DD218631B1 - CLEANING AGENT WITH NO CHEMICAL EFFECT - Google Patents

Description

Field of application of the invention

The invention relates to a liquid detergent that has the character of a multipurpose cleaner and due to its keimindernden or germicidal effect for general use in households, commercial kitchens and other Gemeinschaftsseinrichtuangen, such as baths and saunas, as well as determined in certain areas of the food industry or medicine is.

Characteristic of the known technical solutions

Detergents having a disinfectant action are increasingly in use, particularly in hospitals and other facilities where the introduction or spread of undesirable microorganisms must be controlled. Increasingly, anti-bacterial detergents are also desired for general household use. The known such disinfectant acting mostly cleaning (list of tested disinfection method of 1.2.1979, published in Hygiene and Medicine 4 [1979] 84-105) contain cleaning substances in addition to a wide variety of bioactive agents. Thus, combinations of quaternary ammonium compounds, so-called quats, aliphatic aldehydes or phenols with surfactants are used as disinfectants (DE-AS 2916304, US-PS 4336151.4336152). Halogenated phenols or alkylphenols are also used as biocidal active substances in detergents. Also known is the biocidal effect of alkyltin compounds or sodium hypochlorite contained in detergent formulations.

Finally, it is also known to use hydrogen peroxide usually in the form of its derivatives, in particular as peracetic acid, as antimicrobial active ingredient in cleaners (DL-PS 96833, DE-AS 2622761), or hydrogen peroxide and / or peracetic acid in aqueous sterilization and depyrogenation solutions in the preparation of pharmaceuticals to use (DE-OS 3134050). However, these aqueous sterilization solutions are not cleaners and are not used successfully for cleaning purposes.

All cleaning disinfectants or disinfectant cleaning agents known hitherto have a number of disadvantages which considerably limit their possibilities of use:

- Quaternary ammonium compounds (quats) are highly toxic. Their use in the food industry is particularly problematic. The treated containers and surfaces must be thoroughly rinsed with water.

- Aliphatic aldehydes, especially formaldehyde, have a strong sensitizing effect and so often cause allergies, which prohibit the handling of these substances for a large group of people.

- Particularly disadvantageous affects the poor biodegradability in most compounds. Therefore, the use of these disinfecting detergents is associated with a considerable environmental impact.

- Hypochlorite detergents, when blended with other household chemicals, may release free chlorine, which is an immediate health hazard to the user.

- Containing hydrogen peroxide or peroxygenic compounds finally lose due to decomposition of the active substance very quickly to effectiveness, since so far no sufficient stabilization of these active ingredients in surfactant-containing cleaners.

In addition, the known disinfectant detergents usually have only a low cleaning power and fertility, so that, for example, their use is limited as a full-fledged multipurpose detergent in households.

Object of the invention

The aim of the present invention is a cleaning agent that has improved cleaning properties and, with sufficient germ-reducing effect over a longer period of time allows safe, broad application.

Explanation of the essence of the invention

The object of the present invention is therefore to provide a liquid cleaning agent which contains a germ-reducing active substance which is harmless to the human organism in suitable combination with surfactants and cleaning-enhancing components and which is readily biodegradable in wastewater.

This object is achieved by a cleaning agent with a nucleating effect based on hydrogen peroxide according to the invention in that it 3 to 35Ma .-% anionic and / or nonionic surfactants, 1.5 to 18Ma .-% organic and / or inorganic cleaning adjuvants, 0.5 to 8% by mass of hydrogen peroxide, 0.02 to 4% by mass of complexing agent and 0 to 2% by mass of perfume and balance to 100% by mass of water.

As anionic surfactants, the cleaning agent contains alkanesulfonates, alkylbenzenesulfonates, in particular their sodium salts, alkyl sulfates, ether sulfates, individually or in a mixture. The nonionic surfactants are preferably alkyl polyglycol ethers and / or alkylphenyl polyglycol ethers.

It is particularly advantageous if sodium alkanesulfonates and alkylphenyl polyglycol ethers in a mass ratio of 5: 1 to 1: 1 are used and the alkanesulfonates consist of di- and polysulfonates of up to 10% by mass.

As cleaning auxiliaries alkali metal salts of phosphoric acid and / or of polyphosphoric acids and urea are preferably used, wherein the mass ratio of phosphates / urea 4: 1 to 1: 2.

