CU22932A1 - Procedimiento para la obtención del 2-bromo-5-(2-bromo-2-nitrovinil)-furano - Google Patents

Procedimiento para la obtención del 2-bromo-5-(2-bromo-2-nitrovinil)-furano

Info

Publication number
CU22932A1
CU22932A1 CU20000008A CU20000008A CU22932A1 CU 22932 A1 CU22932 A1 CU 22932A1 CU 20000008 A CU20000008 A CU 20000008A CU 20000008 A CU20000008 A CU 20000008A CU 22932 A1 CU22932 A1 CU 22932A1
Authority
CU
Cuba
Prior art keywords
reaction
bromo
obtaining
nitrovinylfuran
reduce
Prior art date
Application number
CU20000008A
Other languages
English (en)
Inventor
Placeres Teofilo Exiquio Gaitan
Cancio Nilo Ramon Castanedo
Original Assignee
Ct De Bioactivos Quimicos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct De Bioactivos Quimicos filed Critical Ct De Bioactivos Quimicos
Priority to CU20000008A priority Critical patent/CU22932A1/es
Priority to JP2001553758A priority patent/JP2003520793A/ja
Priority to PCT/CU2001/000001 priority patent/WO2001053283A1/es
Priority to AU2001228257A priority patent/AU2001228257A1/en
Priority to MXPA02007064A priority patent/MXPA02007064A/es
Priority to CNB018038425A priority patent/CN1164581C/zh
Priority to DE60100791T priority patent/DE60100791T2/de
Priority to AT01942623T priority patent/ATE250049T1/de
Priority to ES01942623T priority patent/ES2208606T3/es
Priority to US10/181,541 priority patent/US6624316B2/en
Priority to BRPI0107723-6A priority patent/BR0107723B1/pt
Priority to EP01942623A priority patent/EP1249449B1/en
Priority to HK03104639.6A priority patent/HK1052353B/zh
Publication of CU22932A1 publication Critical patent/CU22932A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención se refiere a un nuevo procedimiento de obtención y purificación del 2-bromo-5-(2-bromo-2-nitrovinil)-furano en un paso de reacción a partir del 2-nitrovinilfurano manteniendo los altos índices de pureza y un adecuado rendimiento. El proceso involucra la bromación directa del 2-nitrovinilfurano utilizando desde el inicio de la reacción carbón activado, seguido de la neutralización y deshidrobromación empleando piridina, cristalizando y purificando finalmente el producto obtenido con etanol y carbón. Con el nuevo procedimiento se logra reducir el tiempo de obtención, la reacción pasa de exotérmica a endotérmica lo cual facilita el trabajo de los operarios y permite desarrollar el escalado de la reacción a mayores niveles de producción. Se reducen considerablemente las cantidades de los reactivos que intervienen en la reacción, algunos de los cuales con propiedades tóxicas, disminuye el impacto negativo ambiental del proceso al eliminarse los vapores de bromo y otras sustancias al medio ambiente y reducirse a la mitad los residuales líquidos.
CU20000008A 2000-01-18 2000-01-18 Procedimiento para la obtención del 2-bromo-5-(2-bromo-2-nitrovinil)-furano CU22932A1 (es)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CU20000008A CU22932A1 (es) 2000-01-18 2000-01-18 Procedimiento para la obtención del 2-bromo-5-(2-bromo-2-nitrovinil)-furano
JP2001553758A JP2003520793A (ja) 2000-01-18 2001-01-18 ２−ブロモ−５−（２−ブロモ−２−ニトロビニル）−フランを得る方法
PCT/CU2001/000001 WO2001053283A1 (es) 2000-01-18 2001-01-18 Procedimiento para la obtención de 2-bromo-5-(2-bromo-2-nitrovinil)-furano
AU2001228257A AU2001228257A1 (en) 2000-01-18 2001-01-18 Method for obtaining 2-bromo-5-(2-bromo-2-nitrovinyl)-furan
MXPA02007064A MXPA02007064A (es) 2000-01-18 2001-01-18 Procedimiento para la obtencion de 2-bromo-5-(2-bromo-2-nitrovinil)-furano.
CNB018038425A CN1164581C (zh) 2000-01-18 2001-01-18 2-溴-5-(2-溴-2-硝基乙烯基)-呋喃的合成方法
DE60100791T DE60100791T2 (de) 2000-01-18 2001-01-18 Verfahren um 2-brom-5-(2-brom-2-nitrovinyl)-furan zu erhalten
AT01942623T ATE250049T1 (de) 2000-01-18 2001-01-18 Verfahren um 2-brom-5-(2-brom-2-nitrovinyl)-furan zu erhalten
ES01942623T ES2208606T3 (es) 2000-01-18 2001-01-18 Procedimiento de obtencion de 2-bromo-5-(2-bromo-2-nitrovinil)-furano.
US10/181,541 US6624316B2 (en) 2000-01-18 2001-01-18 Method for obtaining 2-bromo-5-(2-bromo-2-nitrovinyl)-furan
BRPI0107723-6A BR0107723B1 (pt) 2000-01-18 2001-01-18 processo para a obtenÇço do 2-bromo-5-(2-bromo-2-nitrovinil)-furano.
EP01942623A EP1249449B1 (en) 2000-01-18 2001-01-18 Method for obtaining 2-bromo-5-(2-bromo-2-nitrovinyl)-furan
HK03104639.6A HK1052353B (zh) 2000-01-18 2003-06-30 2-溴-5-(2-溴-2-硝基乙烯基)-呋喃的合成方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20000008A CU22932A1 (es) 2000-01-18 2000-01-18 Procedimiento para la obtención del 2-bromo-5-(2-bromo-2-nitrovinil)-furano

