AR068978A1 - N-OXIDES OF VENLAFAXINE AND O-DEMETILVENLAFAXINE AS DRUGS - Google Patents

N-OXIDES OF VENLAFAXINE AND O-DEMETILVENLAFAXINE AS DRUGS

Info

Publication number
AR068978A1
AR068978A1 ARP080102685A ARP080102685A AR068978A1 AR 068978 A1 AR068978 A1 AR 068978A1 AR P080102685 A ARP080102685 A AR P080102685A AR P080102685 A ARP080102685 A AR P080102685A AR 068978 A1 AR068978 A1 AR 068978A1
Authority
AR
Argentina
Prior art keywords
venlafaxine
oxides
refers
oxide
demetilvenlafaxine
Prior art date
Application number
ARP080102685A
Other languages
Spanish (es)
Inventor
Stoit Axel
G Kruse Cornelis
Th M Tulp Martinus
A Turski Lechoslaw
Vader Sander
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of AR068978A1 publication Critical patent/AR068978A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente se refiere al N-óxido de venlafaxina y N-óxido de O-desmetilvenlafaxina como prodrogas de venlafaxina y su principal metabolito (activo) O-desmetilvenlafaxina respectivamente, a composiciones farmacéuticas que contienen estos N-óxidos, a métodos para prepararlos, y métodos para preparar composiciones. La presente se refiere al N-óxido, que tiene la fórmula (1) en donde R¹ es H o CH₃, y tautómeros, estereoisómeros, hidratos y solvatos de los mismos. La presente también se refiere a los usos de los N-óxidos y composiciones, particularmente para la fabricación de medicamentos útiles en el tratamiento de afecciones o enfermedades efectivamente tratables aunque con efectos secundarios, con venlafaxina.This refers to venlafaxine N-oxide and O-desmethylvenlafaxine N-oxide as prodrugs of venlafaxine and its main (active) O-desmethylvenlafaxine metabolite respectively, to pharmaceutical compositions containing these N-oxides, to methods for preparing them, and Methods to prepare compositions. This refers to N-oxide, which has the formula (1) wherein R¹ is H or CH₃, and tautomers, stereoisomers, hydrates and solvates thereof. This also refers to the uses of N-oxides and compositions, particularly for the manufacture of medicaments useful in the treatment of conditions or diseases effectively treatable but with side effects, with venlafaxine.

ARP080102685A 2007-06-26 2008-06-23 N-OXIDES OF VENLAFAXINE AND O-DEMETILVENLAFAXINE AS DRUGS AR068978A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07111028 2007-06-26

Publications (1)

Publication Number Publication Date
AR068978A1 true AR068978A1 (en) 2009-12-23

Family

ID=38626380

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080102685A AR068978A1 (en) 2007-06-26 2008-06-23 N-OXIDES OF VENLAFAXINE AND O-DEMETILVENLAFAXINE AS DRUGS

Country Status (6)

Country Link
JP (1) JP2010531326A (en)
CN (1) CN101939293A (en)
AR (1) AR068978A1 (en)
BR (1) BRPI0813658A2 (en)
TW (1) TW200916092A (en)
ZA (1) ZA200908631B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI490189B (en) * 2011-05-16 2015-07-01 江蘇豪森醫藥集團有限公司 O-demethylation of venlafaxine hydrochloride hydrate and their preparation method
CN103570669B (en) * 2013-10-31 2015-07-22 吉林大学 Brain-targeted O-desmethylvenlafaxine phenolic ester prodrug and preparation method and applications thereof
CN111072505A (en) * 2019-12-27 2020-04-28 合肥华方医药科技有限公司 Preparation method of venlafaxine impurity

Also Published As

Publication number Publication date
JP2010531326A (en) 2010-09-24
ZA200908631B (en) 2010-08-25
CN101939293A (en) 2011-01-05
BRPI0813658A2 (en) 2016-10-18
TW200916092A (en) 2009-04-16

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