WO2003055526A3 - Erythropoietin conjugates - Google Patents

Erythropoietin conjugates Download PDF

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Publication number
WO2003055526A3
WO2003055526A3 PCT/DK2002/000871 DK0200871W WO03055526A3 WO 2003055526 A3 WO2003055526 A3 WO 2003055526A3 DK 0200871 W DK0200871 W DK 0200871W WO 03055526 A3 WO03055526 A3 WO 03055526A3
Authority
WO
WIPO (PCT)
Prior art keywords
erythropoietin
polypeptide
erythropoietin conjugates
conjugates
epo
Prior art date
Application number
PCT/DK2002/000871
Other languages
French (fr)
Other versions
WO2003055526A2 (en
Inventor
Kim Vilbour Andersen
Original Assignee
Maxygen Aps
Maxygen Holdings Ltd
Kim Vilbour Andersen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maxygen Aps, Maxygen Holdings Ltd, Kim Vilbour Andersen filed Critical Maxygen Aps
Priority to AU2002351746A priority Critical patent/AU2002351746A1/en
Publication of WO2003055526A2 publication Critical patent/WO2003055526A2/en
Publication of WO2003055526A3 publication Critical patent/WO2003055526A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to polypeptide conjugates exhibiting erythropoietin (EPO) activity, comprising at least one polymer molecule, preferably polyethylene glycol, covalently attached to an attachment site of a polypeptide, e.g. a lysine or cysteine residue or a carbohydrate chain.
PCT/DK2002/000871 2001-12-21 2002-12-18 Erythropoietin conjugates WO2003055526A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002351746A AU2002351746A1 (en) 2001-12-21 2002-12-18 Erythropoietin conjugates

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34350101P 2001-12-21 2001-12-21
US60/343,501 2001-12-21
DKPA200101953 2001-12-21
DKPA200101953 2001-12-21

Publications (2)

Publication Number Publication Date
WO2003055526A2 WO2003055526A2 (en) 2003-07-10
WO2003055526A3 true WO2003055526A3 (en) 2003-12-11

Family

ID=26069119

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2002/000871 WO2003055526A2 (en) 2001-12-21 2002-12-18 Erythropoietin conjugates

Country Status (2)

Country Link
AU (1) AU2002351746A1 (en)
WO (1) WO2003055526A2 (en)

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Patent Citations (6)

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Also Published As

Publication number Publication date
AU2002351746A8 (en) 2003-07-15
AU2002351746A1 (en) 2003-07-15
WO2003055526A2 (en) 2003-07-10

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