Finally, the complexing agents are preferably sodium salts of ethylenediaminetetraacetic acid and / or nitrilotriacetic acid.

Hydrogen peroxide has proven to be a microbistatic component with very good properties, which in addition to its microbistatic effect has the particular advantage of toxic safety, good skin tolerance and easy biodegradability. In the detergent composition according to the invention, the hydrogen peroxide is surprisingly so well stabilized that after a storage period of 1 year more than 90% of its original content is contained in the cleaner.

The detergent according to the invention further has excellent cleaning power and fertility, so that it can be used as a multipurpose cleaner universal in the modern household and with great effectiveness in other areas. While for normal use, the detergent is diluted with water in the ratio of about 1: 300 to 1: 500, it is also possible to use the concentrate undiluted in heavy soiling.

The cleaning agent is particularly suitable for all hard surfaces made of glass, ceramics, enamels, plastics, painted surfaces, wood and metal. However, good results are also achieved, for example, when cleaning textiles and floor coverings.

The preparation of the cleaning agent is carried out in a simple manner by mixing or dissolving the components in water, where appropriate hydrogen peroxide is added as the last component.

Furthermore, the cleaning agent compared to currently used other universal cleaners a much better skin compatibility. Likewise, the toxicity is significantly lower compared to other detergents with germ-reducing effect.

embodiments example 1

A detergent of the following composition is prepared:

Water 66.9Ma .-%

Sodium alkanesulfonate emulsifier E30 12.5% by mass

Alkylphenyl polyglycol ether PräwozellWON 100 5.0Ma .-%

Graham's salt 5.0Ma .-%

Urea 6.0% by mass

ChelaplexIII - Disodium dihydrogenethylenediaminetetraacetate 0.1% by mass

Hydrogen peroxide 4.0Ma .-%

Perfume oil 0.5% by weight

The cleaning effect is tested after the tile test according to TGL 34147 with a 0.1% liquor. Result: 53 tiles. The germ-reducing effect is determined by the bacteriostasis test (W. Weuffen, D. Martin, M. Schade, Pharmacie 18 [1963] 420).

The following table summarizes the minimum inhibitory concentrations of the 1: n diluted detergent versus various strains.

absolute inhibition diminishes. growth

Staphylococcus aureus RLD 1: 1000 1: 2,000

Enterococci (D) 1: 1000 1: 1000

Escherichia coliRLD 1: 500 1: 1000

Proteus mirabilis 1: 250 1: 500

Pseudomonas aeruginosa 1: 250 1: 500

Resistance of the active substance hydrogen peroxide:

After storage for one year at 298K, the hydrogen peroxide content is found to be 3.69 mass%. That's 92.25% of the original amount.

Example 2

A detergent of the following composition is prepared:

Water 70.3 mass%

Sodium alkyl benzene sulfonate - Rodapon N 50 10.0% by mass

Alkyl polyglycol ether Pre-cell F 1618/100 4.0Ma .-%

Graham's salt 4.0Ma .-%

Urea 8.0% by mass

ChelaplexIII - Disodium dihydrogenethylenediaminetetraacetate 0.1% by mass

Hydrogen peroxide 3, 2Ma .-%

Perfume oil 0.4% by mass

The cleaning effect is tested after tile test according to TGL 34147 with a 0.1% liquor. Result: 52 tiles. The determination of the germ-reducing effect and tabulated compilation of the results is carried out as in the example

absolute inhibition diminishes. growth

Staphylococcus aureus RLD 1: 1000 1: 2

Enterococci (D) 1: 500 1: 1000

Escherichia CoIi RLD 1: 250 1:

Proteus mirabilis 1: 250 1:

Pseudomonas aeruginosa 1: 125 1:

Resistance of the active substance hydrogen peroxide:

After storage for one year at 298 K, a hydrogen peroxide content of 3.68% by mass is determined. That's 92.1% of the original amount.

Results of the animal experimental compatibility, determined in Example 1:

1. Acute oral LD ₅₀

Methods: 10 mice (sex ratio 1: 1), strain ICR Schönwalde, body mass 19-25g were used per dose and the mortality rate was determined within 24 hours after oral administration by gavage. The LD ₅₀ and its confidence levels were graphically reported by Litchfield and Wilcoxon, H. Pharmacol, exp. Therap. 96 (1949), 99. The test substances were administered undiluted

Result: The acute oral LD ₅₀ is 5.4 g / kg body mass (upper confidence limit 6.2, lower confidence limit 4.4).

