more C ₁ -C ₄ -alkyl groups,
R _{3 represents} a hydrogen atom or a methyl group,
n represents a number from 1 to 10,
R _{2 is} a branched or unbranched C ₁ -C ₁₈ alkyl radical, a C ₅ -C ₁₂ cycloalkyl radical optionally substituted with one or more C ₁ -C ₄ alkyl groups, when X represents the NH group, and
a branched or unbranched C ₁ -C ₁₈ alkyl radical, a C ₅ -C ₁₂ cycloalkyl radical optionally substituted with one or more C ₁ -C ₄ alkyl groups, or a hydrogen atom, an alkali metal atom, an ammonium group or a group of the formula

means in which
A is a branched or unbranched C ₁ -C ₁₈ -alkyl radical, a C ₅ -C ₁₂ -cycloalkyl or aryl radical, optionally substituted by one or more C ₁ -C ₄ -alkyl groups,
R _{3 represents} a hydrogen atom or a methyl group,
n represents a number from 1 to 10,
when X represents an oxygen atom.

wiedergegeben wird, welches im Folgenden auch als Dioctylbutylamidotriazon (INCI: Dioctylbutamidotriazone) bezeichnet wird und unter der Handelsbezeichnung UVASORB HEB bei Sigma 3 V erhältlich ist.Particularly preferred UV filter substance in the context of the present invention is also an unsymmetrically substituted s-triazine whose chemical structure is represented by the formula

which is also referred to below as Dioctylbutylamidotriazon (INCI: Dioctylbutamidotriazone) and is available under the trade name UVASORB HEB Sigma 3 V.

wiedergegeben wird, wobei R₁, R₂ und A₁ verschiedenste organische Reste repräsentieren.Also in the European Patent Application 775,698 are preferably used bis-Resorcinyltriazinderivate described their chemical structure by the generic formula

is reproduced, wherein R ₁ , R ₂ and A _{1 represent a} variety of organic radicals.

Advantageous For the purposes of the present invention are also the 2,4-bis - {[4- (3-sulfonato) -2-hydroxy-propyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1,3 , 5-triazine Sodium salt containing 2,4-bis - {[4- (3- (2-propyloxy) -2-hydroxy-propyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5 triazine, the 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- [4- (2-methoxyethylcarboxyl) -phenylamino] -1,3,5-triazine, 2,4-bis - {[4- (3- (2-propyloxy) -2-hydroxy-propyloxy) -2-hydroxy] -phenyl} -6- [4- (2-ethylcarboxyl) -phenylamino] 1,3,5-triazine, 2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- (1-methylpyrrol-2-yl) -1,3,5-triazine 2,4-bis - {[4-tris (trimethylsiloxy-silylpropyloxy) -2-hydroxy] phenyl} -6- (4-methoxyphenyl) -1,3,5-triazin, 2,4-bis - {[4- (2 '' - methylpropenyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine and 2,4-bis - {[4- (1 ', 1', 1 ', 3', 5 ', 5', 5'-heptamethylsiloxy-2 "-methyl-propyloxy) -2-hydroxy] - phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine.

gekennzeichnet ist und unter der Handelsbezeichnung Tinosorb^® M bei der CIBA-Chemikalien GmbH erhältlich ist.An advantageous broadband filter for the purposes of the present invention is the 2,2'-methylene-bis (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) phenol), which through the chemical structural formula

characterized and CIBA-Chemikalien GmbH available under the trade name Tinosorb M ^® in.

gekennzeichnet ist.Advantageous broadband filter according to the present invention is further the 2- (2H-benzotriazol-2-yl) -4-methyl-6- [2-methyl-3- [1,3,3,3-tetramethyl-1 - [( trimethylsilyl) oxy] disiloxanyl] propyl] phenol (CAS No .: 155633-54-8) with the INCI name Drometrizole Trisiloxane, which is represented by the chemical structural formula

is marked.

