CY1107163T1 - GANGLIOSITE-CONNECTED RECOVERY ANTIBODIES AND USE THESE IN DIAGNOSIS AND TREATMENT TREATMENT - Google Patents
GANGLIOSITE-CONNECTED RECOVERY ANTIBODIES AND USE THESE IN DIAGNOSIS AND TREATMENT TREATMENTInfo
- Publication number
- CY1107163T1 CY1107163T1 CY20081100107T CY081100107T CY1107163T1 CY 1107163 T1 CY1107163 T1 CY 1107163T1 CY 20081100107 T CY20081100107 T CY 20081100107T CY 081100107 T CY081100107 T CY 081100107T CY 1107163 T1 CY1107163 T1 CY 1107163T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antibodies
- treatment
- diagnosis
- frs
- cell line
- Prior art date
Links
Abstract
Η παρούσα εφεύρεση αναφέρεται στην απόκτηση τροποποιημένων αντισωμάτων με τη βοήθεια της τεχνολογίας ανασυνδυασμένου DNA από το μονοκλωνικό αντίσωμα Ρ3 (MAb P3) ποντικού το οποίο παράγεται από την κυτταρική σειρά υβριδώματος που έχει κατατεθεί υπό τη Συνθήκη της Βουδαπέστης με αριθμό εισαγωγής ECACC 94113026 και από το αντι-ιδιοτυπικό του μονοκλωνικό αντίσωμα 1Ε10 (MAbai 1Ε10) ποντικού που παράγεται από την κυτταρική σειρά υβριδώματος με αριθμό κατάθεσης ECACC 97112901, με αντικειμενικό σκοπό την επίτευξη μονοκλωνικών αντισωμάτων τα οποία διατηρούν τη βιολογική λειτουργία της ειδικής πρόσδεσης στο αντιγόνο των αρχικών αντισωμάτων, αλλά ταυτόχρονα είναι λιγότερο ανοσογονικά. Τα χιμαιρικά αντισώματα της εφεύρεσης περιέχουν τα μεταβλητά πεδία της ανοσοσφαιρίνης ποντικού και τις σταθερές περιοχές της ανθρώπινης ανοσοσφαιρίνης• και αυτά που έχουν εξανθρωποποιηθεί, πέρα από το ό,τι περιέχουν τις σταθερές περιοχές των ανθρώπινων ανοσοσφαιρινών, τροποποιούνται στην περιοχή των πλαισίων ποντικού (FRs) και συγκεκριμένα σε αυτές τις ζώνες που θα μπορούσαν να βρίσκονται σε μια αντιγονική θέση για τα κύτταρα Τ, έτσι αρκετές θέσεις των FRS είναι επίσης ανθρώπινες. Αυτά τα αντισώματα μπορούν να χρησιμοποιηθούν στη διάγνωση και θεραπεία διαφορετικών τύπων όγκων. Η παρούσα εφεύρεση αναφέρεται επίσης στη χρησιμοποίηση των αντισωμάτων για θεραπευτικούς και διαγνωστικούς σκοπούς.The present invention relates to the acquisition of modified antibodies by recombinant DNA technology from the mouse monoclonal antibody P3 (MAb P3) produced by the hybridoma cell line deposited under the Budapest Treaty under accession number ECACC 94113026 and by the anti. -typical mouse monoclonal antibody 1E10 (MAbai 1E10) produced by the hybridoma cell line deposited with ECACC 97112901, with the objective of achieving biologically conserved monoclonal antibodies function of specific binding to the original antibody antigen but at the same time less immunogenic. The chimeric antibodies of the invention contain the murine immunoglobulin variable domains and the human immunoglobulin constant domains; and those that have been humanized, in addition to containing the human immunoglobulin constant domains, are modified in the murine and FRs domain (FR). in particular in these bands that could be in an antigenic position for T cells, so several FRS sites are also human. These antibodies can be used in the diagnosis and treatment of different types of tumors. The present invention also relates to the use of antibodies for therapeutic and diagnostic purposes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20018420 | 2001-04-06 | ||
| EP02759752A EP1411064B1 (en) | 2001-04-06 | 2002-04-08 | Ganglioside-associated recombinant antibodies and the use thereof in the diagnosis and treatment of tumours |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1107163T1 true CY1107163T1 (en) | 2012-10-24 |
Family
ID=42629104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20081100107T CY1107163T1 (en) | 2001-04-06 | 2008-01-31 | GANGLIOSITE-CONNECTED RECOVERY ANTIBODIES AND USE THESE IN DIAGNOSIS AND TREATMENT TREATMENT |
Country Status (2)
| Country | Link |
|---|---|
| CY (1) | CY1107163T1 (en) |
| DE (1) | DE60237322D1 (en) |
-
2002
- 2002-04-08 DE DE60237322T patent/DE60237322D1/en not_active Expired - Lifetime
-
2008
- 2008-01-31 CY CY20081100107T patent/CY1107163T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60237322D1 (en) | 2010-09-23 |
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