DD160449A1 - ABSORBENT WOUND ASSOCIATION - Google Patents

Abstract

The invention relates to an absorbent wound dressing for covering strongly wet, infectious wounds and affected areas in skin and tissue diseases. The wound dressing should be atoxic and tissue-compatible, the wound form well adapted and easily removed, protect against infection, in addition to the wound exudate and bacteria, fungi, toxins, proteins and Entzuendungsmediatoren record, sterilizable and nachsterilisierbar and promote the granulation and epithelization. According to the invention, the absorbent wound dressing consists of spheroidal particles of regenerated cellulose with a diameter of 0.05 to 0.5 mm, optionally after being impregnated with therapeutically active substances, suitably dried with preservation of the macroporous structure, sterilized with gamma rays and in a layer thickness from 2 to 5 mm can be applied to the wound. The applications of the invention are in the field of health care.

Description

gjfrel of the invention: Absorbent wound dressing

Field of application of the invention

The invention relates to an absorbent wound dressing which is used to cover heavily weeping, infectious wounds and affected areas in skin and tissue diseases, and Yerfahren for its production.

Characteristic of the known technical solutions

For the above-mentioned applications, in recent years, besides the powders tested in many years of pharmaceutical practice, in particular composite powders, the

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preferably consist of bactericidal or bacteriostatic agents and a base such as talc, lactose, starch, etc., also natural and synthetic polymers and copolymers have been found suitable u. a · chitin and chitosan (MIT Sea Grant Rep. MITSG 1978, Proc · Is · Couf. Chltin / Chitosan 1977, pp. 296-305), collagen (BE-PS 856603), cross-linked dextrans (ζ.Β · S. Scand J. Plast, Reconstr Surg 10 (1976) pp. 65-72), cellulose derivatives (ζ.Β. UL PS 6807540), polypropylene (GH-PS 472894), flexible polyurethane foams (ζ BH Bohmert, Med., Welt 28 (1977), pp. 826-831, S. Kiene, Dt. Gesundh.-Wesen 34 (1979) S. 2010-2014, W. Kothe et al., Medizin aktuell 10 (1979 ) S. 452 - 453), copolymers of cellulose and acrylic acid (GB-PS 1141271) and those of vinyl esters and unsaturated carboxylic acids (DS-OS 2653135). They are used either alone or as vehicles for active ingredients, eg. B. for bactericides or bacteriostats, bes. Antibiotics and sulfonamides, and for antimycotics; Such wound dressings are also recommended for the treatment of acne vulgaris and psoriasis. 7-

Among the materials that are mainly used drug-free, have mainly cross-linked dextrans and. Flexible polyurethane foams proven, the latter especially as': · λ synthografts. The atoxic, tissue-compatible and biologically inert materials have a relatively coarsely porous structure which enables them to absorb many times their own weight in water. When applied to wetting infectious wounds, they provide excellent wound cleansing and control by removing the wound exudate, bacteria, fungi, inflammatory mediators, toxins and their degradation products from the wound surface. Furthermore, because the materials can absorb proteins including fibrin-fibrinogen cleavage products, scabs are prevented at the same time. The granulation and epithelization on the other hand are promoted.

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The positive effects of the cross-linked dextran and polyurethane saccharide trees are counteracted by some disadvantages which restrict their use. Thus, the water or exudate uptake by the cross-linked dextrans becomes relatively slow. They swell into a gel-like push within which gas permeability is reduced. Dressings made of flexible polyurethane foam must be cut to size as they will otherwise be insufficiently adherent to the wound and, as a result, wound cleansing will be greatly reduced, overlapping with the healthy wound environment must be avoided and such dressings must be very frequent - preferably every 12 hours - be changed, otherwise the granules grow into the material and sirld only under, large-scale bleeding and pain sirld.

Object of the invention

The aim of the invention is a wound dressing, which has the positive effects of cross-linked dextranes and Polyurethaneweiehsch.äume, but at the same time overcomes their disadvantages shown, especially a non-toxic and tissue-compatible wound dressing, the

- the wound shape or the relevant skin and tissue part can be adapted,

- In addition to the pure cover and thus the protection against infection, from exuding wetting exudate quickly and gently removed for the patient,

- removes bacteria, fungi, toxins, proteins and inflammatory mediators in addition to the exudate

- does not swell to a gelatinous layer in the water or Exsudataufnahme,

- sterilizable and sterilizable,

- promotes granulation and epithelialization.

