CY1109288T1 - Αδενοϊικοι φορεις οχηματα με απαλοιφη ε1β - Google Patents

Αδενοϊικοι φορεις οχηματα με απαλοιφη ε1β

Info

Publication number
CY1109288T1
CY1109288T1 CY20091100776T CY091100776T CY1109288T1 CY 1109288 T1 CY1109288 T1 CY 1109288T1 CY 20091100776 T CY20091100776 T CY 20091100776T CY 091100776 T CY091100776 T CY 091100776T CY 1109288 T1 CY1109288 T1 CY 1109288T1
Authority
CY
Cyprus
Prior art keywords
gene
adrenaline
carriers
clearance
treatment
Prior art date
Application number
CY20091100776T
Other languages
English (en)
Inventor
Terry Hermiston
Julie Nye
Original Assignee
Onyx Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Onyx Pharmaceuticals, Inc. filed Critical Onyx Pharmaceuticals, Inc.
Publication of CY1109288T1 publication Critical patent/CY1109288T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Abstract

Παρέχονται ικανοί αντιγραφής, ανασυνδυασμένοι φορείς αδενοϊού που περιέχουν μεταλλάξεις στην Ε1Β περιοχή που επιτρέπουν την εύκολη απαλοιφή ενός γονιδίου ή γονιδίων σε αυτήν και προαιρετικά την υποκατάσταση συνεπώς ενός ετερόλογου γονιδίου που ουσιαστικώς δεικνύει το πρότυπο πρόσκαιρης έκφρασης της E1b περιοχής γονιδίου(-ων) που έχει απαλειφθεί. Τέτοιοι φορείς έχουν εφαρμογές για τη θεραπεία ασθένειας και κατά προτίμηση για τη θεραπεία νεοπλασματικής ασθένειας.
CY20091100776T 1999-01-28 2009-07-21 Αδενοϊικοι φορεις οχηματα με απαλοιφη ε1β CY1109288T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11781499P 1999-01-28 1999-01-28
EP00907050A EP1135514B1 (en) 1999-01-28 2000-01-26 E1b-deleted adenoviral shuttle vectors

Publications (1)

Publication Number Publication Date
CY1109288T1 true CY1109288T1 (el) 2014-07-02

Family

ID=22374975

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100776T CY1109288T1 (el) 1999-01-28 2009-07-21 Αδενοϊικοι φορεις οχηματα με απαλοιφη ε1β

Country Status (10)

Country Link
EP (1) EP1135514B1 (el)
AT (1) ATE431421T1 (el)
AU (1) AU772544B2 (el)
CA (1) CA2360355A1 (el)
CY (1) CY1109288T1 (el)
DE (1) DE60042196D1 (el)
DK (1) DK1135514T3 (el)
ES (1) ES2325303T3 (el)
PT (1) PT1135514E (el)
WO (1) WO2000044922A1 (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030086903A1 (en) 2001-11-02 2003-05-08 Genvec, Inc. Therapeutic regimen for treating cancer
US20030219410A1 (en) * 2002-02-01 2003-11-27 Transgene S.A. Adenoviral vectors for modulating the cellular activities associated to PODs
HUE046565T2 (hu) * 2009-03-02 2020-03-30 Univ California Tumorszelektív adenovírus E1A és E1B mutánsok

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670488A (en) * 1992-12-03 1997-09-23 Genzyme Corporation Adenovirus vector for gene therapy
US5801029A (en) * 1993-02-16 1998-09-01 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
US5981275A (en) * 1997-04-14 1999-11-09 Genzyme Corporation Transgene expression system for increased persistence

Also Published As

Publication number Publication date
DK1135514T3 (da) 2009-09-07
AU2861300A (en) 2000-08-18
EP1135514B1 (en) 2009-05-13
ES2325303T3 (es) 2009-09-01
PT1135514E (pt) 2009-07-20
EP1135514A1 (en) 2001-09-26
DE60042196D1 (de) 2009-06-25
CA2360355A1 (en) 2000-08-03
AU772544B2 (en) 2004-04-29
WO2000044922A1 (en) 2000-08-03
ATE431421T1 (de) 2009-05-15

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