DE10199016I1 - Indole derivatives for the treatment of migraines - Google Patents

Indole derivatives for the treatment of migraines

Info

Publication number
DE10199016I1
DE10199016I1 DE2001199016 DE10199016C DE10199016I1 DE 10199016 I1 DE10199016 I1 DE 10199016I1 DE 2001199016 DE2001199016 DE 2001199016 DE 10199016 C DE10199016 C DE 10199016C DE 10199016 I1 DE10199016 I1 DE 10199016I1
Authority
DE
Germany
Prior art keywords
image
alkyl group
treatment
migraines
indole derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE2001199016
Other languages
German (de)
Other versions
DE10199016I2 (en
Inventor
Forner Dolors Fernandez
Duran Charles Puig
Soto Jose Prieto
Noverola Armando Vega
Mauri Jacinto Moragues
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Almirall Prodesfarma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10719423&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE10199016(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Almirall Prodesfarma SA filed Critical Almirall Prodesfarma SA
Application granted granted Critical
Publication of DE10199016I1 publication Critical patent/DE10199016I1/en
Publication of DE10199016I2 publication Critical patent/DE10199016I2/en
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Fertilizers (AREA)
  • Processing Of Solid Wastes (AREA)

Abstract

A compound of formula (I) <IMAGE> (I) wherein R1 and R2 each represents a hydrogen atom or an alkyl group, Z represents a ring selected from: <IMAGE> II in which +E,uns n+EE represents 4, 5 or 6; <IMAGE> III <IMAGE> IV in which R3 represents hydrogen or an alkyl group and R4 represents an alkyl, methoxy benzyl or R5 NHCO group, R5 being an alkyl group; and <IMAGE> V in which R6 represents an alkyl group. and pharmaceutically acceptable salts thereof are useful in the treatment of migraine and other conditions. They are prepares by decarboxylation of the corresponding indolyl 2-carboxylic acid.
DE2001199016 1992-07-28 1993-07-19 Indole derivatives for the treatment of migraine Active DE10199016I2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929216009A GB9216009D0 (en) 1992-07-28 1992-07-28 New indol derivatives
PCT/EP1993/001901 WO1994002460A1 (en) 1992-07-28 1993-07-19 Indol derivatives for the treatment of migraine

Publications (2)

Publication Number Publication Date
DE10199016I1 true DE10199016I1 (en) 2001-05-23
DE10199016I2 DE10199016I2 (en) 2006-04-06

Family

ID=10719423

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2001199016 Active DE10199016I2 (en) 1992-07-28 1993-07-19 Indole derivatives for the treatment of migraine
DE69323712T Expired - Lifetime DE69323712T2 (en) 1992-07-28 1993-07-19 INDOL DERIVATIVES FOR TREATING MIGRAINE

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69323712T Expired - Lifetime DE69323712T2 (en) 1992-07-28 1993-07-19 INDOL DERIVATIVES FOR TREATING MIGRAINE

Country Status (33)

