CY1124572T1 - Ανασυνδυασμενο γονιδιο dgkk για τη γονιδιακη θεραπεια του συνδρομου ευθραυστου x - Google Patents

Ανασυνδυασμενο γονιδιο dgkk για τη γονιδιακη θεραπεια του συνδρομου ευθραυστου x

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Publication number
CY1124572T1
CY1124572T1 CY20211100744T CY211100744T CY1124572T1 CY 1124572 T1 CY1124572 T1 CY 1124572T1 CY 20211100744 T CY20211100744 T CY 20211100744T CY 211100744 T CY211100744 T CY 211100744T CY 1124572 T1 CY1124572 T1 CY 1124572T1
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CY
Cyprus
Prior art keywords
gene
fragile
syndrome
dgkk
recombinant
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Application number
CY20211100744T
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English (en)
Inventor
Hervé MOINE
Ricardos TABET
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Université De Strasbourg
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Publication date
Application filed by Université De Strasbourg filed Critical Université De Strasbourg
Publication of CY1124572T1 publication Critical patent/CY1124572T1/el

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    • C12N9/10—Transferases (2.)
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    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Η παρούσα εφεύρεση αναφέρεται σε ένα νουκλεϊνικό οξύ που κωδικοποιεί μία ανθρώπινη πρωτεΐνη DGKk που στερείται μίας λειτουργικής περιοχής πλούσιας σε προλίνη και/ή μίας λειτουργικής επαναλαμβανόμενης περιοχής ΕΡΑΡΕ και στη χρήση του στην αγωγή του συνδρόμου εύθραυστου Χ σε έναν ασθενή σε ανάγκη αυτής.
CY20211100744T 2016-09-26 2021-08-19 Ανασυνδυασμενο γονιδιο dgkk για τη γονιδιακη θεραπεια του συνδρομου ευθραυστου x CY1124572T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16306232.6A EP3299456A1 (en) 2016-09-26 2016-09-26 Recombinant dgkk gene for fragile x syndrome gene therapy
PCT/EP2017/074387 WO2018055206A1 (en) 2016-09-26 2017-09-26 Recombinant dgkk gene for fragile x syndrome gene therapy

Publications (1)

Publication Number Publication Date
CY1124572T1 true CY1124572T1 (el) 2022-07-22

Family

ID=57130319

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211100744T CY1124572T1 (el) 2016-09-26 2021-08-19 Ανασυνδυασμενο γονιδιο dgkk για τη γονιδιακη θεραπεια του συνδρομου ευθραυστου x

Country Status (17)

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US (2) US11597936B2 (el)
EP (2) EP3299456A1 (el)
JP (1) JP7189131B2 (el)
CN (1) CN110168082A (el)
BR (1) BR112019005959A2 (el)
CA (1) CA3077105C (el)
CY (1) CY1124572T1 (el)
DK (1) DK3516052T3 (el)
ES (1) ES2883358T3 (el)
HR (1) HRP20211256T1 (el)
HU (1) HUE055699T2 (el)
LT (1) LT3516052T (el)
PL (1) PL3516052T3 (el)
PT (1) PT3516052T (el)
RS (1) RS62236B1 (el)
SI (1) SI3516052T1 (el)
WO (1) WO2018055206A1 (el)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3801638A1 (en) * 2018-06-08 2021-04-14 Novartis AG Cell-based assay for measuring drug product potency

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009622A2 (en) * 2002-07-19 2004-01-29 Cellzome Ag Protein complexes of cellular networks underlying the development of cancer and other diseases
WO2010094061A1 (en) * 2009-02-17 2010-08-26 Murdoch Childrens Research Institute Assay for determining epigenetic profiles of markers of fragile x alleles
AU2012272518A1 (en) * 2011-06-24 2014-01-09 Murdoch Childrens Research Institute Treatment and diagnosis of epigenetic disorders and conditions
WO2017049192A1 (en) * 2015-09-17 2017-03-23 University Of Massachusetts Compositions and methods for modulating fmr1 expression

Also Published As

Publication number Publication date
DK3516052T3 (da) 2021-08-23
US11597936B2 (en) 2023-03-07
SI3516052T1 (sl) 2021-09-30
WO2018055206A1 (en) 2018-03-29
PT3516052T (pt) 2021-08-30
LT3516052T (lt) 2021-09-10
JP2019532637A (ja) 2019-11-14
EP3516052B1 (en) 2021-05-26
PL3516052T3 (pl) 2021-11-29
EP3299456A1 (en) 2018-03-28
HUE055699T2 (hu) 2021-12-28
US20190225950A1 (en) 2019-07-25
CN110168082A (zh) 2019-08-23
CA3077105A1 (en) 2018-03-29
BR112019005959A2 (pt) 2019-06-18
HRP20211256T1 (hr) 2022-01-07
CA3077105C (en) 2024-01-09
RS62236B1 (sr) 2021-09-30
US20230250404A1 (en) 2023-08-10
EP3516052A1 (en) 2019-07-31
JP7189131B2 (ja) 2022-12-13
ES2883358T3 (es) 2021-12-07

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