CY1116939T1 - Μη πιστοτητα μεταγραφης, ανιχνευση και χρησεις αυτης - Google Patents
Μη πιστοτητα μεταγραφης, ανιχνευση και χρησεις αυτηςInfo
- Publication number
- CY1116939T1 CY1116939T1 CY20151101031T CY151101031T CY1116939T1 CY 1116939 T1 CY1116939 T1 CY 1116939T1 CY 20151101031 T CY20151101031 T CY 20151101031T CY 151101031 T CY151101031 T CY 151101031T CY 1116939 T1 CY1116939 T1 CY 1116939T1
- Authority
- CY
- Cyprus
- Prior art keywords
- infidelity
- design
- disease
- transferability
- tracking
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Glass Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pit Excavations, Shoring, Fill Or Stabilisation Of Slopes (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Η παρούσα εφεύρεση αφορά πιστοποίηση ενός νέου μηχανισμού μη πιστότητας μεταγραφής σε κύτταρα. Η εφεύρεση παρέχει συνθέσεις και μεθόδους για να ανιχνεύεται το επίπεδο μη πιστότητας μεταγραφής σε ένα δείγμα, καθώς επίσης η χρήση αυτών, π.χ., για θεραπευτικούς, διαγνωστικούς, σχέσεως μεταξύ φαρμάκων και γονιδίων ή σχεδιασμού φαρμάκων σκοπούς. Όπως θα αποκαλυφθεί, η εφεύρεση είναι ιδιαιτέρως προσαρμοσμένη για ανίχνευση, παρακολούθηση ή θεραπεία πολλαπλασιαστικών διαταραχών κυττάρου, για το σχεδιασμό ή/και τη συστηματική εξέταση φαρμάκων, για σκιαγράφηση ασθενούς ή ασθένειας, πρόβλεψη σοβαρότητας ασθένειας και αξιολόγηση αποτελεσματικότητας φαρμάκου.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06291176A EP1887088A1 (en) | 2006-07-20 | 2006-07-20 | Transcription infidelity, detection and uses thereof |
| EP11173357.2A EP2468885B1 (en) | 2006-07-20 | 2007-07-20 | Transcription infidelity, detection and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116939T1 true CY1116939T1 (el) | 2017-04-05 |
Family
ID=37496681
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20111101225T CY1112125T1 (el) | 2006-07-20 | 2011-12-09 | Μη πιστοτητα μεταγραφης, ανιχνευση και χρησεις αυτης |
| CY20151101031T CY1116939T1 (el) | 2006-07-20 | 2015-11-17 | Μη πιστοτητα μεταγραφης, ανιχνευση και χρησεις αυτης |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20111101225T CY1112125T1 (el) | 2006-07-20 | 2011-12-09 | Μη πιστοτητα μεταγραφης, ανιχνευση και χρησεις αυτης |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8288091B2 (el) |
| EP (3) | EP1887088A1 (el) |
| JP (1) | JP5298013B2 (el) |
| KR (1) | KR101502179B1 (el) |
| AT (1) | ATE524565T1 (el) |
| AU (1) | AU2007275068B2 (el) |
| BR (1) | BRPI0714563B8 (el) |
| CA (1) | CA2658305C (el) |
| CY (2) | CY1112125T1 (el) |
| DK (2) | DK2046986T3 (el) |
| ES (2) | ES2373428T3 (el) |
| HK (1) | HK1128937A1 (el) |
| HU (1) | HUE028135T2 (el) |
| IL (1) | IL196600A0 (el) |
| PL (2) | PL2468885T3 (el) |
| PT (2) | PT2468885E (el) |
| SI (2) | SI2468885T1 (el) |
| TR (1) | TR201112295Y (el) |
| WO (1) | WO2008009751A2 (el) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2071334A1 (en) * | 2007-12-14 | 2009-06-17 | Transmedi SA | Compositions and methods of detecting TIABS |
| EP2080812A1 (en) | 2008-01-18 | 2009-07-22 | Transmedi SA | Compositions and methods of detecting post-stop peptides |
| EP2995688A1 (en) | 2014-09-12 | 2016-03-16 | Genclis | Methods of prognosing and treating triple negative breast cancer |
| WO2017100789A1 (en) * | 2015-12-11 | 2017-06-15 | Expression Pathology, Inc. | Srm/mrm assays |
| EP4148427A1 (en) | 2016-03-18 | 2023-03-15 | Genclis | Molecular origin of allergy |
