CY1106961T1 - Χρηση παραγοντα μειωσης περιεκτικοτητας ομοκυστεϊνης πλασματος για τη μειωση του κινδυνου θρομβοεμβολικης παρενεργειας που προκαλειται απο ορμονες τυπου προγεστερονης - Google Patents
Χρηση παραγοντα μειωσης περιεκτικοτητας ομοκυστεϊνης πλασματος για τη μειωση του κινδυνου θρομβοεμβολικης παρενεργειας που προκαλειται απο ορμονες τυπου προγεστερονηςInfo
- Publication number
- CY1106961T1 CY1106961T1 CY20071101390T CY071101390T CY1106961T1 CY 1106961 T1 CY1106961 T1 CY 1106961T1 CY 20071101390 T CY20071101390 T CY 20071101390T CY 071101390 T CY071101390 T CY 071101390T CY 1106961 T1 CY1106961 T1 CY 1106961T1
- Authority
- CY
- Cyprus
- Prior art keywords
- risk
- reduce
- thomboevological
- parenergy
- homocycine
- Prior art date
Links
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 abstract 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 abstract 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 abstract 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 abstract 1
- 229930003779 Vitamin B12 Natural products 0.000 abstract 1
- 229960004308 acetylcysteine Drugs 0.000 abstract 1
- 229960003237 betaine Drugs 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 abstract 1
- 229960001231 choline Drugs 0.000 abstract 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229960000304 folic acid Drugs 0.000 abstract 1
- 235000019152 folic acid Nutrition 0.000 abstract 1
- 239000011724 folic acid Substances 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 230000009424 thromboembolic effect Effects 0.000 abstract 1
- 235000019163 vitamin B12 Nutrition 0.000 abstract 1
- 239000011715 vitamin B12 Substances 0.000 abstract 1
- 235000019158 vitamin B6 Nutrition 0.000 abstract 1
- 239000011726 vitamin B6 Substances 0.000 abstract 1
- 229940011671 vitamin b6 Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Abstract
Η παρούσα εφεύρεση αφορά φαρμακευτική σύνθεση (συνθέσεις) που περιλαμβάνουν στεροειδή ορμόνη (ορμόνες) τύπου προγεστερόνης και ένωση (ενώσεις) που μειώνουν το επίπεδο ομοκυστεΐνης στο πλάσμα ανθρώπου, ικανές μείωσης του κινδύνου θρομβοεμβολικών παρενεργειών συνθέσεων τύπου προγεστερόνης. Οι παράγοντες μείωσης της περιεκτικότητας ομοκυστεΐνης πλάσματος μπορεί να επιλέγονται από φολικό οξύ, βιταμίνη Β6, βιταμίνη Β12, βεταΐνη, χολίνη, ακετυλοκυστεΐνη και μεταβολικούς προδρόμους, ανάλογα ή και παράγωγα αυτών. Η εφεύρεση επίσης κατευθύνεται στη χρήση των αναφερθέντων παραγόντων μείωσης στο πλάσμα.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9900213A HUP9900213A1 (hu) | 1999-02-01 | 1999-02-01 | Gyógykompozíció(k) gesztagén tipusú hormon tartalmú gyógyszerek thromb-embóliás mellékhatásainak mérséklésére |
EP00903916A EP1148882B1 (en) | 1999-02-01 | 2000-01-28 | Use of a plasma homocysteine content reducing agent for the reduction of the thromboembolic side effect risk induced by gestagen type hormones |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106961T1 true CY1106961T1 (el) | 2012-09-26 |
Family
ID=89997698
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071101390T CY1106961T1 (el) | 1999-02-01 | 2007-10-29 | Χρηση παραγοντα μειωσης περιεκτικοτητας ομοκυστεϊνης πλασματος για τη μειωση του κινδυνου θρομβοεμβολικης παρενεργειας που προκαλειται απο ορμονες τυπου προγεστερονης |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1148882B1 (el) |
AT (1) | ATE368464T1 (el) |
AU (1) | AU2566400A (el) |
CY (1) | CY1106961T1 (el) |
DE (1) | DE60035771T2 (el) |
DK (1) | DK1148882T3 (el) |
ES (1) | ES2286997T3 (el) |
HU (1) | HUP9900213A1 (el) |
PT (1) | PT1148882E (el) |
WO (1) | WO2000044385A1 (el) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3567699A (en) * | 1998-04-17 | 1999-11-08 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Folic acid-containing pharmaceutical compositions, and related methods and delivery systems |
DE102004026671A1 (de) * | 2004-05-28 | 2005-12-15 | Grünenthal GmbH | Darreichungsform zur hormonalen Kontrazeption |
DE102005053771A1 (de) | 2005-11-09 | 2007-05-10 | Grünenthal GmbH | Darreichform zur hormonalen Kontrazeption |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2131292B (en) * | 1982-12-01 | 1987-03-11 | Dr Christopher H Mortimer | Progestational pharmaceutical formulations |
US6214815B1 (en) * | 1998-12-23 | 2001-04-10 | Ortho-Mcneil Pharmaceuticals, Inc. | Triphasic oral contraceptive |
BE1012495A3 (fr) * | 1999-03-02 | 2000-11-07 | Messadek Jallal | La glycine-betaine pour son usage antithrombotique. |
-
1999
- 1999-02-01 HU HU9900213A patent/HUP9900213A1/hu unknown
-
2000
- 2000-01-28 EP EP00903916A patent/EP1148882B1/en not_active Expired - Lifetime
- 2000-01-28 AT AT00903916T patent/ATE368464T1/de not_active IP Right Cessation
- 2000-01-28 DE DE60035771T patent/DE60035771T2/de not_active Expired - Fee Related
- 2000-01-28 DK DK00903916T patent/DK1148882T3/da active
- 2000-01-28 WO PCT/HU2000/000009 patent/WO2000044385A1/en active IP Right Grant
- 2000-01-28 AU AU25664/00A patent/AU2566400A/en not_active Abandoned
- 2000-01-28 ES ES00903916T patent/ES2286997T3/es not_active Expired - Lifetime
- 2000-01-28 PT PT00903916T patent/PT1148882E/pt unknown
-
2007
- 2007-10-29 CY CY20071101390T patent/CY1106961T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2286997T3 (es) | 2007-12-16 |
HUP9900213A1 (hu) | 2000-12-28 |
EP1148882A1 (en) | 2001-10-31 |
DE60035771D1 (de) | 2007-09-13 |
AU2566400A (en) | 2000-08-18 |
DK1148882T3 (da) | 2007-11-26 |
HU9900213D0 (en) | 1999-03-29 |
DE60035771T2 (de) | 2008-04-30 |
EP1148882B1 (en) | 2007-08-01 |
WO2000044385A1 (en) | 2000-08-03 |
ATE368464T1 (de) | 2007-08-15 |
PT1148882E (pt) | 2007-11-08 |
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