CU23553A1 - Péptidos que mimetizan las regiones antigénicas del virus de la hepatitis a - Google Patents

Péptidos que mimetizan las regiones antigénicas del virus de la hepatitis a

Info

Publication number
CU23553A1
CU23553A1 CU20040270A CU20040270A CU23553A1 CU 23553 A1 CU23553 A1 CU 23553A1 CU 20040270 A CU20040270 A CU 20040270A CU 20040270 A CU20040270 A CU 20040270A CU 23553 A1 CU23553 A1 CU 23553A1
Authority
CU
Cuba
Prior art keywords
peptides
mimetize
hepatitis
hepatitis virus
antigenic regions
Prior art date
Application number
CU20040270A
Other languages
English (en)
Inventor
Gonzalez Gustavo Sierra
Blanco Nevis Amin
David Stott
Casanova Frank Camacho
Casanueva Raiza Martinez
Diaz Osmany Larralde
Hernandez Ela Maria Perez
Coronel Arturo Talavera
Original Assignee
Univ Glasgow Div Immunology
Inst Finlay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Glasgow Div Immunology, Inst Finlay filed Critical Univ Glasgow Div Immunology
Priority to CU20040270A priority Critical patent/CU23553A1/es
Priority to CA002623753A priority patent/CA2623753A1/en
Priority to EP05819161A priority patent/EP1832602A1/en
Priority to BRPI0517139-3A priority patent/BRPI0517139A/pt
Priority to PCT/CU2005/000011 priority patent/WO2006060969A1/es
Priority to ZA200705034A priority patent/ZA200705034B/xx
Publication of CU23553A1 publication Critical patent/CU23553A1/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5768—Hepatitis A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
    • C12N2770/32422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32411—Hepatovirus, i.e. hepatitis A virus
    • C12N2770/32434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención describe la obtención de péptidos a partir de librerías al azar de fagos recombinantes que comprenden epítopes capaces de reaccionar con sueros de pacientes convalescientes de hepatitis A. Estas secuencias de aminoácidos no son exactas a la secuencia aminoácidica que se encuentra en los péptidos de las proteínas que conforman las regiones inmunogénicas y neutralizantes del virus de la hepatitis A (VHA). Estos péptidos o sus combinaciones pueden ser útiles en la detección de anticuerpos contra el VHA en muestras biológicas y en la inducción de respuestas inmunes en humanos y animales.
CU20040270A 2004-12-06 2004-12-06 Péptidos que mimetizan las regiones antigénicas del virus de la hepatitis a CU23553A1 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CU20040270A CU23553A1 (es) 2004-12-06 2004-12-06 Péptidos que mimetizan las regiones antigénicas del virus de la hepatitis a
CA002623753A CA2623753A1 (en) 2004-12-06 2005-12-06 Peptides which mimic the antigenic regions of the hepatitis a virus
EP05819161A EP1832602A1 (en) 2004-12-06 2005-12-06 Peptides which mimic the antigenic regions of the hepatitis a virus
BRPI0517139-3A BRPI0517139A (pt) 2004-12-06 2005-12-06 peptìdeos que imitam as regiões antigênicas do vìrus da hepatite a
PCT/CU2005/000011 WO2006060969A1 (es) 2004-12-06 2005-12-06 Péptidos que mimetizan las regiones antigénicas del virus de la hepatitis a
ZA200705034A ZA200705034B (en) 2004-12-06 2007-06-05 Peptides which mimic the antigenic regions of the hepatitis A virus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20040270A CU23553A1 (es) 2004-12-06 2004-12-06 Péptidos que mimetizan las regiones antigénicas del virus de la hepatitis a

Publications (1)

Publication Number Publication Date
CU23553A1 true CU23553A1 (es) 2010-07-20

Family

ID=36577673

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20040270A CU23553A1 (es) 2004-12-06 2004-12-06 Péptidos que mimetizan las regiones antigénicas del virus de la hepatitis a

Country Status (6)

Country Link
EP (1) EP1832602A1 (es)
BR (1) BRPI0517139A (es)
CA (1) CA2623753A1 (es)
CU (1) CU23553A1 (es)
WO (1) WO2006060969A1 (es)
ZA (1) ZA200705034B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115537456A (zh) * 2022-08-01 2022-12-30 北京中医药大学 噬菌体展示介导的免疫多重定量pcr方法及其重组噬菌体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0705841A1 (en) * 1994-10-05 1996-04-10 SORIN BIOMEDICA S.p.A. Peptides havng antigenic activity against hepatitis A virus (HAV)
US7223535B2 (en) * 1996-04-19 2007-05-29 Centers For Disease Control Synthetic peptides immunoreactive with hepatitis A virus antibodies
CA2378924A1 (en) * 1999-07-15 2001-01-25 Howard A. Fields Synthetic peptides immunoreactive with hepatitis a virus antibodies

Also Published As

Publication number Publication date
EP1832602A1 (en) 2007-09-12
BRPI0517139A (pt) 2008-09-30
ZA200705034B (en) 2008-09-25
CA2623753A1 (en) 2006-06-15
WO2006060969A1 (es) 2006-06-15

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Legal Events

Date Code Title Description
FG Grant of patent