CU23698B7 - PROCEDURE FOR THE PREPARATION OF THE CRISTALINA DELTA D FORM OF IVABRADINE CHLORHYDRATE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

PROCEDURE FOR THE PREPARATION OF THE CRISTALINA DELTA D FORM OF IVABRADINE CHLORHYDRATE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

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Publication number
CU23698B7
CU23698B7 CU20060195A CU20060195A CU23698B7 CU 23698 B7 CU23698 B7 CU 23698B7 CU 20060195 A CU20060195 A CU 20060195A CU 20060195 A CU20060195 A CU 20060195A CU 23698 B7 CU23698 B7 CU 23698B7
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CU
Cuba
Prior art keywords
delta
cristalina
procedure
preparation
ivabradine
Prior art date
Application number
CU20060195A
Other languages
Spanish (es)
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CU20060195A7 (en
Inventor
Gerard Damien
Marie-Noelle Auguste
Stephane Horvath
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Servier Lab filed Critical Servier Lab
Priority to CU20060195A priority Critical patent/CU23698B7/en
Publication of CU20060195A7 publication Critical patent/CU20060195A7/en
Publication of CU23698B7 publication Critical patent/CU23698B7/en

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Abstract

La presente invención se refiere a un procedimiento de preparación de la forma cristalina delta d del clorhidrato de ivabradina de fórmula (I) (ESPACIO PARA FÓRMULA) consistiendo en el precalentamientio del acetonitrilo o una mezcla de acetonitrilo y agua, seguidamente se anade el clorhidrato de ivabradina y se enfría la solución obtenida a temperatura ambiente, y se mantiene a esta temperatura hasta la completa cristalización, luego se deshidratan los cristales obtenidos.The present invention relates to a process for preparing the delta d crystalline form of the ivabradine hydrochloride of formula (I) (SPACE FOR FORMULA) consisting of the preheating of acetonitrile or a mixture of acetonitrile and water, then the hydrochloride of Ivabradine and the solution obtained is cooled to room temperature, and is maintained at this temperature until complete crystallization, then the crystals obtained are dehydrated.

CU20060195A 2006-10-11 2006-10-11 PROCEDURE FOR THE PREPARATION OF THE CRISTALINA DELTA D FORM OF IVABRADINE CHLORHYDRATE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM CU23698B7 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CU20060195A CU23698B7 (en) 2006-10-11 2006-10-11 PROCEDURE FOR THE PREPARATION OF THE CRISTALINA DELTA D FORM OF IVABRADINE CHLORHYDRATE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20060195A CU23698B7 (en) 2006-10-11 2006-10-11 PROCEDURE FOR THE PREPARATION OF THE CRISTALINA DELTA D FORM OF IVABRADINE CHLORHYDRATE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (2)

Publication Number Publication Date
CU20060195A7 CU20060195A7 (en) 2010-05-19
CU23698B7 true CU23698B7 (en) 2011-09-21

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CU20060195A CU23698B7 (en) 2006-10-11 2006-10-11 PROCEDURE FOR THE PREPARATION OF THE CRISTALINA DELTA D FORM OF IVABRADINE CHLORHYDRATE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

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CU (1) CU23698B7 (en)

Also Published As

Publication number Publication date
CU20060195A7 (en) 2010-05-19

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