CY1116085T1 - OXYGEN-SUBSTITUTED 3-HETEROYLAMINE-PROPIONIC ACID PRODUCERS AND THEIR USE AS PHARMACEUTICAL SUBSTANCES - Google Patents

OXYGEN-SUBSTITUTED 3-HETEROYLAMINE-PROPIONIC ACID PRODUCERS AND THEIR USE AS PHARMACEUTICAL SUBSTANCES

Info

Publication number
CY1116085T1
CY1116085T1 CY20151100142T CY151100142T CY1116085T1 CY 1116085 T1 CY1116085 T1 CY 1116085T1 CY 20151100142 T CY20151100142 T CY 20151100142T CY 151100142 T CY151100142 T CY 151100142T CY 1116085 T1 CY1116085 T1 CY 1116085T1
Authority
CY
Cyprus
Prior art keywords
heteroylamine
substituted
oxygen
propionic acid
pharmaceutical substances
Prior art date
Application number
CY20151100142T
Other languages
Greek (el)
Inventor
Sven Ruf
Josef Pernerstorfer
Thorsten Sadowski
Georg Horstick
Herman Schreuder
Christian Buning
Thomas Olpp
Bodo Scheiper
Klaus Wirth
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP11701123.9A external-priority patent/EP2528902B1/en
Application filed by Sanofi filed Critical Sanofi
Publication of CY1116085T1 publication Critical patent/CY1116085T1/en

Links

Abstract

Η παρούσα εφεύρεση αναφέρεται στις ενώσεις του χημικού τύπου I, όπου οι A, D, Ε, G, R10, R30, R40, R50 και R60 ορίζονται στις αξιώσεις, και είναι πολύτιμες, φαρμακευτικά δραστικές ενώσεις. Είναι αναστολείς της πρωτεάσης καθεψίνης Α, και μπορούν να χρησιμοποιηθούν για την αντιμετώπιση νοσημάτων όπως είναι παραδείγματος χάριν η αθηροσκλήρυνση, η καρδιακή ανεπάρκεια, οι νεφρικές παθήσεις, οι ηπατοπάθειες ή τα φλεγμονώδη νοσήματα. Η εφεύρεση αναφέρεται επίσης σε διαδικασίες παρασκευής των ενώσεων του χημικού τύπου I, στη χρήση αυτών και στις φαρμακευτικές συνθέσεις που τις περιέχουν.The present invention relates to the compounds of formula I, wherein A, D, E, G, R10, R30, R40, R50 and R60 are defined in the claims, and are valuable, pharmaceutically active compounds. They are inhibitors of cathepsin A protease, and can be used to treat diseases such as atherosclerosis, heart failure, kidney disease, liver disease or inflammatory diseases. The invention also relates to processes for the preparation of the compounds of formula I, their use and the pharmaceutical compositions containing them.

CY20151100142T 2010-01-26 2015-02-12 OXYGEN-SUBSTITUTED 3-HETEROYLAMINE-PROPIONIC ACID PRODUCERS AND THEIR USE AS PHARMACEUTICAL SUBSTANCES CY1116085T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10305080 2010-01-26
US30911910A 2010-03-01 2010-03-01
EP11701123.9A EP2528902B1 (en) 2010-01-26 2011-01-26 Oxygen-substituted 3-heteroaroylamino-propionic acid derivatives and their use as pharmaceuticals

Publications (1)

Publication Number Publication Date
CY1116085T1 true CY1116085T1 (en) 2017-02-08

Family

ID=58457908

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20151100142T CY1116085T1 (en) 2010-01-26 2015-02-12 OXYGEN-SUBSTITUTED 3-HETEROYLAMINE-PROPIONIC ACID PRODUCERS AND THEIR USE AS PHARMACEUTICAL SUBSTANCES

Country Status (1)

Country Link
CY (1) CY1116085T1 (en)

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