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Priority claimed from EP04026125Aexternal-prioritypatent/EP1650183A1/en
Application filed by Cellzome LimitedfiledCriticalCellzome Limited
Publication of CY1112068T1publicationCriticalpatent/CY1112068T1/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Η παρούσα εφεύρεση αφορά ενώσεις που έχουν τον γενικό τύπο (I) με τους ορισμούς των A, Χ, R1-R6 που δίνονται στη συνέχεια, και/ή ένα άλας ή εστέρα αυτών. Επιπλέον, η εφεύρεση αφορά τη χρήση των αναφερθέντων ενώσεων για την αντιμετώπιση της νόσου Αλτσχάιμερ και τη χρήση τους για την τροποποίηση της δράσης της γ-σεκρετάσης.The present invention relates to compounds having the general formula (I) with the definitions of A, X, R 1 -R 6 hereinafter provided, and / or a salt or ester thereof. In addition, the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use to modify the activity of gamma-secretase.
CY20091100636T2004-10-212009-06-16
(DIFFINYL) CARBOXYLIC ACIDS AND THEIR DERIVATIVES
CY1112068T1
(en)
SUBSTITUTED DERIVATIVES OF 3- (4-METOXI-PHENYL) -3H-ISOINDOL-1-ILLUMIN TRIFLUOROACETATE, ITS SALTS OR SOLVATOS PHARMACEUTICALLY ACCEPTABLE, PHARMACEUTICAL FORMULATIONS AND APPLICATIONS.
NEW PRO-DRUGS OF 1-METHYL-2-(4-AMIDINOPHENYLAMINOMETHYL)-BENZIMIDAZOLE-5-YLE-CARBOXYLIC ACID-(N-2-PYRIDYL-N-2-HYDROXYCARBONYLETHYL)-AMIDE, THEIR PREPARATION AND USE AS MEDICINES