CZ308484B6 - 5-Alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidiny pro léčení lymfomů - Google Patents

5-Alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidiny pro léčení lymfomů

Info

Publication number
CZ308484B6
CZ308484B6 CZ2018-58A CZ201858A CZ308484B6 CZ 308484 B6 CZ308484 B6 CZ 308484B6 CZ 201858 A CZ201858 A CZ 201858A CZ 308484 B6 CZ308484 B6 CZ 308484B6
Authority
CZ
Czechia
Prior art keywords
lymphomas
arylbenzyl
pyrazolo
pyrimidines
alkylthio
Prior art date
Application number
CZ2018-58A
Other languages
English (en)
Other versions
CZ201858A3 (cs
Inventor
Libor HavlĂ­ÄŤek
AntonĂ­n Ĺ turc
Eva Řezníčková
Radek JORDA
Vladimír KRYŠtof
Miroslav Strnad
Original Assignee
Univerzita Palackého v Olomouci
Ústav experimentální botaniky AV ČR, v. v. i.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univerzita PalackĂ©ho v Olomouci, Ústav experimentální botaniky AV ČR, v. v. i. filed Critical Univerzita PalackĂ©ho v Olomouci
Priority to CZ2018-58A priority Critical patent/CZ308484B6/cs
Priority to EP19705912.4A priority patent/EP3749670B1/en
Priority to PCT/CZ2019/050002 priority patent/WO2019149295A1/en
Priority to US16/963,782 priority patent/US11186583B2/en
Publication of CZ201858A3 publication Critical patent/CZ201858A3/cs
Priority to HRP20250595TT priority patent/HRP20250595T1/hr
Priority to PL19798206.9T priority patent/PL3874111T3/pl
Priority to ES19798206T priority patent/ES3026566T3/es
Publication of CZ308484B6 publication Critical patent/CZ308484B6/cs

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Operating, Guiding And Securing Of Roll- Type Closing Members (AREA)

Abstract

Řešení se týká 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidinů vzorce I, které jsou účinnými inhibitory kináz a vykazují silné antiproliferativní a proapoptotické účinky u lymfomů, farmaceutických přípravků obsahujících tyto sloučeniny a jejich použití pro léčbu krevních hyperproliferativních onemocnění a Non-Hodgkinových lymfomů.
CZ2018-58A 2018-02-05 2018-02-05 5-Alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidiny pro léčení lymfomů CZ308484B6 (cs)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CZ2018-58A CZ308484B6 (cs) 2018-02-05 2018-02-05 5-Alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidiny pro léčení lymfomů
EP19705912.4A EP3749670B1 (en) 2018-02-05 2019-02-01 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)h-pyrazolo[4,3-d]pyrimidines for treatment of lymphoma
PCT/CZ2019/050002 WO2019149295A1 (en) 2018-02-05 2019-02-01 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)h-pyrazolo[4,3-d]pyrimidines for treatment of lymphoma
US16/963,782 US11186583B2 (en) 2018-02-05 2019-02-01 5-alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidines for treatment of lymphoma
HRP20250595TT HRP20250595T1 (hr) 2018-02-05 2019-10-29 Osovina rolete s ojačanjem
PL19798206.9T PL3874111T3 (pl) 2018-02-05 2019-10-29 Wał rolety ze wzmocnieniem
ES19798206T ES3026566T3 (en) 2018-02-05 2019-10-29 Roller shaft with a reinforcement

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ2018-58A CZ308484B6 (cs) 2018-02-05 2018-02-05 5-Alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidiny pro léčení lymfomů

Publications (2)

Publication Number Publication Date
CZ201858A3 CZ201858A3 (cs) 2019-08-14
CZ308484B6 true CZ308484B6 (cs) 2020-09-16

Family

ID=67477900

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ2018-58A CZ308484B6 (cs) 2018-02-05 2018-02-05 5-Alkylthio-7-[(4-arylbenzyl)amino]-1(2)H-pyrazolo[4,3-d]pyrimidiny pro léčení lymfomů

Country Status (7)

Country Link
US (1) US11186583B2 (cs)
EP (1) EP3749670B1 (cs)
CZ (1) CZ308484B6 (cs)
ES (1) ES3026566T3 (cs)
HR (1) HRP20250595T1 (cs)
PL (1) PL3874111T3 (cs)
WO (1) WO2019149295A1 (cs)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202108572D0 (en) * 2021-06-16 2021-07-28 Carrick Therapeutics Ltd Therapeutic compounds and their use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1348707A1 (en) * 2002-03-28 2003-10-01 Ustav Experimentalni Botaniky AV CR (Institute of Experimental Botany Academy of Sciences of the Czech Republic) Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy
CZ2015509A3 (cs) * 2015-07-20 2017-02-15 Ústav experimentální botaniky AV ČR, v. v. i. 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1348707A1 (en) * 2002-03-28 2003-10-01 Ustav Experimentalni Botaniky AV CR (Institute of Experimental Botany Academy of Sciences of the Czech Republic) Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy
CZ2015509A3 (cs) * 2015-07-20 2017-02-15 Ústav experimentální botaniky AV ČR, v. v. i. 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHERUKUPALLI, S., et al. "An appraisal on synthetic and pharmaceutical perspectives of pyrazolo [4, 3-d] pyrimidine scaffold." Bioorganic & medicinal chemistry, 2018, 26(2): 309-339; ISSN: 0968-0896 *
VYMĚTALOVÁ, L., et al. "5-Substituted 3-isopropyl-7-[4-(2-pyridyl) benzyl] amino-1 (2) H-pyrazolo [4, 3-d] pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases." European journal of medicinal chemistry, 2016, 110: 291-301; ISSN: 0223-5234 *
ZHANG, S., et al. "Anti‐angiogenic effects of novel cyclin‐dependent kinase inhibitors with a pyrazolo [4, 3‐d] pyrimidine scaffold." British journal of pharmacology, 2016, 173(17): 2645-2656; ISSN: 0007-1188 *

Also Published As

Publication number Publication date
US20200361943A1 (en) 2020-11-19
US11186583B2 (en) 2021-11-30
HRP20250595T1 (hr) 2025-07-18
CZ201858A3 (cs) 2019-08-14
WO2019149295A1 (en) 2019-08-08
ES3026566T3 (en) 2025-06-11
EP3749670B1 (en) 2021-10-06
PL3874111T3 (pl) 2025-06-23
EP3749670A1 (en) 2020-12-16

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MM4A Patent lapsed due to non-payment of fee

Effective date: 20230205