CY1108379T1 - Συνθεση της διυδροχλωρικης ισταμινης - Google Patents

Συνθεση της διυδροχλωρικης ισταμινης

Info

Publication number
CY1108379T1
CY1108379T1 CY20081101067T CY081101067T CY1108379T1 CY 1108379 T1 CY1108379 T1 CY 1108379T1 CY 20081101067 T CY20081101067 T CY 20081101067T CY 081101067 T CY081101067 T CY 081101067T CY 1108379 T1 CY1108379 T1 CY 1108379T1
Authority
CY
Cyprus
Prior art keywords
invention disclosed
histamine dihydrochloride
synthesis
bidrochlorine
histamin
Prior art date
Application number
CY20081101067T
Other languages
English (en)
Inventor
Wen-Lung Yeh
Casimir Antczak
Jeffry David Mcgolrick
Michael Joseph Roth
Mark Wrona
Original Assignee
Maxim Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP99968148A external-priority patent/EP1140857B1/en
Application filed by Maxim Pharmaceuticals, Inc. filed Critical Maxim Pharmaceuticals, Inc.
Publication of CY1108379T1 publication Critical patent/CY1108379T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η εφεύρεση που αποκαλύπτεται εδώ αναφέρεται στην παρασκευή φαρμακευτικών ποιοτήτων διυδροχλωρικής ισταμίνης με τη χρήση μίας μη ενζυματικής μεθόδου συνθέσεως δύο σταδίων. Η εφεύρεση που αποκαλύπτεται εδώ περιγράφει τη σύνθεση της διυδροχλωρικής ισταμίνης δια της μη ενζυματικής αποκαρβοξυλιώσεως της ιστιδίνης και τη σταδιακή μετατροπή του αποκαρβοξυλιωμένου προϊόντος στη μορφή διυδροχλωρικού άλατος. Η εφεύρεση που αποκαλύπτεται εδώ θεωρεί ότι ένα τελικό προϊόν διυδροχλωρικής ισταμίνης περιέχον λιγότερη ποσότητα από έκαστο από τα ακόλουθα: 0,8% μονοένυδρη L-ιστιδίνη HCI, 0,1% επί μέρους χρωματογραφικές προσμίξεις και 2% σύνολο προσμίξεων είναι αποδεκτό για φαρμακευτική χρήση.
CY20081101067T 1998-12-23 2008-09-29 Συνθεση της διυδροχλωρικης ισταμινης CY1108379T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11393398P 1998-12-23 1998-12-23
EP99968148A EP1140857B1 (en) 1998-12-23 1999-12-20 Synthesis of histamine dihydrochloride

Publications (1)

Publication Number Publication Date
CY1108379T1 true CY1108379T1 (el) 2014-02-12

Family

ID=51520357

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101067T CY1108379T1 (el) 1998-12-23 2008-09-29 Συνθεση της διυδροχλωρικης ισταμινης

Country Status (2)

Country Link
KR (1) KR20010099867A (el)
CY (1) CY1108379T1 (el)

Also Published As

Publication number Publication date
KR20010099867A (ko) 2001-11-09

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