DD249850A1 - PASTOES MOUTH AND TOOTH CARE - Google Patents

Abstract

The invention is a pastoeses oral and dental care product with improved utility value. A fluorine-containing oral and dental care product is to be developed, which is characterized by additional positive effects on the hard tooth substance. The new pastous oral and dental care contains not only conventional ingredients but also a combination of a known fluorine compound with depot effect, which provides 0.05 to 0.2 wt .-% fluorine based on the inventive agent, and 0.25 to 5 wt. % of one or more physiologically acceptable water-soluble calcium salts without reaction to water insoluble inactive calcium fluoride.

Description

Field of application of the invention

The invention relates to pasty oral and dental care products, which are characterized by an improvement in utility.

Characteristic of the known technical solutions

Mouth and dental care products are known which contain fluorine compounds, such as inorganic and organic salts of hydrogen fluoride, hexafluorosilicic and monofluorophosphoric acid, singly or in combination (DOS 3044448, Schrader, K .: Principles and Formulations of Cosmetics, Dr. Alfred Hüthig, Verlag Heidelberg , 1979, p.403ff.). In addition, pasty oral and dental care products contain calcium-containing or calcium-free water-insoluble abrasives in addition to essential oils, binders and moisturizers and thickeners (Jellinek, J.S .: Cosmetology, Dr. Alfred Hüthig, Verlag Heidelberg, 1979, p.376ff.).

So far, however, there are no pasty oral and dental care containing water-soluble Caicium salts in addition to bioavailable fluorine, as occurs in the prior art, a time-dependent mutual inactivation by formation of the corresponding calcium fluorine compounds, although both bioavailable calcium ions and fluorine an important role in the Remineralization of dental hard tissue in terms of caries prophylaxis (SiIverstone, LM and M .: Remineralization of natural and artificial lesions in human dental enamel in vitro.) Effect of Calcium Concentration of the Calcifyning Fluid Caries Research 15 [1981] 138-157 ; Grube, M. and M: Studies on the Remineraiisation of Initial Caries Stomatol, DDR 36 [1986] 204-209). In contrast to water-soluble calcium salts, water-insoluble calcium-containing substances such. As calcium carbonate and calcium hydrogen phosphate, which are contained in known pasty oral and dental care products, donate calcium ions to the saliva and promote the Remineralisationsprozeß. Such compounds can only work if they get into the bloodstream by ingesting toothpaste which is not customary per se, and from there into the bloodstream.

Object of the invention

The object of the invention is therefore to provide a pasty fluorochemical oral and dental care product, which has a ges + eigerte caries-prophylactic activity by the additional presence of water-soluble Caicium salts.

Explanation of the essence of the invention

The object of the invention is / a pasty oral and dental care by a suitable combination of fluorine and calcium compounds to modify so that their effectiveness is increased without premature inactivation of the active ingredients.

This object is achieved by a pasty oral and dental care product which contains, in addition to customary constituents, a per se known n-alkylamine hexafluorosilicate having 16 to 22 carbon atoms in combination with water-soluble physiologically acceptable calcium salts.

According to the invention, the n-alkylamine hexafluorosilicate provides 0.05 to 0.20 wt .-%, preferably 0.075 to 0.18 wt .-% fluorine, based on the pasty oral and dental care products, while the Caiciumalze to 0.25 to 5.0Gew.-. %, preferably 0.25 to 2.5 wt .-% are included.

Surprisingly, free calcium ions in addition to fluorine remain in the pasty oral and dental care products even after prolonged storage (Table 1), although an inactivation by formation of calcium fluorine compounds was to be expected.

In particular, bioavailable fluorine is detectable in the mouth up to 100 minutes after toothbrushing, after the water-soluble calcium salts have given their well-known pasty effect on the remineralizing power of the saliva immediately after application of the pasty oral and dental care product (Table 2).

Table 1

storage % Fluorine % Calcium at 44 ° C in months 0,150 0.182 0 0.156 0,179 1 0; 148 0,175 2 0,149 0.177 4 0.148 0,179 6

Fluorine was determined with the ion-sensitive electrode, calcium by titration with EDTE in the aqueous filtrate of the toothpaste.

Table 2

Fluorine content in ppm / 0.2ml saliva

Time min

Toothpaste without calcium salt

Toothpaste with 1% calcium lactate

before application 0.057 after application 8.373 15 3,030 10 0.805 20 0.424 30 0,248 40 0,187 60 0.141 100 0.081

0.061 3.987 3.115 1.173 0.388 0.237 0.208 0.109 0.087

The measurement was carried out with the ion-sensitive electrode.

It was particularly interesting that the fluorine content in the saliva after 5 minutes more significantly different between toothpastes with and without soluble calcium salt.

embodiment

The dentifrice base is prepared in a conventional manner and then mixed with the indicated amounts of n-amine hexafluorosilicate and calcium acacia under vacuum to complete homogeneity.

The preparation of the n-alkylamine hexafluorosilicate suspension is described in WP A61 K / 218971 or in DDR-PS 149019.

example 1

Carboxymethylcellulose 2.00%

fumed silica. 1.50%

precipitated silica 5.20%

Calcium pyrophosphate 15.00%

Glycerol 9.00%

Sorbitol 10.00%

Aroma composition 1.00%

Saccharin 0.20%

Sodium salt of pentadecylsulfonate35% 11.00%

n-Alkylamine hexafluorosilicate suspension 5.31% = 0.18 '

Calcium lactate 1.00% water ad 100

Example 2 1.50% ^ 0.1% fluorine hydroxyethyl 1.20% fumed silica 7.00% precipitated silica 18.00% calcium pyrophosphate 8.00% Clycerol 6.00% sorbitol 1.00% aroma composition 0.20% saccharin 2.00% sodium lauryl sulfate 2.95% n-Alkylaminhexafluorsilikat suspension 0.25% calcium chloride 0.50% calcium sorbate Water ad 100 & 0.075% Flour Example 3 2.00% carboxymethylcellulose 1.20% fumed silica 6.00% precipitated silica 20.00% calcium pyrophosphate 20.00% sorbitol 1.00% aroma composition 0.20% saccharin 1.50% Sodium sulphate 2.21% n-Alkyiaminhexafluorsilikat suspension 4.50% calcium lactate 0.50% calcium sorbate Water ad 100

Claims (2)

1. Pastous oral and dental care products, characterized in that, in addition to components known per se, a combination of n-alkylamine hexafluorosilicate with 16 to 22 carbon atoms, which provides 0.05 to 0.2 wt .-% fluorine based on the composition of the invention and 0.25 to 5% by weight of water soluble physiologically acceptable calcium salts, wherein no inactive calcium fluorine compound is formed. 2. Pasty oral and dental care product according to item 1, characterized in that the combination preferably contains 0.075 to 0.18 wt .-% of fluorine in the form of n-alkylamine hexafluorosilicate and 0.25 to 2.5 wt .-% calcium salts.