CZ308484B6 - 5-Alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidiny pro léčení lymfomů - Google Patents

5-Alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidiny pro léčení lymfomů

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Publication number
CZ308484B6
CZ308484B6 CZ2018-58A CZ201858A CZ308484B6 CZ 308484 B6 CZ308484 B6 CZ 308484B6 CZ 201858 A CZ201858 A CZ 201858A CZ 308484 B6 CZ308484 B6 CZ 308484B6
Authority
CZ
Czechia
Prior art keywords
lymphomas
arylbenzyl
pyrazolo
pyrimidines
alkylthio
Prior art date
Application number
CZ2018-58A
Other languages
English (en)
Other versions
CZ201858A3 (cs
Inventor
Libor HavlĂ­ÄŤek
AntonĂ­n Ĺ turc
Eva Řezníčková
Radek JORDA
Vladimír KRYŠtof
Miroslav Strnad
Original Assignee
Univerzita Palackého v Olomouci
Ústav experimentální botaniky AV ČR, v. v. i.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univerzita PalackĂ©ho v Olomouci, Ústav experimentální botaniky AV ČR, v. v. i. filed Critical Univerzita PalackĂ©ho v Olomouci
Priority to CZ2018-58A priority Critical patent/CZ308484B6/cs
Priority to EP19705912.4A priority patent/EP3749670B1/en
Priority to PCT/CZ2019/050002 priority patent/WO2019149295A1/en
Priority to US16/963,782 priority patent/US11186583B2/en
Publication of CZ201858A3 publication Critical patent/CZ201858A3/cs
Publication of CZ308484B6 publication Critical patent/CZ308484B6/cs

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Řešení se týká 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidinů vzorce I, které jsou účinnými inhibitory kináz a vykazují silné antiproliferativní a proapoptotické účinky u lymfomů, farmaceutických přípravků obsahujících tyto sloučeniny a jejich použití pro léčbu krevních hyperproliferativních onemocnění a Non-Hodgkinových lymfomů.
CZ2018-58A 2018-02-05 2018-02-05 5-Alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidiny pro léčení lymfomů CZ308484B6 (cs)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CZ2018-58A CZ308484B6 (cs) 2018-02-05 2018-02-05 5-Alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidiny pro léčení lymfomů
EP19705912.4A EP3749670B1 (en) 2018-02-05 2019-02-01 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)h-pyrazolo[4,3-d]pyrimidines for treatment of lymphoma
PCT/CZ2019/050002 WO2019149295A1 (en) 2018-02-05 2019-02-01 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)h-pyrazolo[4,3-d]pyrimidines for treatment of lymphoma
US16/963,782 US11186583B2 (en) 2018-02-05 2019-02-01 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidines for treatment of lymphoma

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ2018-58A CZ308484B6 (cs) 2018-02-05 2018-02-05 5-Alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidiny pro léčení lymfomů

Publications (2)

Publication Number Publication Date
CZ201858A3 CZ201858A3 (cs) 2019-08-14
CZ308484B6 true CZ308484B6 (cs) 2020-09-16

Family

ID=67477900

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ2018-58A CZ308484B6 (cs) 2018-02-05 2018-02-05 5-Alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidiny pro léčení lymfomů

Country Status (4)

Country Link
US (1) US11186583B2 (cs)
EP (1) EP3749670B1 (cs)
CZ (1) CZ308484B6 (cs)
WO (1) WO2019149295A1 (cs)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1348707A1 (en) * 2002-03-28 2003-10-01 Ustav Experimentalni Botaniky AV CR (Institute of Experimental Botany Academy of Sciences of the Czech Republic) Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy
CZ2015509A3 (cs) * 2015-07-20 2017-02-15 Ústav experimentální botaniky AV ČR, v. v. i. 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1348707A1 (en) * 2002-03-28 2003-10-01 Ustav Experimentalni Botaniky AV CR (Institute of Experimental Botany Academy of Sciences of the Czech Republic) Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy
CZ2015509A3 (cs) * 2015-07-20 2017-02-15 Ústav experimentální botaniky AV ČR, v. v. i. 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHERUKUPALLI, S., et al. "An appraisal on synthetic and pharmaceutical perspectives of pyrazolo [4, 3-d] pyrimidine scaffold." Bioorganic & medicinal chemistry, 2018, 26(2): 309-339; ISSN: 0968-0896 *
VYMĚTALOVÁ, L., et al. "5-Substituted 3-isopropyl-7-[4-(2-pyridyl) benzyl] amino-1 (2) H-pyrazolo [4, 3-d] pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases." European journal of medicinal chemistry, 2016, 110: 291-301; ISSN: 0223-5234 *
ZHANG, S., et al. "Anti‐angiogenic effects of novel cyclin‐dependent kinase inhibitors with a pyrazolo [4, 3‐d] pyrimidine scaffold." British journal of pharmacology, 2016, 173(17): 2645-2656; ISSN: 0007-1188 *

Also Published As

Publication number Publication date
CZ201858A3 (cs) 2019-08-14
EP3749670B1 (en) 2021-10-06
WO2019149295A1 (en) 2019-08-08
US11186583B2 (en) 2021-11-30
US20200361943A1 (en) 2020-11-19
EP3749670A1 (en) 2020-12-16

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MM4A Patent lapsed due to non-payment of fee

Effective date: 20230205