CY1114264T1 - STABLE AND SOLVENT ANTIBODIES THAT INHIBIT TNF (ALFA) - Google Patents
STABLE AND SOLVENT ANTIBODIES THAT INHIBIT TNF (ALFA)Info
- Publication number
- CY1114264T1 CY1114264T1 CY20131100659T CY131100659T CY1114264T1 CY 1114264 T1 CY1114264 T1 CY 1114264T1 CY 20131100659 T CY20131100659 T CY 20131100659T CY 131100659 T CY131100659 T CY 131100659T CY 1114264 T1 CY1114264 T1 CY 1114264T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antibodies
- tnfα
- stable
- alfa
- solvent
- Prior art date
Links
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- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται σε ιδιαίτερα σταθερά και διαλυτά scFv αντισώματα και Fab τμήματα ειδικά για τον TNFα, τα οποία περιέχουν ειδικές αλληλουχίες ελαφριάς και βαριάς αλύσου, οι οποίες έχουν βελτιστοποιηθεί αναφορικά με τη σταθερότητα, τη διαλυτότητα, την in vitro και in vivo πρόσδεση του TNFα και τη χαμηλή ανοσογονικότητα. Τα αντισώματα που αναφέρονται έχουν σχεδιαστεί για τη διάγνωση ή/και αντιμετώπιση των διαταραχών που σχετίζονται με τον TNFα. Περιγράφονται επίσης νουκλεϊκά οξέα, οι φορείς και τα κύτταρα ξενιστές για την έκφραση των ανασυνδυασμένων αντισωμάτων της εφεύρεσης, οι μέθοδοι απομόνωσής τους και η χρήση των αναφερθέντων αντισωμάτων στην ιατρική.The present invention relates to highly stable and soluble scFv antibodies and Fab fragments specific for TNFα, containing specific light and heavy chain sequences that have been optimized for stability, solubility, in vitro and in vivo binding of TNFα. and low immunogenicity. The antibodies mentioned are designed to diagnose and / or treat disorders related to TNFα. Also described are nucleic acids, vectors and host cells for the expression of the recombinant antibodies of the invention, their methods of isolation and the use of said antibodies in medicine.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68797105A | 2005-06-07 | 2005-06-07 | |
| US78535306A | 2006-03-23 | 2006-03-23 | |
| EP11002906.3A EP2390267B1 (en) | 2005-06-07 | 2006-06-06 | Stable and soluble antibodies inhibiting TNF(alpha) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1114264T1 true CY1114264T1 (en) | 2016-10-05 |
Family
ID=58448764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20131100659T CY1114264T1 (en) | 2005-06-07 | 2013-08-01 | STABLE AND SOLVENT ANTIBODIES THAT INHIBIT TNF (ALFA) |
Country Status (1)
| Country | Link |
|---|---|
| CY (1) | CY1114264T1 (en) |
-
2013
- 2013-08-01 CY CY20131100659T patent/CY1114264T1/en unknown
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