DE03704136T1 - Verwendung von ribozymen zur detektion ebenfalls vorhandener agenzien - Google Patents
Verwendung von ribozymen zur detektion ebenfalls vorhandener agenzien Download PDFInfo
- Publication number
- DE03704136T1 DE03704136T1 DE03704136T DE03704136T DE03704136T1 DE 03704136 T1 DE03704136 T1 DE 03704136T1 DE 03704136 T DE03704136 T DE 03704136T DE 03704136 T DE03704136 T DE 03704136T DE 03704136 T1 DE03704136 T1 DE 03704136T1
- Authority
- DE
- Germany
- Prior art keywords
- reovirus
- virus
- ribozyme
- composition
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000702263 Reovirus sp. Species 0.000 claims abstract 31
- 238000000034 method Methods 0.000 claims abstract 27
- 102000053642 Catalytic RNA Human genes 0.000 claims abstract 18
- 108090000994 Catalytic RNA Proteins 0.000 claims abstract 18
- 108091092562 ribozyme Proteins 0.000 claims abstract 18
- 238000003776 cleavage reaction Methods 0.000 claims abstract 7
- 230000007017 scission Effects 0.000 claims abstract 7
- 230000000694 effects Effects 0.000 claims abstract 4
- 230000001717 pathogenic effect Effects 0.000 claims abstract 4
- 231100000255 pathogenic effect Toxicity 0.000 claims abstract 4
- 210000004027 cell Anatomy 0.000 claims 22
- 241000700605 Viruses Species 0.000 claims 19
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 12
- 244000005700 microbiome Species 0.000 claims 12
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 5
- 208000015181 infectious disease Diseases 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 230000010076 replication Effects 0.000 claims 3
- 101710091045 Envelope protein Proteins 0.000 claims 2
- 241000700635 Orf virus Species 0.000 claims 2
- 241000702244 Orthoreovirus Species 0.000 claims 2
- 101710188315 Protein X Proteins 0.000 claims 2
- 102100021696 Syncytin-1 Human genes 0.000 claims 2
- 241000700618 Vaccinia virus Species 0.000 claims 2
- 210000005170 neoplastic cell Anatomy 0.000 claims 2
- 208000003265 stomatitis Diseases 0.000 claims 2
- 241000701161 unidentified adenovirus Species 0.000 claims 2
- 241000712461 unidentified influenza virus Species 0.000 claims 2
- 208000005925 vesicular stomatitis Diseases 0.000 claims 2
- 208000003322 Coinfection Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
- C12N2310/121—Hammerhead
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
- C12Q2521/337—Ribozyme
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/14—Reoviridae, e.g. rotavirus, bluetongue virus, Colorado tick fever virus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36073002P | 2002-02-28 | 2002-02-28 | |
| US360730P | 2002-02-28 | ||
| PCT/CA2003/000264 WO2003072811A2 (en) | 2002-02-28 | 2003-02-26 | The use of ribozymes in the detection of adventitious agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE03704136T1 true DE03704136T1 (de) | 2005-12-15 |
Family
ID=27766245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE03704136T Pending DE03704136T1 (de) | 2002-02-28 | 2003-02-26 | Verwendung von ribozymen zur detektion ebenfalls vorhandener agenzien |
Country Status (16)
| Country | Link |
|---|---|
| EP (2) | EP1481084B1 (enExample) |
| JP (3) | JP4369243B2 (enExample) |
| AR (1) | AR038849A1 (enExample) |
| AT (1) | ATE519860T1 (enExample) |
| AU (1) | AU2003206587B2 (enExample) |
| BR (1) | BR0307882A (enExample) |
| CA (1) | CA2374388C (enExample) |
| DE (1) | DE03704136T1 (enExample) |
| DK (1) | DK1481084T3 (enExample) |
| ES (1) | ES2241506T3 (enExample) |
| MX (1) | MXPA04008277A (enExample) |
| NZ (1) | NZ534488A (enExample) |
| TR (1) | TR200501513T3 (enExample) |
| TW (1) | TWI329132B (enExample) |
| WO (1) | WO2003072811A2 (enExample) |
| ZA (1) | ZA200406231B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1306959C (zh) * | 2004-09-21 | 2007-03-28 | 中国科学院武汉病毒研究所 | 草鱼呼肠孤病毒抗原亚单位疫苗制备方法 |
| US10260049B2 (en) | 2005-08-01 | 2019-04-16 | Virocure, Inc. | Attenuated reovirus |
| US10668119B2 (en) | 2005-08-01 | 2020-06-02 | Virocure, Inc. | Attenuated reovirus |
| US10369171B2 (en) | 2007-03-13 | 2019-08-06 | Virocure, Inc. | Attenuated reoviruses for selection of cell populations |
| TW201738562A (zh) * | 2009-05-28 | 2017-11-01 | 亞培生物股份有限公司 | 體外病原體檢驗技術 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US5254678A (en) | 1987-12-15 | 1993-10-19 | Gene Shears Pty. Limited | Ribozymes |
| US5168053A (en) | 1989-03-24 | 1992-12-01 | Yale University | Cleavage of targeted RNA by RNAase P |
| US5225337A (en) | 1989-09-25 | 1993-07-06 | Innovir Laboratories, Inc. | Ribozyme compositions and methods for use |
| US5225347A (en) | 1989-09-25 | 1993-07-06 | Innovir Laboratories, Inc. | Therapeutic ribozyme compositions and expression vectors |
| EP0653488B1 (en) | 1992-07-02 | 2003-04-09 | Sankyo Company Limited | Looped, hairpin ribozyme |
| JPH08507203A (ja) * | 1992-12-04 | 1996-08-06 | イノーバー ラボラトリーズ，インコーポレイテッド | 調節可能な核酸治療およびそれらの使用方法 |
| PT931830E (pt) | 1993-02-16 | 2001-08-30 | Onyx Pharma Inc | Virus citopaticos para terapia e profilaxia de neoplasia |
| PT1486211E (pt) | 1993-04-30 | 2009-02-02 | Wellstat Biologics Corp | Composições para tratamento do cancro utilizando vírus |
| WO1995010608A1 (en) * | 1993-10-15 | 1995-04-20 | Foundation For Research And Technology - Hellas (Fo.R.T.H.) | Asymmetric hammerhead ribozymes and nucleotide sequences for their construction |
| US5631359A (en) | 1994-10-11 | 1997-05-20 | Ribozyme Pharmaceuticals, Inc. | Hairpin ribozymes |
| US6107027A (en) * | 1994-12-14 | 2000-08-22 | University Of Washington | Ribozymes for treating hepatitis C |
| US6110461A (en) * | 1997-08-13 | 2000-08-29 | Oncolytics Biotech Inc. | Reovirus for the treatment of neoplasia |
| US6136307A (en) | 1997-08-13 | 2000-10-24 | Oncolytics Biotech Inc. | Reovirus for the treatment of cellular proliferative disorders |
| NZ518945A (en) | 1997-10-09 | 2007-03-30 | Wellstat Biologics Corp | Treatment of neoplasms with viruses |
| US6307041B1 (en) | 1998-03-28 | 2001-10-23 | University Of Utah Research Foundation | Circular, hairpin, circular/hairpin, lariat, and hairpin-lariat hammerhead ribozymes |
| WO2000024912A1 (en) * | 1998-10-23 | 2000-05-04 | The Children's Medical Center Corporation | Use of a self-cleaving rna motif to modulate gene expression |
| US7122645B2 (en) * | 2000-03-27 | 2006-10-17 | Smithkline Beecham Corporation | Detection of viable agents |
| TWI289158B (en) | 2000-08-10 | 2007-11-01 | Oncolytics Biotech Inc | Method of producing infectious reovirus |
-
2002
- 2002-03-04 CA CA002374388A patent/CA2374388C/en not_active Expired - Fee Related
-
2003
- 2003-02-25 TW TW092103911A patent/TWI329132B/zh not_active IP Right Cessation
- 2003-02-26 DK DK03704136.5T patent/DK1481084T3/da active
- 2003-02-26 EP EP03704136A patent/EP1481084B1/en not_active Expired - Lifetime
- 2003-02-26 AU AU2003206587A patent/AU2003206587B2/en not_active Ceased
- 2003-02-26 BR BR0307882-5A patent/BR0307882A/pt not_active IP Right Cessation
- 2003-02-26 AT AT03704136T patent/ATE519860T1/de not_active IP Right Cessation
- 2003-02-26 DE DE03704136T patent/DE03704136T1/de active Pending
- 2003-02-26 JP JP2003571491A patent/JP4369243B2/ja not_active Expired - Fee Related
- 2003-02-26 MX MXPA04008277A patent/MXPA04008277A/es active IP Right Grant
- 2003-02-26 ES ES03704136T patent/ES2241506T3/es not_active Expired - Lifetime
- 2003-02-26 WO PCT/CA2003/000264 patent/WO2003072811A2/en not_active Ceased
- 2003-02-26 NZ NZ534488A patent/NZ534488A/en unknown
- 2003-02-26 TR TR2005/01513T patent/TR200501513T3/xx unknown
- 2003-02-26 EP EP11176991A patent/EP2439286A1/en not_active Withdrawn
- 2003-02-26 AR ARP030100637A patent/AR038849A1/es unknown
-
2004
- 2004-08-04 ZA ZA2004/06231A patent/ZA200406231B/en unknown
-
2008
- 2008-09-12 JP JP2008235697A patent/JP2009005712A/ja not_active Withdrawn
-
2012
- 2012-03-29 JP JP2012077593A patent/JP5615865B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| TWI329132B (en) | 2010-08-21 |
| AR038849A1 (es) | 2005-01-26 |
| EP1481084A2 (en) | 2004-12-01 |
| ES2241506T1 (es) | 2005-11-01 |
| AU2003206587B2 (en) | 2007-03-15 |
| JP5615865B2 (ja) | 2014-10-29 |
| TR200501513T3 (tr) | 2005-06-21 |
| JP2009005712A (ja) | 2009-01-15 |
| BR0307882A (pt) | 2004-12-28 |
| DK1481084T3 (da) | 2011-09-26 |
| TW200404099A (en) | 2004-03-16 |
| ATE519860T1 (de) | 2011-08-15 |
| CA2374388A1 (en) | 2003-08-28 |
| WO2003072811A2 (en) | 2003-09-04 |
| MXPA04008277A (es) | 2004-11-10 |
| NZ534488A (en) | 2008-04-30 |
| ZA200406231B (en) | 2005-11-30 |
| EP2439286A1 (en) | 2012-04-11 |
| HK1067664A1 (en) | 2005-04-15 |
| EP1481084B1 (en) | 2011-08-10 |
| JP2005518797A (ja) | 2005-06-30 |
| JP4369243B2 (ja) | 2009-11-18 |
| AU2003206587A1 (en) | 2003-09-09 |
| CA2374388C (en) | 2005-07-12 |
| WO2003072811A3 (en) | 2004-02-05 |
| ES2241506T3 (es) | 2011-12-13 |
| JP2012125257A (ja) | 2012-07-05 |
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| DE03704136T1 (de) | Verwendung von ribozymen zur detektion ebenfalls vorhandener agenzien | |
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