2. IT ₅₀ (Tempus irritans)

Methods: Five albino guinea pigs (300-400g body mass were used per group, the animals were shaved on their backs.) After 24 h, 0.2 ml 5% test substance solution was pipetted onto the test area and massaged digitally into the skin for 30 sec. The test substance solution was applied 1 times / h for 10 days.

Result: After 10-day exposure, no skin reactions were detectable until the 12th reading day, i. the cleaner was tolerated without irritation in a dilution of 1:20.

3. Eye irritation

Method: The test substance was concentrated and applied at the application concentration of 1: 750 diluted on the guinea pig eye. Experimental procedure and evaluation were carried out according to Kranz and coworker Z. ges. Hygiene 24 (1978) 863-866

 Result:

test substance

Example 1 4.6 4.8 - - - - -

F = stimulus index for the period of the first 5 h after application Conj. = Stimulus index on the conjunctiva corn. = Stimulus index on the cornea

Example 3

A cleaning agent containing 50.9% by weight of water, 28.5% by weight of sodium alkanesulfonate and otherwise analogous composition as in Example 1 has in particular an increased cleaning action after the tile test. Result: 68 tiles.

Step Example! 4

In a modification of Example 1, the cleaning agent contains 11.2% by weight of alkylphenyl polyglycol ether, 73.2% by weight of water and no anionic surfactant.

Result of the test: - Cleaning effect: 44 tiles

- minimal inhibitory concentration (absolute inhibition) against Pseudomonas aeruginosa: 1: 125 diluted cleaner

Example 5

The cleaning agent of Example 1 contains no nonionic surfactant and correspondingly 71.9 Ma .-% water. The cleaning effect is reduced to 37 tiles after the tile test.

I.Tag 2 day irritation index 4th day 5th day F Conj. Corn. Conj. Com. З.Тад Conj. Corn. Conj. Com. Солі.Согп. Conj. Corn.

Example 6

The cleaning agent of Example 1 contains, instead of 4% by mass, 6.7% by mass of hydrogen peroxide. Result of the test: - Cleaning effect: 46 tiles after tile test

- minimal inhibitory concentration (absolute inhibition) over Pseudomonas aeruginosa: 1: 500 • diluted cleaner

Example 7

The cleaning agent of Example 1 contains Chelaplex III in a concentration of 2.3% by mass instead of 0.1% by mass and correspondingly less water. In particular, the resistance of the active substance hydrogen peroxide is markedly increased. After a storage period of 6 months at 298 K, the content of hydrogen peroxide is still 98.57% of the original amount.

Example 8

In a modification of Example 1, the detergent contains 10% by weight of Graham's salt and 5.2% by weight of urea and 62.7% by weight of water.

Result of the test: - Cleaning effect: 58 tiles.

- Hydrogen peroxide content after storage for 6 months at 298K: 3.78 mass%

Claims (7)

Invention claim: 1. Detergent with germ-reducing effect, characterized in that it From 3 to 35% by mass of anionic and / or nonionic surfactants, 1.5 to 18% by weight of organic and / or inorganic cleaning auxiliaries, 0.5 to 8% by weight of hydrogen peroxide, 0.02 to 4% by mass of complexing agent and 0 to 2% by mass of perfume and balance to 100% by mass of water. 2. Cleaning agent according to item 1, characterized in that it contains as anionic surfactants alkanesulfonates, alkylbenzenesulfonates, in particular their sodium salts, alkyl sulfates, ether sulfates, individually or in a mixture. 3. Cleaning agent according to item 1, characterized in that it contains as non-ionic surfactants alkylpolyglycol ethers and / or AlkylphenyIpolyglykolether. 4. Cleaning agent according to item 1 to 3, characterized in that it contains Natriumalkansulfonate and Alkylphenylpolyglykolether in the mass ratio 5: 1 to 1: 1. 5. Cleaning agent according to item 4, characterized in that it contains alkanesulfonates which consist of up to 10% by mass of di- and polysulfonates. 6. Cleaning agent according to item 1, characterized in that it contains as cleaning auxiliaries alkali metal salts of phosphoric acid and / or of polyphosphoric acids and ureas, wherein the mass ratio of phosphates / urea 4: 1 to 1: 2. 7. Cleaning agent according to item 1, characterized in that it contains as complexing agents sodium salts of ethylenediaminetetraacetic acid and / or nitrilotriacetic acid.