CY1108542T1 - Εμβολιο πολυσακχαριτη για μολυνσεις απο σταφυλοκοκκο - Google Patents

Εμβολιο πολυσακχαριτη για μολυνσεις απο σταφυλοκοκκο

Info

Publication number
CY1108542T1
CY1108542T1 CY20081100741T CY081100741T CY1108542T1 CY 1108542 T1 CY1108542 T1 CY 1108542T1 CY 20081100741 T CY20081100741 T CY 20081100741T CY 081100741 T CY081100741 T CY 081100741T CY 1108542 T1 CY1108542 T1 CY 1108542T1
Authority
CY
Cyprus
Prior art keywords
infections
vaccine
staffic
polysycharite
adhesin
Prior art date
Application number
CY20081100741T
Other languages
English (en)
Inventor
Gerald B Pier
David Mckenney
Ying Wang
Original Assignee
The Brigham And Women΄S Hospital, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Brigham And Women΄S Hospital, Inc. filed Critical The Brigham And Women΄S Hospital, Inc.
Publication of CY1108542T1 publication Critical patent/CY1108542T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Η εφεύρεση αναφέρεται σε συνθέσεις του καψικού πολυσακχαρίτη/συγκολλητίνης (PS/A) των σταφυλόκοκκων. To PS/A μπορεί να απομονωθεί ή να συντεθεί και περιλαμβάνει διάφορες τροποποιήσεις της δομής του αυτοφυούς PS/A της βασιζόμενης στο χημικό χαρακτηρισμό του PS/A. Η εφεύρεση αναφέρεται επίσης στη χρήση του PS/A ως εμβολίου για την επαγωγή ενεργητικής ανοσίας σε μολύνσεις προκαλούμενες από τους Staphylococcus aureus, S. epidermidis, άλλους συγγενείς αρνητικούς ως προς πηκτάση σταφυλόκοκκους και οργανισμούς φέροντες τον τόπο ica (ενδοκυτταρικής συγκολλητίνης) και στη χρήση αντισωμάτων κατευθυνόμενων κατά του PS/A για την επαγωγή παθητικής ανοσίας στην ίδια κατηγορία μολύνσεων.
CY20081100741T 1998-07-15 2008-07-16 Εμβολιο πολυσακχαριτη για μολυνσεις απο σταφυλοκοκκο CY1108542T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9311798P 1998-07-15 1998-07-15
EP99934091A EP1096952B1 (en) 1998-07-15 1999-07-15 Polysaccharide vaccine for staphylococcal infections

Publications (1)

Publication Number Publication Date
CY1108542T1 true CY1108542T1 (el) 2014-04-09

Family

ID=22237266

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100741T CY1108542T1 (el) 1998-07-15 2008-07-16 Εμβολιο πολυσακχαριτη για μολυνσεις απο σταφυλοκοκκο

Country Status (11)

Country Link
EP (2) EP1096952B1 (el)
JP (1) JP5490341B2 (el)
AT (1) ATE395931T1 (el)
AU (1) AU771563C (el)
CA (1) CA2333931C (el)
CY (1) CY1108542T1 (el)
DE (1) DE69938784D1 (el)
DK (1) DK1096952T3 (el)
ES (1) ES2308844T3 (el)
PT (1) PT1096952E (el)
WO (1) WO2000003745A2 (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7252828B2 (en) 1998-07-15 2007-08-07 The Brigham And Women's Hospital, Inc. Polysaccharide vaccine for staphylococcal infections
US20030021766A1 (en) * 2001-01-12 2003-01-30 Michael Vajdy Nucleic acid mucosal immunization
US7157443B2 (en) 2001-12-11 2007-01-02 Merck & Co., Inc. Staphylococcus aureus exopolysaccharide and process
EP1467755A1 (en) * 2001-12-21 2004-10-20 Antigenics Inc. Compositions comprising immunoreactive reagents and saponins, and methods of use thereof
EP1565478B1 (en) 2002-11-12 2017-08-02 The Brigham And Women's Hospital, Inc. Polysaccharide vaccine for staphylococcal infections
AU2003290867A1 (en) 2002-11-12 2004-06-03 The Brigham And Women's Hospital, Inc. Methods and products for treating staphylococcal infections
US7786255B2 (en) * 2004-04-21 2010-08-31 The Bringham and Women's Hospital, Inc. Poly-N-acetyl glucosamine (PNAG/dPNAG)-binding peptides and methods of use thereof
AU2014277807B2 (en) * 2004-04-21 2017-05-25 Beth Israel Deaconess Medical Center, Inc. Poly-N-acetyl glucosamine(PNAG/DPNAG)-binding peptides and methods of use thereof
AU2012205180B2 (en) * 2004-04-21 2014-10-09 Beth Israel Deaconess Medical Center, Inc. Poly-N-acetyl glucosamine(PNAG/DPNAG)-binding peptides and methods of use thereof
RU2419628C2 (ru) * 2004-09-22 2011-05-27 ГлаксоСмитКлайн Байолоджикалз с.а. Иммуногенная композиция для применения в вакцинации против стафилококков
NZ553776A (en) * 2004-09-22 2010-05-28 Glaxosmithkline Biolog Sa Immunogenic composition comprising staphylococcal PNAG and Type 5 and/or 8 Capsular polysaccharide or oligosaccharide.
EP1998802A2 (en) * 2006-03-30 2008-12-10 GlaxoSmithKline Biologicals S.A. Immunogenic composition
KR101573648B1 (ko) 2008-07-21 2015-12-01 더 브리검 앤드 우먼즈 하스피털, 인크. 합성 베타-1,6 글루코사민 올리고당에 관한 방법 및 조성물
US10828360B1 (en) * 2020-02-04 2020-11-10 OneBioPharma, Inc. Methods for inhibiting biofilm formation

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Also Published As

Publication number Publication date
AU5000199A (en) 2000-02-07
PT1096952E (pt) 2008-08-27
JP5490341B2 (ja) 2014-05-14
DK1096952T3 (da) 2008-08-25
EP1096952A2 (en) 2001-05-09
DE69938784D1 (de) 2008-07-03
JP2002520374A (ja) 2002-07-09
ATE395931T1 (de) 2008-06-15
CA2333931C (en) 2013-09-03
EP1096952B1 (en) 2008-05-21
CA2333931A1 (en) 2000-01-27
WO2000003745A3 (en) 2000-04-20
ES2308844T3 (es) 2008-12-01
AU771563B2 (en) 2004-03-25
WO2000003745A2 (en) 2000-01-27
EP1967203A1 (en) 2008-09-10
AU771563C (en) 2004-10-28

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