| WO2018187216A1 (en) * | 2017-04-03 | 2018-10-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Expression cassettes and methods for detecting transcription errors |
| WO2020185790A1 (en) | 2019-03-10 | 2020-09-17 | Ultima Genomics, Inc. | Methods and systems for sequence calling |
| WO2021030268A2 (en) | 2019-08-09 | 2021-02-18 | Nutcracker Therapeutics, Inc. | Microfluidic apparatus and methods of use thereof |
| KR102334576B1 (ko) * | 2019-08-12 | 2021-12-07 | 한국생명공학연구원 | 융합 단백질 및 이를 포함하는 바이오 이미징용 조성물 |
| EP4211268A1 (en) * | 2020-09-10 | 2023-07-19 | Ultima Genomics, Inc. | Methods and systems for sequence and variant calling |
| EP4162948A1 (en) | 2021-10-05 | 2023-04-12 | Genclis | Transcription infidelity derived chimeric immunogens and uses thereof |
| WO2023104904A2 (en) | 2021-12-08 | 2023-06-15 | Genclis | The sars-cov-2 and variants use two independent cell receptors to replicate |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4979330A (en) | 1989-10-10 | 1990-12-25 | Rorant Julius W | Suction insect trap device |
| US6120992A (en) | 1993-11-04 | 2000-09-19 | Valigene Corporation | Use of immobilized mismatch binding protein for detection of mutations and polymorphisms, and allele identification in a diseased human |
| WO2001040804A2 (en) * | 1999-12-03 | 2001-06-07 | Koninklijke Nederlandse Akademie Van Wetenschappen | Clearance of aberrant protein in correlation with disease |
| US20020132259A1 (en) | 2001-02-21 | 2002-09-19 | Wagner Robert E. | Mutation detection using MutS and RecA |
| US20060110762A1 (en) * | 2004-11-10 | 2006-05-25 | Sanjay Kapil | Porcine reproductive and respiratory syndrome virus receptor components and uses thereof |
-
2006
- 2006-07-20 EP EP06291176A patent/EP1887088A1/en not_active Withdrawn
-
2007
- 2007-07-20 PT PT111733572T patent/PT2468885E/pt unknown
- 2007-07-20 AT AT07787788T patent/ATE524565T1/de active
- 2007-07-20 PT PT07787788T patent/PT2046986E/pt unknown
- 2007-07-20 KR KR1020097003423A patent/KR101502179B1/ko active IP Right Grant
- 2007-07-20 PL PL11173357T patent/PL2468885T3/pl unknown
- 2007-07-20 EP EP11173357.2A patent/EP2468885B1/en not_active Not-in-force
- 2007-07-20 AU AU2007275068A patent/AU2007275068B2/en active Active
- 2007-07-20 BR BRPI0714563A patent/BRPI0714563B8/pt active IP Right Grant
- 2007-07-20 DK DK07787788.4T patent/DK2046986T3/da active
- 2007-07-20 HU HUE11173357A patent/HUE028135T2/en unknown
- 2007-07-20 PL PL07787788T patent/PL2046986T3/pl unknown
- 2007-07-20 WO PCT/EP2007/057541 patent/WO2008009751A2/en active Application Filing
- 2007-07-20 TR TR2011/12295U patent/TR201112295Y/tr unknown
- 2007-07-20 SI SI200731705T patent/SI2468885T1/sl unknown
- 2007-07-20 SI SI200730791T patent/SI2046986T1/sl unknown
- 2007-07-20 DK DK11173357.2T patent/DK2468885T3/da active
- 2007-07-20 US US12/374,431 patent/US8288091B2/en active Active
- 2007-07-20 CA CA2658305A patent/CA2658305C/en active Active
- 2007-07-20 ES ES07787788T patent/ES2373428T3/es active Active
- 2007-07-20 JP JP2009519996A patent/JP5298013B2/ja active Active
- 2007-07-20 EP EP07787788A patent/EP2046986B1/en active Active
- 2007-07-20 ES ES11173357.2T patent/ES2553435T3/es active Active
-
2009
- 2009-01-19 IL IL196600A patent/IL196600A0/en active IP Right Grant
- 2009-06-08 HK HK09105086.5A patent/HK1128937A1/xx unknown
-
2011
- 2011-12-09 CY CY20111101225T patent/CY1112125T1/el unknown
-
2015
- 2015-11-17 CY CY20151101031T patent/CY1116939T1/el unknown
Also Published As
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