DE10021560A1 - Skin care composition used as insect repellent action, contains combination of extracts of neem tree and cloves - Google Patents

Abstract

Skin care composition (I) having insect repellent action contains (in addition to cosmetic carrier(s)): (a) an extract of components of the neem tree and (b) a clove extract.

Description

The invention relates to a skin care product insect repellant effect.

To protect against stinging or biting blood-sucking Insects are a range of insect repellant preparations have been developed to prevent such Settle insects on the skin and after done Blood meal cause itchy and reddened skin irritation. A number of preparations are known, the synthetic ones Contain substances and a very strong one show insect repellant or killing effect. Examples are Autan® (Bayer AG, DE, Leverkusen) or PreVent® (AgroPharm Ltd., UK, Penn). These preparations show a good one Effect, however, exist for a number of consumers because of the synthetic origin of the active ingredients Application concerns. Especially for infants or Small children are therefore required preparations that are "organic" act, i.e. contain active substances of biological origin. Especially for applications in areas where no there is excessive pressure on blood-sucking insects or no transmission of serious diseases through such A number of preparations are to be feared by insects offered, which are based on natural substances. Examples are contraindications Mück® (Pfleger, DE, Bamberg), Jungle Milk® (CLAWA Naturheilmittel GmbH, DE, Castrop-Rauxel), MosQuito® (Paulus & Thewalt GmbH & Co, DE, Höhr-Grenzhausen), Zanzarin® (Engelhard Arzneimittel GmbH & Co. KG, DE, Frankfurt / Main) or ticks Pech® Gel (floracell dermo-pharmaceutical preparations, DE, Flax). However, the effects of these preparations are often not sufficient. The preparations often show only a weak one  or short-term effect. Some of the preparations are also made by not tolerate and cause sensitive users Redness of the skin.

The oil from the seed of the neem tree, Azadirachta indica, is in Indian folk medicine for the treatment of small wounds and generally used for skin care. At the same time, it serves as an abrasion, also for defense against biting and sucking Insects. It is non-toxic and skin-friendly, but shows an intense smell of onions and garlic. Because of this unpleasant smell cannot be found in undiluted or slightly diluted form can be applied. These However, concentrations are required to get one to achieve insect repellant effect.

A repellant is known from DE 195 32 447 A1 Pest control known. The preparation contains one insect repellant active ingredient, which consists of components of Neem tree, especially leaves, bark or seeds will be produced. The preparation is used to manufacture Creams, lotions or similar personal care products are used. The object of the invention is an insect repellent To provide skin care products that are natural Starting materials based and after application to the skin long-term protection against biting and stinging insects.

The task is solved by a skin care product with an insect repellent effect, comprising:
one or more cosmetic carrier materials, an extract from components of the neem tree, an extract from components of the clove tree.

Surprisingly, it was found that the combination an extract from parts of the neem tree with a  Extract from clove leaves, stems or buds a very good insect repellent effect can be achieved. This was not to be expected because of the repellant effect the extract from parts of the neem tree not is satisfactory and on the other hand by Eugenol, the Main component of clove oil, according to R. Demenjoz, Arch. Exp. Path. Pharmac. 208, 165 (1949); Römpp Chemie Lexikon, Thieme Verlag, Stuttgart 9th edition, p. 1266, insects are attracted, the active ingredient is therefore an attractant and not a repellant.

Cosmetic carrier materials are the usual basis for ointments, gels, lotions, creams, aqueous or oily Understood solutions. These carriers are per se to the person skilled in the art known. Such carriers can, for example, according to information in corresponding standard works, e.g. B. Andreas Dromsch: The cosmetic preparations, vol. 3 (lipid-containing and emulsified Formulations), Verlag f. Chem. Industrie, H. Ziolkowsky GmbH, Augsburg, 4th ed. 1994. Since that Care products applied to the skin are suitable especially lotions, spray-on solutions or even solid ones Forms of preparation that have an application in the form of pens enable.

