AR068978A1 - N-OXIDES OF VENLAFAXINE AND O-DEMETILVENLAFAXINE AS DRUGS - Google Patents
N-OXIDES OF VENLAFAXINE AND O-DEMETILVENLAFAXINE AS DRUGSInfo
- Publication number
- AR068978A1 AR068978A1 ARP080102685A ARP080102685A AR068978A1 AR 068978 A1 AR068978 A1 AR 068978A1 AR P080102685 A ARP080102685 A AR P080102685A AR P080102685 A ARP080102685 A AR P080102685A AR 068978 A1 AR068978 A1 AR 068978A1
- Authority
- AR
- Argentina
- Prior art keywords
- venlafaxine
- oxides
- refers
- oxide
- demetilvenlafaxine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
- C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente se refiere al N-óxido de venlafaxina y N-óxido de O-desmetilvenlafaxina como prodrogas de venlafaxina y su principal metabolito (activo) O-desmetilvenlafaxina respectivamente, a composiciones farmacéuticas que contienen estos N-óxidos, a métodos para prepararlos, y métodos para preparar composiciones. La presente se refiere al N-óxido, que tiene la fórmula (1) en donde R¹ es H o CH₃, y tautómeros, estereoisómeros, hidratos y solvatos de los mismos. La presente también se refiere a los usos de los N-óxidos y composiciones, particularmente para la fabricación de medicamentos útiles en el tratamiento de afecciones o enfermedades efectivamente tratables aunque con efectos secundarios, con venlafaxina.This refers to venlafaxine N-oxide and O-desmethylvenlafaxine N-oxide as prodrugs of venlafaxine and its main (active) O-desmethylvenlafaxine metabolite respectively, to pharmaceutical compositions containing these N-oxides, to methods for preparing them, and Methods to prepare compositions. This refers to N-oxide, which has the formula (1) wherein R¹ is H or CH₃, and tautomers, stereoisomers, hydrates and solvates thereof. This also refers to the uses of N-oxides and compositions, particularly for the manufacture of medicaments useful in the treatment of conditions or diseases effectively treatable but with side effects, with venlafaxine.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07111028 | 2007-06-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR068978A1 true AR068978A1 (en) | 2009-12-23 |
Family
ID=38626380
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080102685A AR068978A1 (en) | 2007-06-26 | 2008-06-23 | N-OXIDES OF VENLAFAXINE AND O-DEMETILVENLAFAXINE AS DRUGS |
Country Status (6)
Country | Link |
---|---|
JP (1) | JP2010531326A (en) |
CN (1) | CN101939293A (en) |
AR (1) | AR068978A1 (en) |
BR (1) | BRPI0813658A2 (en) |
TW (1) | TW200916092A (en) |
ZA (1) | ZA200908631B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI490189B (en) * | 2011-05-16 | 2015-07-01 | 江蘇豪森醫藥集團有限公司 | O-demethylation of venlafaxine hydrochloride hydrate and their preparation method |
CN103570669B (en) * | 2013-10-31 | 2015-07-22 | 吉林大学 | Brain-targeted O-desmethylvenlafaxine phenolic ester prodrug and preparation method and applications thereof |
CN111072505A (en) * | 2019-12-27 | 2020-04-28 | 合肥华方医药科技有限公司 | Preparation method of venlafaxine impurity |
-
2008
- 2008-06-23 CN CN2008800220292A patent/CN101939293A/en active Pending
- 2008-06-23 TW TW097123310A patent/TW200916092A/en unknown
- 2008-06-23 AR ARP080102685A patent/AR068978A1/en not_active Application Discontinuation
- 2008-06-23 BR BRPI0813658A patent/BRPI0813658A2/en not_active IP Right Cessation
- 2008-06-23 JP JP2010513873A patent/JP2010531326A/en not_active Withdrawn
-
2009
- 2009-12-04 ZA ZA200908631A patent/ZA200908631B/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2010531326A (en) | 2010-09-24 |
ZA200908631B (en) | 2010-08-25 |
CN101939293A (en) | 2011-01-05 |
BRPI0813658A2 (en) | 2016-10-18 |
TW200916092A (en) | 2009-04-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |