DD276092A1 - PROCESS FOR THE PREPARATION OF ALKYL AND ARALKYLTHIO CYANOFORMHYDRAZONES - Google Patents
PROCESS FOR THE PREPARATION OF ALKYL AND ARALKYLTHIO CYANOFORMHYDRAZONES Download PDFInfo
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- DD276092A1 DD276092A1 DD32047388A DD32047388A DD276092A1 DD 276092 A1 DD276092 A1 DD 276092A1 DD 32047388 A DD32047388 A DD 32047388A DD 32047388 A DD32047388 A DD 32047388A DD 276092 A1 DD276092 A1 DD 276092A1
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- German Democratic Republic
- Prior art keywords
- alkyl
- preparation
- aralkylthio
- cyanoformhydrazones
- general formula
- Prior art date
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Diese Erfindung betrifft ein Verfahren zur Herstellung von Alkyl- und Aralkylthio-cyanoformhydrazonen. Das Wesen der Erfindung besteht in der Umsetzung von Natriumcyanohydrazonothioformiat-monohydrat mit Alkyl- und Aralkylhalogeniden.This invention relates to a process for the preparation of alkyl and aralkylthio-cyanoformhydrazones. The essence of the invention is the reaction of sodium cyanohydrazonothioformate monohydrate with alkyl and aralkyl halides.
Description
Die Erfindung betrifft ein Verfahren zur Herstellung von Alkyl- und Aralkylthiocyanoformhydrazonen durch Reaktion von Alkyl- und Arylhalogeniden mit Natriumcyanohydrazonothloformiat-monohydrat. Derartige Verbindungen haben Interesse als Zwischenprodukte für die Synthese von potentiell biologisch aktiven Substanzen.The invention relates to a process for the preparation of alkyl and Aralkylthiocyanoformhydrazonen by reaction of alkyl and aryl halides with Natriumcyanohydrazonothloformiat monohydrate. Such compounds are of interest as intermediates for the synthesis of potentially biologically active substances.
Bekannt ist lediglich das Methylthio-cysnoformhydrazon. Es wurde durch Umsetzung von Natriumcyanohydrazonothioformiatrrionohydrat mit Dimethylsulfat In mäßigen Ausbeuten hergestelltOnly the methylthio-cysnoformhydrazone is known. It was prepared by reacting Natriumcyanohydrazonothioformiatrrionohydrat with dimethyl sulfate in moderate yields
H. U. Kibbel, T.Tesch, Z. anorg. allg. Chem. 476,33-40, (1981) H. U. Kibbel, T.Tesch, Z. anorg. General Chem. 476, 33-40, (1981)
Ziel der Erfindung ist das Auffinden eines einfachen technischen Verfahrens zur Darstellung der Ti'.elverbindungen aus technisch leicht zuganglichen Ausgangsstoffen und in hohen Ausbeuten, welche zugleich eine breite Variation des Substituendenmusters gestattet.The aim of the invention is to find a simple technical process for preparing the Ti'.elverbindungen from technically readily available starting materials and in high yields, which also allows a wide variation of the substituent pattern.
denen R obige Bedeutung besitzt, umgesetzt worden.where R has the above meaning, has been implemented.
grau-weiß gefärbten Reaktionsprodukte nach dem Absaugen und Waschen mit Wasser umkristallisiert.gray-white colored reaction products are recrystallized after filtration with suction and washing with water.
Die Erfindung wird durch nachfolgend aufgeführtes Beispiel und die Daten der Tabelle näher erläutert, ohne darauf beschrankt zu sein.The invention is explained in more detail by the example listed below and the data of the table, without being limited thereto.
0,01 Mol Natriumcyanohydrezonothloformlat-monohydrat werden mit 0,01 Mol Alkyl· bzw. Arelkylhalogenld In 60mi Methanol 1 ,6-3 Stunden bei Raumtemperatur gerührt. Die filtrierte Reaktionslösung wird bis zum Festprodukt eingeengt, mit Wasser versetzt und erneut filtriert, mit Wasser gewaschen und aus Ethanol/Wassbr umkristallisiert.0.01 mol of sodium cyanohydrezonothloformate monohydrate are stirred with 0.01 mol of alkyl or aralkyl halide in 60 ml of methanol for 1 to 6 hours at room temperature. The filtered reaction solution is concentrated to the solid product, mixed with water and filtered again, washed with water and recrystallized from ethanol / Wassbr.
4-CI-CH4-CH, Cl4-CI-CH 4 -CH, Cl
4-Br-C,H4-CHi Br4-Br-C, H 4 -CHi Br
4-NOrC,H4-CH, Br4-NO r C, H 4 -CH, Br
CHi ICHi I
λ% 09Ζλ% 09Ζ
N0-S-C=N-NH2-H2O CNN 0 -SC = N-NH 2 -H 2 O CN
R-XR-X
ι:ι:
R-S-C=N-NH2 CNRSC = N-NH 2 CN
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DD32047388A DD276092A1 (en) | 1988-10-05 | 1988-10-05 | PROCESS FOR THE PREPARATION OF ALKYL AND ARALKYLTHIO CYANOFORMHYDRAZONES |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DD32047388A DD276092A1 (en) | 1988-10-05 | 1988-10-05 | PROCESS FOR THE PREPARATION OF ALKYL AND ARALKYLTHIO CYANOFORMHYDRAZONES |
Publications (1)
Publication Number | Publication Date |
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DD276092A1 true DD276092A1 (en) | 1990-02-14 |
Family
ID=5602958
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DD32047388A DD276092A1 (en) | 1988-10-05 | 1988-10-05 | PROCESS FOR THE PREPARATION OF ALKYL AND ARALKYLTHIO CYANOFORMHYDRAZONES |
Country Status (1)
Country | Link |
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DD (1) | DD276092A1 (en) |
-
1988
- 1988-10-05 DD DD32047388A patent/DD276092A1/en not_active IP Right Cessation
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