Under an extract from components of the neem tree is on each extract from leaves, seeds, bark or branches of the Neembaumes understood. The extract can, for example, by Pressing the seeds, but also by extraction with a suitable solvent, for example high-boiling Petroleum ether or water can be obtained. Such Extracts are mixtures of active ingredients with fluctuating Composition, with the individual components of the Neembaumes different concentrations and Compositions result. Active ingredient for the effect Azadirachtin is particularly effective against insects. The repellant However, the effect is mainly with the total extract, i.e. without a further purification of the extract with separation into the  Individual components observed. As starting material for the The seeds of the neem tree are particularly suitable for extraction. they have and contain a high concentration of active ingredient large amounts of oily ingredients that are nourishing Can have an effect on the skin.

Under a clove extract, each extract is made up of ingredients the carnation understood. Such extracts are called clove oil known and are, for example, by extraction of Clove leaves, stems and buds extracted.

The extract from components of the neem tree and / or the Clove extract is preferably extracted from Plant components made with carbon dioxide. The Extraction with carbon dioxide is extremely gentle, so that those contained in the vegetable raw materials Active ingredients are not decomposed, so the extracts are very have a high content of eugenol. In particular, the Carbon dioxide extract of components of the neem tree, especially the seeds (such an extract is others also referred to as "neem extract") other extraction methods considerably less intensive Smell of onions or garlic. A suitable one Extraction is described, for example, in PCT / EP 96/04420 described. This extract also shows no skin irritants Properties, so that it can be used by users with sensitive Skin is easily tolerated. The same applies to the clove extract. It is known that clove extracts at sensitive users in higher doses to skin irritation being able to lead. The one by treatment with supercritical Experience has shown that extract made from carbon dioxide gets better tolerate what is probably due to its higher purity is due.

The content of extract from the ingredients in the skin care product the neem tree or clove extract is not in itself  subject to special restrictions. Suitable Concentrations are mainly chosen by the cosmetic carrier materials or by the desired Intensity of the smell determined. Have proven to be suitable Salaries highlighted, based on the weight of the Skin care product the extract from components of the neem tree in an amount of 1 to 60%, preferably 5 to 40%, in particular 10 to 40% is contained, and / or the Clove extract in an amount of 1 to 60%, preferably 5 to 50%, especially 10 to 40% is included.

Clove extracts have their own smell and can be in higher doses have an irritating effect on the skin. For The skin care product can modify these properties further plant extracts with anti-inflammatory, disinfectant and / or analgesic effect, especially essential vegetable oils. The specialist a large number of plant extracts are available Available. In addition to a modification of the smell of Skin care product is especially the effect of this Active ingredients as a preservative or antioxidant from Interest.

Extracts have proven to be suitable as further plant extracts of plants selected from the Group formed by Pimenta racemosa, Coriandrum sativum, Matricaria chamomila, Foeniculum vulgare, Lavendula officinalis, Rosmarinus officinalis, Vanilla planifolia.

The further plant extracts which are particularly preferred by extracting plant material with carbon dioxide won. The skin care product is then particularly mild and compatible, which makes it particularly suitable for an application in small children.

The invention is explained in more detail by means of examples.  

1. Production of a skin care product according to the invention in Form of a lotion

The extracts of the plants used were extracted suitable parts of plants with supercritical carbon dioxide produced. This is for the extraction of neem oil in the Application WO 97/25867 described.

An exemplary recipe is given in Table 1. The Figures for the salary are based on weight of the lotion and are given in%. The for the next to the Neem extract and the clove extract specified areas of the Plant extracts can vary depending on the smell you want Lotion can be varied.

Table 1 Exemplary composition of an insect repellant lotion according to the invention. Figures in% by weight, based on the composition

Aqua 55-65 Clove oil (Szygium aromaticum) 10-20 CO2 neem oil (Azadirachta indica) 10-20 Sucrose ester 2-4 Glycerin 2-4 Lanolin Oil 3-4 Polyglyceryl-3-methylglucose distearate 3-4 Pimenta racemosa 0.2-1 Zinc Ricinoleate 1.5-2.5 Coriandrum sativum 0.2-1 Matricaria chamomila 0.3 Acrylates cross polymer 0.1-0.2 Foeniculum vulgare 0.1-0.2 Lavendula officinalis 0.1-0.2 Rosmarinus officinalis 0.1-0.2 Vanilla planifolia 0.001-0.003

2. Patch test

The lotion produced under 1 was in a 1% Vaseline trituration by patch test on 20 sensitive Patients tested. The skin test was done after 48 and after 72 Hours read and after erythema formation, infiltration or Papulovesicular reactions assessed. None could allergic reactions are found.