The UV-B filters may be oil-soluble or water-soluble. Advantageous oil-soluble UV-B filter substances are z. B .:
3-benzylidene camphor derivatives, preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor;
4-aminobenzoic acid derivatives, preferably (2- ethylhexyl) 4- (dimethylamino) benzoate, 4- (dimethylamino) benzoic acid amyl ester;
2,4,6-trianilino- (p-carbo-2'-ethyl-1'-hexyloxy) -1,3,5-triazine;
Esters of benzalmalonic acid, preferably di (2-ethylhexyl) 4-methoxybenzalmalonate;
Esters of cinnamic acid, preferably 4-methoxycinnamic acid (2-ethylhexyl) ester, 4-methoxycinnamic acid isopentyl ester; Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone and UV-bound to polymers.

advantageous water-soluble UV-B filter substances are z. B .: salts of 2-phenylbenzimidazole-5-sulfonic acid, such as its sodium, Potassium or its triethanolammonium salt, and the sulfonic acid even; Sulfonic acid derivatives of the 3-benzylidene camphor, such as B. 4- (2-oxo-3-bomylidenemethyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bomylidenemethyl) sulfonic acid and its Salts.

A further light protection filter substance according to the invention to be used advantageously is ethylhexyl-2-cyano-3,3-diphenylacrylate (octocrylene), which is under the name Uvinul ^® N 539 available from BASF and is characterized by the following structure:

It may also be of considerable advantage to use polymer-bound or polymeric UV filter substances in preparations according to the present invention, in particular those as described in US Pat WO-A-92/20690 to be discribed.

Further may it be advantageous, according to the invention further UV-A and / or UV-B filters in cosmetic or dermatological preparations to incorporate, for example, certain salicylic acid derivatives such as 4-isopropylbenzylsalicylate, 2-ethylhexylsalicylate (= octylsalicylate), Homomenthyl.

All Particularly advantageous are preparations according to the invention, characterized in that the UV-absorbing light Substance or substances are chosen or will be out the group butylmethoxydibenzoylmethane, ethylhexylmethoxycinnamate, Octocrylene, ethylhexyl salicylate, homosalates, phenylbenzimidazole sulfonic acid, Disodium phenyldibenzimidazole tetrasulfonate, benzophenone-3, methylene-bis-benzotriazolyltetramethylbutylphenol, Diethylaminohydroxybenzoylhexylbenzoate, bis-ethylhexyloxyphenolmethoxyphenyltriazine.

Advantageous is in particular a use according to the invention, characterized in that the preparations are 0.0001 to 10% by weight, in particular 0.001 to 5% by weight, very particularly 0.01 to 4% by weight of apiogalacturonans or an apiogalacturonane contained extract of Zostera marina, based on the Total weight of the preparation.

Advantageous contain the preparations according to the invention 0.1-5 wt .-% of one or more UV light absorbing Substances, preferably 0.5-2.5 wt .-% of at one or several UV light absorbing substances, particularly preferred 1-2 wt .-% of one or more UV light absorbing Substances.

invention Cosmetic and dermatological preparations can be used in different forms exist. So they can z. Legs Solution, an anhydrous preparation, an emulsion or Micro-emulsion of the water-in-oil (W / O) or oil-in-water type (O / W), a multiple emulsions, for example of the water-in-oil-in-water type (W / O / W), a gel, a solid stick, an ointment or even an aerosol represent. It is also advantageous in accordance with the invention To present folic acid and / or its derivatives in encapsulated form, z. In collagen matrices and other common encapsulation materials, z. As cellulose encapsulates, in gelatin, wax matrices or encapsulated liposomally.

In particular wax matrices like those in the DE-OS 43 08 282 have been described, have turned out to be favorable.

The cosmetic and dermatological according to the invention Preparations may contain cosmetic adjuncts, as commonly used in such preparations be, for. B. preservatives, bactericides, perfumes, Substances for preventing foaming, dyes, pigments, which have a coloring effect, thickener, surface-active Substances, emulsifiers, softening, moisturizing and / or moisturizing Substances, fats, oils, waxes or other common Components of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.

• – Mineralöle, Mineralwachse
• – Öle, wie Triglyceride der Caprin- oder der Caprylsäure, ferner natürliche Öle wie z. B. Rizinusöl;
• – Fette, Wachse und andere natürliche und synthetische Fettkörper, vorzugsweise Ester von Fettsäuren mit Alkoholen niedriger C-Zahl, z. B. mit Isopropanol, Propylenglykol oder Glycerin, oder Ester von Fettalkoholen mit Alkansäuren niedriger C-Zahl oder mit Fettsäuren;
• – Alkylbenzoate;
• – Siliconöle wie Dimethylpolysiloxane, Diethylpolysiloxane, Diphenylpolysiloxane sowie Mischformen daraus.