Country Link
US (1) US5565447A (en)
EP (1) EP0605697B1 (en)
JP (1) JP2716585B2 (en)
KR (1) KR100191830B1 (en)
CN (1) CN1035179C (en)
AT (1) ATE177080T1 (en)
BR (2) BR9305589A (en)
CA (1) CA2120028C (en)
CZ (1) CZ282659B6 (en)
DE (2) DE10199016I2 (en)
DK (1) DK0605697T3 (en)
EC (1) ECSP930953A (en)
EG (1) EG20340A (en)
FI (1) FI109998B (en)
GB (1) GB9216009D0 (en)
GR (1) GR3029915T3 (en)
HK (1) HK1011680A1 (en)
HU (2) HUT70518A (en)
IL (1) IL106387A (en)
LU (1) LU90758I2 (en)
MX (1) MX9304524A (en)
MY (1) MY113266A (en)
NL (1) NL300053I2 (en)
NO (1) NO180231C (en)
NZ (1) NZ254152A (en)
PL (1) PL174352B1 (en)
RU (1) RU2117667C1 (en)
SG (1) SG48708A1 (en)
TW (1) TW235297B (en)
UA (1) UA27818C2 (en)
UY (1) UY23624A1 (en)
WO (1) WO1994002460A1 (en)
ZA (1) ZA935316B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2712591B1 (en) * 1993-11-19 1996-02-09 Pf Medicament New arylpiperazines derived from indole, their preparation and their therapeutic use.
FR2731224B1 (en) * 1995-03-02 1997-05-30 Pf Medicament NOVEL BI-TRYPTAMINIC SULFONAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
GB9523462D0 (en) * 1995-11-16 1996-01-17 Merck Sharp & Dohme Therapeutic agents
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US6310066B1 (en) 1998-04-29 2001-10-30 American Home Products Corp. Antipsychotic indolyl derivatives
US6204274B1 (en) 1998-04-29 2001-03-20 American Home Products Corporation Indolyl derivatives as serotonergic agents
US6066637A (en) * 1998-06-19 2000-05-23 American Home Products Corporation Indolyl derivatives as serotonergic agents
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
WO2006129190A1 (en) * 2005-06-03 2006-12-07 Glenmark Pharmaceuticals Limited Process for the preparation of almotriptan
US20070112055A1 (en) * 2005-09-30 2007-05-17 Glenmark Pharmaceuticals Limited Crystalline forms of almotriptan and processes for their preparation
DE102006027229A1 (en) * 2006-06-09 2007-12-20 Grünenthal GmbH 1,3-Disubstituted 4-methyl-1H-pyrrole-2-carboxylic acid amides and their use for the preparation of medicaments
EP2081893B1 (en) * 2006-10-19 2011-03-23 Auspex Pharmaceuticals, Inc. Substituted indoles
TWI321616B (en) 2007-03-27 2010-03-11 Coretronic Corp Centrifugal blower
CZ302424B6 (en) * 2007-06-13 2011-05-11 Zentiva, A. S. Process for preparing almotriptan of high purity
CN101842352A (en) * 2007-08-02 2010-09-22 基因里克斯(英国)有限公司 Novel process
CN103724252A (en) * 2012-10-12 2014-04-16 苏州四同医药科技有限公司 Preparation method of almotriptan
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2082175B (en) * 1980-08-12 1984-05-02 Glaxo Group Ltd Heterocyclic compounds
IT1170387B (en) * 1982-06-07 1987-06-03 Glaxo Group Ltd HETEROCYCLIC COMPOUNDS, PROCEDURE TO PREPARE THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB2162532B (en) * 1984-08-04 1988-08-03 Ritchie Swanson John Decontaminant wash composition
GB8431426D0 (en) * 1984-12-13 1985-01-23 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
SI9111010B (en) * 1990-06-07 2005-02-28 Astrazeneca Ab 3,5-disubstituted indole derivatives as "5-ht1-similar" receptor agonists

Also Published As

Publication number Publication date
CN1087629A (en) 1994-06-08
ECSP930953A (en) 1994-08-15
DE10199016I2 (en) 2006-04-06
US5565447A (en) 1996-10-15
DE69323712D1 (en) 1999-04-08
IL106387A0 (en) 1993-11-15
SG48708A1 (en) 1998-05-18
HU9400869D0 (en) 1994-06-28
DK0605697T3 (en) 1999-09-27
AU4570793A (en) 1994-02-14
KR100191830B1 (en) 1999-06-15
MX9304524A (en) 1994-04-29
ATE177080T1 (en) 1999-03-15
HUT70518A (en) 1995-10-30
UY23624A1 (en) 1993-08-10
EP0605697B1 (en) 1999-03-03
GB9216009D0 (en) 1992-09-09
DE69323712T2 (en) 1999-07-01
RU2117667C1 (en) 1998-08-20
LU90758I2 (en) 2001-06-11
NO180231B (en) 1996-12-02
GR3029915T3 (en) 1999-07-30
NL300053I2 (en) 2002-04-02
NO941019L (en) 1994-03-22
TW235297B (en) 1994-12-01
JP2716585B2 (en) 1998-02-18
JPH06511261A (en) 1994-12-15
CN1035179C (en) 1997-06-18
NO180231C (en) 1997-03-12
BR1100061A (en) 2000-04-18
MY113266A (en) 2002-01-31
NZ254152A (en) 1996-12-20
AU661190B2 (en) 1995-07-13
BR9305589A (en) 1996-01-02
PL302917A1 (en) 1994-09-05
EP0605697A1 (en) 1994-07-13
NL300053I1 (en) 2001-11-01
PL174352B1 (en) 1998-07-31
HU211243A9 (en) 1995-11-28
CA2120028A1 (en) 1994-02-03
CZ66494A3 (en) 1994-12-15
ZA935316B (en) 1994-02-14
WO1994002460A1 (en) 1994-02-03
HK1011680A1 (en) 1999-07-16
CZ282659B6 (en) 1997-08-13
FI109998B (en) 2002-11-15
CA2120028C (en) 1999-03-23
EG20340A (en) 1998-10-31
IL106387A (en) 1997-04-15
UA27818C2 (en) 2000-10-16
FI941413A (en) 1994-03-25
NO941019D0 (en) 1994-03-22
FI941413A0 (en) 1994-03-25

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