CZ43494A3

CZ43494A3 - Preparation for treating injuries

Info

Publication number: CZ43494A3
Application number: CZ94434A
Authority: CZ
Inventors: Jana Phmr Simkova
Original assignee: Leciva
Priority date: 1994-02-25
Filing date: 1994-02-25
Publication date: 1995-05-17
Also published as: CZ279665B6

Abstract

This preparation for the treatment of injuries contains 0.5 to 6% by weight of polysaccharide β-glucan, 0.1 to 30% by weight of glycerol, 0.3 to 10% by weight of a derivative of cellulose, such as carboxymethyl cellulose and its sodium salt, hydroxyethyl cellulose and hydroxypropyl cellulose, and 54 to 99% by weight of purified water and 0.05 to 0.25 % by weight of preservatives. The preparation can also contain substances with an antimicrobial effect.

Description

Technical field -r

BACKGROUND OF THE INVENTION The present invention relates to a wound treatment composition, for example, after surgical procedures or minor superficial injuries, as well as to the treatment of long-term non-healing wounds, ulcers, fistulae, burns, frostbites and bedsores.

BACKGROUND OF THE INVENTION Various rinses, dressings, powders, creams or ointments of a hydrophilic or hydrophobic nature are commonly used to treat wounds to disinfect, cover, prevent secondary wound infections, and accelerate the granulation and epithelization process by their ingredients. From this review, it can be seen that wound treatment can be varied and the various options listed above are generally combined. Thus, very often, the method of cleaning the wound, combining the wound, and preventing the formation of secondary infection is combined by covering the wound with a dressing. Often, an ointment, cream, gel or backing containing disinfectants or antimicrobial or healing agents is also applied to the wound under the dressing. So-called liquid plastic dressings are known which contain disinfectants, for example nitrofural. These liquid dressings are applied to the skin and sprayed onto the skin by spraying an acrylic polymer solution which, upon drying, forms a continuous layer on the skin that protects the wound from secondary infection. The use of this dressing requires the use of a pressurized spray bottle and the plastic dressing must be removed with gasoline or alcohol.

SUMMARY OF THE INVENTION

The combination of all the necessary effects for wound treatment is provided by the composition according to the invention which contains 0.5 to 6.0% w / w. β-glucan polysaccharide, 0.1 to 30 wt. % glycerol and 0.3 to 10 wt. cellulose derivatives such as hydroxyethylcellulose, carboxymethylcellulose and its sodium salt and hydroxypropylcellulose, and 54 to 99% by weight). purified water and 0.05 to 0.25 µmol. preservatives. The composition may contain antimicrobial agents such as antibiotics. β-glucan is a neutral polysaccharide prepared from the cell walls of Saccharomyces cerevisiae, chemically the β- (1-3) -D-polyglucose with β- (1-6) -D-polyglucose side chains. It exhibits immunomodulatory effects without -2-undesirable side-effects, significantly enhancing phagocytic activity. At the same time it acts by local application of acceleration of granulation and epithelialization of postoperative wounds and especially wounds, which are difficult to heal, such as pressure ulcers, leg ulcers, burns and the like. It is applied to the wound by light application directly from the tube or by a suitable tool.

Cellulose derivatives in aqueous media form gels that adhere perfectly to the wound and, upon drying, form a film that acts as a dressing, that is, to protect the wound from secondary infection. The presence of glycerol provides the flexibility of the formed film. The product contains a preservative that ensures microbiological safety even after opening the original packaging. The product may contain a substance that is capable of destroying any microbial contamination by the frames. Various antibiotics, antimycotics or antiseptics may be applied. It follows from the above review that the present invention provides all the modern requirements for rapid wound treatment, its application is very simple and is removed if necessary by washing with water or mechanical peeling. Examples Example 1. Composition of β- (1-6) -D-glucan 2.00 5.00 d 0.25 1.50 to 100.00 g β- (1-3) -D-glucan with side chains from Saccharomyces cerevisiae (hereinafter β-glucan)

Glycerol 85¾ Poles (Hexametylvylene biquanide) hydrochlorides

Hydroxyethylcellulose

Purified water

Method of preparation The preparation is prepared by adding β-glucan to the purified water / glycerol mixture in the duplicating vessel, homogenizing the suspension and mixing it with hydroxyetylcellulose. After the prescribed amount of hydroxyethyl cellulose has been poured in, the vessel is sealed, evacuated, its content is perfectly homogenized and heated to 90 ° C. Thereafter, the composition is kept at this temperature with slow stirring for 30 minutes. At the end of this time, the vacuum is removed, the polysaccharide preservative (hexamethylsulfanyl hydrochloride) is added in the form of 20 µl of aqueous solution, the vessel is closed again, evacuated - 3 - and homogenized perfectly. The contents of the flask are then cooled to 25-30 ° C with slow stirring.

In the same manner, the preparation of Example 2 was prepared. Example 2. Composition β-Glucan Glycerol 85¾ Poles (hexamethyllene biquanide) Hydrochloride Hydroxyethylcellulose Water purified up to 5.00 5.00 0.25 1.50 100.00 g Example 3. Composition β-Glucamine Sodium CarboxymethylVyleelulozy Glycerol 85¾ ^ Methylparaben Purified water 2.00 2.00 10.00 0.20 to 100.00 g

Method of preparation Purified water is sterilized by boiling in a closed container, the prescribed amount of methylparaben is dissolved in it, the prescribed amount of glycerol and β-glucan are added. The suspension was homogenized perfectly in a vacuum vessel and cooled to 30 ° C. Then the prescribed amount of sodium carboxymethylcellulose is poured, the vessel is evacuated again, its content is perfectly homogenized and cooled to 25 ° C.

Composition β-glucan Hydroxypropylcellulose Glycerol 85¾ Preservative (mixture of imidazolidinyl urea, propylparaben with dehydroacetic acid and triethylene glycol) Purified water up to 3.00 1.50 0.50 0.20 100.00 g

Method of preparation Purified water is sterilized by boiling in a sealed duplicate vessel, a prescribed amount of glycerol is added and cooled to 35 ° C. A preservative is added at this temperature and β-glucan is added while stirring. After the homogenization of the suspension is complete, the prescribed amount of hydroxypropylcellulose is poured under continuous stirring. The container is then sealed, evacuated and its contents homogenized to remove clumps. In doing so, it is cooled slightly to 25 ° C. and < - 4- - 4- Example 5. Composition β-glucan 2,50 Hydroxyetylcellulose 2,50 Trimethyitetradecylammonium bromide 0,50 MetKylparaben 0,20 Glycerol 85¾ 5,00 Purified water to 100,00

Method of preparation Purified water is sterilized by boiling in a sealed duplicate vessel and then methylparaben is dissolved therein. Add the prescribed amount of glycerol and add β-glucan while stirring. The contents of the flask are cooled to 30 ° C and the prescribed amount of trimetltetradecylammonium bromide is added as a 20µl solution. Thereafter, hydroxyethyl cellulose is added to the mixture continuously and stirred continuously. After the prescribed amount of hydroxyethylcellulose has been poured, the vessel is evacuated and the formulation is perfectly homogenized. Example 6. Composition of β-glucan 2,00 Hydroxyethyl cellulose 0.80 MetVyparaben 0.20 Neomycin sulfate 0.30 Glycerol 85¾ 8.00 Purified water to 100.00 g

Method of preparation Purified water is sterilized by boiling in a sealed duplicating vessel. Methyl paraben is then dissolved therein, the prescribed amount of glycerol is added and the solution is cooled to 30 ° C. Thereafter, neomycin sulfate and β-glucan are dispersed while stirring. The vessel is evacuated and the suspension is perfectly homogenized. Then add the prescribed amount of hydroxyetyl cellulose under continuous stirring. The vessel is evacuated again and the formulation is homogenized and cooled to 25 ° C. The preparation with a higher glycerol content was more supple, dries more slowly. A preparation that contains only a small amount of glycerol / forms a film that is more friable and may peel off from the wound or skin.

All raw materials / used in the preparation are allowed for use in dermatologists i - 5 -

Industrial Applicability The product is intended for the pharmaceutical industry using dermatology, surgery and veterinary human traumatology.

Claims

A wound treatment composition comprising 0.5 to 6 beta-glucan polysaccharide, 0.1 to 30% w / w. glycerol, 0.3 to 10 wt. a cellulose derivative such as carboxymethylcellulose and its sodium salt, hydroxyethylcellulose and hydroxypropylcellulose, and 54 to 99% hpot. purified water and 0.05 to 0.25% by weight. purity of 99% hydrotreated water Purified water-1 preparation with antimicrobial agent: that it contains folding