CU23609B7 - PROCESS TO PRODUCE 3-OXO-PREGN-4-ENO-21,17-CARBOLACTONES BY METAL FREE OXIDATION OF 17- (3-HYDROXYPROPIL) -3,17-DIHYDROXYANDROSTANS - Google Patents
PROCESS TO PRODUCE 3-OXO-PREGN-4-ENO-21,17-CARBOLACTONES BY METAL FREE OXIDATION OF 17- (3-HYDROXYPROPIL) -3,17-DIHYDROXYANDROSTANSInfo
- Publication number
- CU23609B7 CU23609B7 CU20080007A CU20080007A CU23609B7 CU 23609 B7 CU23609 B7 CU 23609B7 CU 20080007 A CU20080007 A CU 20080007A CU 20080007 A CU20080007 A CU 20080007A CU 23609 B7 CU23609 B7 CU 23609B7
- Authority
- CU
- Cuba
- Prior art keywords
- oxo
- carbolactones
- pregn
- eno
- produce
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000003647 oxidation Effects 0.000 title abstract 2
- 238000007254 oxidation reaction Methods 0.000 title abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- BMAXQBBOPJUDSD-OHPXTLHMSA-N (5S,8R,9S,10S,13S,14S)-17-(3-hydroxypropyl)-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthrene-3,17-diol Chemical class OCCCC1(CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2CC[C@H]2CC(CC[C@]12C)O)O BMAXQBBOPJUDSD-OHPXTLHMSA-N 0.000 abstract 1
- ROTZYFNEYFKWQU-DUGPHZPDSA-N (8R,9S,10S,13S,14S,17S)-10,13-dimethylspiro[2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-17,5'-oxolane]-2',3-dione Chemical class C([C@H]1[C@H]2[C@@H]([C@]3(CCC(=O)CC3CC2)C)CC[C@@]11C)C[C@]11CCC(=O)O1 ROTZYFNEYFKWQU-DUGPHZPDSA-N 0.000 abstract 1
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 abstract 1
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 abstract 1
- 229960004845 drospirenone Drugs 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Este invento se refiere a Procesos para producir 3-oxo-pregnano-21,17-carbolactonas de fórmula II, así como 3-oxo-pregn-4-eno-21,17-carbolactonas de fórmula III por oxidación libre de metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos de fórmula I. Además, la invención se refiere al hemisolvato en diclorometano de 6beta, 7beta, 15beta, 16beta-dimetileno-3-oxo-17alfa-pregnan-5beta-ol-21,17-carbolactona (IV) así como a un proceso para producir drospirenona.This invention relates to Processes for producing 3-oxo-pregnan-21.17-carbolactones of formula II, as well as 3-oxo-pregn-4-eno-21.17-carbolactones of formula III by metal-free oxidation of 17 - (3-hydroxypropyl) -3,17-dihydroxyandrostanes of formula I. In addition, the invention relates to the hemisolvate in dichloromethane of 6 beta, 7 beta, 15 beta, 16 beta-dimethylene-3-oxo-17 alpha-pregnan-5 beta-ol-21 , 17-carbolactone (IV) as well as a process to produce drospirenone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20080007A CU23609B7 (en) | 2008-01-18 | 2008-01-18 | PROCESS TO PRODUCE 3-OXO-PREGN-4-ENO-21,17-CARBOLACTONES BY METAL FREE OXIDATION OF 17- (3-HYDROXYPROPIL) -3,17-DIHYDROXYANDROSTANS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20080007A CU23609B7 (en) | 2008-01-18 | 2008-01-18 | PROCESS TO PRODUCE 3-OXO-PREGN-4-ENO-21,17-CARBOLACTONES BY METAL FREE OXIDATION OF 17- (3-HYDROXYPROPIL) -3,17-DIHYDROXYANDROSTANS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20080007A7 CU20080007A7 (en) | 2010-05-19 |
| CU23609B7 true CU23609B7 (en) | 2010-12-08 |
Family
ID=43401426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU20080007A CU23609B7 (en) | 2008-01-18 | 2008-01-18 | PROCESS TO PRODUCE 3-OXO-PREGN-4-ENO-21,17-CARBOLACTONES BY METAL FREE OXIDATION OF 17- (3-HYDROXYPROPIL) -3,17-DIHYDROXYANDROSTANS |
Country Status (1)
| Country | Link |
|---|---|
| CU (1) | CU23609B7 (en) |
-
2008
- 2008-01-18 CU CU20080007A patent/CU23609B7/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CU20080007A7 (en) | 2010-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant of patent |