CS738585A2 - Zpusob vyroby l fenylalaninu a l tryptofanu - Google Patents
Zpusob vyroby l fenylalaninu a l tryptofanuInfo
- Publication number
- CS738585A2 CS738585A2 CS857385A CS738585A CS738585A2 CS 738585 A2 CS738585 A2 CS 738585A2 CS 857385 A CS857385 A CS 857385A CS 738585 A CS738585 A CS 738585A CS 738585 A2 CS738585 A2 CS 738585A2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- tryptofanu
- fenylalaninu
- racemate
- ester
- extracted
- Prior art date
Links
- 150000008575 L-amino acids Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000012670 alkaline solution Substances 0.000 abstract 2
- 238000003776 cleavage reaction Methods 0.000 abstract 2
- 230000002255 enzymatic effect Effects 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000007017 scission Effects 0.000 abstract 2
- 150000008574 D-amino acids Chemical class 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 108010027597 alpha-chymotrypsin Proteins 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1. A process for the preparation of aromatically substituted L-amino acids by enzymatic cleavage of the racemate of the lower alkyl esters (except tert.-butylester) using alpha-chymotrypsin in the weakly acid pH range and extraction of the ester of the D form, which comprises the reaction mixture obtained in the enzymatic cleavage being made weakly alkaline, the ester of the D-amino acid being extracted from this alkaline solution using an organic solvent, and being racemized, whereupon the racemate is returned to the process, and the extracted alkaline solution being made weakly acid, whereupon the L-amino acid is isolated from it.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843438189 DE3438189A1 (en) | 1984-10-18 | 1984-10-18 | METHOD FOR PRODUCING AROMATICALLY SUBSTITUTED L-AMINO ACIDS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS738585A2 true CS738585A2 (en) | 1987-12-17 |
| CS258132B2 CS258132B2 (en) | 1988-07-15 |
Family
ID=6248201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS857385A CS258132B2 (en) | 1984-10-18 | 1985-10-16 | Method of l-phenylalanine and l-tryphtofan production |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0178553B1 (en) |
| JP (1) | JPS61108398A (en) |
| AT (1) | ATE56472T1 (en) |
| CA (1) | CA1265083A (en) |
| CS (1) | CS258132B2 (en) |
| DE (2) | DE3438189A1 (en) |
| DK (1) | DK475585A (en) |
| ES (1) | ES8609186A1 (en) |
| FI (1) | FI854025A7 (en) |
| GR (1) | GR852491B (en) |
| HU (1) | HUT39414A (en) |
| IL (1) | IL76740A0 (en) |
| NO (1) | NO854127L (en) |
| PT (1) | PT81320B (en) |
| ZA (1) | ZA857971B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3618465A1 (en) * | 1986-06-02 | 1987-12-03 | Hoechst Ag | CARRYING OUT BIO CATALYST REACTIONS IN A FLUID BED REACTOR WITH A 2-PHASE LIQUID SYSTEM |
| DE3622662A1 (en) * | 1986-07-05 | 1988-01-14 | Hoechst Ag | METHOD FOR CONTINUOUS BIOCATALYTIC IMPLEMENTATION OF SUBSTRATES WHICH ARE SLIGHTLY SOLUBLE IN AQUEOUS SOLUTIONS |
| US5002871A (en) * | 1986-08-18 | 1991-03-26 | The Coca-Cola Company | Enzymatic membrane method for the synthesis and separation of peptides |
| DE3839379A1 (en) * | 1988-11-22 | 1990-05-23 | Hoechst Ag | METHOD FOR PRODUCING TRIPEPTIDES |
| US5025325A (en) * | 1989-10-13 | 1991-06-18 | Hewlett-Packard Company | Graphics scaling method for high resolution printers |
| DE19546532C2 (en) * | 1995-12-13 | 2000-04-20 | Degussa | Process for obtaining optically active L-alpha-aminocarboxylic acids from corresponding racemic D, L-alpha-aminocarboxylic acids |
| FR2778671B1 (en) | 1998-05-14 | 2002-07-05 | Rhone Poulenc Agrochimie | NEW PROCESS FOR THE PREPARATION OF SYNTHESIS INTERMEDIATES |
| HU228360B1 (en) | 2001-09-25 | 2013-03-28 | Hoffmann La Roche | Enzymatic process for the preparation of substituted 2-amino-3-(2-amino-phenylsulfanyl)-propionic acid |
| JP5028672B2 (en) * | 2007-05-23 | 2012-09-19 | ボイス パテント ゲーエムベーハー | Waste paper cutting rotor |
| JP4934881B2 (en) * | 2007-05-23 | 2012-05-23 | ボイス パテント ゲーエムベーハー | Waste paper cutting rotor |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA947214A (en) * | 1971-04-02 | 1974-05-14 | Antoine D'iorio | Resolution of racemates of ring-substituted phenylalanines |
| US3878043A (en) * | 1973-01-02 | 1975-04-15 | Univ Southern Illinois | Method for preparing L-dopa and novels compounds useful therein |
-
1984
- 1984-10-18 DE DE19843438189 patent/DE3438189A1/en not_active Withdrawn
-
1985
- 1985-10-04 EP EP85112563A patent/EP0178553B1/en not_active Expired - Lifetime
- 1985-10-04 AT AT85112563T patent/ATE56472T1/en not_active IP Right Cessation
- 1985-10-04 DE DE8585112563T patent/DE3579663D1/en not_active Expired - Fee Related
- 1985-10-14 HU HU853963A patent/HUT39414A/en unknown
- 1985-10-15 GR GR852491A patent/GR852491B/el unknown
- 1985-10-16 CS CS857385A patent/CS258132B2/en unknown
- 1985-10-16 ES ES547901A patent/ES8609186A1/en not_active Expired
- 1985-10-16 FI FI854025A patent/FI854025A7/en not_active Application Discontinuation
- 1985-10-17 NO NO854127A patent/NO854127L/en unknown
- 1985-10-17 JP JP60230056A patent/JPS61108398A/en active Pending
- 1985-10-17 PT PT81320A patent/PT81320B/en unknown
- 1985-10-17 CA CA000493202A patent/CA1265083A/en not_active Expired - Fee Related
- 1985-10-17 IL IL76740A patent/IL76740A0/en unknown
- 1985-10-17 DK DK475585A patent/DK475585A/en not_active Application Discontinuation
- 1985-10-17 ZA ZA857971A patent/ZA857971B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE3438189A1 (en) | 1986-04-24 |
| ATE56472T1 (en) | 1990-09-15 |
| ES8609186A1 (en) | 1986-09-01 |
| CA1265083A (en) | 1990-01-30 |
| PT81320A (en) | 1985-11-01 |
| ZA857971B (en) | 1986-05-28 |
| EP0178553A2 (en) | 1986-04-23 |
| DK475585D0 (en) | 1985-10-17 |
| DK475585A (en) | 1986-04-19 |
| CS258132B2 (en) | 1988-07-15 |
| FI854025A0 (en) | 1985-10-16 |
| PT81320B (en) | 1987-05-18 |
| FI854025L (en) | 1986-04-19 |
| IL76740A0 (en) | 1986-02-28 |
| FI854025A7 (en) | 1986-04-19 |
| EP0178553A3 (en) | 1987-04-29 |
| NO854127L (en) | 1986-04-21 |
| DE3579663D1 (en) | 1990-10-18 |
| ES547901A0 (en) | 1986-09-01 |
| JPS61108398A (en) | 1986-05-27 |
| EP0178553B1 (en) | 1990-09-12 |
| HUT39414A (en) | 1986-09-29 |
| GR852491B (en) | 1986-02-11 |
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