CY1116194T1 - OSTRADIOL-PREGNANCY DAY RELEASE PACKAGING - Google Patents
OSTRADIOL-PREGNANCY DAY RELEASE PACKAGINGInfo
- Publication number
- CY1116194T1 CY1116194T1 CY20151100346T CY151100346T CY1116194T1 CY 1116194 T1 CY1116194 T1 CY 1116194T1 CY 20151100346 T CY20151100346 T CY 20151100346T CY 151100346 T CY151100346 T CY 151100346T CY 1116194 T1 CY1116194 T1 CY 1116194T1
- Authority
- CY
- Cyprus
- Prior art keywords
- estradiol
- formulations
- administered
- progesterone
- ostradiol
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει σκευάσματα οιστραδιόλης-προγεστερόνης βραδείας αποδέσμευσης τα οποία είναι δυνατό να χρησιμοποιηθούν είτε σε θεραπεία αντισύλληψης είτε σε θεραπεία ορμονικής υποκατάστασης. Τα σκευάσματα περιέχουν μορφοποιημένα σωματίδια οιστραδιόλης που βρίσκονται σε ημι-κρυσταλλική μορφή και παρουσιάζουν ιδιαίτερα χαμηλούς ρυθμούς διάλυσης. Τα μορφοποιημένα σωματίδια περιέχουν οιστραδιόλη και βρίσκονται στη σύνθεση σε μία γραμμομοριακή αναλογία 1:1 με χοληστερόλη, και χορηγούνται σε συνδυασμό με προγεστερόνη. Τα σκευάσματα βραδείας αποδέσμευσης της παρούσας εφεύρεσης προσφέρουν τα δύο πλεονεκτήματα ενός σκευάσματος σε χαμηλή δόση οιστραδιόλης με ένα δοσολογικό σχήμα μικρής συχνότητας. Τα σκευάσματα είναι δυνατό να χορηγηθούν από την παρεντερική οδό μία φορά το μήνα ή σπανιότερα.The present invention provides slow release estradiol-progesterone formulations which can be used in either contraceptive therapy or hormone replacement therapy. The formulations contain formulated estradiol particles in a semi-crystalline form and exhibit particularly low dissolution rates. The formulated particles contain estradiol and are synthesized in a 1: 1 molar ratio with cholesterol, and are administered in combination with progesterone. The slow release formulations of the present invention offer the two advantages of a low dose estradiol formulation with a low frequency dosage regimen. The formulations can be administered by the parenteral route once a month or less frequently.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47793903A | 2003-06-13 | 2003-06-13 | |
| EP20040736545 EP1663161B1 (en) | 2003-06-13 | 2004-06-10 | Slow release estradiol-progesterone formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116194T1 true CY1116194T1 (en) | 2017-02-08 |
Family
ID=58457922
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100346T CY1116194T1 (en) | 2003-06-13 | 2015-04-09 | OSTRADIOL-PREGNANCY DAY RELEASE PACKAGING |
| CY20151100365T CY1116203T1 (en) | 2003-06-13 | 2015-04-21 | OSTRADIOL-PREGNANCY NIGHT RELEASE PREPARATION |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100365T CY1116203T1 (en) | 2003-06-13 | 2015-04-21 | OSTRADIOL-PREGNANCY NIGHT RELEASE PREPARATION |
Country Status (1)
| Country | Link |
|---|---|
| CY (2) | CY1116194T1 (en) |
-
2015
- 2015-04-09 CY CY20151100346T patent/CY1116194T1/en unknown
- 2015-04-21 CY CY20151100365T patent/CY1116203T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1116203T1 (en) | 2017-02-08 |
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