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Essence of the invention

- Task

The invention has for its object to develop on the basis of cellulose, a wound dressing, the biologically inert, d. H. is atoxic and tissue-compatible, and has the aforementioned properties.

Features of the invention

It has now been found that regenerated cellulose (perlcellulose) prepared according to the copying standard CS-UR 17264-0 and dried by a suitable process produces an absorbent wound dressing with the desired qualities. For this purpose, the regenerated cellulose (perlcellulose) is classified and freed from mechanical impurities. packed in suitable containers and sterilized with gamma rays. The classification is done by sieving, for which z * B. ski, vibration or shaker sieves can be used · The mechanical impurities can be removed by air classification or magnetically in drum separators. As packaging material Glasr ,, plastic or metal containers are suitable.

The regenerated cellulose used as a wound dressing (pearl \. Cellulose) consists of spherical, macroporous particles, having a diameter of 0.05 to 0.5 mm, preferably 'from 0.05 to 0.3 mm.

The pore structure ensures that the wound dressing can absorb aqueous oil secretions in an amount of 1.5 to 5 g HpO / g dry matter; The granular macrostructure remains largely intact, so that the powdered material in a layer thickness of 2 to 5 mm, preferably 2 to 3 mm, applied to the wound material can be rinsed with water effortlessly and largely painless again.

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While the aqueous exudate is primarily taken up in the macropores of the cellulosic parts, the capillary forces acting in the voids between the particles also remove bacteria, fungi, toxins, proteins and inflammatory mediators from the wound surface. The exudate uptake is faster than with the crosslinked dextrans and the cellulosic particles do not swell. If desired, therapeutically active substances can also be applied to the surface of the cellulose particles.

The following examples describe the preparation of the wound dressing and its impregnation with an active substance *

Example embodiments;

1. 100 g of perlcellulose (regenerated cellulose in Porm of *, spherical particles, prepared according to the CS-UR 172640 and a suitable drying method) by. Sieben with a vibrating or vibrating screen classified, the grain size range of 0.05 to 0.3 mm by air separation or magnetic in a drum separator of mechanical impurities, sealed in a suitable glass-v plastic or metal container vacuum-tight and sterilized with gamma rays.

2. 10 g of perlcellulose are washed with 500 ml of a 1% eth.anoliscb.en solution of bacitracin and subsequently with 500 ml of diethyl ether and dried in vacuo at room temperature to the weight. In this case, the antibiotic on the porous perl cellulose in an amount of 45 mg / g dry matter, d. h. 2,300 international units, precipitated.

Claims (9)

223 467 6 Invention claim Absorbent wound dressing, characterized in that it consists of spherical particles of regenerated cellulose. 2. Absorbent wound dressing according to item 4, characterized in that the spherical particles have a diameter of 0.05 to 0.5 mm, preferably 0.05 to 0.3 mm. 3- Absorbent wound dressing according to points 1 and 2, characterized in that the spherical particles contain an inacroporous structure which already has real pores in the dry state. 4. Absorbent wound dressing according to item & quot ; 1 to 3, dadurc, characterized in that it is sterilized by gamma rays. 5. Absorbing wound dressing after, the points, η. 1 to 4, characterized in that it is applied in powder form in a layer thickness of 2 to 5 mm, preferably 2 "to 3 mm, on the wounds. 6. Absorbent wound dressing according to: characterized in that it contains aqueous wound secretions in an amount of 1.5 to 5 g EUO / g dry matter including bacteria, fungi ,. Toxins, proteins and inflammatory mediators. 7. Absorbent wound dressing according to the points, characterized in that it can be washed off the wounds with water. 223 A67 8. A process for the preparation of an absorbent wound dressing, characterized in that from the produced according to CS-UR 172640 and a suitable drying process Sph.ariscb.en regenerated cellulose particles of the particle size range. G, 05 to 0.5 mm, preferably 0.05 to 0.3 mm, isolated, freed of mechanical impurities, packed in suitable containers and by. Gamma rays is sterilized. 9. Method according to. Point 8, characterized in that - the cellulose extracts "in addition, with therapeutic  'effective substances are impregnated in dissolved form