CY1114005T1 - PEG-URINARY OXIDATIVE CONNECTORS AND USE OF THESE - Google Patents
PEG-URINARY OXIDATIVE CONNECTORS AND USE OF THESEInfo
- Publication number
- CY1114005T1 CY1114005T1 CY20131100416T CY131100416T CY1114005T1 CY 1114005 T1 CY1114005 T1 CY 1114005T1 CY 20131100416 T CY20131100416 T CY 20131100416T CY 131100416 T CY131100416 T CY 131100416T CY 1114005 T1 CY1114005 T1 CY 1114005T1
- Authority
- CY
- Cyprus
- Prior art keywords
- peg
- urinary
- oxidative
- connectors
- poly
- Prior art date
Links
Landscapes
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Μια φυσικά προκύπτουσα ή ανασυνδυασμένη ουρική οξειδάση (ουρικάση) ομοιοπολικά συνδεδεμένη με πολυ(αιθυλενική γλυκόλη) ή πολυ(αιθυλενικό οξείδιο) (και τα δύο αναφέρονται ως PEG), όπου ένας μέσος όρος 2 έως 10 κλώνων PEG είναι συζευγμένοι σε κάθε υπομονάδα ουρικάσης και η PEG έχει μέσο μοριακό βάρος μεταξύ 5kDa και l00kDa. Τα προκύπτοντα συζεύγματα PEG-ουρικάσης είναι ουσιαστικά μη ανοσοποιητικά και διατηρούν το 75% τουλάχιστον της ουρικολυτικής δραστικότητας του μη τροποποιημένου ενζύμου.A naturally occurring or recombinant urinary oxidase (uricase) covalently linked to poly (ethylene glycol) or poly (ethylene oxide) (both referred to as PEG), where an average of 2 to 10 PEG clones are conjugated to each urinary subunit and PEG has an average molecular weight between 5kDa and l00kDa. The resulting PEG-uricase conjugates are substantially non-immune and retain at least 75% of the uricolytic activity of the unmodified enzyme.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21931898A | 1998-08-06 | 1998-08-06 | |
EP09175303A EP2158923B1 (en) | 1998-08-06 | 1999-08-02 | Peg-urate oxidase conjugates and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1114005T1 true CY1114005T1 (en) | 2016-07-27 |
Family
ID=58448992
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20131100416T CY1114005T1 (en) | 1998-08-06 | 2013-05-27 | PEG-URINARY OXIDATIVE CONNECTORS AND USE OF THESE |
Country Status (1)
Country | Link |
---|---|
CY (1) | CY1114005T1 (en) |
-
2013
- 2013-05-27 CY CY20131100416T patent/CY1114005T1/en unknown
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1119848T1 (en) | INSULATED TETRAMIC URINATION | |
NZ509595A (en) | Peg-urate oxidase conjugates and use thereof | |
AU7761594A (en) | Polyethylene glycols | |
WO2003055526A3 (en) | Erythropoietin conjugates | |
AU2001296962A1 (en) | Pegylated interleukin-10 | |
DK0973819T3 (en) | Non-antigenic branched polymer conjugates | |
DE69434448D1 (en) | POLYMER PEPTIDE CONJUGATE | |
CA2323048A1 (en) | Poly(ethylene glycol) derivatives with proximal reactive groups | |
PT1157037E (en) | GCSF CONJUGATES | |
WO2003040211A3 (en) | Branched polymers and their conjugates | |
CY1106886T1 (en) | NEUBLASTIN POLYMER COGNITION PRODUCTS AND METHODS OF USE | |
CY1114005T1 (en) | PEG-URINARY OXIDATIVE CONNECTORS AND USE OF THESE | |
AU2003285286A1 (en) | Conjugates of insulin-like growth factor binding protein-4 and poly (ethylene glycol) |