DD236256A1 - SKIN AND HAIR CARE - Google Patents

Abstract

The invention relates to skin and hair care products, as they are common in cosmetics and pharmacy as anti-dandruff. The hitherto most effective active ingredients, the selenium disulphide and the salts and derivatives of pyrithione, require due to their properties special measures in the construction, manufacture and packaging of anti-dandruff agents. These, as well as other suggested remedies, lead to stimulation of the sebaceous glands in multiple use, resulting in a strong and fast greasy hair. The object of the invention was to use active substances which do not require such measures and which do not additionally stimulate sebum secretion secretion when the agents are used. The object was achieved by incorporating 2-mercaptoquinoxalines, which may contain an adjacent hydroxyl or amino group, into the chosen bases and application forms in concentrations of 0.01 to 2.00% as active ingredients.

Description

Object of the invention

It is the object of the invention to develop cosmetic and pharmaceutical skin and hair care products with an active ingredient which does not have said galenic deficiencies, is economically accessible, has a good anti-dandruff effect and does not cause additional scalp fat.

Explanation of the essence of the invention

The object was to develop cosmetic and pharmaceutical skin and hair care products with an active ingredient which has sufficient solubility in the galenic bases, is stable against atmospheric oxygen and light, has a normalizing influence on the increased cell formation and disturbed keratinization Sebaceous gland activity is not additionally stimulated, but normalized.

The object is achieved in that in the cosmetic and pharmaceutical skin and hair care products at least one compound of general formula (1)

SH

has been incorporated, in which R may be hydrogen, or a hydroxy or amino group.

The compounds of formula (1) are already known. Their production and properties are u. a. in DE-PS 1117 586 and Chem. Pharm. Bull. (Tokyo) 9 (1961), 941-944. Since they have a certain insecticidal and acaricidal activity, they are mainly used as pesticides. But they should also be suitable for the treatment of fungal skin diseases or collagenoses. However, a regulatory effect on increased cell neoformation and disturbed keratinization was unpredictable and completely surprising from this application.

For the inventive use of these compounds, the most diverse skin and hair care products come into consideration. Particularly advantageous is the use in shampoos, since at the same time the loose flakes are washed off during cleaning and so are accompanied by cleaning and dandruff treatment. Since these compounds dissolve sufficiently well in the cosmetic and pharmaceutical bases, these shampoos need no special requirements in terms of composition and consistency. Therefore, it is also possible to use the customary surfactants, emulsifiers, solubilizers, refatting agents, consistency regulators, pearlescing agents, pigments, other auxiliaries and active substances, as well as perfume oils, dyes, etc. This also applies to other forms of application, such as lotions, creams, gels, aerosols, aqueous-alcoholic solutions, etc. The required in the skin and hair care agents drug concentrations are fundamentally dependent on the nature of the application of these agents. For those who spend a long time on the scalp, such. As hair lotions, tonic, tinctures, hair fixatives, can already meet a concentration between 0.01 and 0.5%. Agents that remain on the skin only for a short time, such as shampoos, hair conditioners, but also concentrates, may have a higher concentration. It should suitably be between 0.5 and 1.0%, but it can also be significantly higher. The concentration of active ingredients required in each case results ultimately from the type of cosmetic or pharmaceutical agent, its application and the desired effect, taking into account the possible influence between the active ingredient and the basis. Even at higher concentrations, the proposed active ingredients are excellent mucous membrane compatible. Thus, according to the method of NEUMANN and AALBERS in the conjunctival test on the rabbit eye irritation indices between 7 and 8 were found for the 1% solutions. In this test, the observed irritations are related to those of a 2% aqueous solution of sodium dodecylsulfate, which have an irritation index of 10. The sodium dodecyl sulfate is known as an extremely mucous compatible surfactant. In the pH range from 4 to 8, which is suitable for Externa, the active substances are resistant to hydrolysis and light and do not react with atmospheric oxygen. When using these active ingredients according to the invention, therefore, no additional requirements have to be placed on the technology or the packaging in the production and packaging of the skin and hair care products. The excellent effectiveness of the skin and hair care products according to the invention could be convincingly demonstrated in the application test on 28 test persons. Of these subjects, about 45% had a strong dandruff infestation and about 55% had a less severe one. In 12 people, the scalp was mostly dry, in the other 16 people very greasy. The selected care product corresponded to a hair tonic and was as simple as possible to eliminate other influences. It contained: isopropanol 40 g, 2-hydroxy-3-mercapto-quinoxaline 0.08 g, perfume 0.08 g and water 58.8 g. The hair tonic was used by the test persons daily or every other day over a period of 4 weeks, depending on dandruff. This was followed by a final assessment, taking into account the use of the subjects. Conspicuous were the excellent anti-dandruff action even in very persistent cases, the simultaneous decay of the increased sebaceous gland activity and the good tolerability of the test preparation. A negative influence on the manageability or the appearance of the hair was not indicated by any test person.

embodiments

1. shampoo 20.00 Sodium lauryl ether sulfate (28% WAS) Natriumlaurylpolyglykolethersulfo- 30.00 succinate (40% WAS) 2.50 Kokosfettsäurepolydiethanolamid Ethoxylated, hydrogenated lanolin 2.00 (20 EO) 0.10 2-mercapto-quinoxaline 0.90 2-hydroxy-3-mercaptoquinoxaline 0.50 perfume oil ad 100.00 water

2nd course shampoo

Sodium lauryl ether sulfate (28% WAS)

Natriumlaurylpolyglykolethersulfo-

succinate (40% WAS)

