CU20160044A7 - DERIVATIVES OF 2,4 DIOXO-1,2,3,4-TETRAHYDROTIENE (2,3-d) PYRIMIDINE-6-CARBOXAMIDS AS ANTAGONISTS OF A2b RECEPTORS OF ADENOSINE - Google Patents
DERIVATIVES OF 2,4 DIOXO-1,2,3,4-TETRAHYDROTIENE (2,3-d) PYRIMIDINE-6-CARBOXAMIDS AS ANTAGONISTS OF A2b RECEPTORS OF ADENOSINEInfo
- Publication number
- CU20160044A7 CU20160044A7 CUP2016000044A CU20160044A CU20160044A7 CU 20160044 A7 CU20160044 A7 CU 20160044A7 CU P2016000044 A CUP2016000044 A CU P2016000044A CU 20160044 A CU20160044 A CU 20160044A CU 20160044 A7 CU20160044 A7 CU 20160044A7
- Authority
- CU
- Cuba
- Prior art keywords
- antagonists
- tetrahydrotiene
- dioxo
- adenosine
- pyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
La presente soiLicitud se relaciona con novedosos derivados de 2,4-dioxo-1,2,3,4-tetrahidrotieno[2,3-d]pirimidina-6-carboxamida ("tienouracil"-carboxamidas), con fórmula general I ESPACIO PARA FÓRMULA como antagonistas de receptores A2b de adenosina y a los medicamentos que los comprenden, solos o en combinación con uno o más compuestos activos adicionales seleccionados del grupo de los inhibidores de PDE 5 activadores de sGC, estimuladores de sGC, análogos de protaciclina, antagonistas de protaciclina, antagonistas de endotelina, de los agentes antifibróticos, los agentes antiinflamatorios, inmunomodulantes inmunosupresores y/o citotóxivos y/o los compuestos de inhibición de la cascada de transducción de la señalThe present application relates to novel derivatives of 2,4-dioxo-1,2,3,4-tetrahydrotiene [2,3-d] pyrimidine-6-carboxamide ("thienouracil" -carboxamides), with general formula I SPACE FOR FORMULA as adenosine A2b receptor antagonists and the drugs that comprise them, alone or in combination with one or more additional active compounds selected from the group of sGC activating PDE 5 inhibitors, sGC stimulators, protacycline analogs, protacycline antagonists , endothelin antagonists, antifibrotic agents, anti-inflammatory agents, immunosuppressive and / or cytotoxic immunomodulants and / or signal transduction cascade inhibition compounds
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13187487 | 2013-10-07 | ||
EP14152518 | 2014-01-24 | ||
PCT/EP2014/071113 WO2015052065A1 (en) | 2013-10-07 | 2014-10-02 | Cyclic thienouracil-carboxamides and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CU20160044A7 true CU20160044A7 (en) | 2016-09-30 |
Family
ID=51655757
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CUP2016000044A CU20160044A7 (en) | 2013-10-07 | 2016-04-07 | DERIVATIVES OF 2,4 DIOXO-1,2,3,4-TETRAHYDROTIENE (2,3-d) PYRIMIDINE-6-CARBOXAMIDS AS ANTAGONISTS OF A2b RECEPTORS OF ADENOSINE |
Country Status (24)
Country | Link |
---|---|
US (2) | US9604996B2 (en) |
EP (1) | EP3055313B1 (en) |
JP (1) | JP2016532721A (en) |
KR (1) | KR20160065957A (en) |
CN (1) | CN105793267B (en) |
AP (1) | AP2016009128A0 (en) |
AU (1) | AU2014334040A1 (en) |
BR (1) | BR112016007238A2 (en) |
CA (1) | CA2926223A1 (en) |
CR (1) | CR20160155A (en) |
CU (1) | CU20160044A7 (en) |
DO (1) | DOP2016000076A (en) |
EA (1) | EA201600318A1 (en) |
ES (1) | ES2659043T3 (en) |
IL (1) | IL244751A0 (en) |
MX (1) | MX2016004250A (en) |
NI (1) | NI201600047A (en) |
PE (1) | PE20160562A1 (en) |
PH (1) | PH12016500608A1 (en) |
SG (1) | SG11201602397XA (en) |
TN (1) | TN2016000121A1 (en) |
TW (1) | TW201607950A (en) |
UY (1) | UY35771A (en) |
WO (1) | WO2015052065A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107074783B (en) * | 2014-11-03 | 2020-06-05 | 拜耳制药股份公司 | Hydroxyalkyl substituted phenyl triazole derivatives and uses thereof |
UY36586A (en) | 2015-03-26 | 2016-10-31 | Bayer Pharma AG | HETEROCICLILMETILTIENOURACILOS AND USE OF THE SAME |