Publications (1)

Publication Number Publication Date
CU22932A1 true CU22932A1 (es) 2004-02-20

Family

ID=5459164

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20000008A CU22932A1 (es) 2000-01-18 2000-01-18 Procedimiento para la obtención del 2-bromo-5-(2-bromo-2-nitrovinil)-furano

Country Status (13)

Country Link
US (1) US6624316B2 (es)
EP (1) EP1249449B1 (es)
JP (1) JP2003520793A (es)
CN (1) CN1164581C (es)
AT (1) ATE250049T1 (es)
AU (1) AU2001228257A1 (es)
BR (1) BR0107723B1 (es)
CU (1) CU22932A1 (es)
DE (1) DE60100791T2 (es)
ES (1) ES2208606T3 (es)
HK (1) HK1052353B (es)
MX (1) MXPA02007064A (es)
WO (1) WO2001053283A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU23506B6 (es) * 2005-09-26 2010-04-13 Ct Bioactivos Quimicos Univers Composiciones farmacéuticas que contienen derivados nitrovinilfuránicos para el tratamiento de la leishmaniosis y la tripanosomosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2668481B1 (fr) * 1990-10-31 1994-06-10 Potasse Produits Chimiques Procede de debromation de derives dibromes du naphtalene.
CU22446A1 (es) * 1994-04-21 2001-06-01 Ct De Bioactivos Quimicos Procedimiento de obtención del 1-(5-bromofur-2-il)-2-bromo-2-nitroeteno y su acción como microcida
JPH10309464A (ja) * 1997-03-12 1998-11-24 Daikin Ind Ltd １，１，１，３，３−ペンタフルオロプロパンの製造方法

Also Published As

Publication number Publication date
US6624316B2 (en) 2003-09-23
HK1052353B (zh) 2005-05-06
JP2003520793A (ja) 2003-07-08
DE60100791D1 (de) 2003-10-23
CN1164581C (zh) 2004-09-01
WO2001053283A1 (es) 2001-07-26
AU2001228257A1 (en) 2001-07-31
US20030130529A1 (en) 2003-07-10
MXPA02007064A (es) 2003-09-25
HK1052353A1 (en) 2003-09-11
EP1249449B1 (en) 2003-09-17
ATE250049T1 (de) 2003-10-15
BR0107723A (pt) 2003-07-22
EP1249449A1 (en) 2002-10-16
DE60100791T2 (de) 2004-07-01
BR0107723B1 (pt) 2013-01-22
ES2208606T3 (es) 2004-06-16
CN1395572A (zh) 2003-02-05

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