The lipid phase can advantageously be selected from the following substance group:

• - mineral oils, mineral waxes
• - Oils such as triglycerides of capric or caprylic, further natural oils such. Castor oil;
• Fats, waxes and other natural and synthetic fats, preferably esters of fatty acids with lower C-number alcohols, e.g. With isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with alkanoic acids of low C number or with fatty acids;
• - alkyl benzoates;
• - Silicone oils such as dimethylpolysiloxanes, diethylpolysiloxanes, diphenylpolysiloxanes and mixed forms thereof.

The oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions in the context of the present invention is advantageously chosen from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a Chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched Alcohols of a chain length of 3 to 30 carbon atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 3 to 30 carbon atoms. Such ester oils can then are advantageously selected from the group isopropyl myristate, Isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyl dodecyl palmitate, Oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate and synthetic, semi-synthetic and natural mixtures of such esters, z. B. jojoba oil.

The aqueous phase of the invention Preparations optionally contains advantageous alcohols, Diols or polyols of low C number, and their ethers, preferably Ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or -monobutyl ether, propylene glycol monomethyl, -monoethyl- or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products, furthermore lower C number alcohols, e.g. Ethanol, Isopropanol, 1,2-propanediol, glycerol and in particular one or more Thickener, which or which are chosen advantageous can be selected from the group silicon dioxide, aluminum silicates, Polysaccharides or their derivatives, for. Hyaluronic acid, Xanthan gum, hydroxypropyl methylcellulose, particularly advantageous from the group of polyacrylates, preferably a polyacrylate from the Group of so-called carbopols, for example carbopols of the types 980, 981, 1382, 2984, 5984, each alone or in combination.

Especially Mixtures of the abovementioned solvents are used. For alcoholic solvents, water can be another Be part of it.

invention Emulsions are advantageous and contain z. As mentioned fats, oils, Waxes and other fatty substances, as well as water and an emulsifier, as he usually does for such a type of formulation is used.

gels according to the invention usually contain Low C-number alcohols, e.g. Ethanol, isopropanol, 1,2-propanediol, Glycerol and water or an above-mentioned oil in Presence of a thickening agent that is oily-alcoholic Preferably, silica or an aluminosilicate is included aqueous-alcoholic or alcoholic gels preferably a polyacrylate.

When Blowing agent for the invention, from Aerosol containers are sprayable preparations the usual known volatile, liquefied Propellants, for example hydrocarbons (propane, butane, isobutane) suitable, which are used alone or in mixture with each other can. Also, compressed air is advantageous to use.