3. Test for repellant effect 3.1 test insects

Female Aedes aegypti- Mosquitos used. These are common worldwide Carrier of various diseases, such as yellow fever and Dengue fever. The insects were drawn from eggs in the laboratory and received none after hatching the adult animals Food.

3.2 Test procedure

There were 30-40 hungry mosquitoes in a cubic Mesh cage of 45 cm edge length inserted. Two Test subjects (A, B) each took 1.5-2 ml of the test preparation on the forearm. They led the Forearm in the cage, hand with a glove was covered. Puncture attempts by the glove were not made counted. If there were no or only a few stitches, the Leave the forearm in the cage for 5 minutes. Done stitches after a short trial period, d. H. with defective repelling effect, the test duration was shorter chosen. If little or no puncture attempts were made,  the test after a waiting period of 30 or 60 minutes repeated until the effect of repellance subsided, i.e. H. a the number of stitches increased significantly.

3.3 Comparative drugs

The lotion according to the invention (“neem lotion”) was compared with commercially available preparations. The following were selected for comparison:
Preparations with synthetic active ingredients:
Autan® (lotion) (Bayer AG, DE, Leverkusen, active ingredient: DEET)
PreVent® (Lotion) (AgroPharm Ltd, UK, Penn; active ingredient Pyrethrine, PBO).

The following were selected as comparative products based on natural products:
Contra Mück® (Pfleger, DE, Bamberg; active ingredient: essential oils)
Jungle Milk® (Clawa Naturheilmittel GmbH, DE, Castrop-Rauxel; active ingredient: essential oils)
MosQuito® (Paulus & Thewalt GmbH & Co, DE, Höhr-Grenzhausen; active ingredient: essential oils)
Zanzarin® (Engelhard GmbH & Co. KG, DE, Frankfurt / Main; active ingredient: cistus oil)
Zecken Pech® Gel (floracell dermo-pharmaceutical preparations, DE, Leiningen; active ingredient: neem extract).

A control was also applied without repelling performed the forearm.

The results of the test are given in Table 2.

3.4 Repelling effect of individual components of the skin care product according to the invention

To evaluate the repelling effects of essential oils, the skin care product to modify its properties be added was neem oil, which is obtained by extraction of Neem seeds with carbon dioxide were obtained alone or with Addition of various essential oils in 3.2 described test method tested. The test results are given in Table 3.

With neem oil alone as well as with the addition of essential oils, no or only a very slight repelling effect is observed. A clear effect is only observed with Mentha piperita and Eugenol, the main component of clove oil. The best effect is achieved with a mixture of neem oil and clove oil (Szygium aromaticum) or a lotion with the composition given in Table 1.

Claims (6)

1. A skin care product with an insect repellent effect, comprising:
one or more cosmetic carrier materials,
an extract from components of the neem tree,
a clove extract. 2. Skin care agent according to claim 1, wherein the extract of Components of the neem tree and / or the clove extract by extracting plant components with Carbon dioxide is made. 3. Skin care product according to claim 1 or 2, wherein based on the weight of the skin care product's extract Components of the neem tree in an amount of 1 to 60%, preferably contain 5 to 50%, in particular 10 to 40% and / or the clove extract in an amount of 1 to 60%, preferably 5 to 40%, in particular 10 to 40% is included. 4. Skin care product according to one of claims 1 to 3, wherein the skin care product with other plant extracts anti-inflammatory, disinfectant and / or contains analgesic effect, especially etheric Vegetable oils. 5. Skin care product according to claim 4, wherein the further Plant extracts are selected from extracts of Plants from the group formed by Pimenta racemosa, Coriandrum sativum, Matricaria chamomila, Foeniculum vulgare, Lavendula officinalis, Rosmarinus officinalis, Vanilla planifolia. 6. Skin care product according to one of claims 4 or 5, wherein the other plant extracts by extracting Plants are extracted with carbon dioxide.