Laurinsäureimidazolin

Kokosfettsäurepolydiethanolamid

diglycol stearate

Ethoxylated, hydrogenated lanolin

2-hydroxy-3-mercaptoquinoxaline

2-amino-3-mercaptoquinoxaline

perfume oil

water

ad

10.00

25.00 8.00 3.00 3.00

2,00 1,10 0,20 0,90 100,00

3. Hair tonic 20.00 isopropanol ethanol 35,00 menthol 0.10 2-hydroxy-3-mercaptoquinoxaline 0.10 perfume oil 0.30 water ad 100.00 4. Tonic as an aerosol isopropanol 60,00 Cetylstearylalkohol 2.00 stearyltrimethylammonium 0.30 menthol 0.10 2-mercaptoquinoxaline 0.08 2-amino-3-mercaptoquinoxaline 0.10 perfume oil 0.30 water 28,00 Dichlorodifluoromethane 4.00 dichlorotetrafluoroethane 6.00 5. Spa emulsion, type O / W cetyl alcohol 5.00 glycerol 4.00 isopropyl myristate 10.00 Wheat germ oil 1.00 Ethoxylated, hydrogenated lanolin (20 EO) 1.50 2-hydroxy-3-mercaptoquinoxaline 0.80 perfume oil 0.40 preservative 0.20 water ad 100.00

The quantities of all examples were in grams. The preparation of the skin and hair care products is possible by the usual methods in cosmetics and pharmacy. Special measures that could result from the use of the active ingredients are not required.

Claims (2)

1. skin and hair care products for the treatment of dandruff, characterized in that they contain as active ingredient at least one compound of the general formula in which R is hydrogen or a hydroxy or amino group, in admixture with a carrier customary for skin or hair care products. - 1 - / α <£ ΌΗ Invention claim: 2. skin and hair care products according to item 1, characterized in that the active ingredients alone or in a mixture in the chosen bases and application forms are used in concentrations of 0.01 to 2.00%. Field of application of the invention The invention relates to cosmetic and pharmaceutical skin and hair care products containing an active ingredient for controlling dandruff, especially dandruff. Characteristic of the known technical solutions The most common deficiency symptoms that appear on the hairstyle are the greasy hair and dandruff. The dandruff themselves are different in quantity and shape. From a dry scalp, they are repelled as small particles, with a concomitant increased sebaceous gland activity, they stick to larger, greasy aggregates. The dandruff is not only limited to the scalp, but affects the whole organ skin. It is often difficult to distinguish dandruff from serious skin conditions, such as seborrheic dermatitis or psoriasis, which are also accompanied by increased and visible dandruff. Clinical laboratory investigations on dandruff development and underlying cell kinetics have shown that dandruff formation is characterized by significant overproduction of horny cells and, at the same time, disturbance of the keratinization process. For example, a nest-like parakeratosis is recognizable in the epidermal stratum corneum, and the rate of new cell formation in the germ layer and the migration rate of the cells have increased significantly. As causes of these phenomena constitutional and externally acting factors are discussed, such as a chronic irritation by metabolic products of the predominantly on the scalp abundant microorganisms or by components of their enzymatically degraded sebum. Of particular importance is attributed to the microorganism Pityrosporum ovale. Nevertheless, it is not possible to combat the scales with antimicrobial agents, as they are commonly used for disinfection or preservation and how the z. B. with the use of phenols, hydroxyquinolines or quaternary ammonium compounds has been tried. Although the increased dandruff formation is always caused, an effective active substance must bring the increased cell formation as well as the qualitatively and quantitatively disturbed keratinization back to a normal level. The currently most effective dandruff treatment agents include the selenium disulfide or Zn salt or the derivatives of 2-mercapto-pyridine N-oxide (pyrithione). Nevertheless, these agents do not meet the high demands that are made especially on a cosmetic, the selenium disulfide may be used only limited because of its general toxicity anyway. They are relatively toxic, not hydrolysis resistant, are oxidized by the atmospheric oxygen and are insufficiently stable when exposed to light. Such negative properties may affect the effectiveness of the care product or necessitate additional measures in the production and packaging which lead to a significant increase in the cost of the product. In particular, the effort required when using the insoluble active ingredients selenium disulfide and Zn-pyrithione becomes clear. The corresponding care products, predominantly shampoos, gels and lotions, must here have a high viscosity, so that the active ingredients can not sediment and even with prolonged storage inhomogeneity is prevented. If, in addition, the expected dermatological and utility-value-forming properties are considered, which include the effectiveness, it must be stated that the 5-hydroxy-tetralines or indanes proposed in DE-OS 3 215 341, which are described in DE-OS 3 045 340 mentioned 4-oxo-2-thioxo-1,3-thiazolidines, mentioned in DE-OS 3 022 799 2-oxo-tetrahydro-1,3,5-thiadiazines or in DE-AS 2 234 009 proposed 1-hydroxy 2-pyridone does not fully meet the requirements. Another deficiency is evident in the application of the care products prepared thereafter. Although it is usually after repeated application of the remedy, the dandruff more or less back, but at the same time the sebaceous secretion is stimulated, the hair gets greasy and sticky faster. This feature is therefore particularly unpleasant, because dandruff is usually accompanied by an increased sebaceous gland activity anyway. According to DE-OS 3,142,296, the 1-hydroxytetralins and the 1-hydroxyindanes are preferably not said to have this deficiency, but it is rightly only spoken that a much slower re-oiling occurs and so this phenomenon is only slightly delayed.