AU2017292918B2 (en) * | 2016-07-07 | 2021-11-11 | Cardurion Pharmaceuticals, Llc | Methods for treatment of heart failure |
WO2018041771A1 (en) | 2016-09-02 | 2018-03-08 | Bayer Pharma Aktiengesellschaft | (1-methylcyclopropyl)methyl-substituted thienouraciles and use thereof |
US20200016159A1 (en) * | 2016-09-23 | 2020-01-16 | Bayer Aktiengesellschaft | N3-cyclically substituted thienouracils and use thereof |
WO2024037532A1 (en) * | 2022-08-16 | 2024-02-22 | 深圳市康哲生物科技有限公司 | Salt type and crystal form of thienopyrimidinone derivative |
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US5344830A (en) | 1992-12-10 | 1994-09-06 | Merck & Co., Inc. | N,N-diacylpiperazine tachykinin antagonists |
SE9702001D0 (en) | 1997-05-28 | 1997-05-28 | Astra Pharma Prod | Novel compounds |
DE19834044A1 (en) | 1998-07-29 | 2000-02-03 | Bayer Ag | New substituted pyrazole derivatives |
DE19834047A1 (en) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituted pyrazole derivatives |
WO2000012514A1 (en) | 1998-08-28 | 2000-03-09 | Astrazeneca Ab | Novel compounds |
DE19943639A1 (en) | 1999-09-13 | 2001-03-15 | Bayer Ag | Dicarboxylic acid derivatives with novel pharmaceutical properties |
DE19943634A1 (en) | 1999-09-13 | 2001-04-12 | Bayer Ag | Novel dicarboxylic acid derivatives with pharmaceutical properties |
DE19943635A1 (en) | 1999-09-13 | 2001-03-15 | Bayer Ag | Novel aminodicarboxylic acid derivatives with pharmaceutical properties |
DE19943636A1 (en) | 1999-09-13 | 2001-03-15 | Bayer Ag | Novel dicarboxylic acid derivatives with pharmaceutical properties |
AR031176A1 (en) | 2000-11-22 | 2003-09-10 | Bayer Ag | NEW DERIVATIVES OF PIRAZOLPIRIDINA SUBSTITUTED WITH PIRIDINE |
EP1370562A1 (en) | 2001-02-14 | 2003-12-17 | Warner-Lambert Company LLC | Thieno[2,3-d]pyrimidindione derivatives as matrix metalloproteinase inhibitors |
PA8539301A1 (en) * | 2001-02-14 | 2002-09-30 | Warner Lambert Co | INHIBITORS OF THE METALOPROTEINASE OF THE MATRIX |
DE10110749A1 (en) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituted aminodicarboxylic acid derivatives |
DE10110750A1 (en) | 2001-03-07 | 2002-09-12 | Bayer Ag | Novel aminodicarboxylic acid derivatives with pharmaceutical properties |
US6951849B2 (en) | 2001-10-02 | 2005-10-04 | Acadia Pharmaceuticals Inc. | Benzimidazolidinone derivatives as muscarinic agents |
KR100960827B1 (en) * | 2001-12-20 | 2010-06-08 | 오에스아이 파마슈티컬스, 인코포레이티드 | PYRROLOPYRIMIDINE A2b SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE |
DE10220570A1 (en) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamate-substituted pyrazolopyridines |
WO2004014916A1 (en) | 2002-08-13 | 2004-02-19 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
DE102004017934A1 (en) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New alkyne compounds having MCH antagonist activity and medicaments containing these compounds |
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GB0412467D0 (en) | 2004-06-04 | 2004-07-07 | Astrazeneca Ab | Chemical compounds |
WO2006083005A1 (en) | 2005-02-03 | 2006-08-10 | Takeda Pharmaceutical Company Limited | Fused pyrimidine derivative and used thereof |
CA2644996A1 (en) | 2006-03-02 | 2007-09-13 | Cv Therapeutics, Inc. | A2a adenosine receptor antagonists |
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JP2010511628A (en) * | 2006-12-01 | 2010-04-15 | ギリアード・パロ・アルト・インコーポレイテッド | A2A adenosine receptor antagonist |
WO2008115912A1 (en) | 2007-03-21 | 2008-09-25 | Sanofi-Aventis | Regio-specific synthesis of 4-bromo-3-methyl-5-propoxy-thiophene-2-carboxylic acid |
US7928111B2 (en) | 2007-06-08 | 2011-04-19 | Senomyx, Inc. | Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors |
US7947629B2 (en) * | 2007-08-06 | 2011-05-24 | Schlumberger Technology Corporation | Method of acidizing sandstone formations |
GB0718432D0 (en) * | 2007-09-21 | 2007-10-31 | Vernalis R&D Ltd | New chemical compounds |
AU2010211672B2 (en) | 2009-02-06 | 2016-08-04 | Nippon Shinyaku Co., Ltd. | Aminopyrazine derivative and medicine |
DE102010021637A1 (en) | 2010-05-26 | 2011-12-01 | Bayer Schering Pharma Aktiengesellschaft | Substituted 5-fluoro-1H-pyrazolopyridines and their use |
CN106977530A (en) | 2010-07-09 | 2017-07-25 | 拜耳知识产权有限责任公司 | Ring fusion pyrimidine and triazine and its be used for treat and/or prevention of cardiovascular disease purposes |
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DE102010043379A1 (en) | 2010-11-04 | 2012-05-10 | Bayer Schering Pharma Aktiengesellschaft | Substituted 6-fluoro-1H-pyrazolo [4,3-b] pyridines and their use |
CN104105485B (en) | 2011-11-11 | 2017-04-12 | 吉利德阿波罗公司 | Acc inhibitors and uses thereof |
-
2014
- 2014-10-02 MX MX2016004250A patent/MX2016004250A/en unknown
- 2014-10-02 CN CN201480066573.2A patent/CN105793267B/en not_active Expired - Fee Related
- 2014-10-02 CA CA2926223A patent/CA2926223A1/en not_active Abandoned
- 2014-10-02 EP EP14777656.1A patent/EP3055313B1/en not_active Not-in-force
- 2014-10-02 WO PCT/EP2014/071113 patent/WO2015052065A1/en active Application Filing
- 2014-10-02 EA EA201600318A patent/EA201600318A1/en unknown
- 2014-10-02 AP AP2016009128A patent/AP2016009128A0/en unknown
- 2014-10-02 SG SG11201602397XA patent/SG11201602397XA/en unknown
- 2014-10-02 PE PE2016000459A patent/PE20160562A1/en not_active Application Discontinuation
- 2014-10-02 JP JP2016546163A patent/JP2016532721A/en active Pending
- 2014-10-02 AU AU2014334040A patent/AU2014334040A1/en not_active Abandoned
- 2014-10-02 ES ES14777656.1T patent/ES2659043T3/en active Active
- 2014-10-02 KR KR1020167011778A patent/KR20160065957A/en not_active Application Discontinuation
- 2014-10-02 TN TN2016000121A patent/TN2016000121A1/en unknown
- 2014-10-02 BR BR112016007238A patent/BR112016007238A2/en not_active Application Discontinuation
- 2014-10-02 US US15/027,519 patent/US9604996B2/en not_active Expired - Fee Related
- 2014-10-03 UY UY0001035771A patent/UY35771A/en not_active Application Discontinuation
- 2014-10-03 TW TW103134497A patent/TW201607950A/en unknown
-
2016
- 2016-03-24 IL IL244751A patent/IL244751A0/en unknown
- 2016-04-04 CR CR20160155A patent/CR20160155A/en unknown
- 2016-04-04 PH PH12016500608A patent/PH12016500608A1/en unknown
- 2016-04-05 DO DO2016000076A patent/DOP2016000076A/en unknown
- 2016-04-06 NI NI201600047A patent/NI201600047A/en unknown
- 2016-04-07 CU CUP2016000044A patent/CU20160044A7/en unknown
-
2017
- 2017-02-02 US US15/423,447 patent/US20170145029A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
IL244751A0 (en) | 2016-04-21 |
TN2016000121A1 (en) | 2017-10-06 |
BR112016007238A2 (en) | 2017-08-01 |
US20170145029A1 (en) | 2017-05-25 |
CN105793267A (en) | 2016-07-20 |
US9604996B2 (en) | 2017-03-28 |
DOP2016000076A (en) | 2016-05-15 |
CR20160155A (en) | 2016-07-21 |
NI201600047A (en) | 2016-09-21 |
WO2015052065A1 (en) | 2015-04-16 |
TW201607950A (en) | 2016-03-01 |
KR20160065957A (en) | 2016-06-09 |
SG11201602397XA (en) | 2016-05-30 |
PH12016500608A1 (en) | 2016-06-13 |
AU2014334040A1 (en) | 2016-04-28 |
EA201600318A1 (en) | 2016-09-30 |
EP3055313A1 (en) | 2016-08-17 |
JP2016532721A (en) | 2016-10-20 |
US20160244461A1 (en) | 2016-08-25 |
ES2659043T3 (en) | 2018-03-13 |
PE20160562A1 (en) | 2016-06-05 |
CN105793267B (en) | 2018-02-06 |
MX2016004250A (en) | 2016-07-12 |
UY35771A (en) | 2015-04-30 |
CA2926223A1 (en) | 2015-04-16 |
EP3055313B1 (en) | 2017-11-22 |
AP2016009128A0 (en) | 2016-04-30 |
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