The following examples are intended to illustrate the present invention without limiting it. All amounts, proportions and percentages are, unless otherwise stated, percentages by weight, based on the weight and the total amount or on the total weight of the preparations. Example of an O / W emulsion example 1 Wt .-% stearic acid 2 cetyl alcohol 2.5 PEG-20 Stearate 3 C12-15 alkyl benzoate 5 butylene 1 Isohexadecan 2 glycerin 5 Uvinul T 150 (2,4,6-tris [anilino (p-carbo-2'-ethyl-1'-hexyloxy)] - 1,3,5-triazine 2 Neo) Heliopan AP ^® (phenylene-1,4-bis- (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid bis-sodium salt) 2 Benzophenone-3 2 Ethyl hexyl salicylate 1 Octocrylene ((ethylhexyl-2-cyano-3,3-diphenylacrylate)) 2 Bis-Ethylhexyloxyphenol Methoxyphenyltriazine 2 Zostera marina extract 4 Vitamin E acetate 0.6 EDTA 0.2 Perfume, preservative qs Dyes, etc. qs sodium hydroxide qs water ad 100.0 Example of an O / W emulsion Example 2 Wt .-% Glyceryl stearate citrate 2.5 sorbitan 0.5 stearyl 2 Carbomer 0.1 Xanthan gum 0.4 C _12-15 alkyl benzoate 5 Butylene glycol dicaprylate / dicaprate 5 octyldodecanol 2 cyclomethicone 5 butylene 5 glycerin 3 C18-38 acid triglycerides 0.5 Titanium dioxide 5 Butyl methoxydibenzoylmethane 2 Octocrylene (ethylhexyl-2-cyano-3,3-diphenylacrylate) 2 Bis-Ethylhexyloxyphenol Methoxyphenyltriazine 1 Zostera marina extract 2 Na ₂ H ₂ EDTA 0.1 water ad 100 Example of an O / W emulsion Example 3 Wt .-% Glyceryl stearate SE 1 Emulgade® F ^® 2.5 cetearyl 1 C _12-15 alkyl benzoate 6 Acrylates / C _10-30 alkyl acrylate bulk polymer 0.1 Xanthan gum 0.4 cyclomethicone 10 Isohexadecan 5 glycerin 5 ethylhexylmethoxycinnamate 4 Butyl methoxydibenzoylmethane 2 Parsol ^® 1789 (4- (tert-butyl) -4'-methoxydibenzoylmethane) 2 Zostera marina extract 1 EDTA 0.2 Perfume, preservative qs Dyes, etc. qs sodium hydroxide qs water ad 100.0 Example of a hydrodispersion Example 4 Wt .-% Cetyl alcohol 2 Sodium carbomer 0.3 Acrylates / C10-30 Alkyl Acrylate Crosspolymer 0.1 Butyl methoxydibenzoylmethane 0.5 Disodium phenyl dibenzimidazole tetrasulfonate 1.5 Phenylbenzimidazole sulfonic acid 1 Bis-Ethylhexyloxyphenol Methoxyphenyltriazine 2.5 Ethylhexylmethoxycinnamate 3 Octocrylene (ethylhexyl-2-cyano-3,3-diphenylacrylate) 1 Titanium dioxide 0.5 Butylene glycol dicaprylate / dicaprate 6 lanolin 0.35 PVP hexadecene copolymer 0.5 Ethylhexyloxyglycerin 1 glycerin 5 Zostera marina extract 2.5 Trisodium EDTA 0.2 Perfume, preservatives qs Sodium hydroxide or potassium hydroxide q s water ad 100 Example of a hydrodispersion Example 5 Wt .-% Acrylates / C10-30 alkyl acrylate bulk polymer 0.3 Ceteareth-20 1 Butyl methoxydibenzoylmethane 3.5 Neoheliopan AP ^® (phenylene-1,4-bis- (2-benzimidazyl) -3,3'-5,5'-tetrasulfonic acid bis-sodium salt) 1 Tinosorb ^® S (2,4-bis - {[4- (2-ethyl-hexyloxy) -2-hydroxy] -phenyl} -6- (4-methoxyphenyl) -1,3,5-triazine) 1 Tinosorb M ^® 2,2'-methylene-bis- (6- (2H-benzotriazol-2-yl) -4- (1,1,3,3-tetramethylbutyl) -phenol) 2 Phenylbenzimidazole sulfonic acid 2 Ethylhexyl methoxycinnamate 7 C _12-15 alkyl benzoate 2.5 Phenethyl benzoate 3 C18-36 triglyceride fatty acid 1 PVP hexadecene copolymer 0.5 glycerin 5 Zostera marina extract 3 Vitamin E acetate 0.5 Trisodium EDTA 0.5 Perfume, preservatives qs Sodium hydroxide or potassium hydroxide q s water ad 100

QUOTES INCLUDE IN THE DESCRIPTION

This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.

Cited patent literature

• - EP 570838 A1 [0039]
• - EP 775698 [0041]
• WO 92/20690 A [0048]
• - DE 4308282 A [0054]

Claims (4)

Preparations containing apiogalacturonanes or an extract of Zostera marina containing apiogalacturonan and one or more UV light absorbing substances. In particular, an inventive invention is advantageous Use, characterized in that the preparations 0.0001 to 10 wt .-%, in particular 0.001 to 5 wt .-%, very particularly 0.01 to 4% by weight of apiogalacturonans or apiogalacturonans contained extract of Zostera marina, based on the Total weight of the preparation. Preparations according to one of the preceding claims, containing 0.1-5 wt .-% of one or more UV light absorbing substances, preferably 0.5-2.5% by weight on at one or more UV light absorbing substances, in particular preferably 1-2% by weight of one or more UV-absorbing light Substances. Preparations according to one of the preceding claims, characterized in that the UV-absorbing light Substance or substances are chosen or will be out the group butylmethoxydibenzoylmethane, ethylhexylmethoxycinnamate, Octocrylene, ethylhexyl salicylate, phenylbenzimidazole sulfonic acid, disodium phenyldibenzimidazole tetrasulfonate, Benzophenone-3, methylene-bis-benzotriazolyltetramethylbutylphenol, Diethylaminohydroxybenzoylhexylbenzoate, bis-ethylhexyloxyphenolmethoxyphenyltriazine.